Genome-wide DNA methylation and transcriptome sequencing analyses of lens tissue in an age-related mouse cataract model. by Yuzhu Hu, Dongmei Su, Yue Zhang, Yanjiang Fu, Sijia Li, Xiaoya Chen, Xiao Zhang, Shunfei Zheng, Xu Ma, Shanshan Hu

“…DNA methylation is known to be associated with cataracts. …”
Get full text

DNA-mediated self-assembly oxidative damage amplifier combined with copper and MTH1 inhibitor for cancer therapy by Cui Ren, Zhiyong Shi, Xiaowen Zhang, Xueer Yu, Yang Gao, Zhi Qi, Yu Chen, Yong Wang

“…It entails producing hypertoxic reactive oxygen species (ROS) that damage the DNA of tumor cells and other biomacromolecules. …”
Get full text

Electrochemical detection of human papillomavirus DNA based on an ultrasensitive electrochemical sensing platform using N-graphene paper by Jia Wang, Juelan Ye, Gang Li

“…DNA detection was achieved through characteristic oxidation signals of guanine bases, which displayed a wide linear dynamic range (0.5–100 μg/mL), low detection limit (75 pg/mL), and excellent reproducibility (relative standard deviation <3.5 %). …”
Get full text

Correlation of Grade of Urothelial Cell Carcinomas and DNA Histogram Features Assessed by Flow Cytometry and Automated Image Cytometry by Marco G. W. Bol, Jan P. A. Baak, Bianca v. Diermen, E. A. M. Janssen, Susanne B. K. Buhr-Wildhagen, Kjell-Henning Kjellevold

“…Objective: To analyse how DNA ploidy and S-phase fraction (SPF) by flow cytometry (FCM) and an optimised fully automatic DNA image cytometer (ICM) correlate with grade in TaT1 urothelial cell carcinomas (UC) of the urinary bladder. …”
Get full text

Context effects on repair of 5′‐overhang DNA double‐strand breaks induced by Cas12a in Arabidopsis by Sébastien Lageix, Miguel Hernandez, Maria E. Gallego, Jérémy Verbeke, Yannick Bidet, Sandrine Viala, Charles I. White

Subjects: Get full text

TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD by Zhuhe Liu, Yunmeng Bai, Bingtian Xu, Haixia Wen, Kechun Chen, Jingfang Lin, Yuanyuan Wang, Jiangping Xu, Haitao Wang, Fudong Shi, Jigang Wang, Honghao Wang

“…Abstract Abnormality in transactivating response region DNA binding protein 43 (TDP43) is well-recognized as the pathological hallmark of neurodegenerative diseases. …”
Get full text

A Diagnosis of Maternal 22q Duplication and Mosaic Deletion following Prenatal Cell-Free DNA Screening by Melissa A. Hicks, Emilie Lalonde, Jessica Zoladz, Bernard Gonik, Salah Ebrahim

“…We describe a case of germline 22q11.21 microduplication syndrome with concurrent mosaic 22q11.2 deletion in a pregnant patient, identified by chromosomal microarray and FISH after noninvasive prenatal genetic screening (cfDNA) results discordant with family history. The patient was referred to maternal-fetal medicine (MFM) at 14 weeks’ gestation secondary to an SNP-based cfDNA result of a suspected maternal 22q11.2 deletion and a fetal risk of 1 in 2 for 22q11.2 deletion syndrome. …”
Get full text

Intraspecific epigenomics divergence in brown bears (Ursus arctos): insights from genome-wide DNA methylation patterns by Paolo Colangelo, Paolo Colangelo, Ian Marc Bonapace, Laura Gramolini, Emanuela Solano, Emanuela Solano, Elisa Desiato, Paolo Franchini, Leonardo Gentile, Roberto Guadagnini, Oddmund Kleven, Jonas Kindberg, Jonas Kindberg, Alexander Kopatz, Paolo Ciucci

Get full text

Circle-seq reveals that eccDNA may be a key blood biomarker for HBV-associated liver cancer by Xiao K. Ran, Xiao F. Zhao, Zhen W. Wei, Hua Z. Pang, Yan F. Tang, Rong Liu, Tie X. Wu, Xu D. Liu

Subjects: “…extrachromosomal circular DNA…”
Get full text

褐马鸡非损伤性取样、微量取样DNA提取的初步研究 by 武玉珍, 王孟本, 张峰

Subjects: Get full text

Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA by Tobias Solli Iveland, Lars Hagen, Mirta Mittelstedt Leal de Sousa, Nina Beate Liabakk, Per Arne Aas, Animesh Sharma, Bodil Kavli, Geir Slupphaug

“…Importantly, CRISPR/Cas9 knockout of the uracil-DNA glycosylase UNG did not affect γH2AX activation or sensitivity to pemetrexed. …”
Get full text

First-Principles Simulation of the Interaction Between DNA Nucleotides and One-Dimensional Carbon Chain in Electrical Based Sequencing by Zeina Salman, Jin-Woo Kim, Steve Tung

Subjects: “…DNA sequencing…”
Get full text

Glycogen homeostasis and mitochondrial DNA expression require motor neuron to muscle TGF-β/Activin signaling in Drosophila by Heidi Bretscher, Michael B. O’Connor

“…Instead, loss of Actβ reduces levels of nuclearly encoded genes required for mtDNA replication, transcription, and translation and mtDNA levels. …”
Get full text

Epstein-Barr 病毒DNA 多聚酶基因扩增和表达载体构建 by 谢民强, 杨　林

“…【目的】扩增Epstein-Barr 病毒(EBV)DNA 多聚酶基因, 构建高效表达载体。【方法】根据EBV 全基因序列, 在 EBV DNA 多聚酶基因的3′、5′端设计一对附加EcoRⅠ 和Hind Ⅲ 酶切位点的特异性引物, 以B95-8细胞DNA 为模板, 采用改良 PCR 方法扩增出EBV DNA 多聚酶基因(3 044 bp)。…”
Get full text

Uridine-cytidine kinase 2 is correlated with immune, DNA damage repair and promotion of cancer stemness in pan-cancer by Jinlong Tian, Yanlei Li, Yu Tong, Yuan Zhang, Tingxiao Zhao, Yao Kang, Qing Bi

Subjects: Get full text

随机引物引导的乙型肝炎病毒DNA探针标记和重复杂交

“…用这种方法还制备地高辛素标记的HBV DNA探针,并在探针浓度为20 ug/L条件下,对32p探针杂交过的样膜重复杂交。结束检出HBV DNA灵敏度为0.05 Pg,检测HBsAg和HBeAg双阳性血清,HBV DNA阳性率为73％（22/30）。…”
Get full text

Immunodeficiency, Centromeric Instability, and Facial Dysmorphism (ICF) Syndrome: How HSCT alters the impairment of the DNA methylation process by Wojciech Homa, Joanna Wanat, Izabela Dzikowska, Agata Siejka, Daria Stefaniak, Aleksandra Warunek, Gabriela Gronowicz, Michał Chról, Weronika Zielińska

“…Advances in molecular biology and genetics enabled insights into the DNA methylation machinery, which allowed us to gain a more precise understanding of the pathogenesis of ICF and also opened up opportunities for the development of new therapeutic options. …”
Get full text

DNA Damage and Augmented Oxidative Stress in Bone Marrow Mononuclear Cells from Angiotensin-Dependent Hypertensive Mice by Bianca P. Campagnaro, Clarissa L. Tonini, Breno V. Nogueira, Dulce E. Casarini, Elisardo C. Vasquez, Silvana S. Meyrelles

“…Much evidence confirms that angiotensin II is directly involved in NAD(P)H oxidase activation and consequent superoxide anion production, which can damage DNA. The current study was performed to examine the effects of angiotensin-II-dependent hypertension in bone marrow mononuclear cells (BM-MNC); dihydroethidium staining was used to assess reactive oxygen species (ROS) production, and the comet assay was used to assess DNA fragmentation in 2K1C hypertensive mice 14 days after renal artery clipping. …”
Get full text

定量 PCR 分析 HBsAg 阳性肝癌患者 手术前后血清 HBV DNA 变化

“…方法: 以常规聚合酶链反应 ( PCR)方法检测了 20 例 HBV 血清学标志阳性肝癌患者血清中的 HBV DNA ; 应用荧光能量转移定量聚合酶链反应(QPCR) 测定肝癌手术切除前后病人血清中 HBV DNA 量的变化情况。…”
Get full text

Microbial-based natural products as potential inhibitors targeting DNA gyrase B of Mycobacterium tuberculosis: an in silico study by Tilal Elsaman, Magdi Awadalla Mohamed, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Abualgasim Elgaili Abdalla

Subjects: Get full text