Importance of infarct topography in determination of stroke mechanism and recurrence risk: a post-hoc analysis of the dabigatran acute treatment of stroke trial by Michael D Hill, Ken Butcher, Kelvin Ng, Mukul Sharma, Shelagh B Coutts, Brian H Buck, Thalia Field, Erol Cimen, Laura C Gioia, Jodi Miller, Oscar R Benavente

“…The question is clinically relevant to optimise secondary stroke prevention investigations and treatment.Design We conducted a retrospective analysis of the dabigatran treatment of acute stroke II (DATAS II) trial (ClinicalTrials.gove NCT NCT02295826), in which patients underwent diffusion-weighted imaging (DWI) at baseline and 30 days after randomisation to one of two antithrombotic therapies. …”
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Pan-cancer analysis of the transcriptional expression of histone acetylation enzymes in solid tumors defines a new classification scheme for gliomas by Junhao Zhang, Lingbo Li, Aiwei Tang, Chucheng Wang, Yupeng Wang, Yongqi Hu, Guangting He, Guangting He, Wangjun Liao, Wangjun Liao, Wangjun Liao, Rui Zhou

“…Notably, the AC-V subtype comprised over 95% of glioma patients, suggesting glioma patients exhibited distinct expression patterns of histone acetylation-modifying enzymes compared to patients with other solid tumors. Therefore, we re-conducted the consensus clustering analysis specifically within the context of gliomas and identified five subtypes, denoted “AC-GI” to “AC-GV”, which were characterized by differences in HATs/HDACs expression patterns, biological and immune status, genetic alterations, and clinical outcomes. …”
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Cost–Benefit Analysis of in vivo Reflectance Confocal Microscopy for Melanoma Diagnosis in a Real-World Clinical Setting by Bruno GM, Di Matteo S, Longo C, Stanganelli I, Farnetani F, Borsari S, Mazzoni L, Ciardo S, Raucci M, Magi S, Bassoli S, Spadafora M, Mandel VD, Casari A, Chester J, Kaleci S, Colombo GL, Pellacani G

“…., Health Economics & Outcomes Research, Milan, Italy; 3Azienda Unità Sanitaria Locale – IRCCS di Reggio Emilia, Skin Cancer Center, Reggio Emilia, Italy; 4Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy; 5Skin Cancer Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”, Meldola, Italy; 6Department of Medicine and Surgery, University of Parma, Parma, Italy; 7Dermatology Unit, Department of Surgical, Medical, Dental & Morphological Sciences with Interest Transplant, Oncological & Regenerative Medicine, University of Modena and Reggio Emilia, Modena, 41125, Italy; 8Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy; 9Porphyria and Rare Diseases Unit, San Gallicano Dermatological Institute-IRCCS, Roma, Italy; 10Department of Drug Sciences, CEFAT-Center of Pharmaceuticals Economics and Medical Technologies Evaluation, University of Pavia, Pavia, Italy; 11Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Dermatology Clinic, Sapienza University of Rome, Rome, Italy*These authors contributed equally to this workCorrespondence: Giacomo Matteo Bruno, Department of Drug Sciences, University of Pavia, Pavia, Italy, Email giacomomatteo.bruno@unipv.itBackground: In a recent prospective, multicenter, two-arm randomized controlled trial (RCT), we demonstrated that adjunctive reflectance confocal microscopy (RCM) in routine clinical practice provides clinical benefits, including safe melanoma detection and a 43.3% reduction in the number needed to excise (NNE).Methods: A cost–benefit analysis was conducted based on NNEs for standard care (5.3) and adjunctive RCM (3.0). …”
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Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling by Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie Pan

“…Overexpression and knockdown experiments of miR-17-5p and MINK1 were conducted to investigate their roles in regulating ULBP2 expression and subsequent JNK/c-Jun activation. …”
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The Effect of Enriched Daphnia sp. with Different Source of Oil on the Survival Rate and the Growth of Oreochromis niloticus Larvae by I. Mokoginta, Dedi Jusadi, T.L. Pelawi

“…ABSTRACT This experiment was conducted to evaluate best source of oil to enriched Daphnia sp. before fed it to Oreochromis niloticus larvae. …”
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Temporal changes in Plasmodium falciparum genetic diversity and multiplicity of infection across three areas of varying malaria transmission intensities in Uganda by Alex Mwesigwa, Steven M. Kiwuwa, Benson Musinguzi, Hakiim Kawalya, James Davis Katumba, Andrew Baguma, Irene M. Mutuku, Ismail Abiola Adebayo, Samuel L. Nsobya, Pauline Byakika-Kibwika, Joan N. Kalyango, Charles Karamagi, Joaniter I. Nankabirwa

“…Methods A total of 220 P. falciparum-positive dried blood spot (DBS) filter paper samples from participants in a study conducted during 2011–2012 and 2015–2016 were analyzed. …”
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Molecular epidemiology of extended-spectrum beta-lactamases and carbapenemases-producing Shigella in Africa: a systematic review and meta-analysis by Namwin Siourimè Somda, Rabbi Nyarkoh, Abel Tankoano, Ouindgueta Juste Isidore Bonkoungou, Patience B. Tetteh-Quarcoo, Eric S. Donkor

“…An extensive literature search was conducted through electronic databases including PubMed, Scopus, Web of Sciences, African Journals Online (AJOL) and Google scholar using specific keywords. …”
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Comparing multi-texture fibrosis analysis versus binary opacity-based abnormality detection for quantitative assessment of idiopathic pulmonary fibrosis by Sebastian Nowak, Dominik Creuzberg, Maike Theis, Carmen Pizarro, Alexander Isaak, Claus C. Pieper, Julian A. Luetkens, Dirk Skowasch, Alois M. Sprinkart, Daniel Kütting

“…Also, Kaplan-Meier analysis with log rank test between subgroups separated by median OFL and MTFL were conducted. No significant difference between OFL and MTFL was observed (median and interquartile range: OFL = 29% [20-38%], MTFL = 31% [19-45%]; P = 0.44). …”
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Genome-wide association mapping and genomic prediction analyses reveal the genetic architecture of grain yield and agronomic traits under drought and optimum conditions in maize by Manigben Kulai Amadu, Yoseph Beyene, Vijay Chaikam, Pangirayi B. Tongoona, Eric Y. Danquah, Beatrice E. Ifie, Juan Burgueno, Boddupalli M. Prasanna, Manje Gowda

“…To dissect the genetic architecture of grain yield and flowering traits under drought stress, a genome-wide association study (GWAS) was conducted on a panel of 236 maize lines testcrossed and evaluated under managed drought and optimal growing conditions in multiple environments using seven multi-locus GWAS models (mrMLM, FASTmrMLM, FASTmrEMMA, pLARmEB, pKWmEB, ISIS EM-BLASSO, and FARMCPU) from mrMLM and GAPIT R packages. …”
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Effect of Buyang Huanwu Decoction Foot Bath on Pulmonary Rehabilitation of Patients with Chronic Obstructive Pulmonary Disease at Stable Phase by HUANG Huirong, HAN Xueqi, LIU Qinyu, XUE Jialu, YU Zhenling, CHEN Bin, MIAO Shaofang, CHEN Shuifeng

“…After discarding the residue, the decoction was placed in a bucket, and foot bath was conducted when the temperature dropped to about 40 ℃. …”
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Factors associated with the discontinuation of modern contraceptive methods among lactating women in nine West African high-fertility countries: findings of the most recent demogra... by Abou Coulibaly, Adama Baguiya, Denise Kpebo, Augustin Zango, Halima Tougri, Franck Garanet, Seni Kouanda

“…Methods This was a secondary analysis of retrospective data of the most recent Demographic and Health Surveys (DHS) data from nine high-fertility rate countries, conducted mostly between 2018–2021. We reported weighted frequencies of modern contraceptives discontinuation (binary variable, coded 1 and 0). …”
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Retrospective analysis of the occurrence, potential risk factors and medical significance of pulmonary complications after total shoulder arthroplasty from the National Inpatient S... by Mengning Dong, Huitong Liang, Jinlang Fu, Zeying Guo, Hao Xie, Qinfeng Yang, Qingmei Yu, Xiaomin Hou

“…As a result, the healthcare system in USA could face a considerable financial strain due to the emergence of subsequent pulmonary problems. This study aimed to conduct a thorough examination of the prevalence, influential factors and medical importance of pulmonary complications, with emphasis on pneumonia, respiratory failure and pulmonary embolism (PE) following total shoulder arthroplasty (TSA) procedures in USA. …”
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HMGB-1 as a predictor of major bleeding requiring activation of a massive transfusion protocol in severe trauma by Michal Frelich, Marek Bebej, Jan Pavlíček, Filip Burša, Vojtěch Vodička, Zdeněk Švagera, Adéla Kondé, Ondřej Jor, Markéta Bílená, Tereza Romanová, Peter Sklienka

“…Previous work has shown that higher levels of HMGB-1 are associated with a higher use of red blood cell transfusions. We conducted a retrospective analysis of previous prospective single-center study to assess the value of admission HMGB-1 levels in predicting activation of MTP in the emergency department. …”
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Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma by Yan Liao, Junkai Chen, Hao Yao, Ting Zheng, Jian Tu, Weidong Chen, ZeHao Guo, Yutong Zou, Lili Wen, Xianbiao Xie

“…LASSO regression analysis was conducted to identify prognostic genes and construct an SLC-related prognostic signature. …”
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Nitrogen dynamic and precise management to predict corn yield in tropical upland acid soils by A. Kasno, A.A. Rivaie, C. Tafakresnanto, E. Pratiwi, E. Karmawati, A.F. Siregar, M. Hatta, M.T. Sutriadi

“…This research aims to determine nitrogen dynamics and precise nitrogen nutrient management in corn cultivation using a leaf chlorophyll meter and nitrogen response tests to predict corn yield in tropical upland acid soils.METHODS: This research was conducted in an Ultisol and verified in an Oxisol. …”
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Rationale, design, and methodology of My Body Is Fit and Fabulous at school (MyBFF@school) study: a multi-pronged intervention program to combat obesity among Malaysian schoolchild... by Abdul Halim Mokhtar, Ruziana Mona Wan Mohd Zin, Abqariyah Yahya, Fuziah Md. Zain, Rusidah Selamat, Zahari Ishak, Muhammad Yazid Jalaludin

“…Three assessments i.e. at baseline, month-3 and month-6 were conducted. Anthropometric, clinical examination, blood, physical fitness, nutrition, and psychology parameters were collected. …”
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Analisis Perbandingan Algoritma Machine Learning dan Deep Learning untuk Klasifikasi Citra Sistem Isyarat Bahasa Indonesia (SIBI) by Mohammad Farid Naufal, Selvia Ferdiana Kusuma

“…The results of research conducted using 5 cross-validation, CNN with the Xception architecture has highest F1 Score of 99.57%, with an average training time of 1.387 seconds. …”
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On the Subject, Purpose and Method of Religious Education as a Practical Metaphysics by Süleyman Gümüş

“…Thus, pedagogy can be conducted in harmony with the general principles of subjectification. …”
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The impact of radiation-related lymphocyte recovery on the prognosis of locally advanced esophageal squamous cell carcinoma patients: a retrospective analysis by Hongshan Ji, Ping Zhang, Chanjun Zhen, Liyuan Fu, Dongjie Lv, Wenwen Bai, Rui Zhang, Jing Li, Hang Gao, Yajing Wang, Qiuying An, Yuhao Su, Hanyu Si, Xueying Qiao, Zhiguo Zhou

“…Kaplan-Merier’s analysis and Cox analysis were conducted to compare survival outcomes. Binary logistic regression analyses was employed to ascertain factors associated with lymphocyte recovery. …”
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Comprehensive health assessment of retired martial arts athletes: bone density, dietary intake, physical activity, and wellbeing by Tasneem Alshaer, Nihad Battikhi, Adam Tawfiq Amawi, Khalid Trabelsi, Khalid Trabelsi, Haitham Jahrami, Haitham Jahrami, Philippe Bouedo, Hadeel Ali Ghazzawi

“…The differences were explored in weight changes, bone density, quality of life, happiness, stress, insomnia, physical activity, and dietary intake to understand how martial arts impact these health dimensions.MethodsA descriptive case-control study was conducted among 30 retired male elite athletes and 20 age-matched non-athletes. …”
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