Cochlear implantation in vestibular schwannoma: A game changer? A narrative review by Luis Lassaletta, Miryam Calvino, Isabel Sánchez-Cuadrado, José Manuel Morales-Puebla, Javier Gavilán

“…The aim of this paper is to discuss the current role of CIs in patients with VS, addressing the most controversial topics such as the variability of outcomes, the emerging clinical scenarios, the lack of consistent prognostic factors, and the need for an intraoperative tool to aid decision-making in challenging cases. …”
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Multidisciplinary, multicenter consensus for the care of patients affected with Sturge–Weber syndrome by May El Hachem, Andrea Diociaiuti, Angela Galeotti, Francesca Grussu, Elena Gusson, Alessandro Ferretti, Carlo Efisio Marras, Davide Vecchio, Simona Cappelletti, Mariasavina Severino, Carlo Gandolfo, Simone Reali, Rosa Longo, Carmen D’Amore, Lodovica Gariazzo, Federica Marraffa, Marta Luisa Ciofi Degli Atti, Maria Margherita Mancardi, and the Sturge-Weber Syndrome Multidisciplinary Group

“…Conclusions The present consensus developed by a multidisciplinary group of experts from Italian reference centres comprises practical recommendations for SWS global management, including currently controversial issues. Specific statements for all disease aspects, from skin manifestations and neurological and ocular signs and symptoms to oral and maxillofacial care, are provided. …”
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Impact of vancomycin area under the curve in early or later phase on efficacy and nephrotoxicity in patients with enterococcal bloodstream infections: a multicenter study by Piyawadee Tangvichitrerk, Dhitiwat Changpradub, Jatapat Hemapanpairoa, Piraporn Juntanawiwat, Wichai Santimaleeworagun

“…Abstract Background The optimal pharmacokinetic and pharmacodynamic (PK/PD) parameters of vancomycin that can improve outcomes in enterococcal infections remain controversial. To clarify the therapeutic target for this antibiotic, this study aimed to determine vancomycin PK/PD parameters associated with efficacy in the early (during 72 h) or later (after 72 h) phase of treatment and nephrotoxicity in enterococcal bloodstream infection patients. …”
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Relationship between age and delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage requiring invasive mechanical ventilation: a secondary analysis by Qing-qing Wu, Wei-wen Chen, Tian-lai Lin, Cun-rong Chen, Zhi-rong Ding, You-li Chen

“…Abstract The association between age and delayed cerebral ischemia (DCI) has long been controversial. This study aimed to explore the relationship between age and DCI in patients with aneurysmal subarachnoid hemorrhage (aSAH) requiring invasive mechanical ventilation (IMV). …”
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Identification and characterization of the functional tetrameric UDP-glucose pyrophosphorylase from Klebsiella pneumoniae by Isabel Ramón Roth, Pavel Kats, Timm Fiebig, Françoise Routier, Roman Fedorov, Larissa Dirr, Jana I. Führing

“…Uniquely, enterobacterial species harbor a second gene, galF, encoding a protein with high homology to UGP, whose function is somewhat controversial. Here, we show that the galF gene of the opportunistic pathogen Klebsiella pneumoniae encodes a dimeric protein that has lost UGP activity, likely due to a combination of active site mutations and an inability to tetramerize, whereas the functional K. pneumoniae UGP, encoded by galU, is an active tetramer. …”
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Outpatient chemotherapy drug costs and expensive chemotherapy drug use in 340B and Non-340B hospitals: an observational study by Jianhui Hu, David R. Nerenz

“…Abstract Background The 340B Drug Pricing Program has been controversial since its inception in 1992, a major criticism being that 340B hospitals use more outpatient drugs, and more expensive drugs, because of financial incentives to “make money” through the program. …”
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Ethical issues raised in the care of the elderly during the SARS-CoV-2 pandemic and possible solutions for the future: a systematic review of qualitative scientific literature by Mohamed Amine Bouchlaghem, Zoé Estey-Amyot, Erika Ethier, Miruna Anohim, Marie-Laurence Ouellet-Pelletier, Lyse Langlois, Félix Pageau

“…Abstract Background The COVID-19 pandemic has led governments worldwide to make ethically controversial decisions. As a result, healthcare professionals are facing several ethical dilemmas, especially in terms of healthcare services provided to senior citizens. …”
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Telomere Length and Oxidative Damage in Children and Adolescents with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis by Leping Ma, Cui Liu, Ran Song, Yeping Qian, Feng Zhang

“…However, whether telomere length (TL) and oxidative indicators are significantly changed in ASD patients compared with controls remains controversial. The aim of this study was to determine the associations of ASD with TL and oxidative indicators by performing a meta-analysis of all published evidence. …”
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Association of caffeine intake and sleep duration with bone mineral density: a cross-sectional study from National Health and Nutrition Examination Survey between 2011 and 2018 by Yuxue He, Wenjia Zou, Fei Xiao

“…Abstract Objective The association between sleep duration, caffeine intake, and bone mineral density (BMD) is not well understood, with previous studies providing controversial results. This study explores the associations among caffeine intake, sleep duration, and BMD. …”
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Contradictions of students’ motivation for participation in the activities of voluntary organisations by A. V. Starshinova

“…Participation in volunteering under the influence of external factors in case of unformed or controversial intrinsic motivation for this activity causes dissatisfaction with the work and termination of activities.Aim. …”
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The Great Vietnamese Famine of 1944-45 Revisited by Geoffrey Gunn

“…While such charged issues as the Nanjing Massacre, the comfort women, forced labor and unit 731 have long been the subject of intense debate in the historical memory wars, in textbook controversies and museum exhibits, the Vietnamese famine, and Japan’s role in creating it, appear to have disappeared from Japanese war memory and commemoration whether in textbooks or museum representations. …”
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Evaluation of polymorphisms at the 3´ UTR SLC11A1 gene microsatellites and their associations with the outcome of Brucella abortus infection in Bos taurus cattle by F.C. Hasenauer, M.E. Caffaro, M.A. Poli, Carlos A. Rossetti

“…., aunque su relevancia en la prevención de la brucelosis bovina es controversial. El objetivo de este estudio fue reevaluar el rol de esos polimorfismos frente a una infección por B. abortus en bovinos de razas europeas. …”
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Delayed PCI 12 Hours after the Onset of Symptoms Is Associated with Improved Outcomes for Patients with ST-Segment Elevation Myocardial Infarction: A Real-World Study by Wen-Juan Xiu, Hai-Tao Yang, Ying-Ying Zheng, Yi-Tong Ma, Xiang Xie

“…However, it remains controversial whether PCI delayed beyond the recommended time window of 12 h after the onset of symptoms is applicable to STEMI. …”
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Is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea: a case–control study in China? by Qi Chen, Yifei Gao, Yunhui Tang, Luling Lin, Mingzhi Zhao, George Qiaoqi Chen, Shouzhen Chen

“…However, recent studies indicated that women with normal BMI were also more likely to develop endometriosis, suggesting the association with BMI is controversial. We therefore investigated the association of BMI and surgically diagnosed endometriosis in a cohort of Chinese women.Design Retrospective case–control study.Setting Tertiary hospital.Patients 709 women with endometriosis and 807 age matched controls between January 2018 and August 2019.Intervention Age at diagnosis, parity, gravida, BMI and self-reported dysmenorrhoea status were collected and the association of BMI and endometriosis was analysed.Measurement and main results Overall, the median BMI was not different between patients and controls (21.1 kg/m2 vs 20.9 kg/m2, p=0.223). …”
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Clinical and ultrasound assessment of body composition in preterm infants at discharge: an observational study by Beatriz del Rey Hurtado de Mendoza, Montserrat Izquierdo Renau, Elsa García González, Carla Balcells-Esponera, Emilio J Inarejos Clemente, Isabel Iglesias-Platas

“…Objectives While the target of growth of very preterm infants (VPIs) during Neonatal Intensive care unit (NICU) admission is still controversial, the most accepted objective is that they should follow their intrauterine trajectory in terms of growth and body composition (BC). …”
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Indicators of Glucose Metabolism in Children and Adolescents Characterized as Having “Metabolically Healthy” and “Metabolically Unhealthy” Obesity by Maria Baltogianni, Niki Dermitzaki, Vasileios Giapros, Foteini Balomenou, Chrysoula Kosmeri, Fani Ladomenou, Evanthia Kantza, Anastasios Serbis

“…Background/Objectives: Some individuals with obesity may exhibit fewer metabolic disturbances and face a lower long-term risk of complications; however, the existence of this so-called “metabolically healthy obesity” (MHO) compared to “metabolically unhealthy obesity” (MUO) remains controversial. We hypothesized that children with MHO might have a more favorable profile than children with MUO. …”
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Food-specific IgG Antibody Levels in Indian Subjects: A Retrospective Analytical Study by Shailesh Desai, Moumita Misra, Raj Jatale, Alap Christy, Shibani Ramchandran

“…However, testing for such antibodies for diagnosis of adverse food reactions remains controversial. This study aimed was to understand the significance of food-specific IgG antibodies among patients who presented with food-dependent gastrointestinal symptoms viz upset stomach, bloating, etc. …”
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The predictors of successful methotrexate treatment of tubal ectopic pregnancy by Eiman Abdelfattah-Arafa, Hager Farag Abdussalam, Mohamed Omar Saad, Walid El Ansari

“…Background The pre-treatment characteristics of the patient and ectopic pregnancy to determine the patients who are likely to successfully respond to methotrexate (MTX) therapy remain controversial. This study investigated the outcomes of ectopic pregnancy after one and two MTX doses and their independent predictors.Methods Retrospective cross-sectional study of women who consented to MTX treatment in 2017–2018 at our institution (N = 317). …”
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Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value by Xavier Mariette, Gaetane Nocturne, Pascale Chretien, Claire Goulvestre, Paul Cioni, Eric Ballot, Dounia Khelifi-Touhami

“…Compared to anti-SS-A antibody positivity, the significance of the immunological profile anti-SS-B positive/anti-SS-A negative remains controversial. We aimed to evaluate the prevalence and diagnostic significance of isolated anti-SS-B antibodies.Methods We conducted a retrospective study across three hospitals of the Assistance Publique—Hôpitaux de Paris. …”
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Intertwined depressive and cognitive trajectories and the risk of dementia and death in older adults: a competing risk analysis by Jufen Liu, Ziyang Ren, Yushan Du, Lirong Nie

“…Background Depressive symptoms and cognitive impairment often interact, rendering their associations controversial. To date, their joint trajectories and associations with dementia and death remain underexplored.Aims To explore the interactions between depressive symptoms and cognitive function, their developmental trajectories and the associations with all-cause dementia, Alzheimer’s disease (AD) and all-cause death in older adults.Methods Data were from the Health and Retirement Study. …”
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