Magnolol induces cell death through PI3K/Akt‐mediated epigenetic modifications boosting treatment of BRAF‐ and NRAS‐mutant melanoma by Abdullah Al Emran, Brinda Reddy Chinna Chowdary, Farzana Ahmed, Heinz Hammerlindl, Antje Huefner, Nikolas K. Haass, Wolfgang Schuehly, Helmut Schaider

“…Here, we show that magnolol, a constituent of Magnolia officinalis, induced G1 arrest, apoptosis and cell death in BRAF‐ and NRAS‐mutant melanoma cells at low concentration, with no effect in BRAF‐ and NRAS wild‐type melanoma cells and human keratinocytes. …”
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Anti-Inflammatory Activity of Diterpenoids from Celastrus orbiculatus in Lipopolysaccharide-Stimulated RAW264.7 Cells by Hyun-Jae Jang, Kang-Hoon Kim, Eun-Jae Park, Jeong A. Kang, Bong-Sik Yun, Seung-Jae Lee, Chan Sun Park, Soyoung Lee, Seung Woong Lee, Mun-Chual Rho

“…Although various pharmacological studies of C. orbiculatus extract has been reported, an anti-inflammatory mechanism study of their phytochemical constituents has not been fully elucidated. In this study, compounds 1–17, including undescribed podocarpane-type trinorditerpenoid (3), were purified from C. orbiculatus and their chemical structure were determined by high-resolution electrospray ionization mass (HRESIMS) and nuclear magnetic resonance (NMR) spectroscopic data. …”
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Simultaneous GC-FID Quantification of Main Components of Rosmarinus officinalis L. and Lavandula dentata Essential Oils in Polymeric Nanocapsules for Antioxidant Application by Perla Giovanna Silva-Flores, Luis Alejandro Pérez-López, Verónica Mayela Rivas-Galindo, David Paniagua-Vega, Sergio Arturo Galindo-Rodríguez, Rocío Álvarez-Román

“…In this study, EO were isolated by hydrodistillation in a Clevenger-type apparatus and characterized by GC-MS and GC-FID analyses. The major constituents of EO-R. officinalis were camphor (39.46%) and 1,8-cineole (14.63%), and for EO-L. dentata were 1,8-cineole (68.59%) and β-pinene (11.53%). …”
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Hexane extract from Lindera communis roots: wound healing properties and membrane-disruptive activities against methicillin-resistant Staphylococcus aureus by Miaomiao Wang, Miaomiao Wang, Miaomiao Wang, Xian Hu, Xian Hu, Xian Hu, Liya Liu, Liya Liu, Liya Liu, Liya Liu, Yi Zhong, Yi Zhong, Yi Zhong, Wanlin Li, Wanlin Li, Wanlin Li, Qing Zhang, Qing Zhang, Qing Zhang, Congli Xu, Chunlin Long, Chunlin Long, Chunlin Long, Chunlin Long, Chunlin Long

“…To explore the antibacterial activities of L. communis plants, we investigated the chemicals, antibacterial activities and wound healing and of the n-hexane fraction of L. communis roots (LCH).MethodsOur study included detecting phytochemical constituents, determining minimum inhibitory concentration (MIC) for different extract fractions, analyzing growth curves, assessing membrane integrity, monitoring potential changes in the membrane using scanning electron microscopy, and evaluating wound healing in rat excisional wounds.ResultsBased on our findings, humulene-type sesquiterpenes, guaiane-type sesquiterpenes, and lauric acid were identified from the LCH, responsible for antibacterial and wound healing activities. …”
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Nutritional, Chemical, Antioxidant and Antibacterial Screening of <i>Astragalus cicer</i> L. and <i>Astragalus glycyphyllos</i> L. Different Morphological Parts by Saba Shahrivari-Baviloliaei, Agnieszka Konopacka, Liege Aguiar Pascoalino, Filipa Reis, Dawid Kunkowski, Spyridon A. Petropoulos, Pawel Konieczynski, Ilkay Erdogan Orhan, Alina Plenis, Agnieszka Viapiana

“…The mineral analysis revealed zinc and iron as the major constituents. Regarding the plants’ antioxidant and antibacterial activity, both <i>Astragalus</i> species had antioxidant potential, and their water extracts showed antibacterial activity against <i>S. aureus</i> and <i>E. coli</i>. …”
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The current and future cancer burden in the Gulf Cooperation Council (GCC) countries by Saleh A. Alessy, Saleh A. Alqahtani, Jerome Vignat, Amid Abuhmaidan, Amani E. L. Basmi, Najla Al Lawati, Ameera Ali A‐Nooh, Wael Shelpai, Samar Alhomoud, Ali Al‐Zahrani, Freddie Bray, Ariana Znaor

“…Conclusion The sharp increase in the estimated cancer incidence and mortality predicted over the next decades in the region requires workforce and financial planning for the healthcare systems in the constituent countries, alongside broader strengthening of national cancer prevention and control efforts.…”
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Pretreatment of Ascorbic Acid Inhibits MPTP-Induced Astrocytic Oxidative Stress through Suppressing NF-κB Signaling by Xiaokang Zeng, Kai Xu, Ji Wang, Yunqi Xu, Shaogang Qu

“…Astrocytes are a major constituent of the central nervous system (CNS). Astrocytic oxidative stress contributes to the development of Parkinson’s disease (PD). …”
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Cigarette and e-cigarette reversely regulated autophagy via distinct level of ROS in vitro by Yao Wang, Jialing Zhong, Zuyi Jin, An Luo, Zehong Wu, Xingtao Jiang, Jianwen Chen, Peiqing Liu, Min Li

“…In this study, the conventional cigarette and seven flavored e-cigarettes, along with their constituents, including solvents, nicotine, and seven flavoring agents were tested. …”
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Association of serum magnesium and calcium with metabolic syndrome: a cross-sectional study from the Qatar-biobank by Raneem Alsheikh, Haneen Aldulaimi, Rami Hinawi, Fatima Al-Sadi, Alanoud Al-Baker, Aldana Alkuwari, Muhammad Sameer, Ghalya Al-Abdulla, Zumin Shi, Giridhara Rathnaiah Babu

“…Abstract Background and objectives Metabolic syndrome (MetS) and its constituent comorbidities, along with mineral imbalances, pose a significant health burden in the Qatari population. …”
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Phytochemical screening and neuro-pharmacological activity of Mimosa pudica flowers: Integrating in vitro, in silico and in vivo approaches by Fahmida Alam, Rashedul Alam, A.T.M. Yusuf, Joya Datta Ripa, Raktim Das Nithin, Sourav Barua, Mohammed Fazlul Kabir, Seong-Tshool Hong, Hea-Jong Chung

“…We employed sophisticated laboratory techniques to carefully extract and examine the chemical constituents of M. pudica. This examination uncovered a wide range of advantageous phytochemicals, such as alkaloids, flavonoids, tannins, and saponins. …”
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Short path molecular distillation of the essential oil from Pinus roxburghii oleoresin affords volatile fractions with powerful antioxidant and antimicrobial activities comparable... by Muhammad Adnan Ayub, Hawraz Ibrahim M. Amin, Rameen Waseem, Kamaran Younis M. Amin, Muhammad Asif Hanif, Amjad Hussain, Kovan Dilawar Issa, Jorge Ramírez, Chabaco Armijos, Muhammad Zubair, Giovanni Vidari

“…Longifolene, 3-carene, α-pinene and β-pinene were identified by GC-MS analysis as the main constituents of the P. roxburghii turpentine essential oil and the most active fractions and sub-fractions. …”
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A Novel Construction of Substitution Box Based on Polynomial Mapped and Finite Field With Image Encryption Application by Abid Mahboob, Muhammad Asif, Imran Siddique, Aysha Saleem, Muhammad Nadeem, Dariusz Grzelczyk, Jan Awrejcewicz

“…In the modern block cipher, the substitution box (S-box) is a nonlinear constituent that plays a substantial role to create the confusion in ciphertext. …”
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Antimicrobial Activity of Aspergillus sp. from the Amazon Biome: Isolation of Kojic Acid by Josy Caldas Rodrigues, Weison Lima da Silva, David Ribeiro da Silva, Carolina Rabelo Maia, Clarice Virginia Santos Goiabeira, Haile Dean Figueiredo Chagas, Gigliola Mayara Ayres D’Elia, Gleica Soyan Barbosa Alves, Viviane Zahner, Cecilia Veronica Nunez, Ormezinda Celeste Cristo Fernandes

“…The fractions of interest had their chemical constituents elucidated by nuclear magnetic resonance and mass spectrometry. …”
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In Vitro Evaluation of the Antifungal Activity of Ghassoul-Based Formulations with Oregano and Thyme Essential Oils against Penicillium sp. by Hamid Ziyat, Mohammed Naciri Bennani, Safae Allaoui, Jamal Houssaini, Hasna Nait M’barek, Soukaina Arif, Hassan Hajjaj

“…Their chemical compositions were analyzed by the GC-MS technique. The main constituents of thyme EO were thymol (67.13%), ρ-cymene (4.85%), Z-caryophyllene (1.77%), and γ-terpinene (2.74%). …”
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Dual-phase medium-entropy diboride–carbide ceramics with metal element exchange during sintering by Pai Peng, Ji-Xuan Liu, Xiao-Ting Xin, Weichao Bao, Yongcheng Liang, Fangfang Xu, Guo-Jun Zhang

“…More interesting phenomena can be expected if chemical interactions between the constituent phases exist. In this study, spark plasma sintering was used to prepare fully dense dual-phase (Zr,Hf,Ta)B2–(Zr,Hf,Ta)C ceramics from self-synthesized equimolar medium-entropy diboride and carbide powders. …”
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Effect of Opuntia ficus-indica Mucilage Edible Coating in Combination with Ascorbic Acid, on Strawberry Fruit Quality during Cold Storage by Giorgia Liguori, Raimondo Gaglio, Luca Settanni, Paolo Inglese, Fabio D’Anna, Alessandro Miceli

“…It is characterized by high levels of vitamin C, folate, vitamin E, β-carotene, and phenolic constituents as well asanthocyanins that are strictly related to health benefits. …”
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An Integrated Approach Exploring the Synergistic Mechanism of Herbal Pairs in a Botanical Dietary Supplement: A Case Study of a Liver Protection Health Food by Liang Chen, Chun Hu, Molly Hood, Juntao Kan, Xiaona Gan, Xue Zhang, Yi Zhang, Jun Du

“…A total of sixteen chemical constituents of White Peony and Licorice were isolated and identified, which interact with 73 liver protection-related targets. …”
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To Link Life Histories to Historical Narratives by Irène Dos Santos

“…Cet article éclaire dans une première partie le tournant sociétal et académique que constitue l’émergence de contre-récits mémoriels. Il s’agit d’éclairer les acteurs de ces processus et de montrer comment peuvent s’imbriquent, dans ce nouveau rapport politique au passé, mémoire de la dictature et mémoire de la décolonisation. …”
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Financial security as a factor of military security by O. P. Getmanets, D. V. Korobtsova

“…It has been noted that different academic opinions on the constituent elements of financial security depend on the object of consideration. …”
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Investigation of Hydro-Geochemical Characteristics of Groundwater In Port Harcourt City, Nigeria: Implication for Use and Vulnerability by HO Nwankwoala, GJ Udom

“…Iron and Manganese concentrations are above the World Health Organization guide value in majority of the boreholes studied, with maximum value up to 1.60mg/l in Abuloma area. Constituents of the heavy metals as shown in this study reveal that, in some locations, values are slightly higher than the permissible levels. …”
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