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3961
Antibody to dense fine speckled 70 and its significance in a Sub-Himalayan population: A hospital-based study
Published 2022-01-01“…Those with DFS70 band in the immunoblot) underwent tests for other autoantibodies such as antineutrophil cytoplasmic antibodies, and anti-dsDNA. Association analysis was performed in a software package (SPSS version 23). …”
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3962
Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols
Published 2025-02-01“…From the perspective of ROS-mitochondrial pathway, the article elucidates how tea polyphenols behaved the beneficial effects against cardiovascular diseases by modulating the expression of mitochondrial fusion and fission proteins, reducing the opening of mitochondrial membrane permeability transition pore, maintaining cellular calcium homeostasis, mitigating mitochondrial DNA damage and regulating mitochondrial apoptosis signaling pathways. …”
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3963
Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications
Published 2020-01-01“…Excess reactive oxygen species (ROS) production is very harmful to cell constituents, especially proteins, lipids, and DNA, thus causing damage to the cell. Oxidative stress has been associated with a variety of pathologic conditions, including diabetes mellitus (DM), cancer, atherosclerosis, neurodegenerative diseases, rheumatoid arthritis, ischemia/reperfusion injury, obstructive sleep apnea, and accelerated aging. …”
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3964
Safety evaluation of the food enzym endo‐1,4‐β‐xylanase from the genetically modified Bacillus subtilis strain AR‐153
Published 2024-12-01“…The food enzyme is free from viable cells of the production organism and its DNA. It is intended to be used in four food manufacturing processes. …”
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3965
中国人群MEGSIN基因单核苷酸多态性的检测
Published 2006-01-01“…【方法】随机选取208例广东地区汉族个体,提取基因组DNA。对包含外显子、外显子-内含子交界区及5’UTR区、3’UTR区的PCR产物进行直接测序。…”
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3966
Streptomyces sp. strain MUSC 5 from mangrove forest in Malaysia: Identification, antioxidant potential and chemical profiling of its methanolic extract
Published 2020-05-01“… The present study explored the antioxidant potential of a Streptomyces sp. strain MUSC 5 from the mangrove forest soil in the Pahang State, Peninsular of Malaysia and determined the presence of biologically active chemical constituents contained in the methanolic extract. The 16S rRNA genomic DNA extraction, phylogenetic analysis and phenotyping methods were used to confirm identity of strain. …”
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3967
Ecology of prophage-like elements in Bacillus subtilis at global and local geographical scales
Published 2025-01-01“…Laboratory experiments indicate that most predicted prophages are cryptic, as they are not induced under DNA-damaging conditions. Importantly, stress responses increase with the number of predicted prophages, suggesting their influence on host physiology. …”
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3968
Erwinia phage Asesino is a nucleus-forming phage that lacks PhuZ
Published 2025-01-01“…We show that Asesino replicates via a phage nucleus that encloses phage DNA and partitions proteins in the nuclear compartment and cytoplasm in a manner similar to previously characterized nucleus-forming phages. …”
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3969
Computer analysis shows differences between mitochondrial miRNAs and other miRNAs
Published 2025-01-01“…A subclass of miRNAs with as yet unknown specific functions is mitomiRs – mitochondrial miRNAs that are mainly derived from nuclear DNA and are imported into mitochondria; moreover, changes in the expression levels of mitomiRs are associated with some diseases. …”
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3970
Development and characterization of a reverse genetics system for the lineage II Chicava strain of Machupo virus in a guinea pig model.
Published 2025-01-01“…<h4>Methods</h4>We report the development of a reverse genetics system for the MACV lineage II Chicava strain, using a pRF42 plasmid encoding the L and S segment genomic RNA under the transcriptional control of a murine DNA-dependent RNA polymerase I promoter sequence. …”
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3971
Evaluation of Association of Oral Bacterial Profile with HBV and HCV Infection and T Lymphocyte Level in HIV-Positive Patients
Published 2022-01-01“…After primary biochemical test of cultured samples, assessment of bacterial biofilms was done by DNA extraction. Real-time PCR with specific primer of each bacterial species was done, and assessment of the results of real time PCR led to determination of the species of the evaluated bacteria. …”
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3972
Effect of Ethanol Extract of <italic>Hedyotis Diffusa</italic> Willd on Inhibiting Lymphangiogenesis in Colorectal Cancer
Published 2018-10-01“…Phase-contrast microscope, cell DNA content, AnnexinⅤ/PI staining showed that EEHDW did not have significant effect on cell morphological, cell cycle, and cell apoptosis. …”
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3973
Prevalence of Coxiella burnetii in unpasteurized dairy products in west of Iran
Published 2025-05-01“…To analyze the genome of C. burnetii, DNA was purified and molecular detection was performed using nested PCR with primers specific to the IS1111 transposon gene. …”
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3974
Nicotinamide adenine dinucleotide supplementation fails to enhance anesthetic recovery in rodents
Published 2025-01-01“…Abstract Nicotinamide Adenine Dinucleotide (NAD+) is implicated in bioenergetics, DNA repair, and senescence. Depletion of NAD+ is associated with aging and neurodegenerative disease, prompting a growing interest in NAD+ supplementation. …”
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3975
A walk through the development of human leukocyte antigen typing: from serologic techniques to next-generation sequencing
Published 2024-12-01“…HLA typing technology began with serological methods and has evolved rapidly alongside advances in molecular technologies, progressing from DNA-based typing to next- or third-generation sequencing. …”
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3976
Immunization against Lamb Haemonchosis with a Recombinant Somatic Antigen of Haemonchus contortus (rHcp26/23)
Published 2010-01-01“…Our previous results showed that a soluble fraction from adult stages of the nematode (p26/23) induced partial protection against challenge. Recombinant DNA technology was applied to obtain a synthetic protein (rHcp26/23). …”
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3977
Glutathione S-transferase polymorphism in ethnic groups living in Eastern Siberia
Published 2017-11-01“…To this end, genetic typing of DNA samples was performed by polymerase chain reaction. …”
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3978
Porphyra-334, a mycosporine-like amino acid, attenuates UV-induced apoptosis in HaCaT cells
Published 2017-06-01“…Due to their UV-screening capacity and ability to prevent UV-induced DNA damage, MAAs have recently attracted considerable attention in both industry and research in pharmacology. …”
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3979
Oligonucleotide-Based Therapy for FTD/ALS Caused by the C9orf72 Repeat Expansion: A Perspective
Published 2013-01-01“…Two basic mechanisms have been proposed as being potentially responsible for c9FTD/ALS: loss-of-function of the protein encoded by this gene (associated with aberrant DNA methylation) and gain of function through the formation of RNA foci or protein aggregates. …”
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3980
The impact of PD-L1 polymorphisms on the efficacy of immune checkpoint inhibitors depends on the tumor proportion score: a retrospective study
Published 2025-02-01“…Method Patients treated with immune checkpoint inhibitor monotherapy for non-small cell lung cancer at Kyoto University Hospital until January 2023, with TPS data and biological specimens available for SNP measurement, were eligible for this study. Genomic DNA was extracted from peripheral blood leukocytes. …”
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