Two-dimensional semantic morphological feature extraction and atlas construction of maize ear leaves by Hongli Song, Hongli Song, Weiliang Wen, Weiliang Wen, Ying Zhang, Ying Zhang, Yanxin Zhao, Xinyu Guo, Xinyu Guo, Chunjiang Zhao, Chunjiang Zhao, Chunjiang Zhao

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ASB1 engages with ELOB to facilitate SQOR ubiquitination and H2S homeostasis during spermiogenesis by Jinxing Lv, Tiantian Wu, Jiajia Xue, Cong Shen, Wenxin Gao, Xia Chen, Yueshuai Guo, Mingxi Liu, Jun Yu, Xiaoyan Huang, Bo Zheng

“…Subsequent investigations unveiled that Asb1 knockout (Asb1-KO) mice encountered excessive oxidative stress and decreased hydrogen sulfide (H2S) levels in their testes, and severe sperm DNA damage. Notably, the compromised fertility and sperm quality in Asb1-KO mice was significantly ameliorated by administering NaHS, a H2S donor. …”
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Genome skimming provides evidence to accept two new genera (Apiaceae) separated from the Peucedanum s.l. by Bo-Ni Song, Chang-Kun Liu, Chang-Kun Liu, Jiao-Jiao Deng, Wei-Yan Tan, Song-Dong Zhou, Xing-Jin He

“…Therefore, we conducted a comprehensive taxonomic revision of taxa within the polyphyletic Peucedanum s.l. genus in this study.MethodsWe used two molecular datasets (103 plastomes and 43 nrDNA sequences) generated by genome skimming to reconstructed a reliable phylogenetic framework with high support and resolution. …”
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Dynamics of blood microsatellite instability (bMSI) burden predicts outcome of a patient treated with immune checkpoint inhibitors: a case report of hyperprogressive disease by Daria Kravchuk, Alexandra Lebedeva, Alexandra Lebedeva, Olesya Kuznetsova, Olesya Kuznetsova, Alexandra Kavun, Anastasiia Taraskina, Ekaterina Belova, Ekaterina Belova, Ekaterina Belova, Tatiana Grigoreva, Tatiana Grigoreva, Egor Veselovsky, Vladislav Mileyko, Vladislav Mileyko, Vladislav Nikulin, Lidia Nekrasova, Alexey Tryakin, Mikhail Fedyanin, Mikhail Fedyanin, Mikhail Fedyanin, Maxim Ivanov, Maxim Ivanov

“…Typically, somatic mutations are used for tracing the dynamics of the tumor, and the assessment of DNA signatures such as MSI is not currently used for these purposes. …”
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Global insights into the genome dynamics of Clostridioides difficile associated with antimicrobial resistance, virulence, and genomic adaptations among clonal lineages by Mohammad Sholeh, Mohammad Sholeh, Masoumeh Beig, Masoumeh Beig, Ebrahim Kouhsari, Mahdi Rohani, Mohammad Katouli, Farzad Badmasti

“…This study offers a genomic analysis of C. difficile, focusing on sequence types (STs), global distribution, antibiotic resistance genes, and virulence factors in its chromosomal and plasmid DNA.MethodsA total of 19,711 C. difficile genomes were retrieved from GenBank. …”
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DNMT3A Mutations in Patients with Acute Myeloid Leukemia in South Brazil by Annelise Pezzi, Lauro Moraes, Vanessa Valim, Bruna Amorin, Gabriela Melchiades, Fernanda Oliveira, Maria Aparecida da Silva, Ursula Matte, Maria S. Pombo-de-Oliveira, Rosane Bittencourt, Liane Daudt, Lúcia Silla

“…Several molecular markers have been described that help to classify AML patients into risk groups. DNA methyltransferase 3A (DNMT3A) gene mutations have been recently identified in about 22% of AML patients and associated with poor prognosis as an independent risk factor. …”
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The miR-146a SNP Rs2910164 and miR-155 SNP rs767649 Are Risk Factors for Non-Small Cell Lung Cancer in the Iranian Population by Neda K. Dezfuli, Ian M. Adcock, Shamila D. Alipoor, Sharareh Seyfi, Babak Salimi, Maryam Mafi Golchin, Neda Dalil Roofchayee, Mohammad Varhram, Esmaeil Mortaz

“…Allele frequencies from the genomic DNA of blood cells were studied using PCR-RFLP and their association with the risk of lung cancer was evaluated. …”
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dataFishing: An efficient Python tool and user-friendly web-form for mining mitochondrial and chloroplast sequences, taxonomic, and biodiversity data by Luan Rabelo, Davidson Sodré, Oscar David Albito Balcázar, Murilo Furtado do Rosário, Aurycéia Jaquelyne Guimarães-Costa, Grazielle Gomes, Iracilda Sampaio, Marcelo Vallinoto

“…Moreover, it allows the retrieval of DNA sequences, common names, synonyms, conservation status, and species occurrence points. …”
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Mir-483-5p-mediated activating of IGF2/H19 enhancer up-regulates IGF2/H19 expression via chromatin loops to promote the malignant progression of hepatocellular carcinoma by Weiwei Chen, Chutian Wu, Yuting Li, Tonghua Wang, Miaoling Huang, Min Wang, Linjing Long, Yanfang Chen, Shufen Feng, Xuyou Liu, Shaohui Tang

“…Conclusions miR-483-5p-mediated activating of IGF2/H19 enhancer up-regulates IGF2/H19 expression via DNA loops, thereby promoting the malignant progression of HCC.…”
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High, but variable prevalence of Sarcocystis cruzi infections in farm-raised American bison (Bison bison) beef destined for human consumption by Larissa S. de Araujo, Aditya Gupta, Marianne Dias Papadopoulos, Doaa Naguib, Jacquin Battle, Oliver Kwok, Asis Khan, Benjamin Rosenthal, Jitender P. Dubey

“…Frozen tongues were purchased and examined for Sarcocystis infection using light microscopy, histology and quantitative PCR (qPCR) targeting 18S ribosomal DNA (18S rRNA) of S. cruzi. Lesions associated with degenerating sarcocysts were studied. …”
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Protective Effect of Conditioned Medium of Immortalized Human Stem Cells from Exfoliated Deciduous Teeth Against Hair Graying Caused by X-Ray Irradiation via Its Antioxidative Acti... by Yasuhiro Katahira, Eri Horio, Natsuki Yamaguchi, Jukito Sonoda, Miu Yamagishi, Satomi Miyakawa, Fumihiro Murakami, Hideaki Hasegawa, Izuru Mizoguchi, Takayuki Yoshimoto

“…Repetitive subcutaneous administrations of SHED-CM greatly suppressed the development of hair graying, when compared to control medium, resulting in reduced cutaneous expression of 8-hydroxy-2′-deoxyguanosine, the major product of DNA damage induced by reactive oxygen species. Consistent with these in vivo results, SHED-CM significantly inhibited the cell death caused by X-ray irradiation in melanoma cell line B16F10 cells. …”
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Reciprocal regulation between DNMT3A/3B and microRNAs miRs-299-3p/-30e is a causal factor for the downregulation of microRNAs targeting androgen receptor in prostate cancer by Kavya Ganapathy, Christian F. Harrs, Samuel Harris, Stephen J. Staklinski, Ayman Khatib, Jong Y. Park, Ratna Chakrabarti

“…Methods: We performed bisulfite sequencing based promoter methylation analysis with or without treatment with DNA methyl transferase (DNMT) inhibitor 5-Aza-2′-deoxycytidine (AzaC). …”
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A green forage diet enhances microbial diversity in buffalo rumen by Angela Salzano, Giovanna Bifulco, Alfio Calanni Macchio, Valentina Longobardi, Francesca Aragona, Giovan Maria Pacelli, Giuseppe Campanile

“…Rumen fluid samples were immediately collected at the slaughterhouse, and bacterial genomic DNA was extracted to perform metagenomic analyses. …”
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High p16INK4A expression in glioblastoma is associated with senescence phenotype and better prognosis by Soon Sang Park, Tae Hoon Roh, Yoshiaki Tanaka, Young Hwa Kim, So Hyun Park, Tae-Gyu Kim, So Yeong Eom, Tae Jun Park, In-Hyun Park, Se-Hyuk Kim, Jang-Hee Kim

“…Previous studies have identified a few prognostic markers for GBM, including the methylation status of O6-methylguanine-DNA methyltransferase (MGMT) promoter, TERT promoter mutation, EGFR amplification, and CDKN2A/2B deletion. …”
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Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability by Petr Smirnov, Moritz J. Przybilla, Milena Simovic-Lorenz, R. Gonzalo Parra, Hana Susak, Manasi Ratnaparkhe, John KL. Wong, Verena Körber, Jan-Philipp Mallm, George Philippos, Martin Sill, Thorsten Kolb, Rithu Kumar, Nicola Casiraghi, Konstantin Okonechnikov, David R. Ghasemi, Kendra Korinna Maaß, Kristian W. Pajtler, Anna Jauch, Andrey Korshunov, Thomas Höfer, Marc Zapatka, Stefan M. Pfister, Wolfgang Huber, Oliver Stegle, Aurélie Ernst

“…We characterise subclonal variation of chromothripsis and its effects on extrachromosomal circular DNA, cancer drivers and putatively druggable targets. …”
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Characterization and fungicides sensitivity of Colletotrichum species causing Hydrangea macrophylla anthracnose in Beijing, China by Juan Zhao, Juan Zhao, Yanli Cheng, Yanli Cheng, Yayong Liu, Yayong Liu, Xiaojing Shi, Taotao Zhang, Taotao Zhang, Wentao Qin, Wentao Qin

“…Based on morphological characteristics and phylogenetic analysis of six genomic loci including rDNA-ITS, ACT, TUB2, CAL, CHS-1, and GAPDH, these isolates were identified as belonging to six Colletotrichum species. …”
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P-glycoprotein-independent cytotoxic effects of 5-aminopyrazole in L1210 leukemia cells by Lucia Sofrankova, Jana Spaldova, Pavol Stefik, Branislav Pavilek, Dusan Bortnak, Lucia Pavlikova, Ivana Zidekova, Daniel Vegh, Viktor Milata, Albert Breier, Zdena Sulova

“…Cell death assays revealed both apoptosis and necrosis, with apoptosis confirmed by DNA fragmentation and activation of caspases 3/7, 8, and, to a lesser extent, 9, suggesting a predominance of extrinsic apoptosis. …”
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En las entrañas del neoliberalismo: el impacto de AirBnb en la hostelería y el mercado inmobiliario de São Paulo y Río de Janeiro, Brasil by Rita de Cássia Ariza da Cruz, Cristina Pereira de Araujo, Luciano Muniz Abreu

“…Los datos sobre AirBnb se obtuvieron de la plataforma AirDna incluyendo los años completos de 2021, 2022, 2023 y enero de 2024. …”
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Upregulated SAE1 Drives Tumorigenesis and Is Associated with Poor Clinical Outcomes in Breast Cancer by Hong Liu, Jing Wang, Yunhai Li, Feng Luo, Lei Xing

“…The result of GSEA showed that SAE1 was significantly associated with 12 gene sets, including unfolded protein reaction, DNA repair, oxidative phosphorylation, and cell cycle, among others. …”
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FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction by Zhukai Chen, Jiacheng Xu, Kang Fang, Hanyu Jiang, Zhuyun Leng, Hao Wu, Zehua Zhang, Zeyu Wang, Zhaoxing Li, Mingchuang Sun, Ziying Zhao, Anqi Feng, Shihan Zhang, Yuan Chu, Lechi Ye, Meidong Xu, Lingnan He, Tao Chen

“…Furthermore, through serine metabolism, FOXC1 influenced purine metabolism and DNA damage repair, thereby increasing 5-FU resistance. …”
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