Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia by Shuwen Zheng, Yingying Wang, Chuxuan Ni, Rui Guo, Xunan Qiu, Jijun Chen, Lu Wang, Xiaohu Sun, Moye Chen, Yunen Liu, Yuan Yuan, Yuehua Gong

“…Immunohistochemistry staining was conducted to validate hnRNPK, TPT1, OCT1, and CDX2 expression in gastric tissue samples from both human and Mongolian gerbils. …”
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Utilization of primary tumor samples for cancer neoantigen discovery by Yong Li, Steven A Rosenberg, Paul Robbins, Billel Gasmi, Todd D Prickett, Jared J Gartner, Devikala Gurusamy, Stephanie L Goff, Vid Leko, Victoria Hill, Frank J Lowery, Bradley Sinclair White, Sivasish Sindiri, Maria Parkhust, Noam Levin, Eric Groh, Shoshana T Levi, Amy R Copeland, Sanghyun Peter Kim

“…Our study explored the feasibility of using archived formalin-fixed, paraffin-embedded (FFPE) primary tumor samples for cancer neoantigen discovery, to potentially expedite this process and reduce the need for resections normally required for tumor sequencing.Method Whole-exome sequencing was conducted on matched primary and metastatic colorectal cancer samples from 22 patients. …”
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A decade of treating traumatic sternal fractures in a single-center experience in Korea: a retrospective cohort study by Na Hyeon Lee, Seon Hee Kim, Jae Hun Kim, Ho Hyun Kim, Sang Bong Lee, Chan Ik Park, Gil Hwan Kim, Dong Yeon Ryu, Sun Hyun Kim

“…Methods A retrospective cohort study was conducted of patients admitted to a regional trauma center between January 2012 and December 2021. …”
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Identification of common and specific fibrosis-related genes in three common chronic kidney diseases by Zhangning Fu, Xiaodong Geng, Chao Liu, Wanjun Shen, Zheyi Dong, Guannan Sun, Guangyan Cai, Xiangmei Chen, Quan Hong

“…Comparative gene expression analysis among these types of CKD may shed light on its pathogenesis. Therefore, we conducted this study aiming at exploring the common and specific fibrosis-related genes involved in different types of CKD.Methods Kidney biopsy specimens from patients with different types of CKD and normal control subjects were analyzed using the NanoString nCounter® Human Fibrosis V2 Panel. …”
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Seroprevalence of dengue, Zika, and chikungunya in São Sebastião, Brazil (2020–2021): a population-based survey by Tayane Nobre, Andre Luiz Dutra Fenner, Emerson Luiz Lima Araújo, Wildo Navegantes de Araújo, Emmanuel Roux, Pascal Handschumacher, Helen Gurgel, Bruno Dallago, Mariana Hecht, Luciana Hagström, Walter Massa Ramalho, Nadjar Nitz

“…Methods A cross-sectional study was conducted involving 1,535 households. ELISA serological tests were performed to detect IgM and IgG antibodies against dengue, Zika virus, and chikungunya. …”
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Evaluation of musculoskeletal complaints, treatment approaches, and patient perceptions in family medicine clinics in a tertiary center in Jordan: a cross-sectional study by Moh’d S. Dawod, Mohammad N. Alswerki, Ahmad F. Alelaumi, Jehad Feras AlSamhori, Rana J. Rahhal, Lina Khraisat, Eman Mohammad Arabas, Hussein M. Bdair, Reem M. Alhyari, Mohammad Shahin, Mohammad Abu Hilal, Alaa Y. Akel, Aws Khanfar

“…Ethical approval and informed consent were obtained. Analysis was conducted in SPSS with p < 0.05 as the significance threshold. …”
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Characterization and fungicides sensitivity of Colletotrichum species causing Hydrangea macrophylla anthracnose in Beijing, China by Juan Zhao, Juan Zhao, Yanli Cheng, Yanli Cheng, Yayong Liu, Yayong Liu, Xiaojing Shi, Taotao Zhang, Taotao Zhang, Wentao Qin, Wentao Qin

“…Among which, C. gloeosporioides was the most abundant (65 isolates, 57.0%), followed by C. fructicola (33 isolates, 28.9%), C. aenigma (8 isolates, 7.0%), C. truncatum (4 isolates, 3.5%), C. subacidae (2 isolates, 1.8%) and C. sojae (2 isolates, 1.8%). Pathogenicity test conducted on detached leaves of H. macrophylla revealed a distinct variation in virulence among isolates from different Colletotrichum species, and wounding was either essential or conducive to successful infection. …”
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Improving Air Quality and Childhood Respiratory Health in Mongolia: The Impact of the Raw Coal Ban and COVID-19 Restrictions—An Interrupted Time-Series Analysis by Emma Dickinson-Craig, Terkhen Turbat, Karla Hemming, Francis D. Pope, Suzanne E. Bartington, Suvdaa Anjaa, Sumiya Davaa, Rosie Day, Damdindorj Boldbaatar, Chimedsuren Ochir, David Warburton, Graham Neil Thomas, Jargalsaikhan Badarch, Semira Manaseki-Holland

“…Methods: An interrupted time-series analysis was conducted on air quality (PM_2.5, PM₁₀, SO₂, CO) and child (<5 y) severe acute respiratory disease, adjusting for coinciding co-events (COVID-19) where necessary. …”
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Functional and Anatomical Outcomes of Pars Plana Vitrectomy for Lamellar Macular Hole: Long-Term Follow-Up by Fabrizio Giansanti, Cristina Nicolosi, Giuseppe Ruben Barbera, Giulio Vicini, Flavia Lucarelli, Edoardo Traniello Gradassi, Vittoria Murro, Gianni Virgili, Daniela Bacherini

“…Methods: An interventional study on 14 patients (16 eyes) with LMH was conducted. The inclusion criteria included a minimum 36-month follow-up after PPV. …”
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Costs of community-wide mass drug administration and school-based deworming for soil-transmitted helminths: evidence from a randomised controlled trial in Benin, India and Malawi by Judd Walson, ROBIN BAILEY, Katya Galactionova, Maitreyi Sahu, Samuel Paul Gideon, Saravanakumar Puthupalayam Kaliappan, Chloe Morozoff, Sitara Swarna Rao Ajjampur, Khumbo Kalua, Euripide Avokpaho, Moudachirou Ibikounle, Arianna Rubin Means, James Simwanza, Wongani Lungu, Parfait Houngbegnon, Adrian J F Luty, Rachel Pullan

“…We compared the costs of cMDA to SBD to inform decision-making about future updates to STH policy.Design We conducted activity-based microcosting of cMDA and SBD for 2 years in Benin, India and Malawi within an ongoing cMDA trial.Setting Field sites and collaborating research institutions.Primary and secondary outcomes We calculated total financial and opportunity costs and costs per treatment administered (unit costs in 2019 USD ($)) from the service provider perspective, including costs related to community drug distributors and other volunteers.Results On average, cMDA unit costs were more expensive than SBD in India ($1.17 vs $0.72) and Malawi ($2.26 vs $1.69), and comparable in Benin ($2.45 vs $2.47). cMDA was more expensive than SBD in part because most costs (~60%) were ‘supportive costs’ needed to deliver treatment with high coverage, such as additional supervision and electronic data capture. …”
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Effects of dietary Spirulina platensis supplementation on growth performance, whole body composition, antioxidant activity, histological alterations, and resistance to Vibrio parah... by Ragaa A. Ahmed, Samyah D. Jastaniah, Bothaina A. Alaidaroos, Manal E. Shafi, Ehab El-Haroun, Yasmin M. Abd El-Aziz, Ola Hasan Abd El Megeed, Mada M. AL-Qurashi, Safia M.A. Bahshwan, Mohammad Bodrul Munir, Zulhisyam Abdul Kari, Roshmon Thomas Mathew, Moaheda E.H. Eissa, El-Sayed Hemdan Eissa, Amal Elfeky

“…In this context, an eight-week feeding experiment was conducted to investigate the potential effects of dietary S. platensis (SP) on feed utilization, growth performance, antioxidant activity, and muscle and hepatopancreatic histology of Litopenaeus vannamei challenged with Vibrio parahaemolyticus. …”
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Development of Primer Panels for Whole-Genome Amplification and Sequencing of Human Seasonal Coronaviruses: hCoV-OC43, hCoV-HKU1, hCoV-229E, and hCoV-NL63 by Tamila Musaeva, Artem Fadeev, Maria Pisareva, Veronika Eder, Andrey Ksenafontov, Margarita Korzhanova, Valery Tsvetkov, Alexander Perederiy, Irina Kiseleva, Daria Danilenko, Dmitry Lioznov, Andrey Komissarov

“…A detailed phylogenetic analysis of the sequenced genomes was conducted, highlighting the emergence of hCoV-229E subclades 7b.1 and 7b.2, which carry numerous substitutions in the Spike protein. …”
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A randomized, double-blind, Phase 1, single- and multiple-dose placebo-controlled study of the safety and pharmacokinetics of IN-006, an inhaled antibody treatment for COVID-19 in... by Thomas R. Moench, Lakshmi Botta, Brian Farrer, Jason D. Lickliter, Hyunah Kang, Yoona Park, Cheolmin Kim, Marshall Hoke, Miles Brennan, Morgan D. McSweeney, Zachary Richardson, John B. Whelan, Jong Moon Cho, Soo Young Lee, Frances Faurot, Jeff Hutchins, Samuel K. Lai

“…Methods: A Phase 1 study was conducted in healthy volunteers aged 18–55 a Phase 1 unit in Melbourne, Australia (ACTRN12621001235897). …”
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Changes in donor lymphocyte infusion for relapsed patients post-hematopoietic stem cell transplantation: a 30-year single-center experience by Yusuke Uchibori, Shuhei Kurosawa, Yuho Najima, Kyoko Haraguchi, Daichi Sadato, Chizuko Hirama, Yasutaka Sadaga, Kaori Kondo, Chika Kato, Satoshi Sakai, Yasuhiro Kambara, Fumihiko Ouchi, Masashi Shimabukuro, Atsushi Jinguji, Naoki Shingai, Takashi Toya, Hiroaki Shimizu, Takeshi Kobayashi, Hironori Harada, Hironori Harada, Yuka Harada, Yoshiki Okuyama, Noriko Doki

“…A retrospective analysis was conducted on 75 patients who underwent DLI for disease relapse between April 1994 and March 2024. …”
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Clinical assessment of urinary prostate cancer antigen 3 in Chinese population: a large-scale, prospective and multicenter study by Xuan Shu, Jiaming Wang, Wen Cai, Shen Lin, Jiangfeng Li, Xueyou Ma, Yufan Ying, Yat Sai Terry Wang, Xiao Wang, Hong Chen, Chunyu Jin, Ben Liu, Liping Xie, Jindan Luo

“…Methods A prospective study including patients with indication of prostate biopsies from 4 centers was conducted. All patients underwent PCA3 urine tests and prostate biopsies. …”
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Modulation of DAPK1 expression by its alternative splice variant DAPK1-215 in cancer by QingShui Wang, ShuYun Weng, WenTing Zhong, YouYu Lin, Yan Yu, YiMin Huang, LiLin Ge, XiuLi Zhang, FangQin Xue, Yehuda G. Assaraf, Yao Lin

“…Cell migration, invasion, and proliferation assays were conducted in vitro, and a zebrafish model was employed to evaluate metastatic potential. …”
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Efficacy, safety, and biomarker analysis of TACE combined with lenvatinib plus sintilimab in unresectable hepatocellular carcinoma: a real-world study by Lingzhan Meng, Hu Li, Yingjie Ji, Peng Yu, Zizheng Wang, Li Cao, Bin Shi, Yanling Shao, Jin Yan, Yinjie Gao, Zhenyu Zhu

“…Exploratory biomarker analysis was conducted. Results The study included 70 patients with unresectable HCC, predominantly male and infected with Hepatitis B. …”
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NEAT1 regulates BMSCs aging through disruption of FGF2 nuclear transport by Zifei Wang, Wenyu Zhen, Qing Wang, Yuqiang Sun, Siyu Jin, Sensen Yu, Xing Wu, Wenhao Zhang, Yulong Zhang, Fei Xu, Rui Wang, Yuxuan Xie, Wansu Sun, Jianguang Xu, Hengguo Zhang

“…Subsequent RNA pulldown and proteomic analyses, along with single-cell analysis, immunofluorescence, RNA immunoprecipitation (RIP), and co-immunoprecipitation (Co-IP), were conducted to investigate that NEAT1 impairs the nuclear transport of mitotic FGF2 and contributes to BMSCs aging. …”
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Addressing evidence needs during health crises in the province of Quebec (Canada): a proposed action plan for rapid evidence synthesis by Quan Nha Hong, Esther McSween-Cadieux, Maxime Guillette, Luiza Maria Manceau, Jingjing Li, Vera Granikov, Marie-Pascale Pomey, Marie-Pierre Gagnon, Saliha Ziam, Christian Dagenais, Pierre Dagenais, Alain Lesage, Thomas G. Poder, Martin Drapeau, Valéry Ridde, Julie Lane

“…The main objective of this project was thus to develop an action plan for the rapid syntheses of evidence in times of health crisis in Quebec (Canada). Methods We conducted a three-phase collaborative research project. …”
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Mailed smoking cessation support for Aboriginal and Torres Strait Islander people who smoke: protocol for a hybrid type 1 effectiveness – implementation trial by Raglan Maddox, Catherine Chamberlain, Billie Bonevski, Amanual Getnet Mersha, Jamie Bryant, Michelle Kennedy, Nathan Taylor, Cathy Segan, Kayden Roberts-Barker, Zabowie Mills, Kade Booth, Joley Foster

“…This study will assess the implementation and effectiveness of a mailed smoking cessation support programme that includes nicotine replacement therapy (NRT) (Which Way Quit Pack) for Aboriginal and Torres Strait Islander people.Methods and analysis A hybrid type 1 effectiveness—implementation trial will be conducted in Australia from 2023 to 2025. A sample of 500 Aboriginal and Torres Strait Islander people aged over 16 who smoke will be recruited using social media. …”
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