A Real World Report on Intravenous High-Dose and Non-High-Dose Proton-Pump Inhibitors Therapy in Patients with Endoscopically Treated High-Risk Peptic Ulcer Bleeding by Lung-Sheng Lu, Sheng-Chieh Lin, Chung-Mou Kuo, Wei-Chen Tai, Po-Lin Tseng, Kuo-Chin Chang, Chung-Huang Kuo, Seng-Kee Chuah

“…The optimal dose of intravenous proton-pump inhibitor (PPI) therapy for the prevention of peptic ulcer (PU) rebleeding remains controversial. This study aimed to understand the real world experiences in prescribing high-dose PPI and non-high-dose PPI for preventing rebleeding after endoscopic treatment of high-risk PU. …”
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Impact of epinephrine on neurological outcomes in out-of-hospital cardiac arrest after automated external defibrillator use in Japan by Atsushi Kubo, Atsushi Hiraide, Tomohiro Shinozaki, Naoaki Shibata, Kyohei Miyamoto, Shinobu Tamura, Shigeaki Inoue

“…However, the benefit of epinephrine administration after PAD use remains controversial. The purpose of the study was to investigate the impact of epinephrine administration on neurological outcomes in OHCA patients after PAD use. …”
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Manometric Measurement of the Sphincter of Oddi in Patients with Common Bile Duct Stones: A Consecutive Study of the Han Population of China by Yadong Feng, Jie Zhang, Chunhua Jiao, Hong Zhu, Wenfang Cheng, Shunfu Xu, Bin Xiao, Jinliang Ni, Xiaoxing Chen

“…Role of dysfunction of the sphincter of Oddi (SO) in choledocholithiasis is controversial. This study was to evaluate SO motor activity in patients with common bile duct (CBD) stones in the Han population of China. …”
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Microbial mechanisms underlying the reduction of N2O emissions from submerged plant covered system by Yongxia Huang, Min Deng, Shuni Zhou, Yunpeng Xue, Senbati Yeerken, Yuren Wang, Lu Li, Kang Song

“…However, the effect of SP on nitrous oxide (N2O) emissions remains controversial, and the impact of SP-attached biofilms on N2O emissions is often overlooked. …”
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Prevalence and Subtype Analysis of Blastocystis hominis Isolated from Patients in the Northeast of Iran by Mitra Salehi, Jalal Mardaneh, Hamid Reza Niazkar, Mohammadhaasan Minooeianhaghighi, Elahe Arshad, Fateme Soleimani, Alireza Mohammadzadeh

“…Pathogenicity of Blastocystis spp. remains controversial, and it has been suggested that it may be associated with specific subtypes of the organism. …”
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Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta‐analysis and genome‐wide association studie... by Jie Tian, Caiyang Liu, Guanchu Liu, Chunjian Zuo, Huanwen Chen

“…Results from these publications were controversial. We used PubMed, Medline, and Web of Science to identify meta‐analysis articles published before 30 July 2018, that summarize a comprehensive investigation for cumulative evidence of genetic polymorphisms of EC and its subtype risk. …”
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Modulation of stress-related behaviour by preproglucagon neurons and hypothalamic projections to the nucleus of the solitary tract by Marie K. Holt, Natalia Valderrama, Maria J. Polanco, Imogen Hayter, Ellena G. Badenoch, Stefan Trapp, Linda Rinaman

“…However, the afferent inputs driving stress-induced activation of PPG neurons are largely unknown, and the role of PPG neurons in anxiety-like behaviour is controversial. Through chemogenetic manipulations we reveal that cNTS PPG neurons have the ability to moderately increase anxiety-like behaviours in mice in a sex-dependent manner. …”
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A Shorter Circular Stapler Height at the Gastrojejunostomy during a Roux-En-Y Gastric Bypass Results in Less Strictures and Bleeding Complications by Michael Horkoff, Kieran Purich, Noah Switzer, Shalvin Prasad, Neal Church, Xinzhe Shi, Philip Mitchell, Estifanos Debru, Shahzeer Karmali, Richdeep Gill

“…Although recent studies have shown a decreased rate of anastomotic strictures with shorter stapler heights, the optimal circular stapler height to use remains controversial. We therefore completed a retrospective cohort study within the Alberta Provincial Bariatric Program (APBP) to compare outcomes between the 3.5 mm and 4.8 mm stapler heights. …”
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Huge Intravascular Tumor Extending to the Heart: Leiomyomatosis by Suat Doganci, Erkan Kaya, Murat Kadan, Kubilay Karabacak, Gökhan Erol, Ufuk Demirkilic

“…Exact strategy for the surgical treatment of IVL is still controversial. We used one-stage approach, with complete resection of a huge IVL extending from right atrium to right iliac vein. …”
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Electroacupuncture for mild-to-moderate dry eye: study protocol for a multicentre, randomised, single-blind, sham-controlled trial by Yue Zhao, Guang Yang, Yun-Qiong Lu, Mei-Yan Li, Jue Hong, Yan-Ting Yang, Xue-Jun Wang, Xie-He Kong, Zhao Ma, Xin-Yun Huang, Yue-Lan Zou, Xing-Tao Zhou, Xiao-Peng Ma

“…Clinical evidence shows that electroacupuncture (EA) can improve DE symptoms, tear secretion and tear film stability, but it remains controversial whether it is just a placebo effect. We aim to provide solid clinical evidence for the EA treatment of DE.Methods and analysis This is a multicentre, randomised, sham-controlled trial. …”
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Efficacy and Safety of Bevacizumab in the Treatment of Pterygium: An Updated Meta-Analysis of Randomized Controlled Trials by Yi Sun, Bowen Zhang, Xiuhua Jia, Shiqi Ling, Juan Deng

“…Studies investigating efficacy and safety of bevacizumab in pterygium have increased and reported controversial results. Thus, we updated this meta-analysis to clarify the issue. …”
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Self-Reported Executive Functioning in Everyday Life in Parkinson’s Disease after Three Months of Subthalamic Deep Brain Stimulation by Uyen Ha Gia Pham, Stein Andersson, Mathias Toft, Are Hugo Pripp, Ane Eidahl Konglund, Espen Dietrichs, Ulrik Fredrik Malt, Inger Marie Skogseid, Ira Ronit Hebolt Haraldsen, Anne-Kristin Solbakk

“…Studies on the effect of subthalamic deep brain stimulation (STN-DBS) on executive functioning in Parkinson’s disease (PD) are still controversial. In this study we compared self-reported daily executive functioning in PD patients before and after three months of STN-DBS. …”
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Construction and validation of nomograms to predict central lymph node metastasis in clinical node-negative unilateral papillary thyroid carcinoma by Longqing Hu, Bei Qian, Junlin Zhu, Shuting Gao, Li Mei, Shengnan Ruan, Xincai Qu

“…Abstract The scope of neck lymph node dissection remains controversial for unilateral papillary thyroid carcinoma (UPTC) patients with no clinical evidence of lymph node metastasis (cN0). …”
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New evidence on the Late Bronze – Early Iron Age human nutrition in the Crimea (northern Pontic Region) based on the stable isotope analysis and radiocarbon dating by Kulkova Marianna A., Kashuba Maya N., Kulkov Aleksandr M., Kozhukhovskaya Yuliya V., Tikhomirov Vitaliy A., Streltsov Mihail A.

“…The application of geochemical methods (stable isotope δ13C, δ15N analysis, chemical elemental analysis and radiocarbon dating) for studying human and animal bones from burials and cultural layers of archaeological sites of Crimea made it possible to highlight the issues of the development of agriculture and cattle-bгeeding during the Late Bronze – Early Iron Ages. One of the controversial questions is the problem of transition from sedentary forms of agriculture and cattle-breeding to mobile cattle-breeding among ancient communities in the Eurasian steppe and forest-steppe. …”
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Long-Term Outcomes of Coronary and Carotid Artery Disease Revascularization in the FRIENDS Study by Fabrizio Tomai, Anna Piccoli, Fausto Castriota, Luca Weltert, Bernhard Reimers, Gabriele Pesarini, Raoul Borioni, Giovanni De Persio, Roberto Nerla, Andrea Pacchioni, Alberto Cremonesi, Flavio Ribichini

“…The best therapeutic strategy for patients with concomitant carotid obstructive disease (COD) and coronary artery disease (CAD) remains controversial. Methods. This observational registry enrolled, between January 2006 and December 2012, 1022 consecutive patients from high volume institutions with concomitant CAD and COD suitable for endovascular, surgical, or hybrid revascularization in both territories selected by consensus of a multidisciplinary team. …”
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Subsequent Acute Ischemic Stroke in a Patient with Monocular Vision Loss Associated with Isolated Internal Carotid Artery Occlusion: A Case Report by Jessica Seetge, Balázs Cséke, Zsófia Nozomi Karádi, Eszter Szalai, Valéria Gaál, László Szapáry

“…CRAO is associated with a significantly elevated risk of subsequent acute ischemic stroke (AIS), particularly within the first week following diagnosis, yet the role of intravenous thrombolysis (IVT) in this setting remains controversial. This case report presents a unique case of CRAO with concurrent internal carotid artery (ICA) occlusion, followed by an AIS affecting the middle cerebral artery (MCA). …”
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Correlation and diagnostic performance of metal ions in patients with pseudotumor after MoM hip arthroplasty: a systematic review and meta-analysis by He-Xi Li, Qing-Yi Zhang, Ning Sheng, Hui-Qi Xie

“…Although the remaining controversial relationship between metal ions and pseudotumor, metal ion detection had been widely employed in clinic. …”
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Autologous Dermis Graft Implantation: A Novel Approach to Reinforcement in Giant Hiatal Hernias by Balázs Kovács, Mikolt Orosz, Máté Csucska, Saurabh Singhal, Árpád Juhász, Zoltán Lóderer

“…Nonreinforced tensile repair of giant hiatal hernias is susceptible to recurrence, and the role of mesh graft implantation remains controversial. Creating a new and viable choice without the use of high-cost biological allografts is desirable. …”
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Long-term outcomes and lymph node metastasis following endoscopic resection with additional surgery or primary surgery for T1 colorectal cancer by Pin-Chun Chen, Yi-Kai Kao, Po-Wen Yang, Chia-Hung Chen, Chih-I Chen

“…Abstract Optimal management of T1 colorectal cancer (CRC) remains controversial. This study compared the long-term outcomes of endoscopic resection with additional surgical resection (ER + ASR) versus primary surgical resection (PS) in patients with T1 CRC and identified risk factors for lymph node metastasis (LNM). …”
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Is acupuncture effective for knee osteoarthritis? A protocol for a systematic review and meta-analysis by Jing-Wen Yang, Jian-Feng Tu, Myeong Soo Lee, Chuan-Yang Liu, Ling-Yu Qi, Fang-Ting Yu, Shi-Yan Yan, Jin-Ling Li, Lu-Lu Lin, Xiao-Wan Hao, Xin-Tong Su, Li-Qiong Wang

“…The effectiveness of acupuncture for treating KOA remains controversial. This protocol describes the method of a systematic review and meta-analysis evaluating the effectiveness and safety of acupuncture for treating KOA.Methods and analysis Four English databases (PubMed, Embase, Cochrane Library databases and Web of Science) and four Chinese databases (China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Database for Chinese Technical Periodicals, and Wanfang) will be searched from the database inception to 1 September 2021. …”
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