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40181
Gestational diabetes mellitus in previous pregnancy associated with the risk of large for gestational age and macrosomia in the second pregnancy
Published 2025-02-01“…It remains unclear whether a history of GDM in a previous pregnancy raises the risk of LGA or macrosomia in Chinese women planning two or more pregnancies.AimTo analyze the association between previous GDM and the risk of LGA and macrosomia in second pregnancy.MethodA retrospective study was conducted on a cohort of 3,131 women who had experienced two consecutive singleton births. …”
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40182
Ovarian Reserve: A Critical Indicator of Female Reproductive Health
Published 2025-01-01“…Materials and Methods: This narrative review was conducted using PubMed and Scholar database with following search terms: “ovarian reserve”, “diminished ovarian reserve”, “ovarian aging”, "ovarian insufficiency". …”
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40183
Combining Controlled-Release and Normal Urea Enhances Rice Grain Quality and Starch Properties by Improving Carbohydrate Supply and Grain Filling
Published 2025-01-01“…In this study, a two-year field experiment was conducted that included four nitrogen management practices: zero nitrogen input (CK), a local high-yield practice with split urea applications (100% urea, CU), a single basal application of 100% controlled-release nitrogen fertilizer (CRNF), and a basal application blend of 70% controlled-release nitrogen fertilizer with 30% urea (CRNF-CU). …”
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40184
“A torch, a rope, a belly laugh”: engaging with the multiple voices of support groups for people living with rare dementia
Published 2025-01-01“…These results provided confidence to subsequently conduct a thematic analysis of eight completed poems, identifying 15 initial themes. …”
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40185
Post-vaccination campaign evaluation of systemic and mucosal immunity of trivalent oral poliovirus vaccine in Karachi, Pakistan (2020–2021): a cross-sectional studyResearch in cont...
Published 2025-02-01“…Methods: A cross-sectional survey was conducted in four peri-urban sites (Cattle Colony, Ibrahim Hyderi, Ali Akber Shah, Rehri Goth) Karachi, Pakistan. …”
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40186
Intestine-derived fibroblast growth factor 19 alleviates lipopolysaccharide-induced liver injury by regulating bile acid homeostasis and directly improving oxidative stress
Published 2025-01-01“…However, the roles and underlying mechanisms of FGF19 in SALI are still unclear. Methods: We conducted a case–control study that included 58 pediatric patients aged from 1 month to 14-years-old diagnosed with sepsis at Shanghai Children's Hospital from January to December 2018 and 30 healthy individuals. …”
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40187
Phenome-wide association studies between SERINC2 and neuropsychiatric disorders
Published 2025-01-01“…Finally, functional studies on the differential SERINC2 mRNA expression in brains and the potential regulatory effects of disease-risk alleles on SERINC2 mRNA expression, gray matter volumes (GMVs) of subcortical structures, cortical surface area (SA) and average thickness (TH) were conducted.ResultsIn European descent, alcoholism was most significantly associated with SERINC2 variants (245 SNPs with 5.5×10-8≤p ≤ 0.049 and 4.9×10-5≤q ≤ 0.034) that were largely shared across cocaine dependence, marijuana dependence, nicotine dependence, polysubstance dependence, schizophrenia, OCD, and autism (8.2×10-8≤p ≤ 0.050 and 1.9×10-5≤q ≤ 0.049); in Chinese population, bipolar disorder was also significantly associated with SERINC2 variants (10 SNPs: 1.3×10-4≤p ≤ 4.7×10-4 and 0.025≤q ≤ 0.031). …”
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40188
Efficacy and cost-effectiveness of an ACT and compassion-based intervention for women with breast cancer: study protocol of two randomised controlled trials {1}
Published 2025-01-01“…Statistical analyses will be conducted using an intention-to-treat approach. Analyses of moderators and mediators of change will also be performed. …”
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40189
Seroprevalence of Human Herpesvirus Infections in Newly Diagnosed HIV-Infected Key Populations in Dar es Salaam, Tanzania
Published 2021-01-01“…We analyzed 262 archived serum samples of HIV-infected key populations from the integrated biobehavioral surveillance (IBBS) study conducted in Dar es Salaam, Tanzania. The enzyme-linked immunosorbent assay was used to determine IgG and IgM titers for cytomegalovirus (CMV) and herpes simplex virus (HSV) types 1 and 2. …”
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40190
Learning health system research as a catalyst for promoting physician wellness: EHR InBasket Spring cleaning and team‐based compassion practice
Published 2025-01-01“…Methods A modified stepped wedge‐clustered randomized trial was conducted, involving specialties with heavy InBasket workloads. …”
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40191
Shi-Zhen-An-Shen Decoction, a Herbal Medicine That Reverses Cuprizone-Induced Demyelination and Behavioral Deficits in Mice Independent of the Neuregulin-1 Pathway
Published 2021-01-01“…Behavioral tests and brain analyses were conducted after the last treatment. The brain expression of myelin basic protein (MBP) and neuregulin-1 (NRG-1) was assessed using immunohistochemistry and Western blots. …”
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40192
Development and validation of a multidimensional, culturally and socially inclusive Child Resilience Questionnaire (parent/caregiver report) to measure factors that support resilie...
Published 2022-06-01“…Recruitment via a large tertiary hospital’s outpatient clinics, Aboriginal and refugee background communities (Aboriginal and bicultural researchers networks) and nested follow-up of mothers in a pregnancy cohort and a cohort of Aboriginal families.Analysis Exploratory and confirmatory factor analyses conducted to assess the structure and construct validity of CRQ-P/C subscales. …”
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40193
Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review of studies before and during the COVID-19 pandemic
Published 2025-01-01“…We searched for published manuscripts on the medical management of POTS through 6 April 2024 which met pre-specified inclusion criteria. We conducted quality appraisal and assessed risk of bias before extracting the data and performing synthesis to determine the current state of the evidence; particularly in the context of PASC.ResultsThe study search and selection process identified 32 studies that met inclusion criteria, comprising randomized controlled trials, observational studies, and systematic reviews. …”
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40194
Prevalence and determinants of intimate partner violence in pregnancy: a multicentre, binational study
Published 2025-02-01“…Methods A descriptive, cross-sectional study, conducted between February-July 2022, amongst pregnant women attending antenatal care clinics in 17 health facilities across the six geopolitical zones in Nigeria, and three hospitals in three regions in Ghana. …”
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40195
Risks of parasitic helminth disease outbreaks and influence of physico-chemical factors in flood prone areas of Yaoundé, Cameroon
Published 2025-02-01“…The overcrowding and poor hygiene observed in these areas are responsible for the unsmiling variations in environmental cleanliness, exploitation of river water for domestic purposes thus putting them at risk for parasitic disease transmissions. This study was conducted in order to assess the risks of human helminthiases outbreaks in relation to water physico-chemical factors in the city of Yaoundé. …”
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40196
Achieving reliable patient reported outcomes collection to measure health care improvement in a learning health network: lessons from pediatric rheumatology care and outcomes impro...
Published 2025-01-01“…Interviews of physician leaders of high performing sites were conducted by videoconference, audiotranscribed and themes were summarized. …”
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40197
Status of cerebrovascular autoregulation relates to outcome in severe paediatric head injury: STARSHIP, a prospective multicentre validation studyResearch in context
Published 2025-03-01“…Methods: Studying Trends of AutoRegulation in Severe Head Injury in Paediatrics (STARSHIP) (clinicalTrials.gov identifier-NCT0688462), was a prospective, multicentre, observational, research database study conducted across 10 identified UK Paediatric Intensive Care Units from 01.07.2018 till 31.04.2024. …”
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40198
Antifungal activity and mechanism of Phoebe bournei wood essential oil against two dermatophytes
Published 2025-02-01“…Physiological experiment of M. gypseum showed significant differences in protein extravasation, extracellular conductivity and intracellular MDA content after three hours of treatment with 0.450 mg/mL PWEO compared with the control. …”
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40199
Effect of SY009, a novel SGLT1 inhibitor, on the plasma metabolome and bile acids in patients with type 2 diabetes mellitus
Published 2025-01-01“…However, the effects of SY-009 on human plasma metabolomics are still unknown.ObjectiveThis study aimed to explore the effects of SY-009 on plasma metabolomics in patients with T2DM and the potential metabolic regulatory mechanism involved.Study designIn the phase Ib study, a total of 50 participants with T2DM were enrolled and randomly assigned to the 0.5 mg BID, 1 mg BID, 2 mg BID, 1 mg QD, and 2 mg QD dose groups, with a 4:1 random allocation within each group to receive either the SY-009 capsule or placebo. We conducted untargeted and targeted metabolomics analyses on plasma samples from the phase Ib clinical study.ResultsUntargeted metabolomics revealed that, after SY009 treatment, there were differences in metabolic pathways, including primary bile acid biosynthesis; biosynthesis of unsaturated fatty acid; steroid hormone biosynthesis; purine metabolism; phenylalanine, tyrosine and tryptophan biosynthesis. …”
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40200
Association between joint exposure to ambient air pollutants and carotid plaque: The mediating role of cardiometabolic risk factors
Published 2025-01-01“…A modified Poisson regression model was conducted to investigate the relationship between exposure to air pollution and carotid plaque occurrence. …”
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