Combined use of respiratory multiplex PCR and procalcitonin to reduce antibiotic exposure in sickle-cell adult patients with acute chest syndrome (The ANTIBIO-STA study): a randomi... by Alexandre Sabaté-Elabbadi, Armand Mekontso-Dessap, François Lionnet, Aline Santin, Charlotte Verdet, Paul-Louis Woerther, Julien Lopinto, Matthieu Turpin, Alexandra Rousseau, Romane Lacoste-Badie, Keyvan Razazi, Guillaume Voiriot, Muriel Fartoukh

“…We hypothesized that a strategy combining the use of mPCR with repeated PCT measurements would reduce antibiotic exposure during ACS. Methods: We conducted a randomised, controlled, parallel group, open-label study in two French hospitals. …”
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Longitudinal changes in the 6-minute walk test and the Glittre-activities of daily living test in adults with cystic fibrosis by Vera Lucia Barros Abelenda, Cláudia Henrique da Costa, Mônica de Cássia Firmida, Raphael Freitas Jaber de Oliveira, Rogério Rufino, Agnaldo José Lopes

“…Pulmonary function tests, handgrip strength (HGS), and the Cystic Fibrosis Questionnaire-Revised (CFQ-R) were conducted. Measurements were collected at baseline (T1) and 1 year later (T2). …”
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Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population by Yinghao Yao, Xingyong Li, Lan Wu, Jia Zhang, Yuanyuan Gui, Xiangyi Yu, Yang Zhou, Xuefei Li, Xinyu Liu, Shilai Xing, Gang An, Zhenlin Du, Hui Liu, Shasha Li, Xiaoguang Yu, Myopia Associated Genetics Intervention and Consortiums, Hua Chen, Jianzhong Su, Shihao Chen

“…However, the situation in the Chinese population remains unknown. This study was conducted to identify novel genetic variants linked to KC and to evaluate the potential applicability of a polygenic risk model in the Han Chinese population. …”
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Global, regional and national sodium intakes in 1990 and 2010: a systematic analysis of 24 h urinary sodium excretion and dietary surveys worldwide by J Lennert Veerman, Sarah Lewis, John Britton, Bruce Neal, Kathryn G Andrews, Goodarz Danaei, Majid Ezzati, Yanping Li, Yu Chen, Farshad Farzadfar, Jean-Michel Gaspoz, Idris Guessous, Lital Keinan-Boker, Paul Elliott, Carukshi Arambepola, Antonia Trichopoulou, Philippos Orfanos, Martin C Gulliford, Renata Micha, Dariush Mozaffarian, Wen-Harn Pan, Shoichiro Tsugane, Habibul Ahsan, Manami Inoue, Luz Maria Sanchez-Romero, Andrew Fogarty, Christos Pitsavos, Edward Giovannucci, Stefaan De Henauw, Stephen S Lim, Cho-il Kim, Inge Huybrechts, Didier Garriguet, Simón Barquera, Katia Castetbon, Neville Calleja, Peilin Shi, Hsing-Yi Chang, Yasuhiro Matsumura, Hubert Barennes, Guansheng Ma, Shahab Khatibzadeh, Saman Fahimi, John Powles, Morteza Abdollahi, Anahita Houshiar-rad, Eda Koksal, Sahar Zaghloul, Sirje Vaask, Ana Baylin, Simon Forsyth, Rosely Sichieri, Christian Haerpfer, Ian Brown, Demosthenes B Panagiotakos, Jacqui Webster, Androniki Naska, Dorothy Gauci, Rebecca E Engell, Tim E Byers, Stephanie Smith-Warner, Ibrahim Elmadfa, Mayuree Rao, Pamela A Abbott, Enrique O Abeyá Gilardon, Suad N Al-Hooti, Wulf Becker, Peter Bjerregaard, Lesley T Bourne, Mario V Capanzana, Melanie J Cowan, Dulitha N Fernando, Regina M Fisberg, Brahmam NV Ginnela, Wilbur Hadden, Daniel J Hoffman, Nahla C Hwalla, Hajah Masni Ibrahim, Maria D Jackson, Lars Johansson, Hae-Jeung Lee, Chan Mei Fen, Gert BM Mensink, Rafael A Monge-Rojas, Balakrishna Nagalla, Marga C Ocke, Maciej Oltarzewski, Marja-Leena Ovaskainen, Gulden Ayla Pekcan, Stefka Petrova, Noppawan Piaseu, Leanne M Riley, Rusidah BT Selamat, Chansimaly Simmala, Laufey Steingrimsdottir, Gillian Swan, Lucjan Szponar, Heli Tapanainen, Robert Templeton, Anastasia Thanopoulou, Holmfridur Thorgeirsdóttir, Inga Thorsdottir, Aida Turrini, Nowak Verena, Anna Waskiewicz, Gábor Zajkás, Shadi Kalantarian, Pattra Wirojratana, Mary Anne Land, Tricia McKeever, Mohannad Abed Alfattah Al Nsour, Medical Science, Heléne Enghardt Barbieri, Aida Filipovic Hadziomeragic, Nur Indrawaty Lipoeto, Stephen T. McGarvey, Abdulrahman Obaid. Musaiger, Luz Gladys. Posada, Elz˙bieta Halina. Sygnowska

“…Objectives To estimate global, regional (21 regions) and national (187 countries) sodium intakes in adults in 1990 and 2010.Design Bayesian hierarchical modelling using all identifiable primary sources.Data sources and eligibility We searched and obtained published and unpublished data from 142 surveys of 24 h urinary sodium and 103 of dietary sodium conducted between 1980 and 2010 across 66 countries. …”
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Effect of intermittent theta burst stimulation combined with acoustic startle priming motor training on upper limb motor function and neural plasticity in stroke individuals: study... by Jing Zhang, Yu Chen, Mingzhu Wang, Nan Xia, Jinghong Li, Weiqiang Liang, Yangyang Yin, Linhan Zhai, Qiuxia Wang

“…ChiCTR2400085220) and Medical Ethics Committee of Tongji Hospital, affiliated with Tongji Medical College, Huazhong University of Science and Technology (Registration No.TJ-IRB20231109). It will be conducted in the Departments of Rehabilitation Medicine and Radiology at Tongji Hospital in Wuhan, China. …”
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Position in proton Bragg curve influences DNA damage complexity and survival in head and neck cancer cells by Tim Heemskerk, Celebrity Groenendijk, Marta Rovituso, Ernst van der Wal, Wouter van Burik, Konstantinos Chatzipapas, Danny Lathouwers, Roland Kanaar, Jeremy M.C. Brown, Jeroen Essers

“…Complementary in silico studies are conducted to gain insights into the link between cell survival variations, experimentally yielded foci and the number and complexity of double strand breaks (DSBs). …”
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The Human Milk-derived Peptide Drives Rapid Regulation of Macrophage Inflammation Responses in the Neonatal IntestineSummary by Fuqiang Yuan, Xu Han, Masha Huang, Yinglin Su, Yiting Zhang, Mengyuan Hu, Xiang Yu, Weilai Jin, Yun Li, Le Zhang

“…Protein-protein interaction (PPI) analysis, single-cell RNA-seq (scRNA-seq), and co-immunoprecipitation (co-IP) experiments were conducted to explore the mechanism underlying CASB135-150 function. …”
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Efficacy and safety of guanabenz acetate treatment for non-alcoholic fatty liver disease: a study protocol for a randomised investigator-initiated phase IIa study by Atsushi Nakajima, Yasushi Honda, Kento Imajo, Masato Yoneda, Yuji Ogawa, Takaomi Kessoku, Takashi Kobayashi, Anna Ozaki, Asako Nogami, Satoru Saito, Michihiro Iwaki, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Yuki Kasai, Noritoshi Kobayashi

“…In this randomised, open label, parallel-group, phase IIa study, we made attempts to conduct a proof-of-concept assessment by evaluating the efficacy and safety of guanabenz acetate treatment in patients with NAFLD/NASH.Methods and analysis A total of 28 adult patients with NAFLD or NASH and hypertension complications meeting the inclusion/exclusion criteria will be enrolled. …”
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Out-of-Pocket Expenditure (OOPE) on Selected Surgeries in the Obstetrics and Gynaecology Department incurred by Ayushman Bharat Pradhan Mantri Jan Arogya  Yojana (AB-PMJAY), Privat... by Dr. Kumar Sumit, Reena Verma, Prajwal Salins, Helmut Brand, Siddhartha Sankar Acharya, Sagarika Kamath, rajesh kamath, Dr. Vidya Prabhu

“…Methodology A retrospective study was conducted at a tertiary care teaching hospital in Karnataka state of India to analyze OOPE for 905 OBG patients who underwent Cesarean Section(C-Section), Laparoscopic Hysterectomy, Laparoscopic Cystectomy, Laparoscopic Myomectomy and Laparoscopic Assisted Vaginal Hysterectomy (LAVH). …”
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Effectiveness and Safety of Treatments for Early‐Stage Merkel Cell Carcinoma: A Systematic Review and Meta‐Analysis of Randomized and Non‐Randomized Studies by Yves Paul Vincent Mbous, Rowida Mohamed, Usha Sambamoorthi, Murtuza Bharmal, Khalid M. Kamal, Traci LeMasters, Joanna Kolodney, George A. Kelley

“…Methods A systematic review and meta‐analysis of randomized and non‐randomized studies published between January 01, 1972, and January 31, 2023, and having overall survival (OS), local recurrence (LR), regional recurrence (RR), disease‐specific survival (DSS), and/or disease‐free survival (DFS) as outcomes was conducted using the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed (NCBI), Scopus (ELSEVIER), and Web of Science (CLAVIRATE) databases. …”
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Disrupting USP39 deubiquitinase function impairs the survival and migration of multiple myeloma cells through ZEB1 degradation by Jessy Sirera, Saharnaz Sarlak, Manon Teisseire, Alexandrine Carminati, Victoria J. Nicolini, Coline Savy, Patrick Brest, Thierry Juel, Christophe Bontoux, Marcel Deckert, Mickael Ohanna, Sandy Giuliano, Maeva Dufies, Gilles Pages, Frederic Luciano

“…Co-immunoprecipitation and deubiquitination assays were conducted to elucidate the interaction and regulation of ZEB1 by USP39. …”
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A Scoping Review of Existing Policy Instruments to Tackle Overweight and Obesity in India: Recommendations for a Social and Behaviour Change Communication Strategy [version 2; peer... by Lopamudra Tripathy, Suparna Ghosh-Jerath, Neena Bhatia, Kathryn Backholer, Kavita Chauhan, Nishibha Thapliyal, Deepika Bahl, Shalini Bassi, Monika Arora, Seema Chandra, Preetu Mishra

“…Methods Systematic identification and selection of policy instruments using ‘Arksey and O’Malley’ framework was conducted from central government ministry websites, between March and June 2023. …”
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Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach by Syntia Nusanti, Andhika Rachman, Brigitta Marcia Budihardja, Lourisa Ruth Eldinia, Nadia Delima Andini, Arief Kartasasmita, M Sidik, Seskoati Prayitnaningsih, Alida Roswita Harahap, Aria Kekalih, Tjahjono Darminto Gondhowiardjo

“…Methods: A cross-sectional study involving two groups of NAION subjects, a hypercoagulation group and a non-hypercoagulation group, was conducted in the Neuro-Ophthalmology Division, Department of Ophthalmology, FKUI-RSCM Kirana from October 2020 to April 2022. …”
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Clinicopathological Characteristics of Middle-Aged and Elderly Patients with Colorectal Polyps and Risk Factors of Adenomatous Polyps by Rui CHENG, Rui GONG, Wei JIANG, Shutian ZHANG

“…Multivariate logistic regression analysis was conducted to explore the influence of the above factors on the occurrence of colorectal adenoma. …”
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Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons by Sanjana Chauhan, Darrell R. Smith, Shiva Shariati-Ievari, Abhay Srivastava, Sanjiv Dhingra, Michel Aliani, Paul Fernyhough

“…Metabolic profiling of DRG neurons and human neuroblastoma SH-SY5Y cells was conducted. Results: M1R antagonism induced by PZ or MT7 increased Ca2+ influx in DRG neurons and was inhibited by TRPM3 antagonists or in the absence of extracellular Ca2+. …”
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UHPLC-QTOF-MS/MS profiling, molecular networking, and molecular docking analysis of Gliricidia sepium (Jacq.) Kunth. ex. Walp. stem ethanolic extract and its gastroprotective effec... by Aya A. Wafaey, Seham S. El-Hawary, Osama G. Mohamed, Sahar S. Abdelrahman, Alaa M. Ali, Ahmed A. El-Rashedy, Mohamed F. Abdelhameed, Farid N. Kirollos

“…Walp. stem ethanolic extract (GSS) was conducted using ultra-high performance quadrupole time of flight mass spectrometry/mass spectrometry (UHPLC-QTOF-MS/MS) in negative mode, resulting in the identification of 23 compounds belonging to various classes such as flavonoids, fatty acids, triterpenoid saponins, and phenolic acids. …”
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Effect of prenatal multiple micronutrient supplementation on birth weight in Ethiopia: protocol for a pragmatic cluster-randomised trial by Joanna Schellenberg, Charles Opondo, Tanya Marchant, Lars Åke Persson, Masresha Tessema, Atkure Defar, Alemneh Kabeta Daba, Girum Taye, Senait Alemayehu, Elias Asfaw, Anene Tesfa, Bedasa Tessema, Kalkidan Zenebe

“…Responding to that evidence, the government of Ethiopia decided to implement a 21 district pilot of the use of multiple micronutrient supplementation in routine antenatal care and requested an evaluation of implementation outcomes, including on birth weight.Methods and analysis A pragmatic, facility-based, randomised trial is being conducted in 42 districts over five regions of Ethiopia between January 2023 and December 2024. …”
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Microgeographical Variation in <i>Dirofilaria immitis</i> Prevalence in Dogs in Suburban and Urban Areas of Rio De Janeiro, Brazil by Marianna Laura Elis Chocobar, Elizabeth Moreira dos Santos Schmidt, Ângelo Joel Ferreira Mendes, Paul Christopher Duncan Johnson, William Weir, Rossella Panarese

“…The investigation was conducted using a multi-diagnostic approach with binomial generalised linear models (GLMs) applied to investigate the association between the occurrence of infection and potential disease determinants. …”
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Assessment of the general population knowledge about the emergence of Nipah virus outbreak in Bangladesh: A nationwide cross-sectional study by Mobin Ibne Mokbul, Shuvajit Saha, Samiha Nahar Tuli, Fatema Binte Nur, A.M. Khairul Islam, Tariful Islam, Shirsho Shreyan, Alok Bijoy Bhadra, Golam Dastageer Prince, Irfath Sharmin Eva, Mustari Nailah Tabassum, Ferdous Wahid, Md Irfan Bin Kayes, Nazim Hassan Ziad, Mohammad Delwer Hossain Hawlader

“…This cross-sectional nationwide study is a pioneer in assessing knowledge levels of NiV outbreak among the general population in Bangladesh. It was conducted among the general population of Bangladesh from 15th January to 10th February 2024. …”
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Predictors of Noncompliance to Antihypertensive Therapy among Hypertensive Patients Ghana: Application of Health Belief Model by Yaa Obirikorang, Christian Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Daniel Gyamfi, Selorm Philip Segbefia, Michael Opoku Boateng, Dari Pascal Dapilla, Peter Kojo Brenya, Bright Amankwaa, Evans Asamoah Adu, Emmanuel Nsenbah Batu, Adjei Gyimah Akwasi, Beatrice Amoah

“…This descriptive cross-sectional study conducted at Kintampo Municipality in Ghana recruited a total of 678 hypertensive patients. …”
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