lncRNA PANTR1 Upregulates BCL2A1 Expression to Promote Tumorigenesis and Warburg Effect of Hepatocellular Carcinoma through Restraining miR-587 by Xirui Ma, Ziming Mao, Jing Zhu, Huifang Liu, Fengling Chen

“…Due to its poor diagnosis strategy and inefficient clinical intervention, HCC has brought terrible life experiences for patients worldwide. Finding novel curative agents for HCC is urgently needed. In the current study, we hypothesized that lncRNA PANTR1 participates in HCC initiation or progression. …”
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Leveraging Next-Generation Sequencing Application from Identity to Purity Profiling of Nucleic Acid-Based Products by Rucha Wadapurkar, Swarda Deo, Renuka Khanzode, Ajay Singh

“…<b>Background/Objectives</b>: The nucleic acid-based product (NAP) portfolio is expanding continuously and provides safer curative options for many disease indications. Nucleic acid-based products offer several advantages compared to proteins and virus-based products. …”
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Synthesis of N-Methylmorpholinium Derivatives Possessing a 1,3,4-Oxadiazole Core as Feasible Antibacterial Agents against Plant Bacterial Diseases by Xinxin Tuo, Jie Yang, Yedong Zhang, Peiyi Wang

“…The following in vivo bioassays showed that compound 3l could control the rice bacterial blight disease, thereby affording good control efficiencies of 55.95% (curative activity) and 53.09% (protective activity) at the dose of 200 μg/mL. …”
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How Much Time Should Be Waited and What Are the Main Findings to Evaluate the Hepatocellular Carcinoma Response to Regorafenib? A Real-Life Experience by Gustavo Hideki Kawanami, Leopoldo Katsuda, Thiara Barcelos Rocha, Fabio da Silva Yamashiro, Leonardo Pelafsky, Xingshun Qi, Fernando Gomes Romeiro

“…In spite of clear recommendations regarding surveillance and screening methods, most patients are still diagnosed only when they are no longer candidates to curative treatment modalities, while others do not achieve the goals of such treatments, thus increasing the need of anticancer drugs. …”
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Clinical Study on Long-Term Sinus Reversion Rate and Left Atrial Function Recovery of Mitral Valve Disease with Atrial Fibrillation under Modified Surgical Radiofrequency Ablation by Jingle Cui, Ziyang Hu, Tao Li, Ziyang Guo, Weiquan Luo, Zhiyong Huang

“…The modified operation is simple, the curative effect is definite, and the sinus reversion rate is high, which is beneficial to the restoration of left atrial structure, ejection function, and hemodynamic function.…”
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Toward a Next Generation Particle Precipitation Model: Mesoscale Prediction Through Machine Learning (a Case Study and Framework for Progress) by Ryan M. McGranaghan, Jack Ziegler, Téo Bloch, Spencer Hatch, Enrico Camporeale, Kristina Lynch, Mathew Owens, Jesper Gjerloev, Binzheng Zhang, Susan Skone

“…Abstract We advance the modeling capability of electron particle precipitation from the magnetosphere to the ionosphere through a new database and use of machine learning (ML) tools to gain utility from those data. We have compiled, curated, analyzed, and made available a new and more capable database of particle precipitation data that includes 51 satellite years of Defense Meteorological Satellite Program (DMSP) observations temporally aligned with solar wind and geomagnetic activity data. …”
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Automated Defect Detection in Solar Cell Images Using Deep Learning Algorithms by Montaser Abdelsattar, Ahmed Abdelmoety, Mohamed A. Ismeil, Ahmed Emad-Eldeen

“…The research paper performed our studies using a balanced and well-curated dataset of 3,102 images of solar cells with a range of common faults. …”
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Mendelian Susceptibility to Mycobacterial Diseases (MSMD) in a 13-Year-Old Ethiopian Girl with Autosomal Dominant Interferon Gamma Receptor 1(IFN-γ R1) Defect: A Clinical Diagnosti... by Netsanet Azene Gebeyehu, Solomie Jebessa Deribessa, Freeman Alexandra, Messay Tesfaye Demissie, W Mihretu Gebre, Aklilu Melaku Gebremariam, Dagmawit Mitiku Engliz, Tizita Yosef Kidane, Lidya Million Bekele, Abate Yeshidinber Weldetsadik

“…Treatments constitute antimycobacterial, interferon-gamma, surgery, and hematopoietic stem cell transplantation (HSCT), which is the only known curative treatment. The mortality rate ranges from 40% to 80% depending on the severity of the mutation. …”
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Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation by Christin Bürger, Miriam Maschmeier, Anna Hüsing-Kabar, Christian Wilms, Michael Köhler, Martina Schmidt, Hartmut H. Schmidt, Iyad Kabar

“…Liver transplantation (LT) is a curative treatment for hepatocellular carcinoma (HCC) and the underlying primary liver disease; however, tumor recurrence is still a major issue. …”
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Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma by Leonardo do Prado Lima, Carla Jorge Machado, João Bernardo Sancio Rocha Rodrigues, Leonardo de Souza Vasconcellos, Eduardo Paulino Junior, Paula Vieira Teixeira Vidigal, Vivian Resende

“…This study included Child-Pugh A HCC patients undergoing curative surgical resection. Results. A significant difference was observed in the ratio between the different phenotypes (p = 0.002), identifying 12 (29.3%) EPCAM positive tumors and 29 (70.7%) negative tumors. …”
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Third or fourth branchial pouch sinus lesions: a case series and management algorithm by Yun Li, Kexing Lyu, Yihui Wen, Yang Xu, Fanqin Wei, Haocheng Tang, Siyu Chen, Zhangfeng Wang, Xiaolin Zhu, Weiping Wen, Wenbin Lei

“…Conclusion Refining fistula subtypes and adopting corresponding treatment measures can reduce the recurrence rate and improve curative effects. We propose and advocate this treatment algorithm for all third and fourth branchial pouch lesions.…”
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Loss of p53 impairs death receptor expression and confers resistance to CD19 CAR T-cell therapy in BCP-ALL by Willem P. J. Cox, Noël M. M. Dautzenberg, Linde Dekker, Tesa Klenovsek, Annelisa M. Cornel, Marliek van Hoesel, Dorette S. van Ingen Schenau, Reno S. Bladergroen, Roland P. Kuiper, Laurens T. van der Meer, Friso G. Calkoen, Stefan Nierkens, Frank N. van Leeuwen

“…Furthermore, these data underscore the need for alternative curative therapies for this very high-risk patient group.…”
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Decellularized Liver Matrices for Expanding the Donor Pool—An Evaluation of Existing Protocols and Future Trends by Marcin Morawski, Maciej Krasnodębski, Jakub Rochoń, Hubert Kubiszewski, Michał Marzęcki, Dominik Topyła, Kacper Murat, Mikołaj Staszewski, Jacek Szczytko, Marek Maleszewski, Michał Grąt

“…Liver transplantation is the only curative option for end-stage liver disease and is necessary for an increasing number of patients with advanced primary or secondary liver cancer. …”
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LipBengal: Pioneering Bengali lip-reading dataset for pronunciation mapping through lip gesturesHugging Face by Md. Tanvir Rahman Sahed, Md. Tanjil Islam Aronno, Hussain Nyeem, Md. Abdul Wahed, Tashrif Ahsan, R Rafiul Islam, Tareque Bashar Ovi, Manab Kumar Kundu, Jane Alam Sadeef

“…Meticulous annotation and curation further bolster its quality and reliability, making LipBengal a valuable asset for researchers and developers in the field.…”
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Changes in Serum CRP and PCT Levels in Patients with Acute Simple Lower Urinary Tract Infection and Evaluation of the Efficacy of Treatment with Shuangdong Capsules by Yachun Tang, Qun Zhou

“…Group A was treated with basic anti-infective drugs, while group B was treated with Shuangdong capsules, and the duration of treatment in both groups was 14 days. The curative effect of the two groups was analyzed, and the changes in serum PCT and CRP levels were compared before and after treatment and compared with 40 healthy people in the control group. …”
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FusionScan: accurate prediction of fusion genes from RNA-Seq data by Pora Kim, Ye Eun Jang, Sanghyuk Lee

“…We also provide several curative means to help users investigate the details of fusion candidates easily. …”
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Genetic analysis of ocular tumour-associated genes using large genomic datasets: insights into selection constraints and variant representation in the population by Jose S Pulido, Mandeep S Sagoo, Omar A Mahroo, Alexander Tanner

“…We explored these parameters in ocular tumour-associated genes.Methods A curated list of ocular tumour-associated genes was assessed using the genomic databases Genome Aggregation Database (gnomAD) and DatabasE of genomiC varIation and Phenotype in Humans using Ensembl Resources (DECIPHER) and compared with breast and lung cancer-associated gene lists. …”
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Analysis of postoperative morbidity and mortality following surgery for gastric cancer. Surgeon volume as the most significant prognostic factor by Maciej Ciesielski, Wiesław J. Kruszewski, Jakub Walczak, Mariusz Szajewski, Jarosław Szefel, Jacek Wydra, Tomasz Buczek, Maksymilian Czerepko

“…Introduction : Surgical resection is the only potentially curative modality for gastric cancer and it is associated with substantial morbidity and mortality. …”
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Why heads matter in palaeoanthropology: The impacts and consequences of collecting skulls by Lauren Schroeder, Paige Madison, Rebecca R. Ackermann

“…As evidence for this, we quantify the possible effects of skull-collecting by collating available data on the number of skulls versus post-crania curated in a representative South African collection and compare the number of skulls versus post-cranial hominin fossils that form part of species hypodigms. …”
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The effectiveness of music therapy in improving behavioral symptoms among children with autism spectrum disorders: a systematic review and meta-analysis by Xiuyan Gao, Guangjun Xu, Ningning Fu, Qi Ben, Lin Wang, Xiumei Bu

“…However, given the significant heterogeneity and limitations in this study, RCTs with rigorous methodological quality are still required to confirm the curative benefits of MT in autistic children precisely.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024597939.…”
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