A randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome by Kathleen Campbell, Jeffrey L. Neul, David N. Lieberman, Elizabeth Berry-Kravis, Tim A. Benke, Cary Fu, Alan Percy, Bernhard Suter, David Morris, Randall L. Carpenter, Eric D. Marsh, Jana von Hehn

“…Abstract Background Preclinical studies and anecdotal case reports support the potential therapeutic benefit of low-dose oral ketamine as a treatment of clinical symptoms in Rett syndrome (RTT); however, no controlled studies have been conducted in RTT to evaluate safety, tolerability and efficacy. …”
Get full text

Identification and validation of the important role of KIF11 in the development and progression of endometrial cancer by Biying Wang, Lunmin Bao, Xiaoduo Li, Guang Sun, Wu Yang, Nanzi Xie, Ling Lei, Wei Chen, Hailong Zhang, Man Chen, Xing Zhao, Xiufang Wan, Rui Yuan, Hongmei Jiang

“…Functional enrichment analysis of the DEGs was conducted using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. …”
Get full text

Emotion recognition deficits in children and adolescents with autism spectrum disorder: a comprehensive meta-analysis of accuracy and response time by Maryam Masoomi, Mahdieh Saeidi, Rommy Cedeno, Rommy Cedeno, Zahra Shahrivar, Mehdi Tehrani-Doost, Zerimar Ramirez, Divya Aishwarya Gandi, Sasidhar Gunturu, Sasidhar Gunturu

“…This meta-analysis evaluates emotion recognition accuracy and response time in individuals with autism spectrum disorder compared to neurotypical individuals and those with other neurodevelopmental disorders.MethodsThis systematic review with a meta-analysis was conducted following PRISMA guidelines. A comprehensive literature search across PubMed, Scopus, Cochrane Library, and Web of Science identified 13 studies published between 2006 and 2024. …”
Get full text

Growth performance of 7-g Anguilla bicolor bicolor at different density by Eko Harianto, Tatag Budiardi, Agus Oman Sudrajat

“…ABSTRACT   This research was conducted to evaluate the performance of eel production at stocking density of 2 g/L, 3 g/L, and 4 g/L reared in recirculating system for 60 days. …”
Get full text

Programmed Cell Death Ligand 1 (PD-L1) and major Histocompatibility Complex Class I (MHC Class I) Expression Patterns and Their Pathologic Associations in triple-Negative Breast Ca... by Kaewkedsri P, Intarawichian P, Jessadapattarakul S, Kunprom W, Koonmee S, Thanee M, Somintara O, Wongbuddha A, Chadbunchachai P, Nawapun S, Aphivatanasiri C

“…Ponkrit Kaewkedsri,1 Piyapharom Intarawichian,1 Sirawich Jessadapattarakul,1 Waritta Kunprom,1 Supinda Koonmee,1 Malinee Thanee,1 Ongart Somintara,2 Anongporn Wongbuddha,2 Payia Chadbunchachai,3 Supajit Nawapun,3 Chaiwat Aphivatanasiri1 1Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 2Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 3Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCorrespondence: Chaiwat Aphivatanasiri, Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, Email chaiap@kku.ac.thPurpose: This study aims to investigate the clinicopathological characteristics of triple-negative breast cancer (TNBC) in relation to programmed cell death ligand 1 (PD-L1) and major histocompatibility complex class I (MHC class I) expression, with a focus on their prognostic significance.Patients and Methods: A retrospective analysis was conducted on formalin-fixed paraffin-embedded (FFPE) tissue samples from 148 TNBC patients diagnosed between 2008 and 2021. …”
Get full text

Linking winter wheat (Triticum aestivum L) root traits and root water uptake with electrical resistivity tomography by Huijie Gu, Yanzhe Wang, Luca Peruzzo, Baoru Li, Yang Lu, Xiuwei Liu

“…Pot experiments revealed strong positive correlations between root surface area and soil ER (R2 = 0.78, P < 0.001), suggesting that the increase in soil ER due to root absorption greatly outweighs the reduction caused by the roots themselves. Field experiments conducted during the grain-filling phase, when root size was stable, showed significant differences in soil ER changes (defined as the difference between two consecutive ER measurements) among winter wheat cultivars in both shallow (0–40 cm) and deep (40–100 cm) soil layers under various irrigation treatments. …”
Get full text

Famine Exposure in Early Life and Risk of Metabolic Syndrome in Adulthood: Comparisons of Different Metabolic Syndrome Definitions by Feng Ning, Jie Ren, Xin Song, Dong Zhang, Li Liu, Lei Zhang, Jianping Sun, Dongfeng Zhang, Zengchang Pang, Qing Qiao, on behalf of Qingdao Diabetes Prevention Program

“…Two cross-sectional surveys involving randomly selected Chinese adults aged 35–74 years in the Qingdao area were conducted. A total of 9,588 individuals were grouped into four birth cohorts of unexposed (born between January 1, 1962, and December 31, 1975), fetal-exposed (born between January 1, 1959, and December 31, 1961), childhood-exposed (born between January 1, 1949, and December 31, 1958), and adolescence/adult-exposed cohorts (born between January 1, 1931, and December 31, 1948). …”
Get full text

Enhanced Biomechanical Stability in Proximal Humeral Fractures: Finite Element Analysis of a Novel Endosteal Anatomical Support Nail for Improved Fixation in Elderly Patients by Jiawen Chen, Zhonghe Wang, Changda Li, Peiyu He, Zhongxuan Chen, Lijun Sun, Xiaoyan Cao, Na Tian, Xiang Dong, Peifu Tang, Hua Chen

“…The endosteal torus construct includes endosteal anatomical support (EAS) with a flat plane that allows direct fixation of the humeral head fragments and is shaped to conform to the medial side of the medullary cavity of the proximal humerus. We conducted finite element analysis to assess the biomechanical stability of four constructs: EAS with a calcar screw (CS), EAS without CS, non‐EAS with CS, and non‐EAS without CS. …”
Get full text

Factors Influencing the Development of Metachronous Fractures in Patients with Osteoporotic Vertebral Fractures Treated with Conservative Management or Vertebroplasty by Fernando Ruiz Santiago, Lucía Bueno Caravaca, Francisco Garrido Sanz, Paula María Jiménez Gutiérrez, David Luengo Gómez, Mario Rivera Izquierdo, José Manuel Benítez, Antonio Jesús Láinez Ramos-Bossini

“…<b>Objectives:</b> We aimed to analyze potential predictors for the development of metachronous fractures (MFs) after osteoporotic vertebral fractures (OVFs), with particular focus on radiological variables obtained at initial X-rays and computed tomography (CT) examinations, treatment applied (conservative management [CM] versus percutaneous vertebroplasty [PV]), and fractures located at the thoracolumbar junction (T11-L2). <b>Methods:</b> We conducted a two-center, observational retrospective study, including patients with single-level OVFs treated with CM or VP. …”
Get full text

Faktor-Faktor yang Berhubungan dengan Kejadian Pre Eklampsi pada Kehamilan di RSUD Embung Fatimah Kota Batam Tahun 2012 by Dessy Hasmawati

“…This study aims to determine the factors that relate among pregnant women with pre-eclampsia incidence in Batam City Hospital Fatimah Embung 2012 that include maternal age, gestational age, parity, and comorbidities.This type of research uses quantitative analytic research with cross sectional approach. The research was conducted in April 2013. The population is pregnant women who visit the hospital Embung Patimah Batam, sampling a total sampling that all pregnant women with pre-eclampsia as many as 173 people and pregnant women who did not have pre eclampsia as many as 173 people. …”
Get full text

Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy by Jian Cheng, Miaomiao Sun, Xiao Dong, Yang Yang, Xiaohan Qin, Xing Zhou, Yongcheng Fu, Yuanyuan Wang, Jingyue Wang, Da Zhang

“…Differential expression, Kaplan–Meier survival analysis, gene set enrichment analysis, and weighted correlation network analysis were conducted. Functional validation included qPCR, immunohistochemistry, Western blotting, and cell proliferation assays using the SLC1A5 inhibitor V-9302. …”
Get full text

Tea Stem as a Sorbent for Removal of Methylene Blue from Aqueous Phase by Tzan-Chain Lee, Shumao Wang, Zonggui Huang, Zhongxing Mo, Gangxing Wang, Zhuanrong Wu, Chengshun Liu, Hua Han, Tzu-Hsing Ko

“…A series of operating factors, including the initial MB concentration, contact time, pH of solution, dose of tea stem, and ionic strength of solution, were conducted to understand the effect of adsorption of MB onto tea stem. …”
Get full text

Assessment of Chaves Low-Temperature CO2-Rich Geothermal System (N-Portugal) Using an Interdisciplinary Geosciences Approach by J. M. Marques, P. M. Carreira, L. A. Aires-Barros, F. A. Monteiro Santos, M. Antunes da Silva, P. Represas

“…., resistivity and AMT soundings) detected conductive zones concentrated in the central part of the Chaves graben as a result of temperature combined with the salinity of the Chaves low-temperature CO2-rich geothermal waters in fractured and permeable rock formations. …”
Get full text

Magnitude of opportunistic infections and associated factors among HIV-infected individuals attending care and treatment clinics in Dar es Salaam, Tanzania: a hospital-based cross-... by Agricola Joachim, Doreen Kamori, Mtebe Majigo, Doris Andrew Njelekela, Rogath Kishimba, Mololo Noah

“…Objectives This study aims to assess the magnitude of opportunistic infection (OI) and to identify factors associated with OIs among people living with HIV (PLHIV) on antiretroviral treatment (ART), attending HIV care and treatment clinics.Design A hospital-based cross-sectional study.Setting The study was conducted at Muhimbili National Hospital, Mwananyamala and Temeke Regional Referral Hospitals, in Dar es Salaam, Tanzania.Participants We enrolled 382 PLHIV on ART who were attending HIV care and treatment clinics in Dar es Salaam. …”
Get full text

Selection of nitrification and denitrification bacteria with its application in culture medium of Pacific white shrimp (Litopenaeus vannamei) by . Widanarni, Sugiyo Hadi Pranoto, . Sukenda

“… The aim of this study was to obtain nitrification and denitrification bacteria and tested its activity in reducing the ammonia, nitrite and nitrate compounds in culture medium of Pacific white shrimp Litopenaeusvannamei. The research was conducted through several steps: 1) Isolation of nitrification and denitrification bacteria from ponds and mangrove areas, 2) Selection of nitrification and denitrification bacteria  in vitro, and 3) test of the nitrication and denitrification bacteria activities in culture medium of white shrimp. …”
Get full text

Facilitators and barriers to reach and enrollment into a medically tailored meals program within a section 1115 Medicaid pilot: clinic staff perspectives by Sara C. Folta, Jessica Burch, Matthew Alcusky, Arlene S. Ash, Kurt Hager, Jean Terranova, Fang Fang Zhang, Oyedolapo Anyanwu, Zhongyu Li, Dariush Mozaffarian

“…Little is known from the practitioners’ perspective regarding the facilitators and barriers to reaching and enrolling patients in MTM programs.MethodsWe interviewed 19 staff across four ACOs that had implemented MTM interventions. Interviews were conducted from Feb to Aug 2023 and included staff who participated in patient screening, referral, or enrollment. …”
Get full text

Hubungan Konsumsi Antioksidan dari Makanan dengan Beta-Amyloid Plasma sebagai Penanda Gangguan Fungsi Kognitif pada Lanjut Usia by Ratna D Siregar, Nur Indrawati Lipoeto, Yuliarni Syafrita

“…This was a cross-sectional study that was conducted to 145 elderly with age ≥ 60 years, in two districts in West Sumatra, in Lima Puluh Kota city. …”
Get full text

Job burnout and resilience among palliative care professionals in china: a qualitative study by Fang Tan, Yan Wu, Na Li, Chuan Zhang, Shan Chen, Lan Huang, Yang Chen, Jianjun Jiang, Qian Deng

“…Objective We aimed to explore the factors influencing job burnout and resilience among palliative care professionals. Methods We conducted a qualitative study using semistructured interviews and purposeful sampling methods. …”
Get full text

Strategies for Customer Relationship Management Focused on Loyalty by J. Vasco, C. Guerra, F. Favicela, X. Granizo

“… This research examined the customer loyalty process through relational marketing, using Customer Relationship Management (CRM) strategies. A market study was conducted to analyze the current client management approaches. …”
Get full text

Physiological and productivity responses of Tahiti acid lime grafted onto dwarfing rootstocks under different planting and mulching practices by Ana Júlia Borim de Souza, Mariângela Cristofani-Yaly, Patrícia Marluci da Conceição, Fernando Trevizan Devite, Marinês Bastianel, Paulo Vitor Sanches Romero, Pedro Henrique Barrio Padilha, Fernando Alves de Azevedo

“…This experiment was conducted at the “Sylvio Moreira” Citrus Center, Brazil; the experiment focused on different planting and mulching practices and scion-rootstock combinations. …”
Get full text