Effects of Repetitive Hyperbaric Oxygen Treatment in Patients with Acute Cerebral Infarction: A Pilot Study by Cheng-Hsin Chen, Shao-Yuan Chen, Vinchi Wang, Chao-Ching Chen, Kaw-Chen Wang, Chih-Hao Chen, Yi-Chien Liu, Kuo-Cheng Lu, Ping-Keung Yip, Wen-Ya Ma, Chuan-Chieh Liu

“…The role of hyperbaric oxygen therapy (HBOT) in the treatment of acute ischemic stroke is controversial. This prospective study assessed the efficacy and safety of HBOT as adjuvant treatment on 46 acute ischemic stroke in patients who did not receive thrombolytic therapy. …”
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Efficacy of Onabotulinum Toxin A (Botox) versus Abobotulinum Toxin A (Dysport) Using a Conversion Factor (1 : 2.5) in Treatment of Primary Palmar Hyperhidrosis by Hanan Mohamed El Kahky, Heba Mahmoud Diab, Dalia Gamal Aly, Nehal Magdi Farag

“…Results regarding an appropriate conversion factor between them are controversial. Objectives. This paper aims to compare the efficacy of Botox and Dysport in PPH using a conversion factor of 1 : 2.5. …”
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CXCL1-Triggered Interaction of LFA1 and ICAM1 Control Glucose-Induced Leukocyte Recruitment during Inflammation In Vivo by Kirsten Buschmann, Lutz Koch, Natascha Braach, Hanna Mueller, David Frommhold, Johannes Poeschl, Peter Ruef

“…However, the mechanisms of proinflammatory effects of glucose are controversially discussed. We investigated leukocyte recruitment after intravenous injection of glucose in different inflammatory models using intravital microscopy. …”
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Regenerative Medicine for Neurological Disorders by Dong-Hyuk Park, David J. Eve, Yong-Gu Chung, Paul R. Sanberg

“…Finally, the National Institutes of Health guidelines for human stem cell research, clinical trials of commercialized stem cells without larger animal testing, and prohibition of medical tourism were big controversial issues that led to heated discussion.…”
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Tissue-resident immune cells: from defining characteristics to roles in diseases by Jia Li, Chu Xiao, Chunxiang Li, Jie He

“…Currently, the reported TRIC population includes tissue-resident T cells, tissue-resident memory B (BRM) cells, tissue-resident innate lymphocytes, tissue-resident macrophages, tissue-resident neutrophils (TRNs), and tissue-resident mast cells, but unignorably the existence of TRNs is controversial. Previous studies focus on one of them in specific tissues or diseases, however, the origins, developmental trajectories, and intercellular cross-talks of every TRIC type are not fully summarized. …”
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Physical and cognitive-based training in healthy older adults: Evidence from a systematic review and meta-analysis by Fatemeh Adelirad, Zeinab Javadivala, Iman Dianat, Aysan Amrahi Tabieh, Vijay Kumar Chattu

“…Also, as a result, the trainings had a "small to larger" impact on the executive function of older adults (pooled MD: 0.64; 95% CI=0.26 to 1.02, I2=86.2%, P=0.0001). Conclusion: Our controversial results indicated that the non-pharmacological physical-mental training improves executive function which that can affect the ability of elders, while did not support the improvement of attention, processing speed, and verbal memory.…”
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Paradox of Laws on Age of Consent for Children when Testing, or Participating in HIV/AIDS Research and Clinical Trials in South Africa by Paul T. Mtunuse, Tembela Mdunyelwa-Melane

“…Consent for children when testing for or participating in HIV/AIDS research and clinical trials is a controversial issue. The paper submits a finding that while it is welcomed that children below 18 years may undergo testing or consent to research or clinical trials for HIV without parental consent, this is a paradox as it leads to legal contradictions. …”
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Aerosol Inhalation of Heat-Killed Clostridium butyricum CGMCC0313-1 Alleviates Allergic Airway Inflammation in Mice by Laodong Li, Qixiang Sun, Huan Xiao, Qiannan Zhang, Siyue Xu, Lejin Lai, Zhengning Li, Chaoqian Li

“…Epidemiological studies have shown that exposure to beneficial microorganisms can reduce the risk of asthma, but the clinical use of live probiotics is controversial due to the risk of infection. As heat-killed probiotics can also exhibit immunomodulatory activity, this study is aimed at investigating whether heat-killed Clostridium butyricum (HKCB) CGMCC0313-1 could reduce allergic airway inflammation in an ovalbumin-induced mouse model. …”
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Bone Formation with Deproteinized Bovine Bone Mineral or Biphasic Calcium Phosphate in the Presence of Autologous Platelet Lysate: Comparative Investigation in Rabbit by Carole Chakar, Nada Naaman, Emmanuel Soffer, Nicolas Cohen, Nada El Osta, Hervé Petite, Fani Anagnostou

“…Bone substitutes alone or supplemented with platelet-derived concentrates are widely used to promote bone regeneration but their potency remains controversial. The aim of this study was, therefore, to compare the regenerative potential of preparations containing autologous platelet lysate (APL) and particles of either deproteinized bovine bone mineral (DBBM) or biphasic calcium phosphate (BCP), two bone substitutes with different resorption patterns. …”
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Right inferior frontal cortex and preSMA in response inhibition: An investigation based on PTC model by Lili Wu, Mengjie Jiang, Min Zhao, Xin Hu, Jing Wang, Kaihua Zhang, Ke Jia, Fuxin Ren, Fei Gao

“…However, how these two regions contribute to response inhibition remains controversial. Based on the Pause-then-Cancel Model (PTC), this study employed functional magnetic resonance imaging (fMRI) to investigate the functional specificity of two regions in the stopping process. …”
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Asynchronous variation in the holocene asian monsoon recorded by marine sediments and its implication by Jun Yang, Guanglu Zhang, Yanyan Zhao, Yanyan Zhao, Zhishun Zhang, Sheng Liu, Haotian Wei, Xiaoqiang Guo, Guangyao Cao, Lei Yang, Yaru Zhang, Sanzhong Li, Sanzhong Li

“…The long-term evolution of climate during the Holocene remains controversial, as proxy and model data, and multiple proxies, show diverging temperature trends between the different reconstructions. …”
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Prevalence, and Intellectual Outcome of Unilateral Focal Cortical Brain Damage as a Function of Age, Sex and Aetiology by C. M. J. Braun, I. Montour-Proulx, S. Daigneault, I. Rouleau, S. Kuehn, M. Piskopos, G. Desmarais, F. Lussier, C. Rainville

“…Proposals of a sex difference in cognitive recovery from brain damage have also been controversial. Six hundred and thirty five “consecutive” cases with cortical focal lesions including cases of all ages and both sexes were reviewed. …”
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The structure of the multidimensional scale of perceived social support: a meta-analytic confirmatory factor analysis by Hakan Koğar, Esin Yılmaz Koğar

“…In this study, we addressed the controversial factor structure of the MSPSS using a meta-analytic confirmatory factor analysis approach. …”
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A Case of Haematometra Secondary to Cervical Stenosis after Vesicle Vaginal Fistula Surgical Repair by Athanase Lilungulu, Willy Mwibea, Mzee Nassoro, Balthazar Gumodoka

“…Haematometra is a rare postobstetrics fistula surgical repair outcome complication; however the condition can be misinterpreted especially in limited resource areas that lack routine ultrasound guidance and with a slowly progressed increase in size of abdomen accompanied with a history of amenorrhoea together with a history of having unprotective sexual intercourse which may increase the possibility of being controversial to full-term gravid uterus. The causes of haematometra might be either due to congenital abnormality of the vaginal canal or acquired iatrogenically. …”
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Interpretation of the concept of liabilities in lease accounting by Horacio Molina-Sánchez, Marta de Vicente-Lama, María del Mar Ortiz-Gómez

“…Concepts are fundamental in a principles-based standard. IFRS 16 was a controversial standard and subject to strong pressure, especially from preparers, and not only conceptual positions were involved in the deliberation process. …”
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Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease by Jiang Huang, Yi Li, Jianjiang Xiao, Qin Zhang, Guoxu Xu, Guanhui Wu, Tong Liu, Weifeng Luo

“…The retinal changes have been identified in morphology and function in Parkinson’s disease (PD). However, the controversial results suggest that it is incredible that only using a single method for testing retinal change to evaluate Parkinson’s disease. …”
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South Africa’s Non-Aligned Stance on the Russia-Ukraine War: Implications on South Africa’s Economic Trade Relations by Thoriso Ntlailane, Costa Hofisi

“…However, the position of non-alignment by the South African government has been perceived to be controversial and supporting the actions of Russia in the war. …”
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Tinzaparin Provides Lower Lipid Profiles in Maintenance Hemodialysis Patients: A Cross-Sectional Observational Study by Ming-Hsien Tsai, Yu-Wei Fang, Jyh-Gang Leu

“…However, the impact of different heparin types on dyslipidemia is still controversial. In our study, 434 chronic hemodialysis patients were evaluated. …”
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Successful Tocilizumab Therapy for Macrophage Activation Syndrome Associated with Adult-Onset Still’s Disease: A Case-Based Review by Eri Watanabe, Hitoshi Sugawara, Takeshi Yamashita, Akira Ishii, Aya Oda, Chihiro Terai

“…Several biologics have been tried for this complication, but their efficacy and safety remain controversial. We reviewed reported cases of AOSD-associated MAS successfully treated with various biologics. …”
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Safe schools Africa: Ensuring the provision of safe infrastructure for school children on donor-financed road projects by Ayikai Poswayo, George Malekele, Jeffrey Witte, Emmanuel Adanu

“…Making roads safe is not a controversial proposition. The challenge lies in changing the existing practices that allow high-risk roads to be built. …”
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