Trust Region Policy Learning for Adaptive Drug Infusion with Communication Networks in Hypertensive Patients by Mai The Vu, Seong Han Kim, Ha Le Nhu Ngoc Thanh, Majid Roohi, Tuan Hai Nguyen

“…In the field of biomedical engineering, the issue of drug delivery constitutes a multifaceted and demanding endeavor for healthcare professionals. …”
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Epidemiology and transmission patterns of Cryptosporidium spp., and Giardia duodenalis within a One Health framework in rural areas of Eastern Algeria by Sadiya Maxamhud, Nassiba Reghaissia, AbdElKarim Laatamna, Eleni Gentekaki, Anastasios D. Tsaousis

“…Gastrointestinal infections constitute a significant global health concern, particularly in tropical and subtropical regions, caused by various pathogens. …”
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Somatic copy number deletion of chromosome 22q in papillary thyroid carcinoma by Olivia W Lee, Danielle M Karyadi, Stephen W Hartley, Weyin Zhou, Mitchell J Machiela, Shahriar A Zamani, Liudmyla Yu Zurnadzhy, John N Weinstein, Young Joo Park, Jeong-Sun Seo, Gerry A Thomas, Tetiana I Bogdanova, Mykola D Tronko, Lindsay M Morton, Stephen J Chanock

“…The majority of PTC cases with 22qDEL exhibited arm-level loss of heterozygosity (86%); nearly all PTC cases with 22qDEL had losses in 22q12 and 13, which together constitute 70% of the q arm. Our analysis confirmed that 22qDEL occurs more frequently with RAS point mutations (50.4%), particularly HRAS (70.3%), compared with other PTC drivers (9.3%), supporting the conclusion that 22qDEL is unlikely to be a solitary driver of PTC but possibly an important co-factor in carcinogenesis, particularly in PTCs with RAS driver mutations. …”
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Targeted allele-specific FGFR2 knockdown via human recombinant ferritin nanoparticles for personalized treatment of Crouzon syndrome by Federica Tiberio, Martina Salvati, Luca Polito, Giada Tisci, Alessia Vita, Ornella Parolini, Luca Massimi, Lorena Di Pietro, Pierpaolo Ceci, Gianpiero Tamburrini, Alessandro Arcovito, Elisabetta Falvo, Wanda Lattanzi

“…Crouzon syndrome is a rare genetic craniofacial malformation caused by heterozygous gain-of-function mutations in the FGFR2 gene. The resulting constitutive activation of the FGFR2 signaling causes the premature osteogenic differentiation of calvarial mesenchymal stromal cells in skull sutures, leading to early suture ossification. …”
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Research trends and frontiers in rehabilitation after total knee arthroplasty: based on bibliometric and visualization analysis by Runkai Zhao, Haichao Ren, Pengcheng Li, Menglin Fan, Runzhi Zhao, Te Liu, Yan Wang, Quanbo Ji, Guoqiang Zhang

“…Reference and keyword analyses suggest that remote or home-based rehabilitation, the development of novel prehabilitation techniques, and pain management hold significant research potential, constituting current research hotspots. Conclusion This study quantitatively identified and assessed the current research status and trends in perioperative rehabilitation management for TKA through bibliometric and visualization analyses. …”
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Impact of Different Amounts of Biochar as Growth Media on Macronutrient Transport Systems of Carrizo Citrange Rootstocks and Related Expression Analysis by Paola Caruso, Maria Patrizia Russo, Maria Allegra, Biagio Torrisi, Giancarlo Fascella, Giuseppina Las Casas, Concetta Licciardello, Marco Caruso, Alessandra Caruso, Filippo Ferlito

“…Among the alternatives to peat is biochar, which could constitute a valid growing medium component for citrus seedling production. …”
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Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant by Patsy R Tomlinson, Rachel G Knox, Olga Perisic, Helen Su, Gemma V Brierley, Roger L Williams, Robert K Semple

“…PIK3R1 encodes three regulatory subunits of class IA phosphoinositide 3-kinase (PI3K), each associating with any of three catalytic subunits, namely p110α, p110β, or p110δ. Constitutional PIK3R1 mutations cause diseases with a genotype-phenotype relationship not yet fully explained: heterozygous loss-of-function mutations cause SHORT syndrome, featuring insulin resistance and short stature attributed to reduced p110α function, while heterozygous activating mutations cause immunodeficiency, attributed to p110δ activation and known as APDS2. …”
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Chemical Composition, Physicochemical Characteristics, and Nutritional Value of Lannea kerstingii Seeds and Seed Oil by Judicaël Thomas Ouilly, Patrice Bazongo, Adjima Bougma, Nèbpawindé Kaboré, Anne Mette Lykke, Amadé Ouédraogo, Imaël Henri Nestor Bassolé

“…Seeds of L. kerstingii constitute an alternative source of stable vegetable oil and protein for nutritional and industrial applications.…”
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Dynamic switching between brain networks predicts creative ability by Qunlin Chen, Yoed N. Kenett, Zaixu Cui, Hikaru Takeuchi, Andreas Fink, Mathias Benedek, Daniel C. Zeitlen, Kaixiang Zhuang, James Lloyd-Cox, Ryuta Kawashima, Jiang Qiu, Roger E. Beaty

“…Employing a meta-analytic network neuroscience approach, we analyze resting-state fMRI and creative task performance across 10 independent samples from Austria, Canada, China, Japan, and the United States (N = 2433)—constituting the largest and most ethnically diverse creativity neuroscience study to date. …”
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A Novel Authentication Management for the Data Security of Smart Grid by Imtiaz Parvez, Maryamossadat Aghili, Hugo Riggs, Aditya Sundararajan, Arif I. Sarwat, Anurag K. Srivastava

“…The first layer implements an efficient novel encryption method for secure data exchange between meters and control center with the help of two partially trusted simple servers (constitutes the TTP). In this setting, one server handles the data encryption between the meter and control center/central database, and the other server administers the random sequence of data transmission. …”
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Production and characterization of nervous necrosis virus vaccine antigens in wild type and CRISPR/Cas9 genome edited Nicotiana benthamiana and edible crop lettuce Lactuca sativa by Iva Andrasevic, Hang Su, Espen Rimstad, Jihong Liu Clarke

“…Aquaculture constitutes an important source of protein, essential omega-3 fatty acids and bioavailable micronutrients for humans. …”
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Fractionation of Buckwheat Seed Phenolics and Analysis of Their Antioxidant Activity by Karamać Magdalena, Biskup Izabela, Kulczyk Anna

“…TEAC, IC50 and FRAP values were: 1.47±0.01 mmol Trolox eq/g, 0.058±0.003 mg/assay and 2.18±0.05 mmol Fe(II)/g, respectively. Rutin constituted 77.7% of the compounds identified in fraction III. …”
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Educational intervention on oral cancer and its prevention in pre-university students by José Carlos Alvarez Hernández, Eniley Quintana Morales, Ailen Guzmán López, Marino Enrique León Palombí, Marileidi Morales Cabrera, Mara Isabel Morales Pardo

“…<p><strong>Foundation</strong>: the increase in the incidence of oral cancer constitutes a global health problem, there is a need to carry out educational actions that contribute to the prevention of the disease from an early age.…”
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Isolation of Actinobacteria from Date Palm Rhizosphere with Enzymatic, Antimicrobial, Antioxidant, and Protein Denaturation Inhibitory Activities by Maria Smati, Amina Bramki, Fatima Zohra Makhlouf, Rihab Djebaili, Beatrice Farda, Fatima Zohra Abdelhadi, Nahla Abdelli, Mahmoud Kitouni, Marika Pellegrini

“…Arid ecosystems constitute a promising source of actinobacteria producing new bioactive molecules. …”
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Evaluation of the quality, reliability, readability of websites on temporomandibular joint pain by Selcen Eser Mısır, Perihan Dalgalı Evli, Kübra Gülnur Topsakal, Merve Aksoy

“…In addition, those with high credibility constituted %5.4 (n=2) of the total number of sites and %50 (n=1) of these sites were uploaded by private hospitals, and %50 (n=1) by blogs (web logs). …”
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Autoinflammatory Bone Diseases by Fatih Haşlak, Nergis Akay, Ümit Gül, Aybüke Günalp, Elif Kılıç Könte, Sezgin Şahin, Özgür Kasapçopur

“…Autoinflammatory bone diseases (AIBDs) constitute a recently identified subset of autoinflammatory diseases. …”
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Numerical Method of Flexible Pavement considering Moisture and Stress Sensitivity of Subgrade Soils by Jue Li, Jianlong Zheng, Yongsheng Yao, Junhui Zhang, Junhui Peng

“…Firstly, 2D FEM simulations of flexible pavements were performed with half-sine loadings. A constitutive model of subgrade soils was proposed to incorporate soil suction and octahedral shear stress. …”
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Opioid System and Epithelial–Mesenchymal Transition by Marzena Łazarczyk, Dominik Skiba, Michel-Edwar Mickael, Kinga Jaskuła, Agata Nawrocka, Piotr Religa, Mariusz Sacharczuk

“…Clinicians’ vigilance considering treatment with opioids is necessary, bearing in mind extensive data accumulated over decades that have reported the contribution of opioids to immunosuppression, tumour progression, or impaired tissue regeneration, either following opioid use during surgical tumour resection and post-surgical pain treatment, or as a result of other diseases like diabetes, where chronic wounds healing constitutes a challenge. During last few years, an increasing trend for seeking relationships between opioids and epithelial–mesenchymal transition (EMT) in cancer research can be observed. …”
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Colonic Wall Thickening Reported in Abdominal CT: Does It Always Imply Malignancy? by A. Akbas, H. Bakir, M. F. Dasiran, H. Dagmura, E. Daldal, Z. Ozsoy, Z. Ozmen, O. Demir, I. Okan

“…Normal or benign pathological causes were included in the first group, while malignant causes constituted the second group. Whether the two groups differed in terms of CWT, Hb, age, albumin, NLR, PLR, and MPV values was investigated with descriptive statistics. …”
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The Enigmatic Upper Ordovician of the Naturtejo UNESCO Global Geopark (Portugal) by Sofia Pereira, Jorge Colmenar, Cristiana Esteves, Ícaro Dias da Silva, Miguel Pires, Carlos Neto de Carvalho

“…In the Vila Velha de Ródão Syncline, the Barroca da Senhora stream fossil site constitutes a new geosite within the protected area of Portas de Ródão Natural Monument, presenting the most complete Upper Ordovician sequence of this structure. …”
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