Post infectious fatigue and circadian rhythm disruption in long-COVID and other infections: a need for further research by Achilleas Livieratos, Steven W. Lockley, Sotirios Tsiodras

“…Epigenetic changes, including DNA methylation at clock-related loci, particularly in peripheral tissues, further contribute to systemic circadian dysregulation. …”
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Epigenetic Drug Interventions in Breast Cancer: A Narrative Review of Current Research and Future Directions by Sarah Bibi Mungly, Evelyn Priya Peter, Ling-Wei Hii, Chun-Wai Mai, Felicia Fei-Lei Chung

“…While there is strong evidence that epigenetic alterations, consisting of changes in DNA methylation, histone modifications, and non-coding RNAs, play a crucial role in breast cancer initiation and development, additional research is warranted to elucidate the safety profile of long-term interventions involving epigenetic drugs and to validate the role of epigenetic markers in disease diagnosis, prognosis, and personalised treatment. …”
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Spatial integration of multi-omics single-cell data with SIMO by Penghui Yang, Kaiyu Jin, Yue Yao, Lijun Jin, Xin Shao, Chengyu Li, Xiaoyan Lu, Xiaohui Fan

“…Unlike previous tools, SIMO not only integrates spatial transcriptomics with single-cell RNA-seq but expands beyond, enabling integration across multiple single-cell modalities, such as chromatin accessibility and DNA methylation, which have not been co-profiled spatially before. …”
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Pituitary adenoma: important genetic factors and clinical diagnostic issues by G. Juknytė, E. Karinauskė, R. Liutkevičienė

“…Since the development of pituitary adenomas can be significantly influenced by epigenetic changes in pituitary cells, there is currently an increasing focus on the study of epigenetic mechanisms such as DNA methylation, histone modifications, and micro-RNA studies. …”
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Protein Profiling and Histone Deacetylation Activities in Somaclonal Variants of Oil Palm (Elaeis guineensis Jacq.) by Jamilah Syafawati Yaacob, Hwei-San Loh, Rosna Mat Taha

“…The molecular aspects of the occurrence of somaclonal variations are yet to be known, possibly due to gene repression such as DNA methylation, histone methylation and histone deacetylation. …”
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The Role of Epigenetic in Dental and Oral Regenerative Medicine by Different Types of Dental Stem Cells: A Comprehensive Overview by Ahmed Hussain, Hamid Tebyaniyan, Danial Khayatan

“…The epigenetic regulation of gene expression and the regulation of cell fate is mainly governed by deoxyribonucleic acid (DNA) methylation, histone modification, and noncoding RNAs (ncRNAs). …”
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Effect on Multipotency and Phenotypic Transition of Unrestricted Somatic Stem Cells from Human Umbilical Cord Blood after Treatment with Epigenetic Agents by Foued Ghanjati, Simeon Santourlidis

“…The epigenetic mechanism of DNA methylation is of central importance for cellular differentiation processes. …”
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Examining the epigenetic transmission of risk for chronic pain associated with paternal post-traumatic stress disorder: a focus on veteran populations by James Freeman, Sabrina Salberg, Melanie Noel, Richelle Mychasiuk

“…Numerous overlapping neurological pathways are implicated in both PTSD and chronic pain; many of which are susceptible to epigenetic modification, such as DNA methylation, histone modifications, and RNA regulation. …”
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Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer by Gonzalo Carrasco, Alejandro H. Corvalan

“…The epigenetic bases of chronic gastritis, mainly DNA methylation, are presented through examples such as (i) the methylation of the promoter region of E-cadherin in HP-induced chronic gastritis and its reversion after HP eradication and (ii) the association of methylation of the promoter region of Reprimo, a p53-mediated cell cycle arrest gene, with aggressive HP strains in high risk areas for GC. …”
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Epigenetics and Breast Cancers by An T. Vo, Richard M. Millis

“…Enzymes that are involved in DNA methylation and histone modifications have been shown to be altered in several types of breast and other cancers resulting in abnormal patterns of methylation and/or acetylation. …”
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Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome by Mimouni, Nour El Houda, Giacobini, Paolo

“…However, the underlying mechanisms of its transmission remain unknown, thus limiting the development of effective therapeutic strategies.This article highlights how an altered fetal environment (prenatal exposure to high levels of anti-Müllerian hormone) can contribute to the onset of PCOS in adulthood and lead to the transgenerational transmission of neuroendocrine and metabolic traits through alterations in the DNA methylation process.The originality of the translational findings summarized here involves the identification of potential biomarkers for early diagnosis of the syndrome, in addition to the validation of a promising therapeutic avenue in a preclinical model of PCOS, which can improve the management of patients suffering from the syndrome.…”
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Differential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML by Mirazul Islam, Zahurin Mohamed, Yassen Assenov

“…A larger sample cohort and further investigation of the effects observed in this study are required to enable the clinical application of our patient classification aided by DNA methylation.…”
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Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders by I. De Toma, L. Manubens Gil, S. Ossowski, M. Dierssen

“…All known epigenetic mechanisms such as DNA methylation and hydroxymethylation, histone modifications, chromatin remodelling, and noncoding RNAs regulate brain gene expression, both during neurodevelopment and in the adult brain in processes related to cognition. …”
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Interplay between Epigenetics and Genetics in Cancer by Jae Duk Choi, Jong-Soo Lee

“…Genomic instability, which occurs through both genetic mechanisms (underlying inheritable phenotypic variations caused by DNA sequence-dependent alterations, such as mutation, deletion, insertion, inversion, translocation, and chromosomal aneuploidy) and epigenomic aberrations (underlying inheritable phenotypic variations caused by DNA sequence-independent alterations caused by a change of chromatin structure, such as DNA methylation and histone modifications), is known to promote tumorigenesis and tumor progression. …”
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Landscape Of HOXA Genes Methylation in Colorectal Cancer by Muhiddin Ishak, Rashidah Baharudin, Loh Teng-Hern Tan, Learn-Han Lee, Nurul-Syakima Ab Mutalib

“…Our work gave a comprehensive assessment of the DNA methylation pattern of HOXA genes and provide the first evidence of HOXA2, HOXA3 and HOXA4 differential methylation in Malaysian CRC. …”
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Genomic Analysis of Abnormal DNAM Methylation in Parathyroid Tumors by Qing Li, Yonghao Li, Ximei Sun, Xinlei Zhang, Mei Zhang

“…In this study, we performed genomic analysis of abnormal DNA methylation in parathyroid tumors. After data preprocessing, differentially methylated genes were extracted from patients with parathyroid tumors by using t-tests. …”
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Pan-Cancer Analysis of B4GALNT1 as a Potential Prognostic and Immunological Biomarker by Hang Yi, Yiwen Lin, Yutong Li, Yeqi Guo, Ligong Yuan, Yousheng Mao

“…Also, B4GALNT1 was significantly associated with TMB, MSI, MMR, and DNA methylation. Additionally, the sensitivity of 9 drugs was correlated with the expression of B4GALNT1. …”
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Non-coding parts of genomes as the basis of epigenetic heredity by R. N. Mustafin, E. K. Khusnutdinova

“…Transposons regulate the expression of genes in cis and in trans, and also indirectly by the production of small RNAs that affect their own activity, both by altering the DNA methylation and modifying histones, and at the posttranscriptional level. …”
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Role of physical activity in cardiovascular disease prevention: impact of epigenetic modifications by Yi Sun, Zuoying Peng, Hua Liang

“…An increasing body of research indicates that variations in the epigenetic system—such as DNA methylation, histone modifications, and production of non-coding RNA—are essential for maintaining heart health and preventing heart disease. …”
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Epigenetic regulation of bone remodeling and its role in the pathogenesis of primary osteoporosis by B. I. Yalaev, R. I. Khusainova

“…The results of epigenetic studies have significantly increased the understanding of the role of post-translational modifications of histones, DNA methylation and RNA interference in the osteoporosis pathogenesis and in bone remodelling. …”
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