Current status and perspectives of hematopoietic cell transplantation in patients with paroxysmal nocturnal hemoglobinuria by Marek Ussowicz, Dawid Przystupski, Patrycja Mensah-Glanowska, Agnieszka Piekarska

“…Although complement inhibitors have revolutionized treatment, alloHCT remains the only curative therapy, particularly for patients who are refractory to medical management or have severe cytopenia. …”
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Antiulcer Effect of Genus Symphytum L. and Portulaca oleracea L. as Investigated on Experimental Animals by El-Sayed H. Bakr, Amal Al-Ghamdi, Reham Al-Amri, Muna Al-Otaibi, Nada Al-Saad, Ghala Al-Matrafi, Ziad T. Kishmira, Firas Azzeh, Areej A. Almuraee

“…Accordingly, genus Symphytum L. and Portulaca oleracea L. could be used as plants as curative agents against gastric ulcer in experimental rats.…”
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Molecular monitoring of short- and long-term transcriptional effects of hair growth stimulating agents. by Sabrina K Henne, Lara M Hochfeld, Werner Bartmann, Thomas Welss, Markus M Nöthen, Stefanie Heilmann-Heimbach

“…Limited treatment options exist, which are not curative and vary in efficacy and invasiveness. Therapeutic and cosmetic hair growth stimulating agents that alleviate hair loss at a low risk of side effects are therefore of interest. …”
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Recent updates of centromere proteins in hepatocellular carcinoma: a review by Zhongyuan Yang, Wenjiao Chen, Yunhui Liu, Yuxin Niu

“…Owing to the atypical early symptoms and characteristics of HCC, over 80% of HCC patients cannot receive curative treatment. The treatment of HCC is facing a bottleneck, and new treatment methods are urgently needed. …”
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COVID-19 Vaccine Acceptance Level in Ethiopia: A Systematic Review and Meta-Analysis by Addisu Tadesse Sahile, Girma Demissie Gizaw, Tennyson Mgutshini, Zewdu Minwuyelet Gebremariam, Getabalew Endazenaw Bekele

“…The coronavirus disease 2019 pandemic has had a devastating impact on the everyday lives of the world’s population and to this end, the development of curative vaccines was upheld as a welcome panacea. …”
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Research Progress on the Effect of Exercise Rehabilitation on Functional Level and Physical Fitness by YIN Lianhua, ZHENG Yan, WU Lijuan, NI Xuling, CHEN Lidian

“…., so as to achieve the goal of shortening the process of disease rehabilitation and improving its curative effect. However, there are differences in the dimensions and degrees of the influence of different forms of exercise rehabilitation on functional level and physical fitness. …”
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Sporoderm-Removed Spore Powder May Suppress the Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Through PI3K/AKT/mTOR and Erk Pathway by Jingyan Liu Master degree, Tao Zeng Doctor degree

“…Tumor metastasis is a key factor of therapeutic failure in tumor patients, but the underlying molecular mechanism remains to be explored and novel effective curative strategies are urgently required. Emerging evidence suggests that sporoderm-removed Ganoderma lucidum spore powder can suppress tumor growth and metastasis. …”
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Biomedical named entity recognition using improved green anaconda-assisted Bi-GRU-based hierarchical ResNet model by Ram Chandra Bhushan, Rakesh Kumar Donthi, Yojitha Chilukuri, Ulligaddala Srinivasarao, Polisetty Swetha

“…Traditional NER methods rely on dictionaries, rules, or curated corpora, which may not always be accessible. …”
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SequenceCraft: machine learning-based resource for exploratory analysis of RNA-cleaving deoxyribozymes by M. Eremeyeva, Y. Din, N. Shirokii, N. Serov

“…This became possible with the development of a unique curated database of > 350 RNA-cleaving catalytic cores, property-based sequence representations allowing to work with both conventional and chemically modified nucleotides, and optimized kobs predicting algorithm achieving Q2 > 0.9 on experimental data published to date. …”
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Endoscopic Submucosal Dissection for Gastric Tube Carcinoma after Esophagectomy Contributes to Long-Term Outcomes by Satoru Hashimoto, Hiroki Sato, Ken-ichi Mizuno, Kazuya Takahashi, Masafumi Takatsuna, Junji Yokoyama, Hiroshi Ichikawa, Manabu Takeuchi, Masaaki Kobayashi, Shuji Terai

“…Complete resection and curative resection were documented in 80.6% and 48.4% of cases, respectively. …”
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Cytotoxic and Antioxidant Effects of Antimalarial Herbal Mixtures by Isaac Dadzie, Shaibu Adams Avorgbedo, Regina Appiah-Opong, Obed Cudjoe

“…These mixtures with such curative tendencies may also be a source of toxicity to host cells. …”
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Epidemiology of Alzheimer’s Disease and Dementia in Arab Countries: A Systematic Review by Ashraf El-Metwally, Paivi Toivola, Mashael Al-Rashidi, Shanila Nooruddin, Munazza Jawed, Raghad AlKanhal, Hira Abdul Razzak, Nada Albawardi

“…This systematic review highlights the need for population-based studies to provide necessary information for developing preventive and curative strategies specific to the Arab region.…”
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Impact of hydroxyurea on clinical and biological parameters of sickle cell anemia in children in Abidjan by MIREILLE YAYO- AYE, Adia Eusèbe Adjambri, Boidy Kouakou, Rebecca N'guessan-Blao, Louis Missa Adjé, Taïratou Kamagaté, Vincent Yapo, Duni Sawadogo

“… Background: The lives of individuals affected by sickle cell disease are marked by painful crises sometimes accompanied by complications. Curative treatments such as bone marrow transplantation or gene therapy exist, but are not currently performed in Côte d'Ivoire. …”
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Novel Predictive Strategy Using CA19-9 and Fecal Elastase Levels to Make Treatment Decisions for Resectable Pancreatic Cancer: A Retrospective Study by Hyung Sun Kim, Woojin Kim, Won-Gun Yun, Hye-Sol Jung, Youngmin Han, Mirang Lee, Wooil Kwon, Jin-Young Jang, Joon Seong Park

“…<b>Method</b>: A total of 536 patients who underwent curative intent surgery between 2010 and 2019 were included in the study. …”
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Clinicopathological risk factors of oral second primary tumours by Jelena Karan, Miriam P. Rosin, Lewei Zhang, Denise M. Laronde

“…Methods: Patients with oral squamous cell carcinoma, carcinoma in situ, or severe dysplasia were accrued into the Oral Cancer Prediction Longitudinal study within one year post-curative treatment. Data on demographics, risk habits, and primary tumour characteristics were collected. …”
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Determining the effect of frailty on survival in advanced ovarian cancer: study protocol for a prospective multicentre national cohort study (FOLERO) by Daniel Hunde, Niklas Ekerstad, Mihaela Asp, Päivi Kannisto, Madelene Wedin, Charlotte Palmqvist, Pernilla Dahm-Kähler, Yvonne Brandberg, Mirna Abraham-Nordling, Kristina Åhlund, Vilhelm Mörlin, Nina Groes-Kofoed, Sahar Salehi

“…Patients and methods: In this Swedish multi-centre prospective cohort study, where the exposure is frailty, consecutive women with advanced ovarian cancer scheduled for surgery with curative intent are eligible for inclusion. Three different frailty instruments are evaluated preoperatively, blinded to the caregiver. …”
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Allogeneic DNT cell therapy synergizes with T cells to promote anti-leukemic activities while suppressing GvHD by Jongbok Lee, Hyeonjeong Kang, Branson Chen, Yoosu Na, Ismat Khatri, Fraser Soares, Housheng Hansen He, Arjun D. Law, Tianzhong Pan, Armin Gerbitz, Xiaoyu Zhu, Mark D. Minden, Li Zhang

“…Abstract Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a second-line treatment with curative potential for leukemia patients. However, the prognosis of allo-HSCT patients with disease relapse or graft-versus-host disease (GvHD) is poor. …”
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Recommendations for developing, documenting, and distributing data products derived from NEON data by Jeff W. Atkins, Kelly S. Aho, Xuan Chen, Andrew J. Elmore, Rich Fiorella, Wenqi Luo, Danica Lombardozzi, Claire Lunch, Leah Manak, Luis X. dePablo, Allison N. Myers‐Pigg, Sydne Record, Tong Qiu, Samuel Reed, Benjamin Ruddell, Brandon Strange, Christa L. Torrens, Kelsey Yule, Andrew D. Richardson

“…Derived data products are curated, documented, reproducibly‐generated datasets created by applying various processing steps to one or more lower level data products—including interpolation, extrapolation, integration, statistical analysis, modeling, or transformations. …”
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Factors Related to Oral Health-Related Quality of Life of Independent Brazilian Elderly by Karla Giovana Bavaresco Ulinski, Mariele Andrade do Nascimento, Arinilson Moreira Chaves Lima, Ana Raquel Benetti, Regina Célia Poli-Frederico, Karen Barros Parron Fernandes, Marina Lourdes Calvo Fracasso, Sandra Mara Maciel

“…The following variables were associated with a negative impact on OHRQoL: female gender (PR = 1.40; CI 95%: 1.11–1.77); lower class (PR = 1.58; CI 95%: 1.13–2.20); up to 3 occluding pairs of posterior teeth (PR = 1.88; CI 95%: 1.13–3.14); at least one untreated caries (PR = 1.28; CI 95%: 1.06–1.54); curative reasons for the last dental appointment (PR = 1.52; CI 95%: 1.15–2.00); poor self-perception of oral health (PR = 2.49; CI 95%: 1.92–3.24); and poor perception of dental care provided (PR = 1.34; CI 95%: 1.12–1.59). …”
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Pembrolizumab with external radiation therapy effectively controlled TMB-high unresectable recurrent parathyroid cancer: a case report with review of literature by Hiroshi Katoh, Tomoya Mitsuma, Riku Okamoto, Kanako Naito, Takaaki Tokito, Mariko Kikuchi, Takafumi Sangai

“…He demonstrated recurrent hyperparathyroidism at 49 years of age, and underwent a gross curative resection. However, hyperparathyroidism achieved only insufficient improvement, indicating biochemical residual cancer cells. …”
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