Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta. by Jennifer McIntyre, Alison Morrison, Kirsty Maitland, Duncan Berger, Daniel R G Price, Sam Dougan, Dionysis Grigoriadis, Alan Tracey, Nancy Holroyd, Katie Bull, Hannah Rose Vineer, Mike J Glover, Eric R Morgan, Alasdair J Nisbet, Tom N McNeilly, Yvonne Bartley, Neil Sargison, Dave Bartley, Matt Berriman, James A Cotton, Eileen Devaney, Roz Laing, Stephen R Doyle

“…Assembly using PacBio long-reads and Hi-C long-molecule scaffolding together with manual curation resulted in a 573 Mb assembly (N50 = 84 Mb, total scaffolds = 1,286) with five autosomal and one sex-linked chromosomal-scale scaffolds consistent with its karyotype. …”
Get full text

Preliminary Results of Hyperthermic Intraperitoneal Intraoperative Chemotherapy as an Adjuvant in Resectable Pancreatic Cancer by Antonios-Apostolos K. Tentes, Dimitrios Kyziridis, Stylianos Kakolyris, Nicolaos Pallas, Georgios Zorbas, Odysseas Korakianitis, Christos Mavroudis, Nicolaos Courcoutsakis, Panos Prasopoulos

“…Patients with pancreatic cancer undergoing potentially curative resection in combination with HIPEC may be offered a survival benefit. …”
Get full text

Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience by Abdulrahman A. Aljumah, Hadi Kuriry, Mohammed AlZunaitan, Mohammed Al Ghobain, Mohamed Al Muaikeel, Ashwaq Al Olayan, Fahad Azzumeea, Bader Almutairi, Abduljaleel AlAlwan, Hamdan AlGhamdi

“…HCC in Saudi Arabia is associated with high prevalence of HCV. Potentially curative therapies were underutilized in our patients. …”
Get full text

Colorectal Carcinoma with Extremely Low CA19-9 by Yutaka J. Kawamura, Aika Tokumitsu, Junichi Sasaki, Shingo Tsujinaka, Takafumi Maeda, Ken Mizogami, Fumio Konishi

“…Of these, 86 underwent surgery with curative intent. Serum levels of CA19-9 in patients who did not undergo curative resection (𝑁=12) and who developed recurrence (𝑁=10) were less than 2.0 U/mL in all occasions during followup. …”
Get full text

CAR T cells for treating autoimmune diseases by Dimitrios Mougiakakos, Ulrike Koehl, Stephan Fricke, Ulrich Blache, Sandy Tretbar

“…Currently, autoimmune disorders are largely treated by broad immunosuppressive agents and blocking antibodies, which can manage the diseases but often are not curative. Thus, there is an urgent need for advanced therapies for patients suffering from severe and refractory autoimmune diseases, and researchers have considered cell therapy as potentially curative approach for several decades. …”
Get full text

Interrupted time series datasets from studies investigating the impact of interventions or exposures in public health and social science: a data note by Simon L Turner, Elizabeth Korevaar, Amalia Karahalios, Andrew B Forbes, Joanne E McKenzie

“…Data description The repository includes 430 ITS datasets curated from the two empirical studies. The datasets are diverse in the populations, interruptions and outcomes examined, and are methodologically diverse in the outcome types, aggregation time intervals, number of timepoints and segments. …”
Get full text

Reframing the filter bubble through diverse scale effects in online music consumption by Dougal Shakespeare, Victor Chareyron, Camille Roth

“…Abstract The impact of platforms’ algorithmic curation devices on users’ consumption diversity has long since been the subject of debate in popular culture and academia alike. …”
Get full text

Late Endocrine Effects after Stem Cell Transplant in a Young Girl with Griscelli Syndrome by Shana R. Mencher, William V. Tamborlane, Anisha D. Patel

“…Type 2 GS is fatal due to severe immunodeficiency without curative stem cell transplant (SCT). Late endocrinopathies are quite common in other disorders after SCT. …”
Get full text

Therapeutic Effect of Conductive Education Rehabilitation Training on Children with Cerebral Palsy by Yifang CAI, Haiyan HUANG, Xiaofeng QIU

“…The curative effect of conductive education combined with comprehensive rehabilitation therapy for younger age children is superior to the older age children.…”
Get full text

Treatment-related mortality in head and neck cancer patients receiving chemotherapy and radiation: results of a meta-analysis of published trials by Cristina Gurizzan, Michela Cinquini, Lorenzo Legramandi, Carlo Resteghini, Marco Siano, Cristiana Bergamini, Luigi Lorini, Davide Smussi, Alberto Paderno, Lisa Licitra, Paolo Bossi

“…Objectives: A combination of chemotherapy and radiotherapy is employed in the curative and postoperative treatment of locally advanced head and neck cancers (HNC). …”
Get full text

Identifying community-driven priority questions in acoustic backscatter research by Vincent Lecours, Benjamin Misiuk, Benjamin Misiuk, Felix Butschek, Felix Butschek, Philippe Blondel, Giacomo Montereale-Gavazzi, Vanessa L. Lucieer, Chris McGonigle

“…After scaling the responses, the most commonly selected theme was “Post-processing, quality control, data handling, and curation”, followed by “Calibration” and “Data analysis”. …”
Get full text

Verspera, du plan d’époque à la visite virtuelle : une fructueuse collaboration interdisciplinaire by Michel Jordan, Delphine Desbourdes, Nicolas Priniotakis, Wassim Swaileh, Benjamin Ringot, Mathieu da Vinha

“…In the Verspera project, historians, archivists, curators and computer scientists worked together on the very rich corpus of the Ancien Régime plans of the Château de Versailles. …”
Get full text

Mulligan Manipulation Combined with Mckenzie Mechanics Method in Treating 43 Cases of Cervical Spondylotic Radiculopathy by Fuchun WU, Jie CHEN, Wei XU, Guoqing MO

“…Objective:To observe the curative effects of Mulligan manipulation combined with Mckenzie mechanics method for the treatment of cervical spondylotic radiculopathy (CSR).Methods:A total of 86 CSR patients were assigned to the treatment group and the control group by a random number table, and 43 patients in each group. …”
Get full text

Clinical Characteristics and Surgical Prognosis of Hepatocellular Carcinoma with Bile Duct Invasion by Ke-Wei Meng, Mei Dong, Wei-Guo Zhang, Qing-Xian Huang

“…Methods. 413 patients with HCC undergoing curative surgery were divided into two groups with (B+) and without BDI (B−). …”
Get full text

Deanxit Combined with Cognitive Behavioral Therapy in Treating 31 Cases of Post-stroke Depression by Dujuan GE, Liyu WU, Sanfeng SUN, Lei SHANG, Qingjuan YANG, Xiaoru YANG, Qingxi ZHAO

“…Objective:To investigate the curative effects of Deanxit combined with cognitive behavioral therapy for the treatment of post-stroke depression.Methods:60 patients with post-stroke depression were randomly assigned to treatment group (<italic>n</italic>=30) and control group (<italic>n</italic>=30), the treatment group received Deanxit combined with cognitive behavioral therapy, and the control group received Deanxit only for two courses, four weeks as a course. …”
Get full text

In Vivo Antiplasmodial Activity and Toxicological Analyses of the Ethanolic Leaf and Twig Extract of Faurea speciosa Welw. (Proteaceae) by Felix Ayisi, Caleb Nketia Mensah, Lawrence Sheringham Borquaye

“…The antiplasmodial effect against early infection, curative effect against established infection, and prophylactic effect against residual infection were studied in vivo in Plasmodium berghei-infected mice while the carrageenan-induced edema model in chicks was used for anti-inflammatory tests. …”
Get full text

Clinical Outcomes of Ileostomy Closure before Adjuvant Chemotherapy after Rectal Cancer Surgery: An Observational Study from a Chinese Center by Zhen Sun, Yufeng Zhao, Lu Liu, Jichao Qin

“…Temporary ileostomy closure before adjuvant chemotherapy following curative rectal cancer resection can achieve a clinical and oncological safety level equal to stoma closure during or after chemotherapy in selected patients.…”
Get full text

Network Pharmacology Analysis of the Therapeutic Potential of Colchicine in Acute Lung Injury by Fei Sun, Lijuan Zhang, Lulu Shen, Chunman Wang

“…ALI-related genes were curated using databases such as DisGeNET, Therapeutic Target, and Comparative Toxicogenomics Database to curate ALI-related genes. …”
Get full text

Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer by Sung Hoo Kim, Byung Kyu Ahn, Seung Sam Paik, Kang Hong Lee

“…Ninety-eight patients with recurrence in 376 CRC patients, who underwent curative surgery between January 1991 and August 2001, were retrospectively assessed. …”
Get full text

Predicting microRNA target genes using pan-cancer correlation patterns by Shuting Lin, Peng Qiu

“…In the literature, several databases have been constructed to curate known miRNA target genes, which are valuable resources but likely only represent a small fraction of all miRNA-gene interactions. …”
Get full text