Identification and Quality Evaluation of Raw and Processed Asarum Species Using Microscopy, DNA Barcoding, and Gas Chromatography-Mass Spectrometry by Guangzhe Yao, Wenjuan Ma, Xuhua Huang, Qi Jia, Jiayuan Shen, Yanxu Chang, Huizi Ouyang, Jun He

“…Safrole, methyleugenol, and 2,6,6-trimethylcyclohepta-2,4-dien-1-one were identified as significant constituents, the presence of which can be used to differentiate between raw and processed Asarum samples. …”
Get full text

Phytochemical Screening and Cytotoxic Properties of Ethanolic Extract of Young and Mature Khat Leaves by Rashad Alsanosy, Hassan A. Alhazmi, Shahnaz Sultana, Ashraf N. Abdalla, Yassin Ibrahim, Mohammed Al Bratty, David Banji, Ibrahim Khardali, Asaad Khalid

“…Though many of the constituents of khat leaves have been identified, the complete phytochemical profile of young and mature leaves was not performed or compared; also, no evidence is available to affirm the cytotoxicity of young or mature leaves. …”
Get full text

Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4/JNK/ERK/NF-κB Pathway by Yu Long, Yan Xiang, Songyu Liu, Yulu Zhang, Jinyan Wan, Qiyue Yang, Mingquan Cui, Zhimin Ci, Nan Li, Wei Peng

“…Baicalin (BA) is the main effective constituent isolated from the Chinese medical herb Scutellaria baicalensis Georgi, and studies have proved that it has a protective effect on ALI induced by lipopolysaccharide (LPS) due to the anti-inflammatory efficacy. …”
Get full text

Extreme drought-heatwave exacerbates water quality deterioration in China by Jie Jiang, Zhaoli Wang, Zhenxing Zhang, Xushu Wu, Chengguang Lai, Zhaoyang Zeng, Xiaohong Chen

“…The spatiotemporal development was characterized by using meteorological drought index and drought centroid tracking, and the responses of nine water quality constituents to this event were quantified. Results revealed that the drought-heatwave was jointly driven by a significant decrease in precipitation (up to ∼50 % less than usual) and sustained high temperatures (∼2 °C above normal). …”
Get full text

A Network Pharmacology-Based Approach for Exploring Key Active Compounds and Pharmacological Mechanisms of Tangshen Formula for Treatment of Diabetic Nephropathy by Weie Zhou, Xuefeng Zhou, Yuan Zhang, Yuyang Wang, Wenjie Wu, Haojun Zhang, Tingting Zhao, Liang Peng, Hailing Zhao, Ping Li

“…The present findings not only provide new insights for a deeper understanding of the constituent basis and pharmacology of TSF but also provide guidance for further pharmacological studies on TSF.…”
Get full text

Characterization of Essential Oils from Seven <i>Salvia</i> Taxa from Greece with Chemometric Analysis by Spyridon Tziakas, Ekaterina-Michaela Tomou, Panagiota Fraskou, Katerina Goula, Konstantina Dimakopoulou, Helen Skaltsa

“…Chemometric analysis, including PCA, HCA, and a clustered heat map, were applied to identify possible relationships among the samples based on their constituents, chemical groups, and thujone contents. …”
Get full text

Exploring the Underlying Mechanism of Weiling Decoction Alleviates Cold-Dampness Diarrhea Based on Network Pharmacology, Transcriptomics, Molecular Docking and Experimental Validat... by Yannan Zhang, Shuai Zhang, Yimeng Fan, Sijuan Huang, Shimin Wang, Zhihui Hao, Jianzhong Shen

“…<b>Methods</b>: UPLC-HRMS/MS was employed to identify the chemical constituents of WLD and the absorption components in the plasma of WLD-treated rats. …”
Get full text

Shenlian (SL) Decoction, a Traditional Chinese Medicine Compound, May Ameliorate Blood Glucose via Mediating the Gut Microbiota in db/db Mice by Rui-xi Sun, Wei-jun Huang, Yao Xiao, Dou-dou Wang, Guo-hua Mu, He Nan, Bo-ran Ni, Xiao-qiang Huang, Hsuan-chuan Wang, Yi-fan Liu, Qiang Fu, Jin-xi Zhao

“…Shenlian (SL) decoction is a herbal formula composed of Coptis and ginseng, of which berberine and ginsenoside are the main constituents. Even though SL decoction is widely used in treating diabetes in China, the mechanism of its antidiabetes function still needs further study. …”
Get full text

Utilizing ultrasound for the extraction of polysaccharides from the tuber of Typhonium giganteum Engl.: Extraction conditions, structural characterization and bioactivities by Xi Peng, Jing-Ya Wang, Kui-Xu Gao, Zhi-Kun Wang, Qiao-Ling Deng, Yao Wang, Mei-Bian Hu, Yu-Jie Liu

“…Analysis of molecular weight (Mw) revealed the presence of three primary constituents within TGEP-U, and four main components in TGEP-H, and UAE reduced the average Mw of TGEPs. …”
Get full text

The Impact of Atorvastatin on Intraprostatic Biomarkers – Prognostic Value of 3LS-score – Follow-up of ESTO1-Trial by Eemil Lehtonen, Maiju Vertanen, Heimo Syvälä, Teemu Tolonen, Seppo Auriola, Teuvo Tammela, Aino Siltari, Teemu Murtola

“…The 3LS score was calculated by identifying the constituent lipids from the prostate lipidome. Findings: Higher intraprostatic atorvastatin lactone concentrations were associated with reduced Ki67 expression and PSA levels. …”
Get full text

Evaluating Explainable AI Methods in Deep Learning Models for Early Detection of Cerebral Palsy by Kimji N. Pellano, Inga Strumke, Daniel Groos, Lars Adde, Espen F. Alexander Ihlen

“…Individual models within the ensemble show varied results, and neither CAM nor Grad-CAM consistently outperform the other, with the ensemble approach providing a representation of outcomes from its constituent models. Both CAM and Grad-CAM also perform significantly better than random attribution, supporting the robustness of these XAI methods. …”
Get full text

Bioassay-guided isolation and identification of antimutagenic compounds from Morina coulteriana and evaluation of its therapeutic potential by Jasbir Kour, Bashir Ahmad Lone, Amit Kumar, Bashir A. Ganai, Govind Yadav, Prasoon Gupta, Md.Niamat Ali, Seema Akbar

“…Purpose: The present study aimed to determine the antimutagenic/antigenotoxic potential of Morina coulteriana and the bioassay-guided identification of its bioactive constituents. Methods: The methanol crude extract and its subsequent fractions were tested for antimutagenic/antigenotoxic activity in vitro (Ames assay) and in vivo (Chromosomal aberration assay in Balb/c mice). …”
Get full text

In vitro and in vivo investigations of selected varieties of Areca catechu L - Phytochemical analysis, antiulcer, and wound healing activity by R. Deveswaran, D.J. Madhu Kumar, V. Madhavan, Soma Chaki, Misbah Khan, Govind R. Kadambi, B.V. Basavaraj, J. Anbu

“…Further analysis through GC-MS of alcoholic and aqueous extracts identified 11 phytochemical constituents. High-performance thin Layer Chromatography (HPTLC) was employed to quantify the percentage of arecoline, ranging from 0.12 % to 0.95 % in the samples. …”
Get full text

Rhoifolin Suppresses Cell Proliferation and Induces Apoptosis in Hepatocellular Carcinoma Cells In Vitro and In Vivo by Ruolan Chen, Zufa Sabeel, Lu Ying, Youfeng Liang, Rui Guo, Mingxuan Hao, Xiaoyang Chen, Wenjing Zhang, Jian Dong, Yan Liu, Changyuan Yu, Zhao Yang

“…Rhoifolin (ROF), a flavonoid constituent, has previously been shown to suppress the proliferation of breast and pancreatic cancer cells. …”
Get full text

Modeled Respiratory Tract Deposition of Smoke Aerosol from Conventional Cigarettes, Electronic Cigarettes and Heat-not-burn Products by Yawen Li, Huapeng Cui, Li Chen, Meijuan Fan, Junlan Cai, Junwei Guo, Caner U. Yurteri, Xiaoxi Si, Shaofeng Liu, Fuwei Xie, Jianping Xie

“…Combined with knowledge of the harmful aerosol constituents, these deposition data will provide important information for hazard evaluation of new tobacco products.…”
Get full text

Ethnopharmocology, phytochemistry and pharmacology of the genus Orthosiphon: A review by Rui Wang, Ling Qiu, Qing-wen Zhang, Ligen Lin

“…Previous reports have demonstrated the diverse pharmacological properties of extracts and constituents derived from Orthosiphon, such as anti-cancer, anti-diabetic, anti-inflammatory, antioxidant, hepatoprotective, analgesic, and nephroprotective effects. …”
Get full text

Malva neglecta essential oil: A promising approach for bio-preserving mayonnaise and assessing variable correlations through principal component analysis and heat map by Amin Abbasi, Hedayat Hosseini, Hadi Pourjafar, Samaneh Moradi, Saeedeh Shojaee-Aliabadi

“…MNEO was extracted, and the primary chemical constituents were identified using a GC-MS. Based on the determined MIC/MBC, various concentrations of MNEO have been utilized in the preparation of mayonnaise and evaluated for microbial, chemical, and sensorial characteristics for 40 days at 4 °C. …”
Get full text

Menthone lowers H3K27ac levels to inhibit Fusarium proliferatum growth by Li-Yan Zhang, Tian-Tian Li, Hong-Xin Liao, Jin-Rui Wen, Hong-Yan Nie, Fu-Rong Xu, Xiao-Yun Liu, Xian Dong

“…BackgroundThe antifungal properties of essential oils (EOs) and their active constituents have been well documented. Histone acetylation is pivotal in modulating gene expression and influences biological processes in living organisms.ResultsThis study demonstrated that menthone, the primary component of Mentha haplocalyx EO, exhibited notable antifungal activity against Fusarium proliferatum (EC50 = 6.099 mmol/L). …”
Get full text

Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities by Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Kashif Zahoor, Farhat Jabeen, Zinayyera Subhani, Tahira Younis, Muhammad Ali, Iqra Sarfraz, Zeliha Selamoglu

“…This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as Cuscuta chinensis. …”
Get full text

Life-Cycle Assessment of High-Strength Concrete Mixtures with Copper Slag as Sand Replacement by Aysegul Petek Gursel, Claudia Ostertag

“…The system boundary consists of the major production processes of concrete constituents (including Portland cement and fine and coarse aggregates, with CS considered as fine aggregate) from a cradle-to-gate perspective, consisting of relevant life-cycle phases of raw materials extraction, transportation, and production processes at the relevant facility where the production occurs. …”
Get full text