The chromatin remodeling factor OsINO80 promotes H3K27me3 and H3K9me2 deposition and maintains TE silencing in rice by Kangxi Du, Jiabing Wu, Jiachen Wang, Wenhao Xie, Liufan Yin, Xiang Li, Chao Li, Aiwu Dong

“…However, the role of INO80 in modulating the histone variant H2A.Z is controversial. Moreover, whether INO80 helps regulate heterochromatin remains unknown. …”
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Outcome of Different Preemptive Analgesia Modalities in Patients Undergoing Total Knee Replacement Surgeries: A Prospective Randomized Study by Narendra Vaidya, Gourav S. Pawar, Anup P Gadekar, Nilesh A. Patil, Pravin Rameshrao Kutemate, Mohit Kolhapure

“…The use of preemptive analgesia (PA) is still a controversial topic; however, still, it has managed to prevent altered pain perception and pain amplification after surgery. …”
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The Effect of Vitamin D Supplementation on Blood Lipids in Patients with Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials by Hong Gao, YanTao Li, WenNan Yan, Fei Gao

“…Studies have found that vitamin D supplementation may improve blood lipids in patients with polycystic ovary syndrome, but the results are controversial, so this study will further analyze the effect of vitamin D supplementation on blood lipids in patients with polycystic ovary syndrome. …”
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The association of lipids and novel non-statin lipid-lowering drug target with osteoporosis: evidence from genetic correlations and Mendelian randomization by Qingcong Zheng, Rongjie Lin, Du Wang, Rongsheng Chen, Weihong Xu

“…Abstract Background It remains controversial whether lipids affect osteoporosis (OP) or bone mineral density (BMD), and causality has not been established. …”
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Hydrological and Meteorological Drought Monitoring and Trend Analysis in Abbay River Basin, Ethiopia by Kassa Abera Tareke, Admasu Gebeyehu Awoke

“…The definition of drought is very controversial due to its multi-dimensional impact and slow propagation in onset and end. …”
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The effectiveness of music therapy in improving behavioral symptoms among children with autism spectrum disorders: a systematic review and meta-analysis by Xiuyan Gao, Guangjun Xu, Ningning Fu, Qi Ben, Lin Wang, Xiumei Bu

“…Two reviewers extracted the data separately, and any controversies between the authors’ assessments were resolved by conversation or speaking with another author. …”
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Acetaminophen administration reduces acute kidney injury risk in critically ill patients with Clostridium difficile infection: A cohort study. by Yue Liao, Yulong Wang, Daxue Li, Xuewen Qiu

“…However, the association between its administration and acute kidney injury (AKI) among critically ill patients remains controversial, particularly lacking research in patients with Clostridioides difficile infection (CDI). …”
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The Impact of Locoregional Therapy in Nonmetastatic Inflammatory Breast Cancer: A Population-Based Study by Mahvish Muzaffar, Helen M. Johnson, Nasreen A. Vohra, Darla Liles, Jan H. Wong

“…The impact of locoregional therapy on survival in IBC is controversial. Methods. Patients with nonmetastatic IBC between 1988 and 2013 were identified in the Surveillance, Epidemiology, and End Results (SEER) registry. …”
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Neutrophil-to-lymphocyte ratio as a prognostic factor in patients with castration-resistant prostate cancer treated with docetaxel-based chemotherapy: a meta-analysis by Ying Zhang, Xiao Zhou, Ran Xu, Guangcheng Luo, Xinjun Wang

“…Abstract Background In recent years, many studies have illustrated that the neutrophil-to-lymphocyte ratio (NLR) is a prognostic factor of metastatic castration-resistant prostate cancer (mCRPC), but their conclusions are controversial. The aim of this study was to assess the prognostic value of the NLR in patients with mCRPC treated with docetaxel-based chemotherapy. …”
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Effects of levothyroxine therapy on bone and mineral metabolism in hypothyroidism: a systematic review and meta-analysis by Xiaotao Li, Taotao Zhang, Hongling Zhang, Shanshan Liu, Limin Tian

“…However, the effects of levothyroxine (LT4) treatment on bone for hypothyroid patients remain controversial. Methods A systematical search was conducted of several databases, from inception until December 9, 2022, and updated the search using the same search strategy on October 30, 2024, for studies evaluating the effects of LT4 treatment on bone in hypothyroidism including subclinical hypothyroidism (SCH) and overt hypothyroidism (OH). …”
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EU climate countdown: economic risks, adaptation and smart policies by Ana-Elena Varadi, Oana-Ramona Lobont, Sorana Vatavu

“…It proposes a traditional yet controversial method for assessing the correlation between indicators and corresponding causes whilst also considering various indicators to explain the means through which the EU Commission had applied its adopted environmental policies to mitigate environmental risks.…”
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The effects of integrated traditional Chinese and western medicine rehabilitation programs on post-acute ankle sprain: A randomized controlled trial study protocol. by Hang Gao, Xiao Chen, Jiayi Ren, Xinglai Zhang, Yuqian Hu, Zhao Ma, Yuanjia Gu, Jiming Tao, Weian Yuan

“…The current clinical guidelines for post-acute ankle sprains are still controversial. Pain and functional impairment are the most significant symptoms after ankle sprain. …”
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Successful Antiviral Treatment with Direct-Acting Antivirals for Hepatitis C Virus Infection during Peritransplant Period in a Kidney Transplant Recipient by Giovanni Varotti, Ferdinando Dodi, Ernesto Paoletti, Andrea Bruno, Iris Fontana

“…Timing for DAA therapy in HCV positive kidney waitlist patients continues to be controversial, and caution is recommended due to the potential difficult immunosuppressant dose adjustments, particularly in the early posttransplant period. …”
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Predicting Crash Frequency for Urban Expressway considering Collision Types Using Real-Time Traffic Data by Hui Zhang, Siyao Li, Chaozhong Wu, Qi Zhang, Yafen Wang

“…In addition, the traffic characteristics are considered to be a potentially important predictor of traffic accidents; however, their impact on crashes has been controversial. Therefore, a crash frequency predicting model for urban expressway considering collision types is proposed in this study. …”
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Correlation between uric acid levels and bone mineral density in patients with type 2 diabetes mellitus: a systematic review and meta-analysis by Hang Zhao, Cuijuan Qi, Yunjia Zhang, Luping Ren, Shuchun Chen

“…PurposeTo explore the controversial relationship between uric acid (UA) levels and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).Patients and methodsThe PubMed, Embase, and Cochrane Library databases were searched using keywords and related words. …”
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Experience of foreign countries in ensuring procedural guarantees of the rights of participants in criminal proceedings by A. V. Piddubna

“…However, the issues of adaptation of national legislation to the provisions of foreign legislation in terms of guaranteeing each participant in criminal proceedings the protection, defence and realisation of their rights, freedoms and legitimate interests in accordance with international standards remain controversial. At the same time, there are a number of gaps and inconsistencies in the provisions of the criminal procedure legislation, the gradual elimination of which will allow Ukraine to reach the international level as a state that guarantees each participant in criminal proceedings the protection, defence and exercise of their rights, freedoms and legitimate interests in accordance with European standards, as well as reduce the number of applications to the European Court of Human Rights. …”
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MANDIBULR CONDYLE FRACTURE MANAGEMENT OUTCOME IN DEPARTMENT OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, DR. SOETOMO GENERAL ACADEMIC HOSPITAL (2015-2018) by Lobredia Zarasade, Iswinarno Doso Saputro, Nadia Tamara Putri

“…The management of condyle fractures is still controversial because of the prognosis. Management of condyle fractures of the mandible should aim at maximally reducing morbidity, postoperative complications, and aesthetic and/ or functional impairment. …”
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Role of adductor canal block and genicular nerve block on postoperative pain and enhanced recovery in patients undergoing total knee arthroplasty: A randomized clinical trial by Bassel Mohammed Elfokery, Mustafa Seet, Tareef Ashour, Hatem Alharbi, Mujeeb Ashraf, Hatim Alshareef, Mohammad Nyaz, Rayan Bakhreba, Atif Sait

“…Abstract Background: The postoperative pain management for total knee arthroplasty (TKA) remains controversial. This work aimed to assess the role of adductor canal block (ACB) and genicular nerve block (GNB) on postoperative pain and the possibility of enhanced recovery in patients undergoing TKA. …”
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Validity of Accelerometers for the Evaluation of Energy Expenditure in Obese and Overweight Individuals: A Systematic Review by Silvia Pisanu, Andrea Deledda, Andrea Loviselli, Inge Huybrechts, Fernanda Velluzzi

“…Even though the validity of accelerometers for the measurement of energy expenditure (EE) has been demonstrated for normal-weight individuals, the applicability of this instrument in obese individuals remains controversial. This review aims to summarize the level of agreement between accelerometers and the gold standards (indirect calorimetry and doubly labelled water) for the measurement of energy expenditure (EE) in obese or overweight individuals. …”
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¿Cuánto resiste la memoria? Destrucción y patrimonialización de la Villa San Luis de Las Condes by Javiera Bustamante Danilo, Jorge Fabián Placencia Jiménez

“…Se releva la importancia de la acción organizada de los ex pobladores en la defensa y activación patrimonial de los vestigios de la villa –que permitieron su declaratoria como Monumento Histórico en 2017–, y en la controversial puesta en valor del sitio como lugar de memoria en los últimos años. …”
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