Urinary Tract Infections in Children: Changing Trends in Etiology and Local Resistance Patterns over a Three-Year Period by Patrícia Sousa, Lucinda Delgado, Susana Correia-de-Oliveira, Cecília Pereira, Ângela Dias, Ana Cláudia Tavares

“…Methods: We conducted a cross-sectional study including pediatric patients performing urine cultures in a hospital in northern Portugal over two periods: 2019 (group 1) and 2022 (group 2). …”
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Bacterial profile and antibiotic susceptibility pattern of adult lower respiratory tract infections in Colombo, Sri Lanka by Nadeesha Amarasinghe, Muthulingam Athavan, Deepal Jayamanne, Yamuna Rajapakshe, Aflah Sadikeen, Kirthi Gunasekara, Amitha Fernando, Lilani Karunanayake

“…Results: Most of reports (58%) were from patients diagnosed with infective exacerbations of chronic lung diseases. Out of all sputum cultures processed, 404 (29.4%) resulted positive for pathogenic bacterial organisms. …”
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Adipose tissue-derived microRNA-450a-5p induces type 2 diabetes mellitus by downregulating DUSP10 by Jiaojiao Zhu, Yanting Hou, Wei Yu, Jingzhou Wang, Xiaolong Chu, Xueting Zhang, Huai Pang, Dingling Ma, Yihan Tang, Menghuan Li, Chenggang Yuan, Jianxin Xie, Cuizhe Wang, Jun Zhang

“…Moreover, the adipose Dicer-knockout mouse model was constructed to identify adipose tissue as the main source of microRNA-450a-5p. microRNA-450a-5p could inactivate the insulin signal pathway by targeting the inhibited Dual Specificity Phosphatase 10 (DUSP10) and inducing IR and glucose metabolism disorders in vitro cultured hepatocytes and adipocytes. Additionally, microRNA-450a-5p was found to regulate DUSP10 expression and insulin signaling activity, influencing glucose tolerance and insulin sensitivity across various models, including normal diet, HFD-induced obese, adipose tissue-specific microRNA-450a-5p-knockout, and db/db mice. …”
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“Equity” in genomic health policies: a review of policies in the international arena by Prabhathi Basnayake Ralalage, Prabhathi Basnayake Ralalage, Tala Mitchell, Claire Zammit, Gareth Baynam, Gareth Baynam, Emma Kowal, Libby Masey, Julie McGaughran, Tiffany Boughtwood, Misty Jenkins, Gregory Pratt, Angeline Ferdinand

“…The CCs that are covered to a lesser degree are participation, quality, coordination of services, cultural responsiveness and non-discrimination. The CCs of liberty and entitlement are not addressed in any of the selected policies. …”
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Determining and comparing the achieved competencies of graduating nursing students of public and private universities in Iran by Majid Purabdollah, Vahid Zamanzadeh, Akram Ghahramanian, Leila Valizadeh, Mostafa Ghasempour, Saeid Mousavi

“…Data was collected using a nursing competence questionnaire developed in the Iranian cultural context and rated on a 5-point Likert scale (1 = dependent to 5 = independent). …”
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Use of standardized nasal and skin decolonization to reduce rates of bacteremia in patients undergoing extracorporeal membrane oxygenation by Madyson Taylor, Russell L Griffin, Jeremey Walker, Catina James, Angela Akinsanya, Mary Duncan, Rachael A Lee

“…The primary outcome was rate of ECMO-attributable positive blood cultures. Zero-inflated Poisson regression analysis was performed to estimate rate ratios (RRs) for the association between decolonization with BSI rates. …”
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Paracrine Proangiogenic Function of Human Bone Marrow-Derived Mesenchymal Stem Cells Is Not Affected by Chronic Kidney Disease by Femke C. C. van Rhijn-Brouwer, Bas W. M. van Balkom, Diana A. Papazova, Diënty H. M. Hazenbrink, Anke J. Meijer, Isaac Brete, Vidalmar Briceno, Arjan D. van Zuilen, Raechel J. Toorop, Joost O. Fledderus, Hendrik Gremmels, Marianne C. Verhaar

“…While the immunomodulatory capacity of CKD BM MSCs has been established, it is unknown whether CKD affects wound healing and angiogenic potential of MSC-derived CM and EVs. Methods. MSCs were cultured from BM obtained from kidney transplant recipients (N=15) or kidney donors (N=17). …”
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A Systematic Review of Maternal and Child Health Policies in Addressing Stunting: Trends and Challenges by Pratiwi Ramlan, Phill Sukri, Muh. Tang Abdullah, Muhammad Akmal Ibrahim, Jamaluddin Ahmad, Khaeriyad Adri

“…Notwithstanding the implementation of various maternal and child health strategies designed to mitigate stunting, its incidence remains alarmingly high, exhibiting differential efficacy across diverse contexts due to obstacles in policy execution, accessibility issues, and socio-cultural influences. Methods: This study utilized a research methodology that included a bibliometric analysis of publications retrieved from the Scopus Database relating to maternal and child health policies in reducing stunting prevalence using the keywords “maternal and child health policies” and “stunting”. …”
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Kurganless Cemetery of the Sarmatian Times on the Maloe Storozhevoe Hillfort in the Middle Don Basin by Yuriy D. Razuvaev, Aleksandr N. Merkulov, Sergey A. Nelyubov, Yuliya A. Neretina

“…The results of their comprehensive archaeological and anthropological study characterize the little-studied kurganless tradition of the Sarmatian period in the forest-steppe Don region. Ethnical, cultural and chronological attribution of the complexes is based on the ritual and material analogies. …”
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Trends in palliative care utilization among older adult decedents with and without cancer in Taiwan: a population-based comparative studyResearch in context by Yu-Tai Lo, Tzu-Jung Chuang, Yu-Tung Huang, Yi-Lin Wu, Yi-Ching Yang, Chung-Yi Li

“…Interpretation: Efforts to ensure equitable access to palliative care for non-cancer individuals should focus on expanding services, enhancing provider education, and promoting cultural sensitivity to meet the growing need for palliative care integration. …”
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Ethnic Architectural Heritage Identification Using Low-Altitude UAV Remote Sensing and Improved Deep Learning Algorithms by Ting Luo, Xiaoqiong Sun, Weiquan Zhao, Wei Li, Linjiang Yin, Dongdong Xie

“…Ethnic minority architecture is a vital carrier of the cultural heritage of ethnic minorities in China, and its quick and accurate extraction from remote sensing images is highly important for promoting the application of remote sensing information in urban management and architectural heritage protection. …”
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Assessment of Microbiological Indoor Air Quality in Cattle Breeding Farms by Justyna Szulc, Małgorzata Okrasa, Katarzyna Dybka-Stępień, Michael Sulyok, Adriana Nowak, Anna Otlewska, Bogumiła Szponar, Katarzyna Majchrzycka

“…Abstract This study, which was conducted on a farm in central Poland from February till April 2019, aimed to evaluate microbiological threats on cattle breeding premises by counting and identifying the microorganisms (via culturing and high-throughput sequencing), assessing the endotoxin concentrations (via gas chromatography-mass spectrometry [GC-MS]) and analysing the secondary metabolites (including mycotoxins) in the air and sedimented dust (via liquid chromatography-tandem mass spectrometry [LC-MS/MS]) in six barns. …”
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Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway by Tingting Zhang, Mengmeng Zhu, Jialing Ma, Zhenghong Liu, Zhidan Zhang, Meijie Chen, Yaping Zhao, Huaxin Li, Shengnan Wang, Xiaoning Wei, Wenwen Zhang, Xiaoxiao Yang, Peter J. Little, Danielle Kamato, Hao Hu, Yajun Duan, Baotong Zhang, Jianbo Xiao, Suowen Xu, Yuanli Chen

“…The protective effects of Moscatilin against vascular calcification were verified in cultured HASMCs. Unbiased transcriptional profiling analysis and cellular thermal shift assay suggested that Moscatilin suppresses vascular calcification via binding to interleukin 13 receptor subunit A2 (IL13RA2) and augmenting its expression. …”
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Effects of Dietary Inclusion of Canthaxanthin- and α-Tocopherol-Loaded Liposomes on Growth and Muscle Pigmentation of Rainbow Trout (Oncorhynchus mykiss) by Tran Quoc Toan, Viet Anh Dang, Quoc Long Pham, Phi Hung Nguyen, Thu Huong Trinh, Thuy Ha Tran, Van Thinh Do, Van Khoi Le, Xuan Luong Ngo, Tri Nhut Pham, Hai Ha Pham Thi, Manh Do Van, Duy Chinh Nguyen, Thanh Duong Nguyen

“…In this study, we included canthaxanthin- and α-tocopherol-loaded liposomes into fish diets and evaluated the effects of supplemented fish feed on fish growth, color, nutrition, and canthaxanthin deposition in fillets of cultured rainbow trout (Oncorhynchus mykiss). The liposomes were fabricated using lecithin as phospholipids with the initial concentrations (IC = mcanthaxanthin/mlipids, % wt/wt) of canthaxanthin at 0.1%, 0.5%, and 1.0%. …”
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Addressing unmet mental health needs of older adults in Turbo, Colombia: a multi-component psychosocial intervention feasibility study by Clarissa Giebel, Erika Montoya, Gabriel Saldarriaga, Thais Caprioli, Mark Gabbay, Danicza Martinez, Jessica Rua, Maria Isabel Zuluaga

“…In light of limited mental health support across LMICs, this intervention could provide mental health for older adults in other communities in Colombia and elsewhere developed through co-production, cultural adaptation, subject to further evaluation.…”
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Evaluation of nutrient loads conveyed to the deep subalpine lakes of Northern Italy through their main tributaries by Paolo Dezuanni, Paolo Dezuanni, Diego Copetti, Claudia Dresti, Nicolò Pella, Nicolò Pella, Fabio Buzzi, Andrea Fenocchi, Andrea Fenocchi

“…Nutrient pollution is a critical issue for lakes, leading to cultural eutrophication, which damages the ecosystem and prevents water uses. …”
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Functional analysis of heterozygous variants in the SALL1 gene in 2 children with Townes-Brocks syndrome with FSGS by Rong Liang, Bixia Zheng, Chunli Wang, Sanlong Zhao, Wei Zhou, Ying Chen, Ruochen Che

“…The genetic function was investigated through cultured cells transfected with variants. The Sall1 protein expression level was detected by western blotting. …”
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Uvaol attenuates TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells by modulating expression and membrane localization of β-catenin by Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Felipe Henrique da Cunha Xavier, Felipe Henrique da Cunha Xavier, Felipe Henrique da Cunha Xavier, Felipe Henrique da Cunha Xavier, Mônica Silveira Wagner, Kayo Moreira Bagri, Erick Gabriel Alves Ferreira, Romulo Galvani, Romulo Galvani, Romulo Galvani, Romulo Galvani, Claudia Mermelstein, Adriana Cesar Bonomo, Adriana Cesar Bonomo, Adriana Cesar Bonomo, Adriana Cesar Bonomo, Wilson Savino, Wilson Savino, Wilson Savino, Wilson Savino, Emiliano Barreto, Emiliano Barreto

“…The present study aimed to investigate the impact of uvaol upon TGF-β1-induced EMT in a cultured A549 human alveolar epithelial cell line, a classic in vitro model for studies of EMT. …”
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Work–health–personal life conflicts in naive patients with chronic hepatitis B receiving initial treatment in China: a qualitative study by Li Zhang, Ying Chen, Ying Li, Hongmei Wang, Lin Zhu, Xiaoyang Lu, Yingjing Zheng, Donald Patrick, Fengjiao Xu, Mengna Song, Xiao Cheng, Boyan Chen

“…This study aimed to explore the perceptions of role conflicts of treatment-naive patients with CHB in work, personal and sick roles, together with ameliorating factors in the Chinese cultural context.Design A qualitative descriptive study. …”
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Usefulness of a TDM-Guided Approach for Optimizing Teicoplanin Exposure in the Treatment of Secondary Bloodstream Infections Caused by Glycopeptide-Susceptible <i>Enterococcus faec... by Milo Gatti, Matteo Rinaldi, Maddalena Giannella, Pierluigi Viale, Federico Pea

“…Univariate analysis was performed for assessing variables potentially associated with microbiological failure (defined as persistence at the infection site of the index <i>Enterococcus faecium</i> strain after more than 7 days from starting treatment as documented by follow-up blood cultures). Overall, 67 patients (median age 70 years; male 55.2%) were included. …”
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