HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis by Michio Sato, Tsuyoshi Kadomatsu, Jun Morinaga, Yuya Kinoshita, Daisuke Torigoe, Haruki Horiguchi, Sumio Ohtsuki, Shuji Yamamura, Ryoko Kusaba, Takanori Yamaguchi, Goro Yoshioka, Kimi Araki, Tomohiko Wakayama, Keishi Miyata, Koichi Node, Yuichi Oike

“…Conclusion: Our findings suggest that mitochondrial biogenesis in cardiomyocytes decreases with age and could underlie cardiac dysfunction, and that the Caren-HINT1-mitochondrial biogenesis axis may constitute a mechanism linking CR to resistance to cardiac aging. …”
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Patient participation in free cataract surgery: a cross-sectional study of the low-income elderly in urban China by Bo Qu, Hui Chen, Xuhua Tan, Xiaohang Wu, Haotian Lin, Zhenzhen Liu, Lixia Luo, Bo Zhang, Erping Long, Duoru Lin, Weirong Chen, Yizhi Liu, Haofeng Jiang, Jingjing Chen, Zhuoling Lin, Xiaoyan Li, Jinzhu Tang, Yingfen Lin

“…Those patients with a monthly family income of 1000–2999¥ (US$161–482) per capita constituted the largest patient population. The free clinics in the parks and the free cataract surgery were highly rated (9.46 and 9.11 of 10 points) by the beneficiaries.Conclusions The telephone survey revealed a high level of patient satisfaction regarding the free cataract surgery programme. …”
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Heat shock transcription factor 1 facilitates liver cancer progression by driving super‐enhancer‐mediated transcription of MYCN by Yizhe Liu, Qili Shi, Yue Su, Zhiao Chen, Xianghuo He

“…Conclusion The HSF1‐MYCN axis constitutes a transcription‐dependent regulatory mechanism that may function as both a prognostic indicator and a promising therapeutic target in liver cancer. …”
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Acute administration of NLX-101, a Serotonin 1A receptor agonist, improves auditory temporal processing during development in a mouse model of Fragile X Syndrome by Xin Tao, Katilynne Croom, Adrian Newman-Tancredi, Mark Varney, Khaleel A. Razak

“…Conclusions These results suggest that NLX-101 could constitute a promising treatment option for targeting post-synaptic 5-HT1A receptors to improve auditory temporal processing, which in turn may improve speech and language function in FXS.…”
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Split-Cre-mediated GFP expression as a permanent marker for flagellar fusion of Trypanosoma brucei in its tsetse fly host by Ruth Etzensperger, Mattias Benninger, Berta Pozzi, Ruth Rehmann, Arunasalam Naguleswaran, Gabriela Schumann, Jan Van Den Abbeele, Isabel Roditi

“…We showed that cells that acquired the second half Cre through flagellar fusion were permanently modified and that the cells and their progeny constitutively expressed GFP. When tsetse flies were co-infected with N-Cre and C-Cre cells, GFP-positive trypanosomes were observed in the midgut and proventriculus 28–34 days post-infection. …”
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Molecular Detection of Antibiotic-Resistant Genes in Pseudomonas aeruginosa from Nonclinical Environment: Public Health Implications in Mthatha, Eastern Cape Province, South Africa by Mojisola Clara Hosu, Sandeep Vasaikar, Grace Emily Okuthe, Teke Apalata

“…This is concerning as it poses a risk to the environment and constitutes a public health threat. Given the public health relevance, the paper recommends monitoring of multidrug-resistant pathogens in effluent environments.…”
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Bioactive Sesquiterpenoids from <i>Santolina chamaecyparissus</i> L. Flowers: Chemical Profiling and Antifungal Activity Against <i>Neocosmospora</i> Species by Eva Sánchez-Hernández, Jesús Martín-Gil, Vicente González-García, José Casanova-Gascón, Pablo Martín-Ramos

“…Among sesquiterpenoids, which constituted the major fraction (50.4%), compounds featuring cedrane skeleton (8-cedren-13-ol), aromadendrene skeleton (such as (−)-spathulenol, ledol, alloaromadendrene oxide, epiglobulol, and alloaromadendrene), hydroazulene skeleton (ledene oxide, isoledene, and 1,2,3,3a,8,8a-hexahydro-2,2,8-trimethyl-,(3a<i>α</i>,8<i>β</i>,8a<i>α</i>)-5,6-azulenedimethanol), or copaane skeleton (<i>cis</i>-α-copaene-8-ol) were predominant. …”
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Qualitative evaluation of the implementation and national roll-out of the NHS App in England by Claire Reidy, Chrysanthi Papoutsi, Sukriti KC, Bernard Gudgin, Anthony A. Laverty, Felix Greaves, John Powell

“…NHS staff viewed the app as constituting core NHS infrastructure in the long term which made it appealing, even though initially there was less recognition of its immediate value. …”
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A supervised model to identify wolf behavior from tri-axial acceleration by Charlotte Lorand, Léa Bouet, Olivier Devineau, Marianna Chimienti, Alina L. Evans, Peggy Callahan, Mark Beckel, Timothy G. Laske, Ane Eriksen

“…Classification performance was consistently poorer for rare behaviors, which constituted less than 1.1% of the training dataset. …”
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Application of deep learning models on single-cell RNA sequencing analysis uncovers novel markers of double negative T cells by Tian Xu, Qin Xu, Ran Lu, David N. Oakland, Song Li, Liwu Li, Christopher M. Reilly, Xin M. Luo

“…Abstract Double negative T (DNT) cells are a unique subset of CD3 + TCRαβ + T lymphocytes that lack CD4, CD8, or NK1.1 expression and constitute 3–5% of the total T cell population in C57BL/6 mice. …”
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Manière de dire et manière d’exercer la parenté en Kabylie. Pour une approche renouvelée du croisement genre et fait matrimonial by Mohand Anaris

“…This contribution aims to provide a critical examination of the notion of marriage in terms of exchange and the sharing of rights over women.The exercise involves highlighting the limitations of a theory that considers women to only appear in the matrimonial market as objects or symbols whose meaning is constituted outside of them (according to P. Bourdieu) or as the ultimate gift, among those that can be obtained through reciprocal gifts (according to C. …”
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Secondary hyperoxaluria: Cause and consequence of chronic kidney disease by Loreto Mariscal de Gante, Laura Salanova, Mariel Valdivia Mazeyra, Rosario Serrano Pardo, Borja Quiroga

“…Different immunomodulatory drugs, microbiome modifiers and SGLT2 inhibitors could constitute new therapeutic targets. Currently, specific treatments for secondary hyperoxaluria are lacking, making early diagnosis and preventive measures against kidney failure the main therapeutic strategies. …”
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The proneural transcription factor Atoh1 promotes odontogenic differentiation in human dental pulp stem cells (DPSCs) by Camila Sabatini, Huey-Jiun Lin, Galib Ovik, Richard Hall, Techung Lee

“…Developmentally regulated transcription factors hold promise in the quest because these transcriptional regulators constitute the gene regulatory networks driving cell fate determination. …”
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Multi-scale channel attention U-Net: a novel framework for automated gallbladder segmentation in medical imaging by Yiming Zhou, Xiaobo Wen, Xiaobo Wen, Kang Fu, Meina Li, Lin Sun, Xiao Hu

“…The images and ground truth constitute a dataset, which was proportionally divided into a training set (54%), a validation set (6%), and a test set (40%). …”
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Desregulación emocional en población con TDAH; una aproximación teórica/Emotional dysregulation in the population with ADHD. A Theoretical Approach by Alejandra Alpizar

“…English  Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder, whose nuclear symptoms constitute inattention, hyperactivity and impulsivity, the latter may be verbal, motor and cognitive, but also emotional, expressed by emotional dysregulation, which affects a person’s ability to emotionally self-regulate and inhibit emotions. …”
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Modelling Hysteresis in Shape Memory Alloys Using LSTM Recurrent Neural Network by Mohammad Reza Zakerzadeh, Seyedkeivan Naseri, Payam Naseri

“…The complex behavior of shape memory alloys (SMAs), characterized by hysteresis and nonlinear dynamics, results in complex constitutive equations. To circumvent the complexity of solving these equations, a black box neural network (NN) has been employed in this research to model a rotary actuator actuated by an SMA wire. …”
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Control over biopower in cognitive and surveillance capitalism by Stanković-Pejnović Vesna

“…For Negri and Hardt biopower constitutes social relations, inserting individuals and populations in a circuit of value, obedience, and utility. …”
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The Shiism Dimension in Iran's Relations with Europe: The Example of Germany-France-United Kingdom by Orhan Karaoğlu

“…Ten associations and cultural centers, which have been identified as carrying out religious activities on the basis of Shiism, are active in the country on behalf of Iran. Shiites currently constitute 10% of the total number of Muslims in the UK. …”
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Irreducible representation of surface distributions and Piola transformation of external loads sustainable by third gradient continua by dell’Isola, Francesco, Fedele, Roberto

“…Following the nomenclature introduced by Paul Germain, forces are dual in virtual work of virtual displacements, surface and line double forces are dual of the derivatives of virtual displacements in the normal direction(s) of the surfaces and edges constituting the boundary of the continuum, and surface triple forces are dual of the second normal derivatives of virtual displacements. …”
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Detection of Antimicrobial Resistance Genes Associated with Carbapenem Resistance from the Whole-Genome Sequence of Acinetobacter baumannii Isolates from Malaysia by Mohan Rao, Fairuz A. Rashid, Surianti Shukor, Rohaidah Hashim, Norazah Ahmad

“…These findings predict that carriage of carbapenem-resistant genes possibly constitutes the underlying basis of high level of international clone II prevalence. …”
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