The Desmosomal Plaque Proteins of the Plakophilin Family by Steffen Neuber, Mario Mühmer, Denise Wratten, Peter J. Koch, Roland Moll, Ansgar Schmidt

“…These proteins have been implicated in cell signaling, organization of the cytoskeleton, and control of protein biosynthesis under specific cellular circumstances. …”
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Vesicles Generated during Storage of Red Blood Cells Enhance the Generation of Radical Oxygen Speciesin Activated Neutrophils by Herbert Jank, Ulrich Salzer

“…This uptake is different from a phagocytotic process and is enhanced upon interference with the cellular actin cytoskeleton. Preincubation of neutrophils with Vsto vesicles results in an enhanced ROS generation by neutrophils, which is further increased upon fMLP stimulation and during zymosan phagocytosis. …”
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Integrin-Linked Kinase: A Multi-functional Regulator Modulating Extracellular Pressure-Stimulated Cancer Cell Adhesion through Focal Adhesion Kinase and AKT by Shouye Wang, Marc D. Basson

“…The siRNA-mediated loss of function of ILK in regulating increase in adhesion by pressure was not rescued by overexpression of α-parvin, an important ILK binding partner, although pressure promoted ILK–α-parvin association and translocated both ILK and α-parvin from cytosol to membrane/cytoskeleton. ILK may be a key mediator of mechanotransduced signals in cancer cells and an important therapeutic target to inhibit metastatic cancer cell adhesion.…”
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Unraveling the Determinants of Protrusion Formation by Mita Varghese, Peter Gorsevski, Marilyn L. Cayer, Nancy S. Boudreau, Carol A. Heckman

“…We conclude that cells establish functional domains by rearranging the cytoskeleton.…”
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Genotype-phenotype insights of pediatric dilated cardiomyopathy by Ying Dai, Yan Wang, Youfei Fan, Bo Han

“…Research has shown that DCM exhibits notable genetic heterogeneity, with over 100 DCM-related genes identified to date, primarily involving functions such as calcium handling, the cytoskeleton, and ion channels. As human genomic variations are linked to phenotypes, DCM phenotypes are influenced by numerous genetic variations across the entire genome. …”
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Nuclear envelope components in vascular mechanotransduction: emerging roles in vascular health and disease by Tung D. Nguyen, Michael A. Winek, Mihir K. Rao, Shaiva P. Dhyani, Monica Y. Lee

“…Studies implicate nucleoskeletal elements (e.g. nuclear lamina) and the linker of nucleoskeleton and cytoskeleton (LINC) complex in force transmission, emphasizing nucleo-cytoskeletal communication in mechanotransduction. …”
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Tight junction proteins in glial tumors development and progression by Jakub Moskal, Slawomir Michalak, Slawomir Michalak

“…Tight junctions are composed of a group of integral membrane proteins, which include the claudin family, tight junction-associated Marvel protein family, junctional adhesion molecule family, and proteins that anchor the cytoskeleton, such as zonula occludens proteins and the cingulin family. …”
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Exogenous LEA proteins expression enhances cold tolerance in mammalian cells by reducing oxidative stress by Martina Lo Sterzo, Domenico Iuso, Luca Palazzese, Margherita Moncada, Francesca Boffa, Aurora Scudieri, Luisa Gioia, Marta Czernik, Pasqualino Loi

“…Their protective action was due to the mitigation of cold-induced mitochondrial stress and the overproduction of reactive oxygen species (ROS), leading in turn to enhanced cytoskeleton stability and decreased DNA damage. Our studies showed that plant-derived LEA proteins exhibit remarkable cold protection effects in mammalian cells through their potent antioxidant properties, which was found comparable to Vitamin E.…”
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Advances in Focal Segmental Glomerulosclerosis Treatment From the Perspective of the Newest Mechanisms of Podocyte Injury by Zhu Y, Xu G

“…The role of mechanisms such as alterations in the actin cytoskeleton, oxidative stress, mitochondrial dysfunction, and inadequate autophagy within the microenvironment of podocyte injury have garnered increasing attention. …”
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Unique ultrastructural organization of human rod photoreceptors by Tylor R. Lewis, Natalia V. Klementieva, Sebastien Phan, Carson M. Castillo, Keun-Young Kim, Lauren Y. Cao, Mark H. Ellisman, Vadim Y. Arshavsky, Oleg Alekseev

“…These structures have two striking features: they are reinforced by a massive microtubular cytoskeleton and contain electron-dense adhesions that mediate their attachment to outer segments. …”
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Elastic Membrane That Undergoes Mechanical Deformation Enhances Osteoblast Cellular Attachment and Proliferation by G. K. Toworfe, R. J. Composto, M. H. Lee, P. Ducheyne

“…Upon application of a mechanical force to cells cultured on the functionalized silicone membrane in the form of a dynamic equibiaxial strain, 2% magnitude; at 1-Hz frequency for 2 h, the osteoblast cells elicited slightly elevated phalloidin fluorescence, suggesting that there was reorganization of the cytoskeleton. We concluded from this preliminary data obtained that the engineered surface transduced applied mechanical forces directly to the adherent osteoblast cells via integrin binding tripeptide receptors, present in the FN molecules, resulting in the enhanced cellular attachment and proliferation.…”
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Trypsin-instructed bioactive peptide nanodrugs with cascading transformations to improve chemotherapy against colon cancer by Can Wu, Xiao Wei Zhang, Manman Wang, Jinpan Sun, Jianfei Chen, Yanbin Guan, Xin Pang

“…After nanofiber disassembly, the released 1-Pept converts into Pept under the catalysis of intracellular overexpressed trypsin, which then reassembles into denser Pept NFs, inducing a cascade of effects including disruption of the cytoskeleton, mitochondrial dysfunction, and activation of caspase-3. …”
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Deletion of a Putative GPI-Anchored Protein-Encoding Gene Aog185 Impedes the Growth and Nematode-Trapping Efficiency of Arthrobotrys oligospora by Disrupting Transmembrane Transpor... by Hui Peng, Hengqian Lu, Xinyuan Dong, Xiao Liang, Kangliang Sheng, Jingmin Wang, Xiaowei Kong, Xiangdong Zha, Yongzhong Wang

“…Aog185 deletion could damage the intrinsic components of the membrane and cytoskeleton. Specifically, knockout of Aog185 disrupted transmembrane transport homeostasis during the phagocytosis, cell autophagy, and oxidative phosphorylation processes, which were associated with the fusion of cells and organelle membranes, transport of ions and substrates, and energy metabolism. …”
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Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis by Ferah Budak, Salih Haldun Bal, Gulcin Tezcan, Halis Akalın, Guher Goral, Haluk Barbaros Oral

“…The differentially expressed miRNAs and their predicted target genes involved in endocytosis, regulation of actin cytoskeleton, MAPK signaling pathway, and cytokine-cytokine receptor interaction and its chemokine signaling pathway indicate their potential roles in chronic brucellosis and its progression. …”
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Unraveling the Molecular Nexus between GPCRs, ERS, and EMT by Niti Kumari, Somrudee Reabroi, Brian J. North

“…By regulating downstream signaling pathways such as NF-κB, MAPK/ERK, PI3K/AKT, TGF-β, and Wnt/β-catenin, GPCRs also upregulate mesenchymal transcription factors including Snail, ZEB, and Twist superfamilies which regulate cell polarity, cytoskeleton remodeling, migration, and invasion. Likewise, ERS-induced UPR upregulates gene transcription and expression of proteins related to EMT enhancing tumor aggressiveness. …”
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Identification of Signal Pathways and Hub Genes of Pulmonary Arterial Hypertension by Bioinformatic Analysis by Rui-Qi Wei, Wen-Mei Zhang, Zhe Liang, Chunmei Piao, Guangfa Zhu

“…Significant KEGG pathway enrichment included ribosome biogenesis in eukaryotes, RNA transport, proteoglycans in cancer, dilated cardiomyopathy, rheumatoid arthritis, vascular smooth muscle contraction, focal adhesion, regulation of the actin cytoskeleton, and hypertrophic cardiomyopathy. The PPI network identified 10 hub genes including HSP90AA1, CDC5L, MDM2, LRRK2, CFTR, IQGAP1, CAND1, TOP2A, DDX21, and HIF1A. …”
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Transient ocular hypertension remodels astrocytes through S100B. by Weiran Huang, Kenji Matsushita, Rumi Kawashima, Susumu Hara, Yuichi Yasukura, Kaito Yamaguchi, Shinichi Usui, Koichi Baba, Andrew J Quantock, Kohji Nishida

“…Glial fibrillary acidic protein (GFAP), S100B, and actin staining were used to characterize astrocyte morphology and cytoskeleton, with qPCR used to measure mRNA expression. …”
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The Giardia ventrolateral flange is a lamellar membrane protrusion that supports attachment. by William R Hardin, Germain C M Alas, Nikita Taparia, Elizabeth B Thomas, Melissa C Steele-Ogus, Kelli L Hvorecny, Aaron R Halpern, Pavla Tůmová, Justin M Kollman, Joshua C Vaughan, Nathan J Sniadecki, Alexander R Paredez

“…This work supports the emerging view that Giardia's unconventional actin cytoskeleton has an important role in supporting parasite attachment.…”
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Differential proteome analysis of pea roots at the early stages of symbiosis with nodule bacteria by I. V. Leppyanen, A. N. Kirienko, A. A. Lobov, E. A. Dolgikh

“…They may be involved in the regulation of reactions with calcium, the reorganization of the actin cytoskeleton and other important processes in plants. …”
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Activity of Various Cathepsin Proteases and Enrichment of Klotho Protein in the Urine and Urinary Extracellular Vesicles After SARS-CoV-2 Infection by Niharika Bala, Ramish H. Rafay, Sarah C. Glover, Abdel A. Alli

“…The identified proteins were predominantly associated with cellular membranes and with function of the cytoskeleton, enzyme regulation, and signal transduction. …”
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