Multi-omics unveils strain-specific neuroactive metabolite production linked to inflammation modulation by Bacteroides and their extracellular vesicles by Basit Yousuf, Walid Mottawea, Galal Ali Esmail, Nazila Nazemof, Nour Elhouda Bouhlel, Emmanuel Njoku, Yingxi Li, Xu Zhang, Zoran Minic, Riadh Hammami

“…Cell-free supernatants from wild-type (WT, GABA+) and ΔgadB (GABA-) provided GABA-independent reinforcement of epithelial membrane integrity in LPS-treated Caco-2/HT29-MTX co-cultures. EVs from WT and ΔgadB attenuated inflammatory immune response of LPS-treated RAW264.7 macrophages, with reduced pro-inflammatory cytokines (IL-1β and IL-6), downregulation of TNF-α, and upregulation of IL-10 and TGF-β. …”
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Urinary incontinence (UI) in older women in low- and middle-income countries: a rapid review and case study from Burkina Faso by Arthi Kozhumam, Mamadou Bountogo, Dina Goodman Palmer, Carolyn Grieg, Carolyn Grieg, Carolyn Grieg, Maxime Inghels, Maxime Inghels, Sandra Agyapong-Badu, Sandra Agyapong-Badu, Cristina Osborne, Guy Harling, Guy Harling, Guy Harling, Guy Harling, Till Bärnighausen, Till Bärnighausen, Till Bärnighausen, David Rapp, David Rapp, Molly Beestrum, Justine Davies, Justine Davies, Justine Davies, Lisa R. Hirschhorn

“…Additionally, training healthcare providers and developing culturally appropriate interventions will help address stigma and ensure effective management of UI in this vulnerable population.…”
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Interrelationships between social exclusion, mental health and wellbeing in adolescents: insights from a national Youth Survey by K. Filia, S. M. Teo, N. Brennan, T. Freeburn, D. Baker, V. Browne, A. Watson, J. Menssink, A. Prasad, E. Killackey, P. D. McGorry, S. M. Cotton, C. X. Gao

“…Young people who identified as gender diverse, Indigenous, living in a remote/rural or socio-economically disadvantaged area and with a culturally diverse background were more likely to report social exclusion. …”
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Key bacterial vaginosis-associated bacteria influence each other's growth in biofilms in rich media and media simulating vaginal tract secretions by Lúcia G.V. Sousa, Christina A. Muzny, Nuno Cerca

“…While G. vaginalis had a high capacity to form biofilms in both media, F. vaginae and P. bivia biofilm growth was favored when cultured in rich media. Differences were also found in the structure of triple-species biofilms formed in both media, as assessed by confocal laser scanning microscopy. …”
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Psychometric Testing of the CHAMPS Questionnaire in French Canadians with COPD by Susanne Mak, Jean Bourbeau, Nancy E. Mayo, Sharon Wood-Dauphinee, Judith E. Soicher

“…In a previous article, we reported on the cross-cultural adaptation of the Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire to produce a Canadian French version. …”
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Resourceful and economical designing of fermentation medium for lab and commercial strains of yeast from alternative feedstock: ‘transgenic oilcane’ by Shraddha Maitra, Bruce Dien, Kristen Eilts, Nurzhan Kuanyshev, Yoel R. Cortes-Pena, Yong-Su Jin, Jeremy S. Guest, Vijay Singh

“…The industrial strain grew and fermented efficiently under low aeration conditions having an ethanol titer, yield, specific and volumetric productivities of 46.96 ± 0.19 g/l, 0.51 ± 0.00 g/g, 0.27 ± 0.02 g/g.h and 1.95 ± 0.01 g/l.h, respectively, while the lab strain grew better under higher aeration conditions having the ethanol titer, yield, specific and volumetric productivities of 24.93 ± 0.09, 0.27 ± 0.00 g/g, 0.17 ± 0.00 g/g.h and 1.04 ± 0.00 g/l.h, respectively. Acclimation of cultures in a blended medium significantly improved the performance of the yeast strains. …”
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Experiences of Māori and Pacific women recruited into a pregnancy clinical trial in Aotearoa, New Zealand: a Kaupapa Māori qualitative study by Matire Harwood, Benjamin B Albert, Rachel Roskvist, Jamie-Lee Rahiri, Richard Enright, Tania Mullane, Vidit Vinod Satokar

“…In contrast, the major barriers described were time pressures and the distance to the research facility.Conclusions Sixteen Māori and Pacific women who participated in a double-blinded randomised controlled trial shared that successful recruitment of Māori and Pacific women into clinical trials can be promoted by research flexibility participants’ whānau/family responsibilities, effective and culturally safe communication, and research teams striving to build and maintain relationships with participants throughout the trial.Trial registeration number Australian New Zealand Clinical Trials Registry, ACTRN12617001078347p. …”
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Attitudes towards persons with disabilities vs. personality traits of Polish students by Iwona Radlińska, Marta Kożybska, Arkadiusz Prajzner, Łukasz Krzywoszański, Beata Karakiewicz

“…The results indicate the need for further research into factors that modulate attitudes towards persons with disabilities, including a theoretical deepening of the problem and cultural aspects.…”
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Regional antimicrobial resistance gene flow among the One Health sectors in China by Yuqing Feng, Xin Lu, Jiayong Zhao, Hongmin Li, Jialiang Xu, Zhenpeng Li, Mengyu Wang, Yao Peng, Tian Tian, Gailing Yuan, Yuan Zhang, Jiaqi Liu, Meihong Zhang, A La Teng Zhu La, Geruo Qu, Yujiao Mu, Wanshen Guo, Yongning Wu, Yuyu Zhang, Dexiang Wang, Yongfei Hu, Biao Kan

“…Results In this study, we investigated regional ARG transmission among humans, food, and the environment in Dengfeng, Henan Province, China by combining large-scale metagenomic sequencing with culturing of resistant bacterial isolates in 592 samples. …”
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Establishment and evaluation of a UPLC-MS/MS method for simultaneous determination of bongkrekic acid and dehydroacetic acid in rice noodles by Lingguo Zhao, Ronggui Lv, Ronggui Lv, Jiang Song, Xi Chen, Lei Lei, Weixian Zeng, Miaowen She, Miaowen She, Dabing Li, Xiaxia Yu, Zhanguo Liu, Xiao Wang, Yong Liu

“…To investigate the cause of death of the poisoned patient, the toxigenic bacterium Burkholderia gladiolus was isolated and cultured to produce BA. The results showed that the established method could also be used to qualitatively screen BA and its isomer isobongkrekic acid (IBA) in GVC enrichment broth, potato glucose agar and rice sample, which facilitates a rapid and accurate judgement of whether the isolated bacterium strain produces BA. …”
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Shramahara Mahakasya, a traditional polyherbal formulation, induces anti-anxiety activity in hippocampal neurons by effectuating SOD2-mediated protection against oxidative stress by Saakshi Saini, Viney Kumar, Swati Haldar, Samrat Chauhan, Pratibha Demiwal, Souvik Ghosh, Sumeet Gupta, Debabrata Sircar, Bidhan Mahajon, Partha Roy

“…In this study, we investigated the intricate mechanisms through which SM polyherbal extract exerts neuroprotective and anxiolytic effects in cultured HT-22 cells and rodent models. Method: In this study, the chemical composition of SM was first identified using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). …”
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Healthcare Practitioners’ perspectives on paediatric burns management at Korle Bu Teaching Hospital, Ghana by Alberta A. Rockson, Natalie Benjamin-Damons, Sonti Imogene Pilusa

“…Results: Findings revealed four primary themes: strengths of current practices (multidisciplinary approach, experienced practitioners), barriers (lack of formal protocols, infrastructure limitations, financial burdens), contextual factors influencing burn care (psychological trauma, inadequate support, socio-cultural beliefs and socioeconomic status), and recommendations for enhancing burns care (improved social welfare, facility upgrades, staff training and mental health support). …”
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TYRO3 blockade enhances anti-PD-1 therapy response by modulating expression of CCN1 in tumor microenvironment by Miso Park, Da-Sol Kuen, Keon Wook Kang, Yeonseok Chung, Jaewoo Park, Munkyung Choi, Yeonji Kim, Eun Chae Roh, Yong June Choi, Yoon Gyoon Kim, Sung Yun Cho

“…Flow cytometry was used for the quantification of cell populations and immunophenotyping of macrophages and T cells. Co-cultures of macrophages and T cells were performed to verify the role of CCN1 in the tumors.Results TYRO3 blockade boosts antitumor immune responses in both the tumor-draining lymph nodes and tumors in MC38-syngeneic mice models. …”
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How Earth System Models Can Inform Key Dimensions of Marine Food Security in the Alaskan Arctic by Georgina A. Gibson, Hajo Eicken, Henry P. Huntington, Clara J. Deal, Olivia Lee, Katherine M. Smith, Nicole Jeffery, Josephine-Mary Sam

“…Subsistence harvesting activities provide nutritious and culturally vital foods for Alaska Native households and communities. …”
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Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle by Sarah Damery, Kerry Allen, Lisa Dikomitis, Harry Hill, David Coyle, Maatla Tshimologo, Mark Lambie, Simon J Davies, Iestyn Williams, James Fotheringham, Louise Phillips-Darby, Ivonne Solis-Trapala

“…Knowing what drives this unwarranted variation requires in-depth understanding of centre cultural and organisational factors and how these relate to quantifiable centre performance, accounting for competing treatment options. …”
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Social network analysis of key stakeholders in Brucellosis prevention in Western Iran by Meysam Behzadifar, Mohammad Yarahmadi, Ahad Bakhtiari, Sahar Kargar, Saeed Shahabi, Samad Azari, Mariano Martini, Masoud Behzadifar

“…Abstract Background Brucellosis remains a persistent public health challenge in Iran, particularly in rural regions such as Lorestan province, due to systemic, economic, and cultural barriers. Effective disease control requires multisectoral collaboration among stakeholders. …”
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Hantavirus Cardiopulmonary Syndrome and Diffuse Alveolar Hemorrhage in the Era of COVID-19 by Khizar Hamid, Swaminathan Perinkulam Sathyanarayanan, Touba Naim, Muhammad Hamza, Mirza Omer Mahmood Baig, Emad Abu Sitta

“…Bronchoscopy and bronchoalveolar lavage revealed diffuse alveolar hemorrhage (DAH) and were negative for acid-fast bacilli and Nocardia cultures. He was further tested for Hantavirus, Q fever, leptospirosis, toxoplasmosis, and empiric treatment with doxycycline initiated. …”
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Natural Concurrent Infections with Black Spot Disease and Multiple Bacteriosis in Farmed Nile Tilapia in Central Kenya by Daniel W. Wanja, Paul G. Mbuthia, Robert M. Waruiru, Lilly C. Bebora, Helena A. Ngowi

“…Nile tilapia (Oreochromis niloticus) is the most cultured and available fish for Kenyan consumers, and therefore, any tilapine disease deprives them the valuable source of protein. …”
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Effect of Stem Cell-Derived Extracellular Vesicles on Damaged Human Corneal Endothelial Cells by Raffaele Nuzzi, Lola Buono, Simona Scalabrin, Marco De Iuliis, Benedetta Bussolati

“…Bone marrow mesenchymal stem cells (MSCs) were obtained from Lonza, cultured, and characterized. MSC-EVs were obtained from supernatants of MSCs. …”
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High spatial resolution gene expression profiling and characterization of neuroblasts migrating in the peri-injured cortex using photo-isolation chemistry by Takuya Miyamoto, Kazuya Kuboyama, Mizuki Honda, Mizuki Honda, Yasuyuki Ohkawa, Shinya Oki, Shinya Oki, Kazunobu Sawamoto, Kazunobu Sawamoto

“…Experiments using primary cultured neuroblasts showed that application of TGF-β significantly decreased proliferating cells labeled with BrdU. …”
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