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40141
Lipids as key biomarkers in unravelling the pathophysiology of obesity-related metabolic dysregulation
Published 2025-02-01“…Validation of potential metabolites was conducted by assessing their presence through collision-induced dissociation (CID) using a targeted tandem MS approach. …”
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40142
Knowledge, attitudes and practices of healthcare workers towards COVID-19 in three states of Nigeria in 2022
Published 2025-01-01“…This study assessed KAP towards COVID-19 among HCWs (laboratorians, doctors, nurses and pharmacists) in Nigeria from August to December 2022.Method A facility-based cross-sectional study was conducted on 1341 HCWs (laboratorians, doctors, nurses and pharmacists) in 7 healthcare facilities across 3 states in Nigeria. …”
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40143
Orbital cycle records in shallow unconsolidated sediments: implications for global carbon cycle and hydrate system evolution in deep-sea area sediments of the Qiongdongnan Basin
Published 2025-01-01“…Cyclostratigraphic analysis of the Quaternary unconsolidated sediments can help identify climate and sea level changes that correspond to orbital cycles and improve our understanding of the dynamic evolution of hydrates.MethodsUsing the natural gamma-ray log data from the deepwater area well W01 in the Qiongdongnan Basin, Milankovitch cycle analysis was conducted to identify the primary astronomical period in W01. …”
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40144
Levels, Chemical Compositions, and Sources of PM2.5 of Rural and Urban Area under the Impact of Wheat Harvest
Published 2021-04-01“…Abstract Wheat harvesting significantly alters the characteristics of PM2.5 in both rural regions and the adjacent urban areas. We conducted a systematic PM2.5 sampling campaign at two sites, one rural (ARS) and the other urban (UA), in the center of the Beijing-Tianjin-Hebei megalopolis during and after the wheat harvest (WH). …”
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40145
Exploring the allometry between ear saturated water accumulation and dry mass for diagnosing winter wheat water status during the reproductive growth
Published 2025-03-01“…Field experiments involving four water and two nitrogen treatments were conducted from 2019 to 2023 to determine the relationship between ear dry mass (EDM) and SWAE during the reproductive growth phase of winter wheat. …”
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40146
A qualitative process evaluation of SBIRT implementation in pediatric trauma centers using the Science to Service Laboratory implementation strategy
Published 2025-01-01“…Results Thirty-six exit interviews were conducted with site leaders, social workers, and nurses across the 10 IAMSBIRT pediatric trauma centers. …”
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40147
Fermented Cassava Residue Meal Improves Meat Quality by Regulating Muscle Fiber and Enhancing Lipid Metabolism in Huanjiang Mini-Pigs
Published 2025-01-01“…The feeding trial was conducted for 30 days. The findings revealed that dietary CRM and FCRM did not influence the growth performance and diarrhea rate of Huanjiang mini-pigs (<i>p</i> > 0.05). …”
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40148
Estudio psicométrico del cuestionario de intenciones emprendedoras en jóvenes mexicanos - Psychometric study of the entrepreneurial intentions questionnaire in Mexican youth
Published 2025-01-01“…Exploratory (EFA) and confirmatory factor analyses (CFA) were conducted to assess the scale’s structure and validity. …”
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40149
Identification of key miRNAs and target genes in extracellular vesicles derived from low-intensity pulsed ultrasound-treated stem cells
Published 2025-01-01“…MiRNA-mRNA target analysis, functional and pathway enrichment analysis, protein-protein interaction network construction, and hub gene identification were conducted. Validation of differentially expressed miRNAs was performed via RT-qPCR in human umbilical cord mesenchymal stem cells (hUC-MSCs) treated with LIPUS.ResultsTen differentially expressed miRNAs were identified, with six upregulated and four downregulated miRNAs in LIPUS-treated stem cell-derived EVs. …”
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40150
Effectiveness of using implementation frameworks to facilitate the implementation of a stroke management guideline in the traditional Chinese medicine hospitals in China: protocol...
Published 2025-01-01“…Additionally, a cost-effectiveness analysis will be conducted to assess the economic feasibility of the implementation strategies.Ethics and dissemination This trial has been approved by the Institutional Review Board of Southern Medical University (approval number: #202261) and follows all relevant ethical guidelines for research involving human participants. …”
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40151
Investigating the neuroprotective effects of Dracocephalum moldavica extract and its effect on metabolomic profile of rat model of sporadic Alzheimer's disease
Published 2025-02-01“…The histopathological evaluations were conducted in the cortex and hippocampus regions. Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) was used to assess metabolite changes in various brain regions. …”
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40152
A concept of natural genome reconstruction. Part 2. Effect of extracellular double-stranded DNA fragments on hematopoietic stem cells
Published 2025-01-01“…The bioinformatic analysis conducted indicates that the main surface marker proteins of hematopoietic stem cells belong to the indicated groups of factors and contain specific DNA binding sites, including a heparin-binding domain and clusters of positively charged amino acid residues. …”
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40153
The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling
Published 2025-01-01“…AAV2/8-ins2-B7H4 and a control virus were infused via the pancreatic intraduct into high-fat diet (HFD)-treated mice to elucidate the therapeutic effect of B7-H4. RNA sequencing was conducted on primary islets. A Luminex assay was used to quantify cytokine changes in B7-H4 cKO mice. …”
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40154
PD-L1 and IFN-γ modulate Non-Small Cell Lung Cancer (NSCLC) cell plasticity associated to immune checkpoint inhibitor (ICI)-mediated hyperprogressive disease (HPD)
Published 2025-01-01“…In vitro investigations, including the evaluation of cell sensitivity to interferon-gamma (IFN-γ) and cell response to PD-L1 modulation, were conducted to explore the influence of these factors on cell plasticity regulation. …”
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40155
Evaluating the World Health Organization’s Hearts Model for Hypertension and Diabetes Management: A Pilot Implementation Study in Guatemala
Published 2025-01-01“…The study’s objective is to report outcomes from a pilot implementation trial of integrated hypertension and diabetes management based on the HEARTS model in Guatemala. Methods: We conducted a single-arm pilot implementation trial over six months from October 2023 to May 2024 in 11 Guatemalan Ministry of Health primary care facilities in two districts. …”
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40156
Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis
Published 2025-01-01“…This study aimed to evaluate the inflammatory status and clinical outcomes of patients hospitalized with COVID-19, with and without <i>C. difficile</i> co-infection, and to identify the inflammatory markers most predictive of severe disease. Methods: We conducted a retrospective cohort study of 200 hospitalized adults with confirmed COVID-19, of whom 92 had laboratory-confirmed <i>C. difficile</i> infection. …”
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40157
Viral Hepatitis B and Its Implications for Public Health in DR Congo: A Systematic Review
Published 2024-12-01“…<b>Methods:</b> A systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) group guidelines. …”
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40158
Functional near-infrared spectroscopy for the assessment and treatment of patients with disorders of consciousness
Published 2025-02-01“…Specifically, it investigates the potential value of combining fNIRS with brain-computer interfaces (BCIs) and closed-loop neuromodulation systems for patients with DoC, aiming to elucidate mechanisms that promote neurological recovery.MethodsA systematic analysis was conducted on 155 studies published between January 1993 and October 2024, retrieved from the Web of Science Core Collection database.ResultsAnalysis of 21 eligible studies on neurological diseases involving 262 DoC patients revealed significant findings. …”
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40159
Comprehensive genomic and transcriptomic profiling of pulmonary nodules in synchronous multiple primary lung cancer
Published 2025-02-01“…Methods We performed targeted DNA sequencing on tumor specimens and conducted bulk RNA transcriptome analysis on 53 multiple nodules originating from 26 lung cancer patients. …”
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40160
Cognitive impairment in a primary healthcare population: a cross-sectional study on the island of Crete, Greece
Published 2020-09-01“…The objective of this study is to assess the extent of cognitive impairment among elders visiting primary healthcare (PHC) practice settings, to explore associated risk factors and discuss current care challenges for PHC providers.Design A cross-sectional study was conducted between March 2013 and May 2014.Setting Fourteen PHC units located in rural and urban areas of the Heraklion district in Crete, Greece.Participants Consecutive visitors aged at least 60 years attending selected PHC practices.Primary and secondary outcome measures The Mini-Mental State Examination (MMSE) was used to indicate cognitive status. …”
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