Identification of Potential Clusters of Signs and Symptoms to Prioritize Patients’ Eligibility for AADCd Screening by 3-OMD Testing: An Italian Delphi Consensus by Carlotta Spagnoli, Roberta Battini, Filippo Manti, Duccio Maria Cordelli, Andrea Pession, Melissa Bellini, Andrea Bordugo, Gaetano Cantalupo, Antonella Riva, Pasquale Striano, Marco Spada, Francesco Porta, Carlo Fusco

“…Fourteen steering committee members invited a panel of 29 Italian experts to express their opinions on a series of crucial but controversial topics related to using 3-OMD DBS as a screening method in AADCd. …”
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Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children by Yali Zhang, Yali Zhang, Yingying Xu, Yingying Xu, Ling Hu, Ling Hu, Xiaomei Wang

“…However, there are ongoing controversies and challenges in current research concerning the influence of probiotic type, dosage, duration of use, and other factors on efficacy. …”
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Hypertensive load predicts recovery of renal function for patients undergoing revascularisation for renal artery stenosis by Ben Edgar, Rob Pearson, Andrew Jackson, Callum Stove, Ram Kasthuri, Keith Hussey, Christian Delles, Colin Geddes, Patrick Mark, Giles Roditi, Linsay McCallum, David B. Kingsmore

“…The reversibility of renal impairment is not predictable, and thus renal revascularisation is controversial. This study aims to test the hypothesis that the hypertensive response to renal ischaemia reflects viable renal parenchyma, and thus could be used to predict the recovery in renal function. …”
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Delayed Graft Function in Kidney Transplants: Time Evolution, Role of Acute Rejection, Risk Factors, and Impact on Patient and Graft Outcome by Martin Chaumont, Judith Racapé, Nilufer Broeders, Fadoua El Mountahi, Annick Massart, Thomas Baudoux, Jean-Michel Hougardy, Dimitri Mikhalsky, Anwar Hamade, Alain Le Moine, Daniel Abramowicz, Pierre Vereerstraeten

“…Although numerous risk factors for delayed graft function (DGF) have been identified, the role of ischemia-reperfusion injury and acute rejection episodes (ARE) occurring during the DGF period is ill-defined and DGF impact on patient and graft outcome remains controversial. Methods. From 1983 to 2014, 1784 kidney-only transplantations from deceased donors were studied. …”
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Control glucémico en pacientes diabéticos tras tratamientos estomatológicos y uso de profilaxis antibacteriana by Nancy Leonor Ambruster Sánchez, Maritza Peña Sisto, Oscar Rodríguez Reyes

“…Introducción: La administración de agentes antibacterianos para disminuir o eliminar infecciones pre y postoperatorias en diabéticos ha sido un tema polémico y controversial en estomatología durante décadas. Objetivo: Determinar el control glucémico en pacientes diabéticos, tras tratamientos estomatológicos y uso de profilaxis antibacteriana. …”
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Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a M... by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo del Valle-Mondragón, Elizabeth Soria-Castro, Juan Carlos Torres-Narváez, Elizabeth Carreón-Torres, Alicia Sánchez-Mendoza, María Esther Rubio-Ruíz

“…Recently, nonclassical RAS components have been implicated in the pathogenesis of hypertension and myocardial dysfunction; however, their cardiac functions are still controversial. We evaluated if the nonclassical RAS signaling pathways, directed by angiotensin III and angiotensin-(1-7), are involved in the cardioprotective effect of fenofibrate during ischemia in MetS rats. …”
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Nomogram for Predicting Survival in Advanced Gastric Cancer after Neoadjuvant Chemotherapy and Radical Surgery by Yonghe Chen, Dan Liu, Jian Xiao, Jun Xiang, Aihong Liu, Shi Chen, Junjie Liu, Xiansheng Hu, Junsheng Peng

“…However, the survival benefit is still controversial, and prognostic factors remain undetermined. …”
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Endovascular Treatment of Intracranial Artery Dissection: Clinical and Angiographic Follow-Up by Reza Mohammadian, Ali Akbar Taheraghdam, Ehsan Sharifipour, Reza Mansourizadeh, Ali Pashapour, Mohammad Shimia, Ghaffar Shokouhi, Moslem shakeri, Ali Hashemzadeh

“…Intracranial artery dissections are rare and many controversies exist about treatment options. The aim of this study was to evaluate the efficacy and safety of the endovascular approach in patients with an intracranial dissection presenting with different symptoms. …”
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U–Pb Dating and Hf Isotopes Analysis of Detrital Zircons of the Shanxi Formation in the Otuokeqi Area, Northwestern Ordos Basin by Jiaxuan Song, Hujun Gong, Jingli Yao, Huitao Zhao, Xiaohui Zhao, Yunxiang Zhang, Biao Chen

“…The Paleozoic strata are widely distributed in the northwest of the Ordos Basin, and the provenance attributes of the basin sediments during this period are still controversial. In this paper, the detrital zircon LA-MC-ICPMS U-Pb age test was conducted on the drilling core samples of the Shanxi Formation of the Upper Paleozoic in the Otuokeqi area of the Ordos Basin, and the provenance age and the characteristic of the Shanxi formation in the Otuokeqi area in the northwest were discussed. …”
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Optimization of cultivation parameters for bovine respiratory syncytial virus strain Vologda/2019 by V. V. Kirpichenko, S. V. Kononova, I. N. Shumilova, A. A. Nesterov, M. V. Turkova, Ye. A. Bukhon, D. V. Romenskaya, A. V. Sprygin, B. L. Manin, O. P. Byadovskaya

“…There are currently many controversial issues in the study of bovine respiratory syncytial infection. …”
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Investigation of IL-17A Serum Levels in Patients with Nonmelanoma Skin Cancer by Mehdi Ghahartars, Fatemeh Sedaghat, Elham Khajavi, Amir Ali Nejat, Mahyar Malekzadeh, Abbas Ghaderi, Mohammad Javad Fattahi

“…Role of interleukin 17A (IL-17A) in carcinogenesis and cancer growth is controversial. Although some researches support its antitumor activity, some others suggest that it promotes the growth and development of different types of cancer including skin cancer by activation of STAT3. …”
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ABO-Incompatible Adult Living Donor Liver Transplantation in the Era of Rituximab: A Systematic Review and Meta-Analysis by Dipesh Kumar Yadav, Yong Fei Hua, Xueli Bai, Jianying Lou, Risheng Que, Shunling Gao, Yun Zhang, Ji Wang, Qinfen Xie, Muhammad Ibrahim Alhadi Edoo, Vikram Kumar Chutturghoon, Tingbo Liang

“…However, ABOi ALDLT remains a controversial approach in comparison to ABOc ALDLT. Methods. …”
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Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets by Chun-Mei Wang, Ying-Jie Chen, Bo-Cheng Yang, Jia-Wen Yang, Wei Wang, Yang Zeng, Jun Jiang

“…Some research has suggested that vitamin D3 supplementation reduces thyroid inflammation, but this remains controversial.MethodsEAT was induced in female NOD/ShiLtJ mice by giving them water containing 0.05% sodium iodide, and 1μg/kg of 1α,25-(OH)2D3 was injected intraperitoneally every other day. …”
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Impact of Physical Activity on Cancer-Specific and Overall Survival of Patients with Colorectal Cancer by Gaetan Des Guetz, Bernard Uzzan, Thierry Bouillet, Patrick Nicolas, Kader Chouahnia, Laurent Zelek, Jean-François Morere

“…Its influence on cancer-specific (CSS) and overall survival (OS) is controversial. Methods. We performed a literature-based meta-analysis (MA) of observational studies, using keywords “colorectal cancer, physical activity, and survival” in PubMed and EMBASE. …”
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Frequent mutation of K-RAS in addition to BRAF V600E in Ameloblastoma – An immunohistochemical study by Aishwariya Mohanty, Abikshyeet Panda, Pallavi Mishra, Lipsa Bhuyan, Harish Kumar

“…Background: Ameloblastoma is the most frequently encountered, enigmatic odontogenic tumor whose etiopathogenesis is still controversial. Understanding the pathogenic mechanism involved in Ameloblastoma and its proliferation aids in determining the best treatment option at an early stage. …”
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Clinicopathologic Characteristics and Long-Term Outcome of Gastric Cancer Patients with Family History: Seven-Year Follow-Up Study for Korean Health Check-Up Subjects by Jooyoung Lee, Su Jin Chung, Ji Min Choi, Yoo Min Han, Joo Sung Kim

“…However, the long-term prognosis of GC with FHx remains controversial. We aimed to investigate the clinicopathologic characteristics and long-term outcomes of GC according to the presence or absence of GC FHx. …”
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Evaluation of Protocol Biopsy Utility 12 Months after Renal Transplantation: A Multicenter Observational Analysis by Bruno Moulin, Pierre Merville, Karine Renaudin, David Buob, Sophie Ferlicot, Michel Delahousse, Jacques Dantal, Laetitia Albano, Christelle Barbet, Georges Mourad, Laure-Hélène Noel

“…The clinical merit of surveillance kidney graft biopsies remains controversial. A retrospective, multicenter analysis evaluated 12-month surveillance biopsies (SB, 154 patients) versus no SB (NSB, 138 patients (11 with diagnostic biopsy)) in patients >18 months posttransplant with estimated GFR (eGFR) ≥30 mL/min. …”
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Sensitivity, Specificity, Predictive Values, and Accuracy of Three Diagnostic Tests to Predict Inferior Alveolar Nerve Blockade Failure in Symptomatic Irreversible Pulpitis by Daniel Chavarría-Bolaños, Laura Rodríguez-Wong, Danny Noguera-González, Vicente Esparza-Villalpando, Mauricio Montero-Aguilar, Amaury Pozos-Guillén

“…Its success in the presence of preoperative inflammation is still controversial. The aim of this study was to evaluate the sensitivity, specificity, predictive values, and accuracy of three diagnostic tests used to predict IANB failure in symptomatic irreversible pulpitis (SIP). …”
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Short‐ and Long‐Term Efficacy of Hyperbaric Oxygen Therapy in Irradiated Breast Cancer Patients With Long‐Standing Lymphedema: A Prospective Case Series by Imjai Chitapanarux, Siriarrayapa Chachvarat, Patumrat Sripan, Thienchai Pattarasakulchai, Nuttaya Pattamapaspong, Thanat Kanthawang, Montana Buntragulpoontawee

“…ABSTRACT Background Several studies have explored the advantage of treatment with hyperbaric oxygen (HBO) for upper extremity lymphedema in irradiated breast cancer patients and reported controversial results. This prospective case series aimed to document the short‐ and long‐term efficacy of this therapy, focusing on the arm volume and functional assessment in breast cancer patients with a history of long‐standing lymphedema for more than 2 years. …”
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Nuclear Intron Sequence Variation of the <i>Bulinus globosus</i> Complex (Mollusca: Planorbidae): Implications for Molecular Systematic Analyses by Chairat Tantrawatpan, Kotchaphon Vaisusuk, Chrysantus M. Tanga, Warayutt Pilap, Naruemon Bunchom, Ross H. Andrews, Tongjit Thanchomnang, Wanchai Maleewong, Weerachai Saijuntha

“…The species that make up the <i>B. globosus</i> group are genetically complex, and their taxonomic status remains controversial. Genetic variation, heterozygosity, and DNA recombination in <i>B. globosus</i> were examined using the mitochondrial cytochrome c oxidase subunit 1 (<i>COI</i>) and the intron 3 region of the arginine kinase gene (AkInt3). …”
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