应用噬菌体随机肽库筛选 2 型登革病毒 E 蛋白的抗原表位 by 魏惠永, 江丽芳, 郭辉玉

“…【方法】以 DEN2 型特 异的 E 单克隆抗体作为筛选分子,生物淘洗噬菌体随机 12 肽库,将筛选的噬菌体阳性克隆进行 ELISA 检测、DNA 序列测定及展示肽的氨基 酸序列推导,通过展示肽序列与 DEN2 E 蛋白的氨基酸一级结构的对比,确定 E 蛋白的抗原优势表位并用相应的合成肽验证。…”
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An Adverse Outcome Pathway Linking Organohalogen Exposure to Mitochondrial Disease by Brooke McMinn, Alicia L. Duval, Christie M. Sayes

“…Pathway 1 details the downstream consequences of oxidative stress, which include mitochondrial DNA damage, protein aggregation, and depolarization of the mitochondrial membrane. …”
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Salivary biomarkers in cancer - A narrative review by R. Swaathi, Madhu Narayan, Rajkumar Krishnan

“…Antibodies, microorganisms, Deoxyribonucleic acid (DNA), Ribonucleic acid (RNA), lipids, metabolites and proteins are some of the many types of biomarkers. …”
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Cbf11 and Mga2 function together to activate transcription of lipid metabolism genes and promote mitotic fidelity in fission yeast. by Anna Marešová, Michaela Grulyová, Miluše Hradilová, Viacheslav Zemlianski, Jarmila Princová, Martin Převorovský

“…Interestingly, Mga2 binding appears to be dependent on the presence of Cbf11 and Cbf11 likely acts as a tether to DNA, while Mga2 is needed to activate the target genes. …”
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Naked barley: taxonomy, breeding, and prospects of utilization by K. A. Lukina, O. N. Kovaleva, I. G. Loskutov

“…Hypotheses on the centers of its origin are discussed using DNA marker data. The main areas of its cultivation are shown, along with possible reasons for such a predominating or exclusive distribution of naked barley in highland areas. …”
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Study of some virulence genes from uropathogenic Klebsiella pneumoniae and Pseudomonas aeruginosa isolated in Wasit Province, Iraq by Rana H. Raheema, Sabaa Hilal Hadi, Zainab Adil Ghani Chabuck

“…Results: The findings of the biochemical results revealed that 16/100 isolates had a 16% positive response for K. pneumonia, and 13/100 isolates had a 13% positive response for P. aeruginosa. When DNA was recovered from the isolates, the nucleic acid purity was diverse from 1.8 to 2.0, and the concentration fluctuated from 50 to 360 mg/µL. …”
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On mechanisms of antitumor action of tropolon series compounds by G. V. Zhukova, E. A. Lukbanova, T. P. Protasova, E. V. Zaikina, A. A. Kiblitskaya

“…In addition to the disruption in the formation of the cell division spindle, shown for colchicine and colchamine, such phenomena as caspase-dependent apoptosis and some other types of apoptosis, autophagy, limitation of mitochondrial metabolism, DNA damage and demethylation, and accelerated aging of malignant cells etc. have been described. …”
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TopoQual polishes circular consensus sequencing data and accurately predicts quality scores by Minindu Weerakoon, Sangjin Lee, Emily Mitchell, Haynes Heaton

“…This is achieved by sequencing circularized DNA molecules multiple times and combining them into a consensus sequence. …”
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Antibacterial Activity and Mechanisms of Action of Inorganic Nanoparticles against Foodborne Bacterial Pathogens: A Systematic Review by Abayeneh Girma, Birhanu Abera, Bawoke Mekuye, Gedefaw Mebratie

“…Cell wall interaction and membrane penetration, reactive oxygen species production, DNA damage, and protein synthesis inhibition were some of the generalized mechanisms recognized in the current study. …”
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GNE Myopathy in Turkish Sisters with a Novel Homozygous Mutation by Gulden Diniz, Yaprak Secil, Serdar Ceylaner, Figen Tokucoglu, Sabiha Türe, Mehmet Celebisoy, Tülay Kurt İncesu, Galip Akhan

“…The muscle biopsy showed primary myopathic features and presence of rimmed vacuoles. DNA analysis demonstrated the presence of previously unknown homozygous mutations [c.2152 G>A (p.A718T)] in the GNE genes. …”
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Circular dichroism of relativistically–moving chiral molecules by Mitchell R. Whittam, Benedikt Zerulla, Marjan Krstić, Maxim Vavilin, Christof Holzer, Markus Nyman, Lukas Rebholz, Ivan Fernandez-Corbaton, Carsten Rockstuhl

“…Specifically, the effect of a relativistic motion on the transmission circular dichroism (TCD) of three life–essential biomolecules, namely, B–DNA, chlorophyll a, and chlorophyll b, is investigated. …”
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Phosphorylation of histone H3Ser10 in plant cell division by D. B. Loginova, O. G. Silkova

“…It has been shown that this type of modification is required for activation of transcription, DNA damage repair, recombination and also for chromosome condensation and segregation. …”
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Rule-Based Knowledge Acquisition Method for Promoter Prediction in Human and Drosophila Species by Wen-Lin Huang, Chun-Wei Tung, Chyn Liaw, Hui-Ling Huang, Shinn-Ying Ho

“…PromHD utilizes an effective feature-mining algorithm and a reference feature set of 167 DNA sequence descriptors (DNASDs), comprising three descriptors of physicochemical properties (absorption maxima, molecular weight, and molar absorption coefficient), 128 top-ranked descriptors of 4-mer motifs, and 36 global sequence descriptors. …”
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A new strategy for the treatment of advanced ovarian cancer: utilizing nanotechnology to regulate the tumor microenvironment by Zixuan Xiong, Yichun Huang, Shulong Cao, Xuqun Huang, Haiyuan Zhang

“…In the non-immune TME, mechanisms such as apoptosis inhibition, DNA damage response (DDR), and epithelial-mesenchymal transition (EMT) can promote tumor growth, metastasis, and drug resistance. …”
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Community structure of heritable viruses in a Drosophila-parasitoids complex by Varaldi, Julien, Lepetit, David, Burlet, Nelly, Faber, Camille, Baretje, Bérénice, Allemand, Roland

“…After two lab generations, putative DNA and RNA viruses were purified and sequenced. …”
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钝顶螺旋藻多糖抗单纯疱疹病毒2型的作用 by 朱萧, 于红, 张文卿

“…【结果】PSP对Vero细胞毒性极低(TC50为1750μg/mL),对HSV-2无直接灭活作用,可抑制病毒吸附和感染细胞内病毒的复制,其中50μg/mL、100μg/mL、200μg/mL浓度的PSP对病毒复制的抑制率分别为63.94%、81.41%、85.63%;FQ-PCR结果显示随着PSP浓度及作用时间的增加,PSP对HSV-2DNA的抑制作用明显增强,具有良好的剂量和时效关系。【结论】PSP在体外具显著的抗HSV-2病毒作用,此作用发生在病毒吸附、病毒基因复制等多个环节上。…”
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Large Rearrangements in Genes Responsible for Familial Adenomatous Polyposis, <i>MUTYH</i>-Associated Polyposis and Peutz–Jeghers Syndrome in Russian Patients by A. N. Loginova, Yu. A. Shelygin, V. P. Shubin, A. M. Kuzminov, D. Yu. Pikunov, T. A. Saveleva, A. S. Tsukanov

“…For the first time, the expediency of including the method of detecting large rearrangements in routine DNA test list for Russian patients with various hereditary polyposis syndromes is demonstrated. …”
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Diverse Effects of Lead Nitrate on the Proliferation, Differentiation, and Gene Expression of Stem Cells Isolated from a Dental Origin by Mariam Abdullah, Fazliny Abd. Rahman, Nareshwaran Gnanasegaran, Vijayendran Govindasamy, Noor Hayaty Abu Kasim, Sabri Musa

“…Gene expression studies revealed a constant expression of key markers associated with stemness (Oct 4, Rex 1) and DNA repair enzyme markers, but downregulation occurred with some ectoderm and endoderm markers, demonstrating an irregular and untimely differentiation trail. …”
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The role of Anatolia between Asia and Europe: A case study of oak gall wasp species, Cynips quercus (Hymenoptera, Cynipidae) by Serdar Dinç, Serap Mutun

“…In this study, we used DNA sequence data of a western Palearctic oak gall wasp species, Cynips quercus, showing distribution from Europe to Iran to answer the following questions: i) Do the eastern C. quercus populations have higher genetic diversity than the European populations?…”
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Deciphering the Impact of miR-92a-3p on Controlling BCL11A Gene Expression and Its Implication in Easing Thalassemia Symptoms by Mohammed M. Salih Al-Khafaji, Anas Y. Al-Hayawi

“…The process involved the addition of the polyadenosine monophosphate enzyme Poly-A to facilitate the production of mature messenger RNA (mRNA) from DNA. Results: The study revealed significantly elevated miR-92a expression in blood cells. …”
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