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    Life : The science of Biology

    Published 2020
    Subjects:
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    “One Ring to Bind Them All”—Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition by David Monchaud, Anton Granzhan, Nicolas Saettel, Aurore Guédin, Jean-Louis Mergny, Marie-Paule Teulade-Fichou

    Published 2010-01-01
    “…Macrocyclic scaffolds are particularly attractive for designing selective G-quadruplex ligands essentially because, on one hand, they show a poor affinity for the “standard” B-DNA conformation and, on the other hand, they fit nicely with the external G-quartets of quadruplexes. …”
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  8. 708

    The Roles of Several Residues of Escherichia coli DNA Photolyase in the Highly Efficient Photo-Repair of Cyclobutane Pyrimidine Dimers by Lei Xu, Guoping Zhu

    Published 2010-01-01
    “…Escherichia coli DNA photolyase is an enzyme that repairs the major kind of UV-induced lesions, cyclobutane pyrimidine dimer (CPD) in DNA utilizing 350–450 nm light as energy source. …”
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    Shedding Light on the Prognostic and Predictive Value of Circulating Tumor DNA for Management of Patients with Early-Stage Colon Cancer by Rami Yanes MD, Turcin Saridogan MD, PhD, Vikram Gorantla MD, Abigail Overacre PhD, Ronan W. Hsieh MD, James Celebrezze MD, Tara Magge MD, Meghana Singhi MD, Anwaar Saeed MD, Amer H. Zureikat MD, Arvind N. Dasari MD, Ibrahim Halil Sahin MD

    Published 2025-01-01
    “…Several studies have revealed that current clinicopathological factors lack precision. Circulating tumor DNA (ctDNA) is cell-free DNA originating from cancer cells and can be detected even in the absence of radiologically detectable disease among patients with colon cancer. …”
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    Article
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    A select inhibitor of MORC2 encapsulated by chimeric membranecoated DNA nanocage target alleviation TNBC progression by Xiaohan Su, Yunbo Luo, Yali Wang, Peng Qu, Jun Liu, Shiqi Han, Cui Ma, Shishan Deng, Qi Liang, Xiaowei Qi, Panke Cheng, Lingmi Hou

    Published 2025-04-01
    “…Furthermore, the biomimetic nanodrug delivery system (PMD) was designed by encapsulating tetrahedral DNA nanostructures with biomimetic cell membrane, and it can efficiently evade the phagocytosis of immune system and target TNBC tissue. …”
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    Fiddler Crabs (Crustacea: Decapoda: Ocypodidae) From Coastal Ecuador and the Galápagos Islands: Species Descriptions and DNA Barcodes by Carl L. Thurman, John C. McNamara, Hsi‐Te Shih, Mariana V. Capparelli

    Published 2025-01-01
    “…A neighbor‐joining tree was constructed using the Kimura 2‐parameter model with a partial DNA sequence of the cytochrome oxidase‐subunit 1 gene (COI) for a barcoding study. …”
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    线粒体 DNA tRNA leu( UUR) 和 ND1 双重突变 ———糖尿病家系报道 by 张 庆 曾瑞萍 杜传书

    Published 1998-01-01
    “…目的:探讨线粒体 DNA 突变在糖尿病发病中的作用。方法: 采用 PCR -RFLP 、亚克隆及 DNA 序列分析等技术, 对一个母系遗传糖 尿病家系成 员的线 粒体 DNA tRNAleu(UUR)及 其临近区 域进行 了突变分 析。…”
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    Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage by David Reisman, Paula Takahashi, Amanda Polson, Kristy Boggs

    Published 2012-01-01
    “…Numerous studies have demonstrated that p53 transcription is activated before or during early S-phase in cells progressing from G0/G1 into S-phase through the combined action of two DNA-binding factors RBP-Jκ and C/EBPβ-2. Here, we review evidence that this induction occurs to provide available p53 mRNA in order to prepare the cell for DNA damage in S-phase, this ensuring a rapid response to DNA damage before exiting this stage of the cell cycle.…”
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    Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis by Bing Xia, Yan-lin Lu, Jin Peng, Jing-wei Liang, Fang-qin Li, Jiu-yang Ding, Chang-wu Wan, Cui-yun Le, Jia-lin Dai, Jie-Wang, Bing Guo, Jiang Huang

    Published 2025-01-01
    “…Abstract DNA methylation modifications are an important mechanism affecting the process of atherosclerosis (AS). …”
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    DNA Methyltransferase 3B Gene Promoter and Interleukin-1 Receptor Antagonist Polymorphisms in Childhood Immune Thrombocytopenia by Margarita Pesmatzoglou, Marilena Lourou, George N. Goulielmos, Eftichia Stiakaki

    Published 2012-01-01
    “…In this study, we investigated the rs2424913 single-nucleotide polymorphism (SNP) (C46359T) in DNA methyltransferase 3B (DNMT3B) gene promoter and the VNTR polymorphism of IL-1 receptor antagonist (IL-1 Ra) intron-2 in 32 children (17 boys) with the diagnosis of ITP and 64 healthy individuals. …”
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    Mapping genomic regions affecting sensitivity to bovine respiratory disease on chromosome X using selective DNA pooling by Ehud Lipkin, Maria Giuseppina Strillacci, Miri Cohen-Zinder, Harel Eitam, Moran Yishay, Morris Soller, Carlotta Ferrari, Alessandro Bagnato, Ariel Shabtay

    Published 2025-02-01
    “…Kosher scoring of lung adhesions was used as a cost-effective proxy diagnosis. Selective DNA pooling was applied for cost-effective mapping of regions associated with sensitivity to the disease on chromosome X in Israeli Holstein male calves. …”
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    Protocol for detecting eDNA in ecological rare fish using RPA-CRISPR-Cas12a technology by Xing-Yi Wei, Yang Pei, Li Liu, Péter Hamar, De-Sheng Pei

    Published 2025-03-01
    “…Summary: The recombinase polymerase amplification (RPA)-CRISPR-Cas12a-FQ system enables sensitive detection of environmental DNA (eDNA) in rare fish species. Here, we present a protocol for eDNA amplification and Cas12a for target recognition using RPA. …”
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  20. 720

    High Sequence Variations in Mitochondrial DNA Control Region among Worldwide Populations of Flathead Mullet Mugil cephalus by Brian Wade Jamandre, Jean-Dominique Durand, Wann-Nian Tzeng

    Published 2014-01-01
    “…The sequence and structure of the complete mtDNA control region (CR) of M. cephalus from African, Pacific, and Atlantic populations are presented in this study to assess its usefulness in phylogeographic studies of this species. …”
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