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DNA Interaction and DNA Cleavage Studies of a New Platinum(II) Complex Containing Aliphatic and Aromatic Dinitrogen Ligands
Published 2011-01-01“…The interaction of this complex with calf thymus DNA (CT-DNA) was investigated by absorption, emission, circular dichroism (CD), and viscosity measurements. …”
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42
Predicting exacerbation of renal function by DNA methylation clock and DNA damage of urinary shedding cells: a pilot study
Published 2024-05-01“…Abstract Recent reports have shown the feasibility of measuring biological age from DNA methylation levels in blood cells from specific regions identified by machine learning, collectively known as the epigenetic clock or DNA methylation clock. …”
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43
Modeling the consequences of age-linked rDNA hypermethylation with dCas9-directed DNA methylation in human cells.
Published 2024-01-01“…Ribosomal DNA (rDNA) genes encode the structural RNAs of the ribosome and are present in hundreds of copies in mammalian genomes. …”
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Application of DNA Array Technology for Diagnostic Microbiology
Published 2000-01-01“…Microarrays or DNA chips have been hailed as the ultimate experimental tool for research, drug discovery and diagnostics. …”
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46
An Overview of DNA Repair in Amyotrophic Lateral Sclerosis
Published 2011-01-01“…Increasing evidence supports mitochondrial dysfunction and oxidative DNA damage in ALS motor neurons. Several DNA repair enzymes are activated following DNA damage to restore genome integrity, and impairments in DNA repair capabilities could contribute to motor neuron degeneration. …”
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47
Fluorescent DNA Stabilized Silver Nanoclusters as Biosensors
Published 2013-01-01“…DNA stabilized fluorescent silver nanoclusters are promising materials, of which fluorescent properties can be exploited to develop sensors. …”
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48
A Mathematical Model for DNA Damage and Repair
Published 2010-01-01“…In cells, DNA repair has to keep up with DNA damage to maintain the integrity of the genome and prevent mutagenesis and carcinogenesis. …”
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49
Preamplification Procedure for the Analysis of Ancient DNA Samples
Published 2013-01-01“…In ancient DNA studies the low amount of endogenous DNA represents a limiting factor that often hampers the result achievement. …”
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50
Physiological Roles of DNA Double-Strand Breaks
Published 2017-01-01“…Genomic integrity is constantly threatened by sources of DNA damage, internal and external alike. Among the most cytotoxic lesions is the DNA double-strand break (DSB) which arises from the cleavage of both strands of the double helix. …”
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51
DNA Origami Model for Simple Image Decoding
Published 2020-01-01“…DNA origami is the application of self-assembly in nanotechnology. …”
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The DNA Replication Stress Hypothesis of Alzheimer’s Disease
Published 2011-01-01“…Vulnerable neurons of the AD brain exhibit biomarkers of cell cycle progression and DNA replication suggesting a reentry into the cell cycle. …”
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55
Ensuring the Stability of the Genome: DNA Damage Checkpoints
Published 2001-01-01“…The cellular response to DNA damage is vital for the cell�s ability to maintain genomic integrity. …”
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56
Straightforward Procedure for Laboratory Production of DNA Ladder
Published 2012-01-01“…DNA ladder is commonly used to determine the size of DNA fragments by electrophoresis in routine molecular biology laboratories. …”
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Radiotherapy for Melanoma: More than DNA Damage
Published 2019-01-01“…It has long been known that radiation causes not only DNA strand breaks, apoptosis, and necrosis, but also immunogenic modulation and cell death through the induction of dendritic cells, cell adhesion molecules, death receptors, and tumour-associated antigens, effectively transforming the tumour into an individualised vaccine. …”
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58
Numerical Characterization of DNA Sequence Based on Dinucleotides
Published 2012-01-01“…Sequence comparison is a primary technique for the analysis of DNA sequences. In order to make quantitative comparisons, one devises mathematical descriptors that capture the essence of the base composition and distribution of the sequence. …”
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Mathematical analysis and modeling of DNA segregation mechanisms
Published 2018-03-01“…The precise regulation of cell life division is indispensable to the reliable inheritance of genetic material, i.e. DNA, in successive generations of cells. This is governed by dedicated biochemical networks which ensure that all requirements are met before transition from one phase to the next. …”
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Differential Toxicity of DNA Adducts of Mitomycin C
Published 2010-01-01“…The clinically used antitumor agent mitomycin C (MC) alkylates DNA upon reductive activation, forming six covalent DNA adducts in this process. …”
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