Variable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG1 antibody by Jing Dai, Saeed Izadi, Jonathan Zarzar, Patrick Wu, Angela Oh, Paul J. Carter

“…Here, we combined X-ray crystallography with computational modeling to predict regions of an anti-glucagon receptor (GCGR) IgG1 antibody prone to self-interaction. …”
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Complexed Crystal Structure of Saccharomyces cerevisiae Dihydroorotase with Inhibitor 5-Fluoroorotate Reveals a New Binding Mode by Hong-Hsiang Guan, Yen-Hua Huang, En-Shyh Lin, Chun-Jung Chen, Cheng-Yang Huang

“…Based on these lines of molecular evidence, we discussed whether these different binding modes are species- or crystallography-dependent.…”
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Differential expression of DNA fragmentation factor 45 in leukoplakia and oral squamous cell carcinoma and its correlation with TNF-α levels by Sabitha Balakrishnan, Ramya Ramadoss, Rajashree Padmanaban, Rajkumar Krishnan

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Carbonyl-nitrogen multi-resonance emitters for efficient OLEDs with high color purity by Zhiwei Wu, Peng Zou, Jingwen Xu, Xiaobin Dong, Ben Zhong Tang, Zujin Zhao

“…In this work, we wish to report a new carbonyl-nitrogen (C = O/N) skeleton of 5,12-dihydroquinolino[2,3-b]acridine-7,14-dione (QA), and three tailored C = O/N MR molecules are synthesized and fully characterized by crystallography, thermal measurement, cyclic voltammetry, steady-state and transient spectroscopy and theoretical calculation. …”
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Reducing heat load density with asymmetric and inclined double-crystal monochromators: principles and requirements revisited by XianRong Huang, Lahsen Assoufid, Albert T. Macrander

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Exploring the Gating Mechanism of the Human Copper Transporter, hCtr1, Using EPR Spectroscopy by Shahaf Peleg, Shelly Meron, Yulia Shenberger, Lukas Hofmann, Lada Gevorkyan-Airapetov, Sharon Ruthstein

“…While structural details of the transmembrane domain of human Ctr1 have been elucidated using X-ray crystallography and cryo-EM, the transfer mechanisms of copper and the conformational changes that control the gating mechanism remain poorly understood. …”
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Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes: In Vitro Anticancer Studies against “H... by Rosenani A. Haque, Siti Fatimah Nasri, Muhammad Adnan Iqbal, Sawsan S. Al-Rawi, Seyedeh Fatemeh Jafari, Mohamed B. Khadeer Ahamed, A. M. S. Abdul Majid

“…This paper describes synthesis, characterization (NMR, FT-IR, microanalysis, and X-ray crystallography), in vitro anticancer activity of ortho/para-xylyl linked bis-imidazolium salts (4-5) and respective dinuclear Ag(I) N-heterocyclic carbene (NHC) complexes (6-7). …”
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Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells by Mara C. Inniss, Sean G. Smith, Dan Jun Li, Benjamin Primack, Dexue Sun, Grace Y. Olinger, Kerri-Lynn Sheahan, Theresa Ross, Meghan Langley, Violet Young, Andres Alvarado, Shabnam Davoodi, Jiefei Geng, Michael Schebesta, Michelle L. Ols, Jeremy Tchaicha, Jan ter Meulen, Dhruv K. Sethi

“…We develop conditional degrons using library-based screening of mutants and show characterization of one DRD using crystallography and molecular dynamics (MD) simulations. …”
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Crystal structures of three salts of the triphenylsulfonium ion by Rylan Artis, Waylan Callaway, Elizabeth Heyward, Naomi Reyes, Gavin Roberts, Kaitlyn Van Ostenbridge, Clifford W. Padgett, Will E. Lynch

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Diffractometer for element-specific analysis on local structures using a combination of X-ray fluorescence holography and anomalous X-ray scattering by Hiroo Tajiri, Shinji Kohara, Koji Kimura, Sekhar Halubai, Haruto Morimoto, Naohisa Happo, Jens R. Stellhorn, Yohei Onodera, Xvsheng Qiao, Daisuke Urushihara, Peidong Hu, Toru Wakihara, Toyohiko Kinoshita, Koichi Hayashi

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PGMweb: an online tool for visualizing the X-ray beam path through plane grating monochromators by Patrick Yuheng Wang, Murilo Bazan da Silva, Matthew Hand, Hongchang Wang, Peter Chang, Victoria Beilsten-Edmands, Timur K. Kim, Tien-Lin Lee, Kawal Sawhney, Andrew C. Walters

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Crystal structure of di-μ-acetato-κ4O:O′-bis{(acetato-κ2O,O′)tetraaqua[1-(pyridin-2-ylmethylidene-κN)-2-(pyridin-2-yl-κN)hydrazine-κN1]lanthanum(III)} dinitrate hemihydrate... by Mbossé Ndiaye-Gueye, Bocar Traoré, Ibrahima Elhadji Thiam, Ousmane Diouf, Emmanuel Wenger, Abdou Salam Sall, Claude Lecomte, Mohamed Gaye

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Synthesis of Amino Acid Schiff Base Nickel (II) Complexes as Potential Anticancer Drugs In Vitro by Yang Li, Jianfang Dong, Peiran Zhao, Ping Hu, Dawei Yang, Lei Gao, Lianzhi Li

“…Details of structural study of these complexes using single-crystal X-ray crystallography showed that distorted octahedral environment around nickel (II) ion has been satisfied by three nitrogen atoms and three oxygen atoms. …”
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REVIEW ON PROTEIN FOOTPRINTING AS A TOOL IN STRUCTURAL BIOLOGY by Oluwatosin Ogundairo, Oluwatoyin Ayo-Farai, Chinedu Paschal Maduka, Chiamaka Chinaemelum Okongwu, Abdulraheem Olaide Babarinde, Olamide Sodamade

“…Furthermore, the integration of protein footprinting with other structural biology techniques, such as X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy, is explored to showcase the complementary nature of these approaches in achieving a comprehensive understanding of protein structure and function. …”
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Visualization of four-dimensional X-ray absorption fine structure data using a virtual reality system by Haruo Igarashi, Daiki Kido, Yutaka Ishii, Yasuhiro Niwa, Atsushi Okamoto, Masao Kimura

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Mechanism of sensor kinase CitA transmembrane signaling by Xizhou Cecily Zhang, Kai Xue, Michele Salvi, Benjamin Schomburg, Jonas Mehrens, Karin Giller, Marius Stopp, Siegfried Weisenburger, Daniel Böning, Vahid Sandoghdar, Gottfried Unden, Stefan Becker, Loren B. Andreas, Christian Griesinger

“…Here, we used solid-state NMR in conjunction with crystallography, solution NMR and distance measurements to investigate the transmembrane signaling mechanism of a paradigmatic citrate sensing membrane embedded HK, CitA. …”
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Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration by Paul Tamburini, Dennis Vestergaard Pedersen, Denise Devore, Josh Cone, Rekha Patel, Todd Hunter, Fang Sun, Gregers Rom Andersen, Jeffrey Hunter

“…Tarperprumig potently and dose-dependently inhibits to completion in vitro AP-dependent complement C5b-9 formation, AP-dependent hemolysis, and the AP deposition of C3, FP and C9. X-ray crystallography revealed that the isolated FP-binding VHH recognizes the thrombospondin repeat 5 domain of FP, thereby preventing FP from binding to the AP convertase owing to severe steric hindrance. …”
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Syntheses and crystal structures of the cerium-based coordination polymers poly[(acetic acid)bis(μ-5-carboxythiophene-2-carboxylato)bis(μ-thiophene-2,5-dicarboxylato)dicerium(III)]... by Niklas Ruser, Christian Näther, Norbert Stock

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High-resolution imaging of organic and inorganic nanoparticles at nanometre-scale resolution by X-ray ensemble diffraction microscopy by Ning-Jung Chen, Chia-Hui Yeh, Huai-Yu Cao, Nai-Chi Chen, Chun-Jung Chen, Chun-Yu Chen, Yi-Wei Tsai, Jhih-Min Lin, Yu-Shan Huang, Chien-Nan Hsiao, Chien-Chun Chen

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pH‐Dependent Assembly and Stability of Toll‐Like Receptor 3/dsRNA Signaling Complex: Insights from Constant pH Molecular Dynamics and Metadynamics Simulations by Penghui Li, Mingsong Shi, Yibo Wang, Qiong Liu, Xiubo Du, Xiaohui Wang

“…Abstract The pH‐dependent assembly of Toll‐like receptors (TLRs), which triggers a threshold‐like response, is a key principle in immune signaling. While crystallography has revealed the intricate structure of these assembly complexes, the mechanisms underlying their pH dependency remain unclear. …”
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