Ultrastructural studies distinguish skin diversities among Galápagos iguanas by Manuel Scimeca, Rita Bonfiglio, Giuliano Colosimo, Eleonora Candi, Glenn P. Gerber, Gregory A. Lewbart, Alessandro Mauriello, Gerry Melino, Christian Sevilla, Yufang Shi, Ying Wang, Gabriele Gentile

“…These skin characteristics may reduce the penetration power of UV rays into the superficial loose dermis, thereby attenuating potential UV-related damage such as DNA breaks and ROS generation. These findings offer insights into the adaptive strategies of these iguanas.…”
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Optimising primary molecular profiling in non-small cell lung cancer. by R D Schouten, I Schouten, M M F Schuurbiers, V van der Noort, R A M Damhuis, E H F M van der Heijden, J A Burgers, N P Barlo, A S R van Lindert, K W Maas, J J G van den Brand, A A J Smit, J M W van Haarst, B van der Maat, E Schuuring, H Blaauwgeers, S M Willems, K Monkhorst, D van den Broek, M M van den Heuvel

“…Combined analysis of tumour tissue and circulating tumour DNA is a promising approach to allow adequate molecular profiling of more patients.…”
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Activation of PTGS2/NF‐κB signaling pathway enhances radiation resistance of glioma by Cheng Tan, Liang Liu, Xiaoyang Liu, Ling Qi, Weiyao Wang, Guifang Zhao, Libo Wang, Yimeng Dai

“…In addition, PTGS2 activated NF‐κB signaling pathway and prevented DNA damage after radiotherapy. Lastly, PTGS2 was proved to facilitate tumor cell proliferation and improve the radio‐tolerance. …”
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Profiles of systemic lupus erythematosus patients with co-existing sickle cell disease: a coincidence or true association? by Hakeem Babatunde Olaosebikan, Etseoghena Igebu, Adebukola Khairat Orolu, Gbenga Joshua Odunlami, Ilo Azizat Bamisebi, Akin Dada, Ebele Uche, Olufemi Adelowo

“…All had anemia and positive antinuclear antibody, 33% had pancytopenia and 75% had positive anti-dsDNA and anti-Smith. Two are on maintenance hemodialysis, one with interstitial lung disease, and one on long-term anticoagulation due to deep vein thrombosis. …”
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Analysis of genetic polymorphisms in the intron 9–10/exon 10 region of the BRCA1 gene in a population sample of dogs with mammary cancer from Uruguay by Alicia Decuadro, Micaela Sosa, Federico García, Nariné Balemian, María del Carmen Montenegro, Silvia Llambí

“…Peripheral blood was also collected for DNA extraction. A region corresponding to intron 9–10/exon 10 of the BRCA1 gene (ENSCAFE00845051080) was amplified by endpoint PCR, with PCR results subsequently confirmed through agarose gel electrophoresis at 1%. …”
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Genomic Characterization and Functional Validation of Six <i>cis</i>-Regulatory Sequences in Medicinal Plant <i>Andrographis paniculata</i> by Xingbin Lv, Hua Yang, Yufang Hu, Qi Liang, Shuyun Tian, Lang Yang, Mingkun Huang, Ling Zhang, Yanqin Xu

“…With the rapid development of plant biotechnologies, such as transgenesis and gene editing tools, plant-derived CRSs have gradually replaced traditional CRSs, like the <i>35S</i> promoter, to avoid some negative effects caused by exogenous DNA sequences. In this study, we provided a comprehensive analysis of the published genomic data of <i>Andrographis paniculata</i> and identified six candidate <i>ApACRs</i>. …”
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بررسی برخی از پارامترهای فیزیولوژیک و بیوشیمیایی در گیاهان جهش‌یافته AtrecQl4A تحت تنش شوری

“…اعضای خانواده RecQ در ترمیم، رونویسی و نوترکیبی DNA وظایف مهمی بر عهده دارند. گیاه مدل ارابیدوپسیس دارای 7 همولوگ RecQ است. …”
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Diagnostic accuracy of human papillomavirus testing on self-collected samples among women referred for colposcopy by ChunX Yan, Jiong Ma, Xia Zheng, Jing Shu, XiaoJ Wang, XiaoY Chen, Feng Gao, XiaoQ Li, ShanQ M, LongM Huang, XiaoT Yu, XueJ Chen

“…The vaginal and urine samples were collected and analyzed by using a newly developed specific hrHPV PCR test, and matched cervical samples were analyzed by using an approved hrHPV DNA test. The primary outcomes were sensitivity for cervical intraepithelial neoplasia 2 or greater (CIN2 +). …”
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Comprehensive study of Tilapia skin collagen peptide on ileal injury and intestinal flora in rats induced by high altitude hypoxia by Jingyi Wang, Hao Wang, Chunxia Li, Xiaojuan Zhang, Jin Liu, Yanzhou Hu, Ping Qian

“…Furthermore, CP significantly up-regulated the an tioxidant enzymes SOD and GSH-Px and down-regulated MDA in the serum of rats, and improved hypoxia-induced oxidative stress. 16S rDNA sequencing of the intestinal flora revealed that CP significantly reduced the abundance of the pathogenic bacterium Escherichia, increased the abundance of the beneficial bacterium Limosilactobacillu, and significantly increased the levels of acetic acid, isobutyric acid, and isovaleric acid in feces. …”
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A combined recombinase polymerase amplification CRISPR/Cas12a assay for detection of Fusarium oxysporum f. sp. cubense tropical race 4 by Megan Ceris Matthews, Jos van der Linden, Isabelle Robène, Samuel Rozsasi, Beatrix Coetzee, Manuela Campa, Johan Burger, Uzoma Nobel Akwuruoha, Ndubuisi Johnkennedy Madufor, Willem Perold, Umezuruike Linus Opara, Altus Viljoen, Diane Mostert

“…The RPA-Cas12a assay was conducted isothermally, had a sensitivity of up to 10 fg target DNA and did not cross react with any of the 76 non-target isolates included in the specificity testing. …”
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Elucidating genetic variability between randomly bred domestic cats and Persian domestic cats from different geographical locations using microsatellite markers by Shirin Mahmoodi, Ali Hojabr Rajeoni, Mehrshad Zeinolabedini, Arash Javanmard, Mohammad Hossein Banabazi

“…We selected eight STR markers with different chromosomal locations based on polymorphism and observed allele numbers in the next step. DNA extraction was performed using tail hair root, PCR and electrophoresis, and gel staining was performed according to routine laboratory protocol. …”
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Adhesive and injectable hydrogel microspheres for NRF2-mediated periodontal bone regeneration by Yu Wang, Shanshan Jin, Yaru Guo, Yilong Lu, Xuliang Deng

“…Mechanistically, MMS-CY inhibited the premature senescence induced by the inflammation stimulus through the nuclear factor erythroid 2-related factor (NRF2) pathway and reducing the DNA injury. Utilizing in vivo rat periodontitis model, MMS-CY was demonstrated to enhance the periodontal bone regeneration by improving osteogenesis and inhibiting the osteoclastic activity. …”
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The relationship of the carriership of allelic variations in rs2228145 (A > C) of the<i>IL6R</i> gene with the levels of <i>VCAM1</i> and <i>ICAM1</i> gene transcripts in patients... by L. V. Topchieva, V. A. Korneva, I. V. Kurbatova

“…We analyzed samples of DNA isolated from the whole blood of 148 healthy donors and 152 patients with EAH (stages I-II). …”
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TERT de novo mutation-associated dyskeratosis congenita and porto-sinusoidal vascular disease: a case report by Ge Yu, Guijie Xin, Xu Liu, Wanyu Li, Chen Shao, Runping Gao

“…TERT plays an important role in telomeric DNA repair and replication. A TERT c.2286 + 1G/A mutation in a splicing consensus site was identified in a patient with pulmonary fibrosis. …”
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Functional Analysis and Experimental Validation of the Prognostic and Immune Effects of the Oncogenic Protein CDC45 in Breast Cancer by Zhang JN, Li LW, Cao MQ, Liu X, Yi ZL, Liu SS, Liu H

“…Jia-Ning Zhang,1,2,&ast; Lin-Wei Li,1,2,&ast; Man-Qing Cao,1,2,&ast; Xin Liu,1,2 Zi-Lu Yi,1,2 Sha-Sha Liu,1,2 Hong Liu1,2 1The Second Surgical Department of Breast Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China; 2Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hong Liu, Email liuhong_submit@tjmuch.comPurpose: Cell division cycle protein 45 (CDC45) plays a crucial role in DNA replication. This study investigates its role in breast cancer (BC) and its impact on tumor progression.Methods: We utilized the GEO database to screen differentially expressed genes (DEGs) and conducted enrichment analysis on these genes. …”
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From homogeneity to heterogeneity: Refining stochastic simulations of gene regulation by Seok Joo Chae, Seolah Shin, Kangmin Lee, Seunggyu Lee, Jae Kyoung Kim

“…However, this algorithm typically assumes that DNA is homogeneously distributed throughout the nucleus, which is not realistic. …”
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Chronic Atrophic Gastritis Presenting as Hemolytic Anemia due to Severe Vitamin B12 Deficiency by Amanda M. Woodford, Rabhea Chaudhry, Gabriella A. Conte, Varsha Gupta, Madhurima Anne

“…Vitamin B12 is an essential nutrient which plays an important role in neurological function, hematopoiesis, and DNA synthesis. Low levels usually stem from either poor intake or a malabsorptive process. …”
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Experimental and computational studies of Schiff bases derived from 4-aminoantipyrine as potential antibacterial and anticancer agents by Johana Zúñiga-Miranda, Rebeca González-Pastor, Saskya E. Carrera-Pacheco, Cristina Rodríguez-Pólit, Carlos Barba-Ostria, Antonio Machado, Linda P. Guamán, Christian D. Alcivar-León, Jorge Heredia-Moya

“…The Schiff base 3f has a strong binding affinity for DNA gyrase and vitamin D receptor, suggesting potential mechanisms for its antibacterial and anticancer activities.…”
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Comparison of the lower genital tract microbiome composition in patients with benign gynecological disease by Yonghui Shi, Jun Li, Jinjing Xie, Tianye Yang, Qiongyan Ma, Hua Chen, Wenwei Guo

“…Samples were obtained from vaginal secretions. The DNA was isolated from the samples, and the V3-V4 regions were amplified. …”
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Blocks identical by descent in the genomes of the indigenous population of Siberia demonstrate genetic links between populations by N. A. Kolesnikov, V. N. Kharkov, K. V. Vagaitseva, A. A. Zarubin, V. A. Stepanov

“…This makes it possible to fill in a significant gap in the genogeographic picture of the Eurasian population. For this, DNA fragments were analyzed, which had been inherited without recombination by each pair of individuals from their recent common ancestor, that is, segments (blocks) identical by descent (IBD). …”
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