Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulations by Pratibha Pandey, Pratibha Pandey, Sorabh Lakhanpal, Danish Mahmood, Han Na Kang, Byunggyu Kim, Sojin Kang, Jinwon Choi, Seungjoon Moon, Shivam Pandey, Suhas Ballal, Sanjay Kumar, Fahad Khan, Bonglee Kim

“…Bergenin efficiently inhibited the proliferation of human cancer cells by stimulating the production of intracellular reactive oxygen species (ROS), causing DNA damage and leading to cell cycle arrest in the G1/G2 phases by blocking cell signaling pathways. …”
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GADD45β Determines Chemoresistance and Invasive Growth of Side Population Cells of Human Embryonic Carcinoma by Toshihiko Inowa, Keiichi Hishikawa, Yumi Matsuzaki, Takayuki Isagawa, Takumi Takeuchi, Hiroyuki Aburatani, Tadaichi Kitamura, Toshiro Fujita

“…To further characterize the NEC8 SP cells, we used DNA microarrays. Among 38,500 genes, we identified 12 genes that were over-expressed in SP cells and 1 gene that was over-expressed in non-SP cells. …”
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Therapeutic Approaches in Mitochondrial Dysfunction, Inflammation, and Autophagy in Uremic Cachexia: Role of Aerobic Exercise by Yumei Zhang, Yuqing Liu, Xiao Bi, Chun Hu, Feng Ding, Wei Ding

“…We also measured mitochondrial dysfunction in mice by assessing mtDNA, ROS, ATP production, and mitochondrial configuration. …”
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Impact of water stress on <i>Phaeomoniella chlamydospora</i> abundance and Petri disease symptom development in young grapevines by Jared Hrycan, Pat Bowen, Thomas Forge, Miranda Hart, Jose Ramon Úrbez-Torres

“…Additionally, the arbuscular mycorrhizal (AM) fungus Rhizophagus irregularis was inoculated in the soil in the greenhouse experiment to investigate its effects on abiotic stress mitigation and thus, disease development in water stressed and non-stressed grapevines. DNA was extracted from the grapevine wood, and Droplet Digital™ PCR was conducted to determine Pch abundance before and after the experiments. …”
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MATN3 Gene Polymorphism Is Associated with Osteoarthritis in Chinese Han Population: A Community-Based Case-Control Study by Jiaao Gu, Jiesheng Rong, Fulin Guan, Liying Jiang, Shuqing Tao, Guofa Guan, Tianzun Tao

“…The other 312 individuals without any symptoms of osteoarthritis or signs in the radiographs (156 women and 156 men) were considered as healthy controls. After obtaining the DNA of case and control groups, genotypes of the MATN3 SNP6 were determined by polymerase chain reaction followed by restriction enzyme digestion. …”
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Expression analysis of nuclear factor kappa B (NF-κB) in oral squamous cell carcinoma by Dev Arora, Dhanraj M. Ganapathy, Ashikha Shirin Usman Pp, K.P. Ameya, Durairaj Sekar, Kumaravel Kaliaperumal

“…Interestingly, nuclear factor kappa B (NF-κB) is a protein complex that controls transcription of DNA, cytokine production, and cell survival. Thus, this study aims to evaluate the levels of NF-κB in OSCC patients and their adjacent normal tissue. …”
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Prevalence of HIV Drug Resistance Mutations in HIV Type 1 Isolates in Antiretroviral Therapy Naïve Population from Northern India by S. Sinha, H. Ahmad, R. C. Shekhar, N. Kumar, L. Dar, J. C. Samantaray, S. K. Sharma, A. Bhargava, R. M. Pandey, R. L. Mitsuyasu, J. L. Fahey

“…Seventy three chronic HIV-1 infected ART naïve patients eligible for first line ART were enrolled from April 2006 to August 2008. In 68 patients DNA was successfully amplified and sequencing was done. 97% of HIV-1 strains belonged to subtype C, and one each to subtype A1 and subtype B. …”
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Effect of Interleukin-15 on CD11b, CD54, and CD62L Expression on Natural Killer Cell and Natural Killer T-Like Cells in Systemic Lupus Erythematosus by Syh-Jae Lin, Ji-Yih Chen, Ming-Ling Kuo, Hsiu-Shan Hsiao, Pei-Tzu Lee, Jing-Long Huang

“…The percentage of CD11b expressing NK cells and the % inhibition of CD62L expression on NKT-like cells by IL-15 correlated with serum anti-dsDNA levels in SLE patients, respectively. Taken together, we demonstrated the dysfunctional NK and NKT-like cells in SLE patients with regard to CD11b and CD62L expression and their response to IL-15.…”
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Preliminary Evidence of a Horizontal Transfer of Paramutation Phenomenon at the <i>pl1</i> Gene in Maize (<i>Zea mays</i> L.) by Roberto Pilu, Martina Ghidoli, Alessia Follador, Alessandro Passera, Paola Casati, Ervane Laure Cheyep Dinzeu, Elena Cassani, Michela Landoni

“…Despite extensive research, the molecular mechanisms underlying paramutation are still not fully understood, although numerous studies suggest the involvement of RNA-mediated changes in DNA methylation and in the chromatin structure of silenced genes. …”
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Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats by Artur Dembiński, Zygmunt Warzecha, Piotr Ceranowicz, Marcin Dembiński, Jakub Cieszkowski, Tomasz Gosiewski, Małgorzata Bulanda, Beata Kuśnierz-Cabala, Krystyna Gałązka, Peter Christopher Konturek

“…This effect was associated with significant reversion of the acetic acid-evoked decrease in mucosal blood flow and DNA synthesis. Moreover, administration of rifaximin significantly reduced concentration of proinflammatory TNF-α and activity of myeloperoxidase in colonic mucosa. …”
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Changes in Methylation Patterns of Tumor Suppressor Genes during Extended Human Embryonic Stem Cell Cultures by Kyung Min Kang, Jeoung Eun Lee, Ji Eun Park, Hyunjin Kim, Hee Yeon Jang, Minyeon Go, Dong Ryul Lee, Sung Han Shim

“…For each cell line, genomic DNA was extracted from early and late passages of cell cultures. …”
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Complete chloroplast genome of eight Phaius (Orchidaceae) species from China: comparative analysis and phylogenetic relationship by Kaifeng Tao, Lu Tang, Yan Luo, Lu Li

“…It provided a comprehensive investigation of various cp genomic features for phylogenetic implications, including overall genome structure, codon usage, repeat sequences, IR boundaries, DNA polymorphisms, and phylogenetic reconstruction. …”
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IL-13 Augments Histone Demethylase JMJD2B/KDM4B Expression Levels, Activity, and Nuclear Translocation in Airway Fibroblasts in Asthma by Khuloud Bajbouj, Mahmood Y. Hachim, Rakhee K. Ramakrishnan, Huwaida Fazel, Jumana Mustafa, Shahed Alzaghari, Mahmoud Eladl, Jasmin Shafarin, Ronald Olivenstein, Qutayba Hamid

“…Epigenetic alterations, including DNA methylation and histone modifications, have been reported to contribute to asthma pathogenesis. …”
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Gut microbiota and quantitative traits divergence at different altitude of long-tailed dwarf hamsters, Cricetulus longicaudatus by Yue Ren, Mengfan Tao, Xiaoliang Wang, Xinsheng Pu, Guangtong Guo, Kuiyou Chen, Bingyu Zhao, Yu Hou, Xin'gen Yang, Yumei Xu

“…We examined the diversity, abundance, and community structure of the gut microbiota of long-tailed dwarf hamsters from eight regions in Shanxi province during summer using 16S rDNA sequencing technology and analyzed the relationships between these microbiota and environmental variables as well as morphological indicators. …”
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Inhibitory Effects of a Novel PPAR-γ Agonist MEKT1 on Pomc Expression/ACTH Secretion in AtT20 Cells by Rehana Parvin, Erika Noro, Akiko Saito-Hakoda, Hiroki Shimada, Susumu Suzuki, Kyoko Shimizu, Hiroyuki Miyachi, Atsushi Yokoyama, Akira Sugawara

“…MEKT1 also was demonstrated to inhibit the protein-DNA interaction of Nur77/Nurr1-NurRE, Tpit-TpitRE, and Nur77-NBRE by ChIP assay. …”
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بررسی جهش‌های ژن IGHMBP2 مربوط به اختلال عصبی شارکو ماری توث در دو خانواده‌ی خوزستانی به روش WES by نگار زینا, آتوسا مرادزادگان

“…هدف از این مطالعه، شناسایی ژن‌ها و جهش‌های احتمالی دخیل در اختلالات ژنتیکی استخوان و همچنین یافتن جهش‌های جدید عامل این بیماری است که می‌تواند به عنوان اطلاعات پس‌زمینه و کمک به توسعه‌ی پانل‌های طراحی شده برای تشخیص این اختلال استفاده شود.روش‌ها: پس از جمع‌آوری خون محیطی بیماران و سایر شرکت‌کنندگان در مطالعه، ماده DNA به روش Salting out خالص‌سازی و با دستگاه Illumina 100X توالی‌یابی شد. …”
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Characteristics of Egg Production and Discovery of the Prolactin Gene in Indigenous Tropical White Leghorn Layer Chickens of Indonesia by N Pratiwi, T Sartika, Komarudin, T Haryati, T Kostaman, N Azizah, A Sukmara, B Brahmantiyo, Isbandi, H Zaenal, H Nuraini, H Khasanah, MF Ridhillah, F Saputra

“…A total of 185 WL chickens (5 batches) were utilized, with 47 DNA samples sequenced using specific primers for the PRL gene’s exons 2 and 5. …”
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Characterization of the Cannabis sativa glandular trichome epigenome by Lee J. Conneely, Bhavna Hurgobin, Sophia Ng, Muluneh Tamiru-Oli, Mathew G. Lewsey

“…The histone variant H2A.Z was largely found in intergenic regions and enriched in chromatin that contained genes involved in DNA homeostasis. Conclusion We report the first genome-wide histone post-translational modification maps for C. sativa glandular trichomes, and more broadly for glandular trichomes in plants. …”
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CFTR氯通道调控小鼠内毒素血症血小板活化及炎症因子生成 by 胡瑞, 周仪, 李梅, 王冠蕾

“…分离小鼠外周血的血小板，采用免疫印迹法检测TLR4蛋白的表达，采用实时定量PCR法检测炎症因子<italic>IL-1β</italic>、<italic>IL-6、IL-10、TNF-α</italic>和<italic>CRP</italic>的表达。采用腺病毒介导的CFTR cDNA过表达（Ad-CFTR）和应用CFTR矫正剂VX-661处理人巨核细胞株MEG-01，检测CFTR对LPS引起的上述指标变化的影响。…”
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Dataset of shotgun metagenomic evaluation of Sorghum bicolor rhizosphere microbiome in soils preceded by Glycine maxNCBINCBINCBINCBI by Olubukola Oluranti Babalola, Ben Jesuorsemwen Enagbonma

“…Thereafter, the shotgun sequencing was done to assess the microbial composition and functional genes from the extracted DNA. The effective metagenome after QC of the twelve samples include SA1 (99.72%), SA2 (99.50%), SA3 (99.68%), SN1 (99.75%), SN2 (99.76%), SN3 (99.70%), RA1 (99.72%), RA2 (99.77%), RN3 (99.72%), RN1 (99.67%), RN2 (99.68%), and RN3 (99.54%). …”
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