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  1. 40141

    Lipids as key biomarkers in unravelling the pathophysiology of obesity-related metabolic dysregulation by Anis Adibah Osman, Siok-Fong Chin, Lay-Kek Teh, Noraidatulakma Abdullah, Nor Azian Abdul Murad, Rahman Jamal

    Published 2025-02-01
    “…Validation of potential metabolites was conducted by assessing their presence through collision-induced dissociation (CID) using a targeted tandem MS approach. …”
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  2. 40142

    Knowledge, attitudes and practices of healthcare workers towards COVID-19 in three states of Nigeria in 2022 by Alash’le Abimiku, Nifarta Andrew, Elima Jedy-Agba, Rita Okonkwo, Olumide Okunoye, Oyewole Oyedele, Martin Edun, Ugochi Ezenwelu, Asmau Aminu-Alhaji, Aondoakura Kombu, Timothy Attah, Jibreel Jumare, Kenneth Enwerem, Sophia Osawe, Victor Ejeh, Michaela Udioh, Okame Okah-Avae, Elonna Obak, Olusola Anuoluwapo Akanbi, Mary Okoli, Nnaemeka C Iriemenam, McPaul Okoye

    Published 2025-01-01
    “…This study assessed KAP towards COVID-19 among HCWs (laboratorians, doctors, nurses and pharmacists) in Nigeria from August to December 2022.Method A facility-based cross-sectional study was conducted on 1341 HCWs (laboratorians, doctors, nurses and pharmacists) in 7 healthcare facilities across 3 states in Nigeria. …”
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  3. 40143

    Orbital cycle records in shallow unconsolidated sediments: implications for global carbon cycle and hydrate system evolution in deep-sea area sediments of the Qiongdongnan Basin by Yang Dong, Yang Dong, Ren Wang, Ren Wang, Jinqiang Liang, Yulin He, Jinfeng Ren, Wanzhong Shi, Wanzhong Shi, Xiaosong Wei, Xiaosong Wei, Hao Du, Hao Du, Xiangyang Xie, Arthur B. Busbey

    Published 2025-01-01
    “…Cyclostratigraphic analysis of the Quaternary unconsolidated sediments can help identify climate and sea level changes that correspond to orbital cycles and improve our understanding of the dynamic evolution of hydrates.MethodsUsing the natural gamma-ray log data from the deepwater area well W01 in the Qiongdongnan Basin, Milankovitch cycle analysis was conducted to identify the primary astronomical period in W01. …”
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  4. 40144

    Levels, Chemical Compositions, and Sources of PM2.5 of Rural and Urban Area under the Impact of Wheat Harvest by Zhiyong Li, Ziyuan Yue, Dingyuan Yang, Lei Wang, Xin Wang, Zhenxin Li, Yutong Wang, Lan Chen, Songtao Guo, Jinsong Yao, Xiao Lou, Xiaolin Xu, Jinye Wei

    Published 2021-04-01
    “…Abstract Wheat harvesting significantly alters the characteristics of PM2.5 in both rural regions and the adjacent urban areas. We conducted a systematic PM2.5 sampling campaign at two sites, one rural (ARS) and the other urban (UA), in the center of the Beijing-Tianjin-Hebei megalopolis during and after the wheat harvest (WH). …”
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  5. 40145

    Exploring the allometry between ear saturated water accumulation and dry mass for diagnosing winter wheat water status during the reproductive growth by Tingxuan Zhuang, Ben Zhao, Syed Tahir Ata-Ul-Karim, Gilles Lemaire, Xiaojun Liu, Yongchao Tian, Yan Zhu, Weixing Cao, Qiang Cao

    Published 2025-03-01
    “…Field experiments involving four water and two nitrogen treatments were conducted from 2019 to 2023 to determine the relationship between ear dry mass (EDM) and SWAE during the reproductive growth phase of winter wheat. …”
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  6. 40146
  7. 40147

    Fermented Cassava Residue Meal Improves Meat Quality by Regulating Muscle Fiber and Enhancing Lipid Metabolism in Huanjiang Mini-Pigs by Huijiao Jiang, Md. Abul Kalam Azad, Qian Zhu, Hengjia Ni, Xiangfeng Kong

    Published 2025-01-01
    “…The feeding trial was conducted for 30 days. The findings revealed that dietary CRM and FCRM did not influence the growth performance and diarrhea rate of Huanjiang mini-pigs (<i>p</i> > 0.05). …”
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  8. 40148
  9. 40149

    Identification of key miRNAs and target genes in extracellular vesicles derived from low-intensity pulsed ultrasound-treated stem cells by Xin Yin, Xin Yin, Jialian Yi, Fugang Mao, Qisheng Tang, Xinyu Zhang, Xiaoyu Yang, Hongqing Xie, Linping Wang, Shuifen Sun, Xin Yu, Xin Yu, Jie Liu, Lihong Jiang, Lihong Jiang

    Published 2025-01-01
    “…MiRNA-mRNA target analysis, functional and pathway enrichment analysis, protein-protein interaction network construction, and hub gene identification were conducted. Validation of differentially expressed miRNAs was performed via RT-qPCR in human umbilical cord mesenchymal stem cells (hUC-MSCs) treated with LIPUS.ResultsTen differentially expressed miRNAs were identified, with six upregulated and four downregulated miRNAs in LIPUS-treated stem cell-derived EVs. …”
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  10. 40150

    Effectiveness of using implementation frameworks to facilitate the implementation of a stroke management guideline in the traditional Chinese medicine hospitals in China: protocol... by Zhuo Chen, Yefeng Cai, Wenjun He, Yiyuan Cai, Lingrui Liu, Qing Zhao, Sensen lv, Dong (Roman) Xu, Chun Hao, Lanping Zhang, Pengfei Guo, Yuning Shi

    Published 2025-01-01
    “…Additionally, a cost-effectiveness analysis will be conducted to assess the economic feasibility of the implementation strategies.Ethics and dissemination This trial has been approved by the Institutional Review Board of Southern Medical University (approval number: #202261) and follows all relevant ethical guidelines for research involving human participants. …”
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  11. 40151

    Investigating the neuroprotective effects of Dracocephalum moldavica extract and its effect on metabolomic profile of rat model of sporadic Alzheimer's disease by Marjan Talebi, Seyed Abdulmajid Ayatollahi, Mohammad Ali As’Habi, Farzad Kobarfard, Mona Khoramjouy, Farzaneh Niki Boroujeni, Mehrdad Faizi, Alireza Ghassempour

    Published 2025-02-01
    “…The histopathological evaluations were conducted in the cortex and hippocampus regions. Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) was used to assess metabolite changes in various brain regions. …”
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  12. 40152

    A concept of natural genome reconstruction. Part 2. Effect of extracellular double-stranded DNA fragments on hematopoietic stem cells by V. S. Ruzanova, S. G. Oshikhmina, A. S. Proskurina, G. S. Ritter, S. S. Kirikovich, E. V. Levites, Y. R. Efremov, T. V. Karamysheva, M. I. Meschaninova, A. L. Mamaev, O. S. Taranov, A. S. Bogachev, S. V. Sidorov, S. D. Nikonov, O. Y. Leplina, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, E. V. Dolgova, S. S. Bogachev

    Published 2025-01-01
    “…The bioinformatic analysis conducted indicates that the main surface marker proteins of hematopoietic stem cells belong to the indicated groups of factors and contain specific DNA binding sites, including a heparin-binding domain and clusters of positively charged amino acid residues. …”
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  13. 40153

    The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling by Fangzhen Xia, Ziteng Zhang, Zhen Qian, Xiaoyu Fang, Junxue Wang, Yan Wang, Guoting Sun, Yuefeng Yu, Ninjian Wang, Junke Zhen, Yan Liu, Yingli Lu

    Published 2025-01-01
    “…AAV2/8-ins2-B7H4 and a control virus were infused via the pancreatic intraduct into high-fat diet (HFD)-treated mice to elucidate the therapeutic effect of B7-H4. RNA sequencing was conducted on primary islets. A Luminex assay was used to quantify cytokine changes in B7-H4 cKO mice. …”
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  14. 40154
  15. 40155

    Evaluating the World Health Organization’s Hearts Model for Hypertension and Diabetes Management: A Pilot Implementation Study in Guatemala by Irmgardt Alicia Wellmann, Luis Fernando Ayala, Taryn M. Valley, Vilma Irazola, Mark D. Huffman, Michele Heisler, Peter Rohloff, Rocío Donis, Eduardo Palacios, Manuel Ramírez-Zea, David Flood

    Published 2025-01-01
    “…The study’s objective is to report outcomes from a pilot implementation trial of integrated hypertension and diabetes management based on the HEARTS model in Guatemala. Methods: We conducted a single-arm pilot implementation trial over six months from October 2023 to May 2024 in 11 Guatemalan Ministry of Health primary care facilities in two districts. …”
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  16. 40156

    Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis by Flavia Ignuta, Adrian Vlad, Teodor Cerbulescu, Stana Loredana, Felix Bratosin, Ovidiu Rosca, Lavinia Stelea, Daciana Nistor

    Published 2025-01-01
    “…This study aimed to evaluate the inflammatory status and clinical outcomes of patients hospitalized with COVID-19, with and without <i>C. difficile</i> co-infection, and to identify the inflammatory markers most predictive of severe disease. Methods: We conducted a retrospective cohort study of 200 hospitalized adults with confirmed COVID-19, of whom 92 had laboratory-confirmed <i>C. difficile</i> infection. …”
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  17. 40157
  18. 40158

    Functional near-infrared spectroscopy for the assessment and treatment of patients with disorders of consciousness by Nan Wang, Nan Wang, Nan Wang, Yifang He, Sipeng Zhu, Dongsheng Liu, Xiaoke Chai, Xiaoke Chai, Qiheng He, Tianqing Cao, Jianghong He, Jingqi Li, Juanning Si, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Jizong Zhao, Jizong Zhao

    Published 2025-02-01
    “…Specifically, it investigates the potential value of combining fNIRS with brain-computer interfaces (BCIs) and closed-loop neuromodulation systems for patients with DoC, aiming to elucidate mechanisms that promote neurological recovery.MethodsA systematic analysis was conducted on 155 studies published between January 1993 and October 2024, retrieved from the Web of Science Core Collection database.ResultsAnalysis of 21 eligible studies on neurological diseases involving 262 DoC patients revealed significant findings. …”
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  19. 40159

    Comprehensive genomic and transcriptomic profiling of pulmonary nodules in synchronous multiple primary lung cancer by Xingsheng Liu, Kun Qian, Lei Su, Xiaoru Tian, Xin Zhao, Tengteng Wang, Li Han, Zhenzhen Li, Peilong Zhang, Ruotian Wang, Baodong Liu, Yuanbo Li, Xiaogang Tan, Yi Zhang

    Published 2025-02-01
    “…Methods We performed targeted DNA sequencing on tumor specimens and conducted bulk RNA transcriptome analysis on 53 multiple nodules originating from 26 lung cancer patients. …”
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  20. 40160

    Cognitive impairment in a primary healthcare population: a cross-sectional study on the island of Crete, Greece by Panagiotis Simos, Simeon Panagiotakis, Joanna Moschandreas, Dimitrios Boumpas, Antonios Konstantinos Bertsias, Ioanna Tsiligianni, Sophia Papadakis, Ioannis Zaganas, George Duijker, Emmanouil K Symvoulakis, Polyvios Papadokostakis, Kornilia Makri, Eliza Iatraki, Chariklia Tziraki, Maria Basta, Alexandros Vgontzas, Christos Lionis

    Published 2020-09-01
    “…The objective of this study is to assess the extent of cognitive impairment among elders visiting primary healthcare (PHC) practice settings, to explore associated risk factors and discuss current care challenges for PHC providers.Design A cross-sectional study was conducted between March 2013 and May 2014.Setting Fourteen PHC units located in rural and urban areas of the Heraklion district in Crete, Greece.Participants Consecutive visitors aged at least 60 years attending selected PHC practices.Primary and secondary outcome measures The Mini-Mental State Examination (MMSE) was used to indicate cognitive status. …”
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