Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer by Angelica Nogueira Rodrigues, Andreza Karine de Barros Almeida Souto, Diocésio Alves Pinto de Andrade, Larissa Müller Gomes, Sandra Satie Koide, Renata de Godoy e Silva, Bruno Batista de Souza, Juliana Doblas Massaro, Andréia Cristina de Melo, Andrea Morais Borges, Camila Giro, Carlos Augusto Vasconcelos de Andrade, Cesar Martins da Costa, Daniel Luiz Gimenes, Eduardo Caminha Bandeira de Mello, Fernanda Cesar de Oliveira, Frederico Müller de Toledo Lima, Gabriel Lima Lopes, Gustavo de Oliveira Bretas, Gustavo Guerra Jacob, Herika Lucia da Costa Silva, Juliana Ferrari Notaro, Lara Ladislau Alves, Marcos Veloso Moitinho, Mirian Cristina da Silva, Roberto Abramoff, Thais Amaral da Cunha Rauber, Rodrigo Dienstmann, Fernanda Christtanini Koyama

“…In this scenario, access to a validated diagnostic HRD test can optimize treatment selection and increase the effectiveness of the intervention.ObjectiveTo technically validate an in-house next-generation sequencing (NGS)-based HRD test, QIAseq Custom Panel (QIAGEN), by comparing it with the reference assay, MyChoice CDx® Plus HRD (Myriad Genetics), which is used in routine care.MethodsThis is a prospective cohort study conducted at the Oncoclínicas Precision Medicine (OCPM) laboratory using samples from patients with advanced or relapsed platinum-sensitive ovarian cancer eligible for HRD testing in a diagnostic clinical setting at Oncoclínicas and Co. …”
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Facility capacity and provider knowledge for cholera surveillance and diarrhoea case management in cholera hotspots in the Democratic Republic of Congo – a mixed-methods study by Mattias Schedwin, Aurélie Bisumba Furaha, Kelly Elimian, Carina King, Espoir Bwenge Malembaka, Marc K Yambayamba, Thorkild Tylleskär, Tobias Alfvén, Simone E Carter, Placide Welo Okitayemba, Mala Ali Mapatano, Helena Hildenwall

“…Objective Describe facility capacity and provider knowledge for case management of diarrhoea and cholera surveillance in cholera hotspots in the Democratic Republic of Congo (DRC) among health facilities, drug shops, and traditional health practitioners. Methods We conducted a sequential exploratory mixed-method study, using focus group discussions, facility audits, and provider knowledge questionnaires during September and October 2022 in North Kivu and Tanganyika provinces, Eastern DRC. …”
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Maternal health risk factors dataset: Clinical parameters and insights from rural BangladeshMendeley Data by Mayen Uddin Mojumdar, Dhiman Sarker, Md Assaduzzaman, Hasin Arman Shifa, Md. Anisul Haque Sajeeb, Oahidul Islam, Md Shadikul Bari, Mohammad Jahangir Alam, Narayan Ranjan Chakraborty

“…A Chi-Square test analyzed the relationship between preexisting diabetes and risk levels, revealing a significant association with a p-value of 4.85e-119. A Z-test was also conducted to compare clinical parameters between pregnant patients with and without diabetes, with a sample ratio of 337:811. …”
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Size-resolved Compositional Analysis and Source Apportionment of Submicron Aerosol during Lockdown Period Using HR-ToF-AMS by Prodip Acharja, Akash Vispute, Prasanna Lonkar, Suresh W. Gosavi, Sreyashi Debnath, Narendra G. Dhangar, Kaushar Ali, Gaurav Govardhan, Sachin D. Ghude

“…Abstract The size-resolved compositional analysis of non-refractory submicron aerosol (NR-PM1) was conducted using the Aerodyne High-Resolution Time-of-Flight Aerosol Mass Spectrometer (HR-ToF-AMS) instrument over Pune, India during the COVID-19 lockdown period. …”
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Alternative approaches for monitoring and evaluation of lymphatic filariasis following mass drug treatment with ivermectin, diethylcarbamazine and albendazole in East New Britain P... by Krufinta Bun, Benedict Mode, Melinda Susapu, Joyceline Salo, Catherine Bjerum, Michael Payne, Daniel Tisch, Makoto Sekihara, Emanuele Giorgi, Gary J Weil, Peter U Fischer, Leanne Robinson, Moses Laman, Christopher L King

“…<h4>Methods and findings</h4>Two cross-sectional studies were conducted at baseline (N = 49 clusters or villages) and 12 months after mass drug administration (MDA) with IDA (N = 47 villages) to assess lymphatic filariasis (LF) by circulating filarial antigenemia (CFA) and microfilariae (Mf). …”
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Patient experience and burden of haemolytic disease of the foetus and newborn: a systematic review by P. Maurice, J. McCallion, M. Fitzgibbon, J. N. Barthelmes, W. Karmous, E. J. Hardy, S. A. Mitchell, C. R. Mitchell, J. Lee, W. Noel, Andras Borsi, J. M. Jouannic

“…Methods Electronic database searches supplemented by handsearching of grey literature, were conducted to identify studies that reported the clinical patient burden/experience, and economic burden of HDFN in Europe, the Middle East, and Africa (EMEA). …”
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Prevalence, associated factors, management and outcomes of hypokalaemia in hospitalised patients at a South African tertiary centre by C Burton, M-Y Chothia, A Zemlin, S Lahri

“…To evaluate the prevalence, associated factors, management and risk factors for all-cause mortality in hospitalised adult patients with hypokalaemia at a tertiary centre in SA. Methods. We conducted a retrospective cohort study of all adult patients admitted with, or who developed, hypokalaemia during hospitalisation in 2019. …”
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Pattern and Predictors of Maternal Healthcare Services Utilization among Women of Reproductive Age in Lagos, Nigeria by Esther Oluwakemi Oluwole, Alero Ann Roberts, Ifeoma Peace Okafor, Victoria Oluwasola Yesufu

“…Methods: A cross-sectional study was conducted among 453 women of reproductive age selected through multistage sampling between July 2022 and March 2023. …”
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Measurement, determinants and outcomes of maternal care satisfaction in Nigeria: a systematic review by Jane E Hirst, Robyn Norton, Margaret Peden, Edward Mullins, Beatrice Wuraola Ope, Tavleen Wasan

“…Understanding women’s satisfaction with the maternity health system is fundamental, as perceived quality of care is a determinant of service utilisation and improved birth outcomes.Objectives This systematic review aims to explore patients’ satisfaction with maternal healthcare in Nigeria, examining the measurement, determinants, and outcomes of satisfaction.Design A systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines.Data sources Searches were conducted in Embase, Maternity and Infant Care, Global Health, Ovid, Africa Journals Online, Cochrane Central Register of Controlled Trials, MEDLINE, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus and Google Scholar, alongside citation searches of relevant studies.Eligibility criteria Original studies assessing patient satisfaction with maternal health services in Nigeria were included. …”
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Outcomes of Open Reduction and Modified McLaughlin’s Procedure in Neglected Posterior Shoulder Dislocation by Vikas, Jatin Prakash, Karan Maggo, Jujhar Singh, Ankesh Jain, Naval Bhatia

“…Statistical analyses were conducted using paired t-tests and independent sample t-tests. …”
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Efficacy of electroacupuncture for insomnia in cancer patients: a systematic review and meta-analysis by Xiaodong Liu, Ning Xu, Shangpei Wang, Qingjun Jia

“…Electroacupuncture (EA) has been widely applied in managing sleep disorders, particularly in cancer patients or those experiencing insomnia.ObjectivesThis meta-analysis aims to evaluate the efficacy and safety of electroacupuncture for treating cancer-related insomnia.MethodsTwo independent reviewers conducted comprehensive searches across multiple databases, including EMBASE, Web of Science, PubMed, the Cochrane Library, Wanfang Digital Journals, China National Knowledge Infrastructure (CNKI), and the VIP Database for Chinese Technical Periodicals. …”
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Explaining the Antecedents and Consequences of the Glass Cliff in Service Organizations by Sara Kavoosi, Ali Safari, Ali Shaemi Barzoki

“…Through in-depth analysis of the interviews conducted, a comprehensive model outlining causal relationships was formulated. …”
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PATTERNS OF CLINICAL MEDICO-LEGAL CASES: A RETROSPECTIVE STUDY AT A distt headquarter hospital charsadda by Nayella Nijat Bangash, Naheed Siddiqui, Urooj Khushbakhat Khan, Ihsan Ullah, Faiza Nadeem, Farzand Iqbal

“…Statistical analysis, including the Pearson Chi-Square test, was conducted to explore the patterns of MLC in relation to gender, age, and residence. …”
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Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort study by Vin-Cent Wu, Ting-Ya Yang, Min-Hsiang Chuang, Hong-Min Lin, Heng-Chih Pan, Yun Chou, Jui-Yi Chen

“…Kaplan-Meier analyses coupled with log-rank tests were conducted to estimate the survival probabilities.Setting Data were sourced from the TriNetX database spanning records from 25 March 2011 to 5 April 2024.Participants Patients with cancer aged ≥18 years treated with ICPi with or without AKI occurrence.Primary and secondary outcome measures The primary outcome was all-cause mortality, and secondary outcomes included major adverse kidney events (MAKE), major adverse cardiovascular events (MACE), the composite of MAKE or MACE with death, and end-stage renal disease.Results The study identified 926 patients with cancer who developed ICPi-AKI (mean age, 67.1±11.8 years; 57.4% men). …”
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Comparison of the efficacy of the modified S-P approach and the Ganz method for surgical hip dislocation in Pipkin I fractures: an early follow-up study by Hanwen Zhang, Wei Deng, Shengtao Wang, Yong Yin

“…This study aims to compare the clinical efficacy of the modified Smith-Peterson (mS-P) approach and Ganz surgical dislocation (GSD) approach in the treatment of Pipkin I fractures. Methods We conducted a retrospective analysis of patients diagnosed with Pipkin I fractures at Pidu District People’s Hospital from June 2010 to May 2020. …”
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Evaluation of choices and time spent on an open online elective course by undergraduate medical students during the COVID-19 pandemic by Z Mfeka, A Turner, J E Wolvaardt, D Muganhiri

“…Data included identification of the associated competency acquired. Data analysis was conducted using Python, version 3.10.11. Results. …”
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Prescription pattern, glycemic control status, and predictors of poor glycemic control among diabetic patients with comorbid chronic kidney disease in Ethiopia: a facility-based cr... by Oumer Sada Muhammed, Minimize Hassen, Samuel Mamusha

“…Methods A facility-based cross-sectional study was conducted from March 15 to May 15, 2024, from the electronic medical records of diabetic patients with comorbid chronic kidney disease who had received regular treatment and follow-up at the adult diabetes mellitus clinic of Tikur Anbessa Specialized Hospital. …”
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Development of a Web-Based Intervention for Middle Managers to Enhance Resilience at the Individual, Team, and Organizational Levels in Health Care Systems: Multiphase Study by Eva Gil-Hernández, Irene Carrillo, Jimmy Martin-Delgado, Daniel García-Torres, José Joaquín Mira

“…MethodsAn observational study was conducted in 3 phases: design, validation, and pilot study. …”
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Association of blood manganese and selenium levels with hepatic steatosis among adolescents: a nationwide cross-sectional analysis by Bin You, Bin You, Bin You, Bin You, Zhiyuan Chen, Zhiyuan Chen, Zhiyuan Chen, Zhiyuan Chen

“…ObjectiveThis study aimed to investigate the association between blood manganese and selenium levels and hepatic steatosis among adolescents, using data from the National Health and Nutrition Examination Survey (NHANES) 2017–2023.MethodsA cross-sectional analysis was conducted using data from 2,459 adolescents (aged 12–19 years) with complete data on liver ultrasound transient elastography, blood manganese, and selenium levels. …”
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Assessment of occupational hazards in midwifery setting and impact of occupational stress and job satisfaction on midwives’ quality of work-life: multicenter study in IRAN by Nasibeh Sharifi, Azita Fathnezhad-Kazemi, Nazanin Rezaei, Masoumeh Yaralizadeh, Zahra PourMohammad

“…Method This cross-sectional study was conducted in 2023 in Iran, involving midwives working in hospitals (teaching and non-teaching) and health centers. …”
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