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Ultrasound-Assisted Wittig Reaction for the Synthesis of 3-Substituted 4-Chloroquinolines and Quinolin-4(1H)-ones with Extended π-Conjugated Systems
Published 2022-01-01“…Ease execution, mild conditions, and high yields make this method exploitable for the generation of libraries of 3-substituted 4-chloroquinolines and quinolin-4(1H)-ones with extended π-conjugated systems. To demonstrate the usefulness of these compounds as precursors for the synthesis of more complex structures, 3-vinylquinolin-4(1H)-ones were used as dienes in the Diels–Alder reaction with N-methylmaleimide to produce novel acridone derivatives. …”
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Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics
Published 2013-01-01“…This review is focused on the current knowledge of receptor-mediated endocytosis/transcytosis and brain delivery using the Angiopep-2-conjugated system and the molecular Trojan horses. In addition, the role of neonatal Fc receptor (FcRn) in regulating the efflux of Immunoglobulin G (IgG) from brain to blood, and approaches to improve the pharmacokinetics of therapeutic biologics by generating Fc fusion proteins, and increasing the pH dependent binding affinity between Fc and FcRn, are discussed.…”
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Statistical approach to synthesise biogenic silica nanoparticles from rice husk and conjugated with Justicia adhatoda extract as green, slow‐release biocide
Published 2021-06-01“…Moreover, compared with the naked biogenic silica nanoparticles, a better thermal stability was determined for the conjugated system of the extracted compounds. Trial of kinetic release of silica: Justicia adhatoda ∼29% of loaded Justicia adhatoda was released within 1 h and then the rate of release became slow. …”
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Tracing the Geographical Origins of Dendrobe (Dendrobium spp.) by Near-Infrared Spectroscopy Sensor Combined with Porphyrin and Chemometrics
Published 2020-01-01“…The mechanism of TMPP improving the specificity of NIR spectroscopy should be related to the π-π conjugated system and the methoxy groups of TMPP interact with the chemical components of dendrobe. …”
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Roadmap for Designing Donor-<inline-formula><math display="inline"><semantics><mrow><mi mathvariant="bold-sans-serif">π</mi></mrow></semantics></math></inline-formula>-Acceptor Flu...
Published 2025-01-01“…Donor acceptor (D-<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi mathvariant="sans-serif">π</mi></mrow></semantics></math></inline-formula>-A) fluorophores containing a donor unit and an acceptor moiety at each end connected by a conjugated linker gained attention in the last decade due to their conjugated system and ease of tunability. These features make them good candidates for various applications such as bioimaging, photovoltaic devices and nonlinear optical materials. …”
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Discovery of Evolutionary Loss of the Ubiquitin-like Autophagy-Related ATG12 System in a Lineage of Apicomplexa
Published 2025-01-01“…The autophagy-related ubiquitin-like conjugation systems, the ATG8 and ATG12 systems, are universally conserved in eukaryotes. …”
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Canonical and noncanonical autophagy: involvement in Parkinson’s disease
Published 2025-01-01“…In particular, CASM is unique in that it does not require autophagy upstream mechanisms, while the ATG8 conjugation system is involved in a manner different from canonical autophagy. …”
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Structural Evolution of Burmese Amber during Petrifaction Based on a Comparison of the Spectral Characteristics of Amber, Copal, and Rosin
Published 2019-01-01“…., carbonyl groups) or conjugated systems in Burmese amber, copal, and rosin. The evaluation of amber, rosin, and copal solubility in six solvents (ethanol, acetone, 1,4-dioxane, ethylacetate, N,N-dimethylamide, and dichloromethane) demonstrated that solubility decreases in the following order: rosin > copal > Burmese amber. …”
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TWO-POINT BOUNDARY PROBLEM SOLUTION BY NON-GRADIENT RANDOM SEARCH METHOD
Published 2016-03-01“…When solving the task of optimal control estimation of dynamical system by means of Pontryagin’s maximum principle the initial conditions of conjugate set of equations must be determined, provided that dynamical system’s variables values meet the known terminal conditions Y(tk).The problem’s solution lie in random selection of vector of initial conditions in some actual range, numerical integration of basic and conjugate systems and subsequent processing of findings. …”
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MacSyFinder v2: Improved modelling and search engine to identify molecular systems in genomes
Published 2023-03-01“…Finally, we have updated and improved MacSyFinder popular models: TXSScan to identify protein secretion systems, TFFscan to identify type IV filaments, CONJscan to identify conjugative systems, and CasFinder to identify CRISPR associated proteins. …”
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Inhibitory effects of oxyresveratrol on ERK and Smad1/2 phosphorylation and HSC activation in preventing carbon tetrachloride-induced rat liver fibrosis
Published 2021-01-01“…In a parallel study with Res, ORes showed more efficacious protective effect than Res against rat liver fibrosis, which is attributed to extended conjugation system due to the extra hydroxyl group at 2-position on ORes making it more electron-rich and susceptible to oxidation than Res. …”
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Near‐room‐temperature π‐conjugated nematic liquid crystals in molecules with a flexible seven‐membered ring structure
Published 2025-01-01“…Recent advancements have extended the scope of NLC molecules to large calamitic π‐conjugated systems, which heralds prospects for novel applications that exploit their superior electronic or optical functionalities in, for example, electric field controlled fluorescence switch devices. …”
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Evolutionary and functional divergence of Sfx, a plasmid-encoded H-NS homolog, underlies the regulation of IncX plasmid conjugation
Published 2025-02-01“…ABSTRACT Conjugative plasmids are widespread among prokaryotes, highlighting their evolutionary success. Conjugation systems on most natural plasmids are repressed by default. …”
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A density functional theory investigation of the substituent effect on acyclovir and guanine derivatives for applications on energetic materials
Published 2024-12-01“…Fused nitrogen heterocycles of imidazole and pyrimidine, such as acyclovir and guanine, may offer interesting features due to the combination of a coplanar framework and a large conjugate system, which contribute to a reduced sensitivity, and a number of energetic bonds that can be increased by the introduction of explosophore substituents. …”
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