Therapeutic Options for the Management of the Cardiorenal Syndrome by Katerina Koniari, Marinos Nikolaou, Ioannis Paraskevaidis, John Parissis

“…Although it is a frequent clinical entity due to the improved survival of heart failure patients, still its pathophysiology is not well understood, and thus its therapeutic approach remains controversial and sometimes ineffective. Established therapeutic strategies, such as diuretics and inotropes, are often associated with resistance and limited clinical success. …”
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CD9 in acute myeloid leukemia: Prognostic role and usefulness to target leukemic stem cells by Lucas Touzet, Florent Dumezy, Christophe Roumier, Céline Berthon, Claire Bories, Bruno Quesnel, Claude Preudhomme, Thomas Boyer

“…Its role in carcinomagenesis has been widely studied in solid tumors but remains controversial, depending on the cancer type. Although CD9 seems to be associated with unfavorable outcome and disease progression in acute lymphoblastic leukemia (ALL), this marker has not yet been studied in acute myeloid leukemia (AML). …”
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Unloading of Right Ventricle and Clinical Improvement after Ultrasound-Accelerated Thrombolysis in Patients with Submassive Pulmonary Embolism by Sachin Kumar Amruthlal Jain, Brijesh Patel, Wadie David, Ayad Jazrawi, Patrick Alexander

“…The treatment of submassive PE with thrombolysis is controversial, though recent data have favored thrombolysis over conventional anticoagulants in acute setting. …”
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Revisiting Key Entry Routes of Human Epidemic Arboviruses into the Mainland Americas through Large-Scale Phylogenomics by Túlio De Lima Campos, Ricardo Durães-Carvalho, Antonio Mauro Rezende, Otávio Valério de Carvalho, Alain Kohl, Gabriel Luz Wallau, Lindomar José Pena

“…Knowledge about the entry routes and geographic expansion of these arboviruses to the mainland Americas remain incomplete and controversial. Epidemics caused by arboviruses continue to cause socioeconomic burden globally, particularly in countries where vector control is difficult due to climatic or infrastructure factors. …”
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Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation by Xiao-Hua Luo, Ying-Jun Chang, Xiao-Jun Huang

“…The effects of varying degrees of HLA disparity and conditioning regimens are more controversial. As many of these factors and strategies are considered in the setting of haplo-SCT, it is anticipated that haplo-SCT will continue to advance, further expanding our understanding of IR and CMV infection.…”
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Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis by Yan Li, Mi Zhou, Xiuying Lv, Lina Song, Di Zhang, Yan He, Mian Wang, Xue Zhao, Xiaoqing Yuan, Guixiu Shi, Dashan Wang

“…However, limited data from studies about the activity of histone deacetylases (HDACs) and histone acetyltransferase (HAT) in RA are controversial. Those conflicting results may be caused by sample size, medication, and age- and sex-matched controls. …”
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Impact of positive CD4 cells on event‐free survival in follicular lymphoma patients by Cong Li, Na Guo, Shuiyun Han, Haifeng Yu, Tao Lei, Xi Chen, Shuailing Peng, Haiyan Yang, Meijuan Wu

“…Abstract Objective Previous results about prognostic value of CD4+ T cells in follicular lymphoma (FL) remain controversial. Methods Immunohistochemistry was used to examine expression of positive CD4 cells in 103 patients with FL 1‐3A. …”
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Vascular Transdifferentiation in the CNS: A Focus on Neural and Glioblastoma Stem-Like Cells by Sophie Guelfi, Hugues Duffau, Luc Bauchet, Bernard Rothhut, Jean-Philippe Hugnot

“…As some of them appear controversial, further validation will be needed using new technical approaches such as high throughput profiling and functional analyses to avoid experimental pitfalls and misinterpretations.…”
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Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art Review by Sven-Petter Haugvik, Knut Jørgen Labori, Bjørn Edwin, Øystein Mathisen, Ivar Prydz Gladhaug

“…This has resulted in improved long-term survival in patients with locally advanced and metastatic disease treated aggressively, as well as shorter hospital stays and comparable long-term outcomes in patients with limited disease treated minimally invasively. There are still controversies related to issues of surgical treatment of PNETs, such as to what extent enucleation, lymph node sampling, and vascular reconstruction are beneficial for the oncologic outcome. …”
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Posttraumatic Spinal Cord Injury without Radiographic Abnormality by Kivanc Atesok, Nobuhiro Tanaka, Andrew O’Brien, Yohan Robinson, Dachling Pang, Donald Deinlein, Sakthivel Rajaram Manoharan, Jason Pittman, Steven Theiss

“…Although the role of operative treatment in SCIWORA can be controversial, surgical alternatives such as decompression and fusion should be considered in selected patients with clinical and MRI evidence of persistent spinal cord compression and instability.…”
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Association between apolipoprotein E ε4 status and the risk of Alzheimer’s disease: a meta-analysis by Zijun Ren, Zhenting Guan, Qingliang Guan, Hongjian Guan, Hongjian Guan

“…Abstract Background The apolipoprotein E ε4 (APOE ε4) status has a controversial role in predicting Alzheimer’s disease (AD) factors. …”
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Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade by Avantika Chenna, Venu Madhav Konala, Subhasish Bose, Sasmit Roy, Bhaskar Reddy Madhira, Vijay Gayam, Srikanth Naramala, Sreedhar Adapa

“…The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage. There have been controversial hypotheses raised regarding the safety of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in COVID-19 (coronavirus disease 2019). …”
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Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored by Fernando González, René López, Elizabeth Arriagada, René Carrasco, Natalia Gallardo, Eduardo Lorca

“…Replacing brand name products with generics is a controversial issue that we studied after a Chilean Ministry of Health mandate to implement such a switch. …”
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Association between Dental Caries and Obesity in Children and Young People: A Narrative Review by Abdulmonem A. Alshihri, Helen J. Rogers, Mohammed A. Alqahtani, Mohammed S. Aldossary

“…Possible explanations of the controversial association between obesity and dental caries are discussed in this review. …”
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Activities of Non-State Actors and Redefining the Concept of International Legal Personality by Pouria Askari, Zahra MoshrefJavadi

“…A controversial issue in international law is how international legal personality is defined or by what criteria it is conferred. …”
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Serpina3k lactylation protects from cardiac ischemia reperfusion injury by Le Wang, Dandan Li, Fang Yao, Shanshan Feng, Chao Tong, Rongjia Rao, Meiyan Zhong, Xianqiang Wang, Wei Feng, Zhan Hu, Bo Jin, Li Wang, Shengshou Hu, Bingying Zhou

“…Abstract Lactate produced during ischemia-reperfusion injury is known to promote lactylation of proteins, which play controversial roles. By analyzing the lactylomes and proteomes of mouse myocardium during ischemia-reperfusion injury using mass spectrometry, we show that both Serpina3k protein expression and its lactylation at lysine 351 are increased upon reperfusion. …”
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Liquidus curve of uranium–plutonium mixed oxide (MOX) system by Leonid Burakovsky, Dean L. Preston, Andrew A. Green

“…However, the current knowledge of Tm of MOX is limited and controversial, as several reported studies do not converge on the unique behavior of Tm as a function of x. …”
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Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy by Quan Zhuang, Ruoyu Ma, Yanshuang Yin, Tianhao Lan, Meng Yu, Yingzi Ming

“…According to the latest and overall literature reviews, we aim to elucidate the antifibrotic mechanisms and effects of diverse sources of MSCs on renal fibrosis, assess their efficacy and safety in preliminarily clinical application, answer the controversial questions, and provide novel ideas into the MSC cellular therapy of renal fibrosis.…”
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Reread a History: Another Narration from the Biography of Aga Mohammad Khan Qajar A Critique on the Book "Iran's History in the Qajar Period: The Aga Mohammad Khan Era" by Alireza Mollaiy Tavany

“…The life and work of Aga Mohammad Khan Qajar is one of the controversial topics in the Iranian history. There has been much research and historical novels written about him so far. …”
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C-Reactive Protein in Human Atherogenesis: Facts and Fiction by Oliver Zimmermann, Kefei Li, Myron Zaczkiewicz, Matthias Graf, Zhongmin Liu, Jan Torzewski

“…The role of C-reactive protein (CRP) in atherosclerosis is controversially discussed. Whereas initial experimental studies suggested a pathogenic role for CRP in atherogenesis, more recent genetic data from Mendelian randomization trials failed to provide evidence for a causative role of CRP in cardiovascular disease. …”
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