Effect of intravenous urokinase vs best medicine treatment on functional outcome for patients with acute minor stroke (TRUST): a randomized controlled trial by Yongli Tao, Yuan Gao, Lu Zhao, Yafang Xu, Chenyang Jiang, Kai Liu, Hui Fang, Lulu Pei, Xin Wang, Rui Zhang, Jun Wu, Jing Yang, Xinsheng Han, Hongling Guo, Baoguo Xue, Jinlou Li, Yuqian Liu, Hongqiu Gu, Kejin Du, Xin Cheng, Qiang Dong, Duolao Wang, Ferdinando S. Buonanno, MingMing Ning, Yuming Xu, Bo Song, the TRUST Trial Investigators

“…Abstract Background The benefits of intravenous thrombolysis in patients with acute minor stroke remain controversial. For the aim of providing a better therapeutic strategy, high-quality trials are required to validate the efficacy of thrombolytic medicine other than intravenous recombinant tissue plasminogen and tenecteplase. …”
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The prognostic value of circulating tumor DNA in malignant melanoma patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis by Lei Liu, Shufu Hou, Aiping Zhu, Bing Yan, Linchuan Li, Dandan Song

“…However, its prognostic value for MM receiving immune checkpoint inhibitors(ICI) remains controversial. This meta-analysis aimed to elucidate the prognostic significance of ctDNA in this patient population.MethodsWe conducted a comprehensive search of the PubMed, Cochrane Library, CNKI, and EMBASE databases, including studies published up to August 15, 2024, to investigate the prognostic impact of ctDNA in MM patients treated with ICI. …”
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Qualitative evaluation of the implementation and national roll-out of the NHS App in England by Claire Reidy, Chrysanthi Papoutsi, Sukriti KC, Bernard Gudgin, Anthony A. Laverty, Felix Greaves, John Powell

“…Shifting emphasis towards in-person care, challenges with digital inclusion and controversies related to features such as patient access to own records further complicated roll-out. …”
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DEVIATION AND ATROPHY OF MIDDLE PHALANX OF HAND FOLLOWING PARTIAL SEPARATION IN SYNDACTYLY PATIENT: THEIR FAULT OR OURS? by Diana Murtiati Kusuma, Iswinarno Doso Saputro, Sitti Rizaliyana, Beta Subakti Nata’atmadja

“…The timing of sur­gery of all other cases of syndactyly remains somewhat controversial; most suggest surgical correction before age of 18 months, whereas others prefer to wait until after this age. …”
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Use of intraoperative luminescent methods for detecting affected lymph nodes in patients with complicated forms of colon cancer by M. A. Kubrak, S. M. Zavhorodnii, M. B. Danyliuk, A. I. Rylov

“…The issue of the volume of lymphatic dissection in patients with complicated forms of colon cancer and the possibility of using methods of intraoperative visualisation of the affected lymph nodes remains controversial. The aim of the study – to analyse the results of using the intraoperative luminescent method of detecting affected lymph nodes in patients with complicated forms of malignant diseases of the large intestine. …”
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The Relationship between Left Ventricular Diastolic Function Parameters and Coronary Artery Disease Severity by Khadije Mohammadi, Mohammad Masoomi, Mahsa Akrami, Shirin Habibi Khorasani, Mina Moridi, Sara Saidi

“…Background: The relationship between diastolic function parameters and the severity of coronary artery disease (CAD) is controversial. This study aimed to determine the relationship between left ventricular diastolic function and the severity of CAD.Methods: This cross-sectional study included 63 patients with Ischemic heart disease (IHD) or those suspected of having IHD, who underwent angiography. …”
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L-shaped association of body mass index with prognosis in individuals with sepsis: a multicenter cohort study by Kunping Cui, Xiangnan Teng, Wei liu, Xiaoxiao Zhao, Shanling Xu, Lang Bai

“…Abstract Objective The relationship between body mass index (BMI) and sepsis prognosis remains highly controversial and uncertain. This study investigated the association between BMI and prognosis in patients with sepsis. …”
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Impact of invasive infections on clinical outcomes in acute pancreatitis: early predictive factors and implications for prophylactic anti-infective therapy by Fabienne Bender, Theresa König, Matthias Hecker, Moritz Fritzenwanker, Jacqueline Braun, Joern Pons-Kühnemann, Matthias Wolff, Andreas Hecker, Martin Reichert

“…Abstract Background The use of antibiotic therapy in acute pancreatitis remains controversial and is currently recommended only for confirmed infections of peripancreatic necrosis. …”
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Associations between lipid-lowering drugs and urate and gout outcomes: a Mendelian randomization study by Min Liu, Na Yin, Yuhang Zhu, Aili Du, Chunyuan Cai, Pengyuan Leng

“…However, the effects of lipid-lowering drugs on urate and gout remain controversial. The aim of this study was to investigate the genetic association between lipid-lowering drugs and urate and gout.MethodsIn this study, two genetic proxies were employed to approximate lipid-lowering drug exposure: expression quantitative trait loci (eQTL) associated with drug-target genes and genetic variations proximal to or within genes targeted by these drugs, which are linked to low-density lipoprotein cholesterol (LDL-C) levels. …”
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Systemic therapy a risk factor for glaucoma development and progression by A.M. Getmanova, A.Yu. Brezhnev, A.V. Kuroyedov, V.I. Baranov, A.S. Dvornikov

“…However, the data on the effect of systemic medications on the levels of intraocular pressure (IOP) and glaucoma progression remain controversial. Understanding the mechanisms of the effects of systemic medications on IOP levels is of crucial importance. …”
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Predictive value of lymphocyte-associated inflammation index in post-stroke cognitive impairment: a systematic review and meta-analysis by Feng-le Mao, Xia He, Xia-lian Huang, Yue-ming Cheng, Fu-li Qin, Yan-qiu Wang

“…BackgroundThe predictive role of the lymphocyte-associated inflammation index in post-stroke cognitive impairment (PSCI) remains controversial. Therefore, we performed an updated meta-analysis to update the evidence.MethodsThis meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. …”
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Impact of cognition and psychoemotional status on falls in multiple sclerosis by R. Godelienė, E. Sukockienė, V. Danielius, V. Stankunavičiūtė, D. Mickevičienė

“…Data on the influence of psychoemotional factors on the falls are also controversial. Materials and methods. The study was carried out from April 2018 to January 2019 at the Hospital of Lithuanian University of Health Sciences, Neurology Department. …”
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Correlation between Apelin and Some Angiogenic Factors in the Pathogenesis of Preeclampsia: Apelin-13 as Novel Drug for Treating Preeclampsia and Its Physiological Effects on Place... by Reham Z. Hamza, Abdel Aziz A. Diab, Mansour H. Zahra, Ali K. Asalah, Suzan M. M. Moursi, Najah M. Al-Baqami, Fawziah A. Al-Salmi, Mai S. Attia

“…Data regarding the circulating apelin level and its role in PE remains controversial. This study was formulated to assess the serum apelin level in PE, investigate its correlation with some inflammatory, oxidative stress, and angiogenic proteins in a nitric oxide synthase inhibitor; the N (gamma)-nitro-L-arginine methyl ester (L-NAME)-induced rat model of PE and determine whether apelin administration could protect against development of PE. 40 healthy adult female albino rats and 10 adult male albino rats were used in this study. …”
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Outcome of Newborns with Tracheoesophageal Fistula: An Experience from a Rapidly Developing Country: Room for Improvement by Amal Al-Naimi, Sara G. Hamad, Abdalla Zarroug

“…The optimal surgical management has several controversies, particularly in rapidly developing countries. …”
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Correlation of sarcopenia and depressive mood in older community dwellers: a cross-sectional observational study in China by Lei Chen, Yunlu Sheng, Hanmei Qi, Tingting Tang, Jing Yu, Shan Lv

“…Objective Whether sarcopenia is detrimental to depression is still controversial, which may be due to the three components of the sarcopenia. …”
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Circulating Galectin-3 and Aldosterone for Predicting Atrial Fibrillation Recurrence after Radiofrequency Catheter Ablation by Zhong-bao Ruan, Run-feng Gao, Fei Wang, Ge-cai Chen, Jun-guo Zhu, Yin Ren, Li Zhu

“…However, their potential value as predictors of atrial fibrillation (AF) recurrence after radiofrequency catheter ablation (RFCA) is unknown or controversial. Therefore, the aim of this study was to assess the relationship between baseline Gal-3, ALD levels, and AF recurrence in patients performing RFCA. …”
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Outcomes and Complications of Minimally Invasive Glaucoma Surgeries (MIGS) in Primary Angle Closure and Primary Angle Closure Glaucoma: A Systematic Review and Meta-Analysis by Paik B, Chua CH, Yip LW, Yip VC

“…While MIGS can be performed in the same setting as phacoemulsification (MIGS-phaco), it remains controversial if the combined procedure confers a significant advantage over standalone phacoemulsification.Methods: We performed a systematic search of MEDLINE, EMBASE, and Cochrane library for studies reporting outcomes of MIGS in PAC or PACG. …”
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ORGAN-PRESERVING INTERVENTIONS IN SURGICAL CORRECTION OF SPLEEN CYSTS IN CHILDREN by Andriy Kuzyk

“…The surgical approach to splenic cyst treatment in children is rather controversial. There are different organ-preserving surgeries available to treat children with the spleen affected by cystic lesions. …”
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On the Biosynthesis of Bioactive Tryptamines in Black Cohosh (<i>Actaea racemosa</i> L.) by Martin J. Spiering, James F. Parsons, Edward Eisenstein

“…However, its use and safety are controversial. <i>A. racemosa</i> tissues contain the bioactive serotonin analog <i>N</i>-methylserotonin, which is thought to contribute to the serotonergic activities of black cohosh–containing preparations. …”
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Efficacy and Safety of Mesenchymal Stem Cells in Treatment of Complex Perianal Fistulas: A Meta-Analysis by Fang Cheng, Zhong Huang, Zhi Li

“…Local mesenchymal stem cell (MSC) therapy for perianal fistula has shown considerable promise but still remains controversial. Therefore, we performed the meta-analysis to evaluate the efficacy and safety of local MSC therapy for complex perianal fistula. …”
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