CCC2 基因缺陷型酵母对中国人Wilson 病突变热点致病性的研究 by 丰岩清, 李洵桦, 国宁, 梁秀龄, 黄帆, 王莹, 陈曦

“…【方法】应用RT-PCR 和TOPO TA 克隆技术分段克隆ATP7B 的全长cDNA, USE 定点诱变技术制备突变体, 应用酵母功能互补分析的方法研究 Arg778Leu 的致病性。…”
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Evolutionary origins and functional diversification of Auxin Response Factors by Jorge Hernández-García, Vanessa Polet Carrillo-Carrasco, Juriaan Rienstra, Keita Tanaka, Martijn de Roij, Melissa Dipp-Álvarez, Alejandra Freire-Ríos, Isidro Crespo, Roeland Boer, Willy A. M. van den Berg, Simon Lindhoud, Dolf Weijers

“…We reveal the shared origin of ARFs from preexisting domains, uncovering a protein fold homologous to the ARF DNA-binding fold in a conserved eukaryotic chromatin regulator. …”
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Temozolomide Therapy for Aggressive Pituitary Tumors: Results in a Small Series of Patients from Argentina by Oscar D. Bruno, Lea Juárez-Allen, Silvia B. Christiansen, Marcos Manavela, Karina Danilowicz, Carlos Vigovich, Reynaldo M. Gómez

“…In all the patients tested O6-methylguanine-DNA methyltransferase (MGMT) immunoexpression in surgical specimens was absent. …”
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Genetic Variations in Nucleotide Excision Repair Pathway Genes and Risk of Allergic Rhinitis by Wenlong Liu, Qingxiang Zeng, Yinhui Zeng, Yiquan Tang, Renzhong Luo

“…Our finding showed that genetic variations in NER pathway genes: ERCC1 and XPC may affect the risk of AR, which will provide new insights into the genetics of AR from the perspective of DNA damage repair.…”
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The relative biologic effectiveness versus linear energy transfercurve as an output-input relation for linear cellular systems by Quoc T. Luu, Paul DuChateau

“…Although multiple biochemical parts may well be involved, the shape of the RBE-LET curve is reproduced when only three system parameters are related to three biochemical parts: the molecular machinery for DNA double strand break repair; the molecular pathways for handling oxidative stress; and the radiolytic products of the cellular water.    …”
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Effect of Ultrafine Powderization and Solid Dispersion Formation via Hot-Melt Extrusion on Antioxidant, Anti-Inflammatory, and the Human Kv1.3 Channel Inhibitory Activities of Ange... by Yunyao Jiang, Jingpei Piao, Nan Liu, Jincai Hou, Jianxun Liu, Weicheng Hu

“…The process of ultrafine powderization on AGN significantly increased the total phenolic and flavonoid contents, antioxidant activity, and DNA damage protective effect. On the contrary, AGN solid dispersion (AGN-SD) based on Soluplus® showed the highest inhibitory effect on NO production and the human Kv1.3 channel. …”
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Assessment of Protective Effects of Carvacrol on Haloperidol-Induced Oxidative Stress and Genotoxicity in Human Peripheral Blood Lymphocytes by Ehsan Zamani, Alireza Ahmadi Shad, Hediye Fatemi, Saba Mahboubi, Azadeh Motavallian, Mehdi Evazalipour

“…Significant increases in the levels of genotoxicity biomarkers (micronucleus frequency, DNA percentage in tail and tail moment) were observed in haloperidol-treated cells. …”
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Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley’s Toxin by C. Maletzki, U. Klier, W. Obst, B. Kreikemeyer, M. Linnebacher

“…Effects were attributed to necrotic as well as apoptotic cell death as determined by increased Caspase 3/7 levels, raised numbers of cells with sub-G1-DNA, and induced p expression, indicative for cell cycle arrest. …”
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Toll-Like Receptor Signaling and Liver Fibrosis by Tomonori Aoyama, Yong-Han Paik, Ekihiro Seki

“…The liver is constantly exposed to PAMPs, such as LPS and bacterial DNA through bacterial translocation because there is a unique anatomical link, the portal vein system between liver and intestine. …”
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Studies of clinical symptoms of panleukopenia in cats in the Donetsk People’s Republic by I. V. Berdyukova, P. A. Rudenko

“…Feline panleukopenia is a highly contagious viral disease of the members of the family Felidae caused by a DNA-virus of the family Parvoviridae. After infection, the virus is detected in saliva, nasal discharge, urine and feces; it is transmitted through excrements, water, food, and, according to some reports, by bloodsucking insects. …”
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Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo. by Buthaina Al Shueili, Arthur Dantas, Etienne Mahe, Tak Ho Chu, Yang Yang, Elodie Labit, Eren Kutluberk, Nicolas Lasaleta, Anand Masson, Hiba Omairi, Kenichi Ito, Roman J Krawetz, Rajiv Midha, Gregory Cairncross, Karl Riabowol

“…ING5 KO mouse embryo fibroblasts accumulate in G2 of the cell cycle, have high levels of abnormal nuclei and show high basal levels of the γH2AX indicator of DNA damage. KO animals also develop severe dermatitis at a 5-fold higher rate that wild-type littermates. …”
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Loss of p53 Expression in Gastric Epithelial Cells of Helicobacter pylori-Infected Jordanian Patients by Mohammad A. Abu-Lubad, Ghada F. Helaly, Weliam J. Haddadin, Dua’a A. K. Jarajreh, Amin A. Aqel, Munir A. Al-Zeer

“…H. pylori induces the production of reactive oxygen species, DNA damage, and accelerates the degradation of the tumor suppressor protein p53, which may lead to cancer development. …”
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Unlocking genetic diversity for low-input systems in a changing climate through participatory characterization and GWAS of lentil landraces by Elisa Lorenzetti, Mercy Wairimu Macharia, Svenja Mager, Matteo Dell’Acqua, Stefano Carlesi, Paolo Bàrberi

“…Meanwhile, we genotyped the landrace collection with a DNA sequencing approach, obtaining 91,136 high quality single nucleotide polymorphisms (SNPs). …”
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A Review on JC Virus Infection in Kidney Transplant Recipients by Serena Delbue, Mariano Ferraresso, Luciana Ghio, Camilla Carloni, Silvia Carluccio, Mirco Belingheri, Alberto Edefonti, Pasquale Ferrante

“…The polyomavirus (PyV), JC virus (JCV), is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue. …”
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The effect of feed additive ethoxyquin on tilapia growth performance and potential secondary hazard to consumers by Shanjun Chen, Chong Wang, Yanan Liu, Zhigang Zhou, Linglin Fu, Yanbo Wang

“…Additionally, the microbiota in the intestinal content and flesh was analyzed by 16S rDNA sequencing, and the flesh metabolites was measured by LC-MS/MS untargeted metabolomics. …”
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Age-Dependent Loss of Mitochondrial Function in Epithelial Tissue Can Be Reversed by Coenzyme Q10 by Daniel Schniertshauer, Daniel Gebhard, Jörg Bergemann

“…The accumulation of reactive oxygen species damaged mitochondrial DNA and proteins can induce mitochondrial dysfunction within the electron transport chain. …”
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Glucocorticoid receptor: translocation from the cytoplasm to the nuclei, chromatin and intranuclear chaperone cycles by V. M. Merkulov, N. V. Klimova, T. I. Merkulova

“…Upon ligand binding, GR dissociates from chaperon complex and translocates into the nucleus, where it interacts with specific DNA sequences (GREs) in the regulatory regions of target genes and modulates their expression. …”
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Metagenomic investigation of viruses in green sea turtles (Chelonia mydas) by Hongwei Li, Yuan Chen, Zhongrong Xia, Daohua Zhuang, Feng Cong, Yue-Xiao Lian

“…Most viral contigs were DNA viruses that mainly belonged to Caudoviricetes, followed by Crassvirales. …”
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Severe Wound Infection with Photobacterium damselae ssp. damselae and Vibrio harveyi, following a Laceration Injury in Marine Environment: A Case Report and Review of the Literatur... by Jörg Hundenborn, Steffi Thurig, Mechthild Kommerell, Heike Haag, Oliver Nolte

“…Identification was achieved by use of Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry (MALDI-TOF) and confirmed by 16S rDNA sequencing. Data retrieval from bibliography was complicated since P. damselae has been renamed often with a number of synonyms present in the literature: Photobacterium damsela, Vibrio damselae, Vibrio damsela, Pasteurella damselae, and Listonella damsela. …”
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Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice by E. Hattinger, S. Scheiblhofer, E. Roesler, T. Thalhamer, J. Thalhamer, R. Weiss

“…Recently, mRNA vaccines have been introduced as a safety-optimized alternative to plasmid DNA-based vaccines for protection against allergy. …”
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