Recent approaches in the drug research and development of novel antimalarial drugs with new targets by Chinnappanna Naveen Kumar Reddy, Yennam Gopi, Chaitanya Chaitanya Budagam Haima Naga Venkata, Pottathil Shinu, Borah Pobitra, Venugopala Katharigatta N., Deb Pran Kishore, Mailavaram Raghu Prasad

“…To prevent a public health disaster, novel antimalarial agents with single-dosage therapies, extensive curative capability, and new mechanisms are urgently needed. …”
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Innate immune cells in vascular lesions: mechanism and significance of diversified immune regulation by Jinjing Wu, Yulu Qian, Kuang Yang, Shuhua Zhang, Erming Zeng, Daya Luo

“…While it has a remarkable curative effect and survival benefits, it also faces many challenges. …”
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Jack London and White Fang: a lost struggle by Zilberstein, Gleb, Zilberstein, Svetlana, Rocco, Richard M., Righetti, Pier Giorgio

“…The California State Parks curators granted access to artifacts owned by Jack London that are in storage in their Sonoma Barracks in Sonoma, CA. …”
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Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF-κB/NLRP3 Signaling Pathway by Taiqiu Chen, Pengfei Li, Jincheng Qiu, Wenjun Hu, Shaoguang Li, Huihong Shi, Xianjian Qiu, Dongsheng Huang, Wenjie Gao, Anjing Liang

“…We found that aloin had a curative effect on extracellular matrix metabolism and apoptosis in TNF-alpha- (TNF-α-) treated NPCs by inhibiting oxidative stress and the proinflammatory factor expression. …”
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Prediction of protein biophysical traits from limited data: a case study on nanobody thermostability through NanoMelt by Aubin Ramon, Mingyang Ni, Olga Predeina, Rebecca Gaffey, Patrick Kunz, Shimobi Onuoha, Pietro Sormanni

“…We further demonstrate NanoMelt’s potential to streamline nanobody development by guiding the selection of highly stable nanobodies. We make the curated dataset of nanobody thermostability freely available and NanoMelt accessible as a downloadable software and webserver.…”
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Mechanism of Acupuncture and Moxibustion on Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Narrative Review of Animal Studies by Xiaoling Wu, Kai Cheng, Chang Xu, Shaoming Liu, Qianhui Sun, Zhiwen Yang, Xingye Dai, Na Li

“…Acupuncture and moxibustion have been a way to CP/CPPS, showing good curative effect with advantages of safety and affordability. …”
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Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases by Juan Shi, Shuhong Chi, Jing Xue, Jiali Yang, Feng Li, Xiaoming Liu

“…Despite the fact that therapeutic interventions are available for ameliorating disease manifestations, there is no curative therapy currently available for autoimmune disorders. …”
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Autoantibody Response to Murine Double Minute 2 Protein in Immunodiagnosis of Hepatocellular Carcinoma by Mei Liu, Su-jun Zheng, Yu Chen, Ning Li, Peng-fei Ren, Li-ping Dai, Zhong-ping Duan, Jian-Ying Zhang

“…Thus, early detection of HCC may enhance effective and curative management. In this study, autoantibody responses to MDM2 protein in HCC patient’s serum were evaluated by enzyme-linked immunosorbent assay (ELISA) and part sera were evaluated by Western blotting and indirect immunofluorescence assay. …”
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Cernunnos/XLF Deficiency: A Syndromic Primary Immunodeficiency by Funda Erol Çipe, Cigdem Aydogmus, Arzu Babayigit Hocaoglu, Merve Kilic, Gul Demet Kaya, Elif Yilmaz Gulec

“…Fully matched donor screening is in progress for bone marrow transplantation which is curative treatment of the disease. In conclusion, the patients with microcephaly, bird-like face, and severe growth retardation should be evaluated for hypogammaglobulinemia and primary immunodeficiency diseases.…”
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A Successfully Treated Case of Gastrointestinal Stromal Tumor Causing Severe Anemia and Localized Peritonitis Showing Angina Pectoris Resulting in Watershed Cerebral Infarction by Yoshihide Sehara, Yuka Hayashi, Kenichi Ohya, Naoki Kaneko, Mikio Sawada

“…We decided to perform curative surgery after transfusion and successfully resected the mass of the small intestine, which was revealed to be a gastrointestinal stromal tumor (GIST). …”
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A Pseudomonas-based bio-formulation to control bacterial blight of pomegranate caused by Xanthomonas axonopodis pv. punicae by Pavan Kumar, Giandomenico Corrado, Girigowda Manjunatha, Suma Ramegowda, Pradeep Kumar, Boris Basile, Ganadalu Puttaswamy Mutthuraju, Baggana Girish Jasmitha

“…Greenhouse trials with Xap-inoculated plants revealed that preventive application of each of the three isolates was more effective than curative, with UHSPS15A providing the highest protection. …”
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Oncologic Impact of Conservative Treatment Compared with Surgical Treatment of Anastomotic Leakage Following Colorectal Cancer Surgery: A Retrospective Study by Junichi Sakamoto, Atsuko Tsutsui, Chie Hagiwara, Go Wakabayashi

“…Methods: From July 2011 to June 2020, 385 patients underwent curative resection with double-stapling anastomosis for left-sided colon and rectal cancers. …”
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A data-driven latent variable approach to validating the research domain criteria framework by S. K. L. Quah, B. Jo, C. Geniesse, L. Q. Uddin, J. A. Mumford, D. M. Barch, D. A. Fair, I. H. Gotlib, R. A. Poldrack, M. Saggar

“…We examine 84 whole-brain task-based fMRI (tfMRI) activation maps from 19 studies with 6192 participants. A curated subset of 37 maps with a balanced representation of RDoC domains constitute the training set, and the remaining held-out maps form the internal validation set. …”
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Resistance to Radiotherapy in Cancer by Almaz A. Akhunzianov, Elvira V. Rozhina, Yuliya V. Filina, Albert A. Rizvanov, Regina R. Miftakhova

“…Around 50% of all patients will require radiotherapy, 60% of whom are treated with curative intent. Moreover, it is commonly used for palliative treatment. …”
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The Rising Burden of Diabetes and Hypertension in Southeast Asian and African Regions: Need for Effective Strategies for Prevention and Control in Primary Health Care Settings by Viswanathan Mohan, Yackoob K. Seedat, Rajendra Pradeepa

“…To meet the twin challenge of DM and HTN in developing countries, PHCs will have to be strengthened with a concerted and multipronged effort to provide promotive, preventive, curative, and rehabilitative services.…”
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Signal to Noise Ratio as a Cross-Platform Metric for Intraoperative Fluorescence Imaging by Asmaysinh Gharia BA, Efthymios P. Papageorgiou PhD, Simeon Giverts BA, Catherine Park MD, Mekhail Anwar MD, PhD

“…Real-time molecular imaging to guide curative cancer surgeries is critical to ensure removal of all tumor cells; however, visualization of microscopic tumor foci remains challenging. …”
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Effect of Carboxymethyl chitosan-sodium alginate hydrogel loaded with Astragalus membranaceus-Panax notoginseng on wound healing in rats by Jing Li, Jing Li, Linai Li, Yue Yu, Ruixin Qin, Chaoyan Yu, Chen Chen, Youming Dong, Yadong Tan, Yunen Liu, Xuanli Liu

“…The application of new materials may make A. membranaceus-P. notoginseng (AP) play a better curative effect. In this study, we fabricated a Carboxymethyl chitosan-Sodium alginate hydrogel loaded with the extract of Astragalus membranaceus-P. notoginseng (APCS), which showed favorable stability, biocompatibility, and the ability to rapidly release drugs. …”
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Development and pan-cancer validation of an epigenetics-based random survival forest model for prognosis prediction and drug response in OS by Chaoyi Yin, Kede Chi, Zhiqing Chen, Shabin Zhuang, Yongsheng Ye, Binshan Zhang, Cailiang Cai

“…An epigenetics-based Random Survival Forest (RSF) model was constructed using 801 curated epigenetic factors and validated in multiple independent cohorts.ResultsOur analysis revealed distinct epigenetic states in the OS microenvironment, with particular activity in OS cells and osteoclasts. …”
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DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon by Ran Qi, Yunfeng Zhou, Xiaozhen Li, Hong Guo, Lei Gao, Lijuan Wu, Yufeng Wang, Qiang Gao

“…The endoscopic biopsies were collected from patients with Barrett esophagus, while the curative resection tissues were obtained from patients with gastric cancer, CRC, or hepatic carcinoma. …”
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DeepExtremeCubes: Earth system spatio-temporal data for assessing compound heatwave and drought impacts by Chaonan Ji, Tonio Fincke, Vitus Benson, Gustau Camps-Valls, Miguel-Ángel Fernández-Torres, Fabian Gans, Guido Kraemer, Francesco Martinuzzi, David Montero, Karin Mora, Oscar J. Pellicer-Valero, Claire Robin, Maximilian Söchting, Mélanie Weynants, Miguel D. Mahecha

“…Machine learning techniques show promise but require well-structured, high-quality, and curated analysis-ready datasets. Earth observation datasets comprehensively monitor ecosystem dynamics and responses to climatic extremes, yet the data complexity can challenge the effectiveness of machine learning models. …”
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