Integrated analysis of bioinformatics, mendelian randomization, and experimental validation reveals novel diagnostic and therapeutic targets for osteoarthritis: progesterone as a p... by Ziyu Weng, Chenzhong Wang, Bo Liu, Yi Yang, Yueqi Zhang, Chi Zhang

“…Lastly, Mendelian randomization analysis was conducted to examine the causal association between progesterone levels and various OA phenotypes. …”
Get full text

Protective factors, risk factors, and intervention strategies in the prevention and reduction of crime among adolescents and young adults aged 12-24 years: A scoping review protoco... by Rosanna Mary Rooney, Amber Hopkins, Jacob Peckover, Kael Coleman, Rebecca Sampson, Rosa Alati, Sharinaz Hassan, Christina M Pollard, Jaya A R Dantas, Roanna Lobo, Zakia Jeemi, Sharyn Burns, Robert Cunningham, Stephen Monterosso, Lynne Millar, Sender Dovchin, Rhonda Oliver, Ranila Bhoyroo, Getinet Ayano

“…Two independent reviewers conducted eligibility decisions and data extraction. …”
Get full text

Bio-ecological characteristics of Malus genus species in the context of prospective directions in horticulture and landscape forestry by Tetiana Moskalets, Oleksandr Kratiuk, Mariana Ivankiv, Sergii Shevchenko, Nataliia Shevchuk

“…The study aimed to conduct a comparative assessment of representatives of the genus Malus based on morphological traits, biological characteristics, physiological mechanisms of resistance to fungal pathogens, ornamental value, and significance within the frameworks of horticulture, landscape forestry, and shelterbelt afforestation. …”
Get full text

A Case Study Identified a New Mutation in the TTN Gene for Inherited Hypertrophic Cardiomyopathy by Dong J, Liu M, Chen Q, Zha L

“…Candidate variants obtained by WES were verified using Sanger sequencing, pathogenic mutation screening was conducted among family members, and the mutations were systematically analyzed using bioinformatics.Results: WES revealed a novel heterozygous missense mutation, c.20233 C>T (p.R6745C), located in exon 80 of the HCM-related gene TTN, which may be a pathogenic mutation in the family. …”
Get full text

Low-cost male urogenital simulator for penile implant surgery training: a 3D printing approach by Zixi Wang, Carlo Saija, Nicholas Raison, Abdullatif Aydin, Zhouyang Xu, Katie Zuo, Kawal Rhode, Antonia Pontiki

“…To evaluate its training efficacy, we conducted a penile implant surgery training session involving 15 urology trainees and surgeons ranging from specialty training levels ST3 to ST6. …”
Get full text

Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis by Ranju Baral, Clint Pecenka, Elisabeth Vodicka, Andrea Rodríguez, Romina Libster, Julia Dvorkin, Emiliano M Sosa, Andrea Sancilio, Karina Dueñas, Carlos Rojas-Roque, Patricia B Carruitero, Fernando P Polack, Mauricio T Caballero

“…This study aimed to assess the cost incurred for wheezing episodes after a severe RSV infection in children from Argentina, considering both the public health system and societal perspectives.Methods A prospective cohort was conducted from 2014 to 2022 to assess the cost of illness of wheezing episodes after severe RSV disease in children from Buenos Aires, Argentina. …”
Get full text

Health recommender systems to facilitate collaborative decision-making in chronic disease management: A scoping review by Antonia Barbaric, Kenneth Christofferson, Susanne M Benseler, Chitra Lalloo, Alex Mariakakis, Quynh Pham, Joost F Swart, Rae S M Yeung, Joseph A Cafazzo

“…Methods A scoping review was conducted using the framework proposed by Arksey and O’Malley, advanced by Levac et al., in line with the PRISMA-ScR checklist. …”
Get full text

An analysis of ambulance re-contacts after non-conveyance: a retrospective cohort study in the Netherlands by Susanne E. de Loor, Tessa Verheij, Thomas Karol, Franciscus G. M. H. M. Cuppen, Frits van Dijk, Femke Goldstein, Joyce Janssen, Remco H. A. Ebben

“…Therefore, the aim of our study was to analyze the incidence, reasons and outcomes of ambulance re-contacts within 72 h after non-conveyance. Methods We conducted a one year (2022) retrospective study in one EMS region in the Netherlands. …”
Get full text

Microplastics in beach sediments, seawater, and common fish in tourist destinations by M. Go, A. Ybanez, A. Ilano, F. Cababat, L. De La Calzada

“…The quantification of microplastics was conducted under a stereomicroscope.FINDINGS Moalboal exhibited higher average microplastic counts in sediments (0.12 items per gram) and seawater (0.06 items per gram) than Badian, which had 0.08 items per gram in sediments and 0.04 items per gram in seawater. …”
Get full text

The Effects of High Particulate Matter Levels on Platelet Recovery in Patients Receiving Prophylactic Platelet Transfusion by Hantrakool S, Sriwichai M, Shaengkhamnang B, Leetrakool N, Niprapan P, Kawichai S, Punnachet T, Hantrakun N, Piriyakhuntorn P, Rattanathammethee T, Chai-Adisaksopha C, Rattarittamrong E, Tantiworawit A, Norasetthada L, Srichairatanakool S

“…However, its effect on platelet recovery after transfusion remains unclear.Purpose: This study aims to assess the influence of PM2.5 exposure on platelet recovery in patients with hematologic malignancies receiving prophylactic platelet transfusions.Patients and Methods: We conducted a cross-sectional study involving 66 patients with hematologic malignancies who developed chemotherapy-induced thrombocytopenia and received prophylactic platelet transfusions between January and December 2021. …”
Get full text

Accuracy of screening tests for cervical precancer in women living with HIV in low-resource settings: a paired prospective study in Lusaka, Zambia by Nicola Low, Partha Basu, Andreas Limacher, Katayoun Taghavi, Misinzo Moono, Mulindi Mwanahamuntu, Herbert Kapesa, Albert Manasyan, Julia Bohlius, Marie Roumet, Thamsanqa Madliwa, Anne Rutjes

“…We assessed the accuracy of screening tests that can be used in low-resource settings and give results at the same visit.Methods and analysis We conducted a paired, prospective study among consecutive eligible WLHIV, aged 18–65 years, receiving cervical cancer screening at one hospital in Lusaka, Zambia. …”
Get full text

Surgical interventions for degenerative cervical disease: Impact on patient quality of life, mental health, pain relief, and spiritual health by Ching-Ya Huang, Cheng-Shyuan Rau, Jo-Chien Lin, Shiun-Yuan Hsu, Ching-Hua Hsieh

“…Methods: This prospective cohort study was conducted with a purposive sampling of thirty-five patients who were diagnosed with degenerative cervical diseases and consented to surgery. …”
Get full text

Comparing the clinical efficacy of prostate enucleation by the Millin method and enucleation performed using a holmium laser (HoLEP) with a prostate volume more than 80 cm<sup>3</s... by S. N. Volkov, V. S. Stepanchenko, V. I. Tereshchenko, A. R. Dzharimok, O. R. Grigoryan, R. K. Mikheev

“…Purpose of the study was to compare of the average long-term results of classical prostate enucleation using the Millin method and enucleation performed using a holmium laser (HoLEP).Patients and methods. This study, conducted on the basis of the Endocrinology Research Center of the Ministry of Health of the Russian Federation, included 100 patients operated on for obstruction of the prostatic part of the urethra over the period 2020–2023. …”
Get full text

Influence of bottled salad dressings on the development of enamel erosion in the presence or absence of salivary pellicle – An in vitro study by Aishwarya Lakshmi Billa, Jagadeeswara Rao Sukhabogi, Dolar Doshi, Prashant Sharma, T.V.S. Subrahmanyam, Sasikala Jummala

“…Pre and post-experimental assessments of enamel roughness and hardness were conducted using a surface roughness tester and Knoop Hardness indenter, respectively. …”
Get full text

The Influencers and the Adoption of New Products: Model for the Influencer Marketing by Henen Oulhi

“…The field study was conducted from February to June 2023. Due to the broad scope of the study population, the researcher adopted a simple random sampling technique, with the sample size determined using Richard Geiger’s formula, resulting in a representative sample of 384 participants. …”
Get full text

Thyroid function during COVID-19 and post-COVID complications in adults: a systematic review by Anisha Panesar, Palma Gharanei, Natasha Khovanova, Lawrence Young, Dimitris Grammatopoulos, Dimitris Grammatopoulos

“…A comprehensive search of PubMed and EMBASE databases was conducted. The systematic review was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. …”
Get full text

Phase I trial of hydroxychloroquine to enhance palbociclib and letrozole efficacy in ER+/HER2− breast cancer by Akshara Singareeka Raghavendra, Nicole M. Kettner, Danielle Kwiatkowski, Senthil Damodaran, Yan Wang, David Ramirez, Dan S. Gombos, Kelly K. Hunt, Yu Shen, Khandan Keyomarsi, Debu Tripathy

“…The autophagy inhibitor hydroxychloroquine (HCQ) induced on-target senescence at lower palbociclib doses. We conducted a phase I trial (NCT03774472 registered in ClinicalTrials.gov on 8/20/2018) of HCQ (400, 600, 800 mg/day) with palbociclib (75 mg/day continuous) and letrozole, using a 3 + 3 design. …”
Get full text

Perancangan User Experience Aplikasi E-Business Pasar Tradisional Dengan Metode Human Centered Design (Studi Kasus: Pasar Oro-Oro Dowo) by Indrihana Kharismaning Larasati, Widhy Hayuhardhika Nugraha Putra, Retno Indah Rokhmawati

“…The testing for application prototype design is conducted by usability testing approach, which measures the effectiveness, efficiency, and user satisfaction aspects. …”
Get full text

Pengembangan Aplikasi Sistem Penilaian Praktik Pengalaman Lapangan pada Fakultas Ilmu Komputer Universitas Brawijaya Berbasis Web by Rizky Tri Sulistyo, Faizatul Amalia, Tri Afirianto

“…FEP assessment system application testing is conducted through white-box testing (unit testing and integration), black-box testing (validation testing), and compatibility testing with sortites. …”
Get full text

The relationship between activities of daily living and speech impediments based on evidence from statistical and machine learning analyses by Liu Jun, Hongguo Li, Yu Mao, Lan Hu, Dan Wu

“…Statistical analyses, including independent sample t-tests, chi-square tests, Pearson and Spearman correlation tests, and hierarchical multiple linear regression, were conducted using SPSS 25.0. Machine learning algorithms, specifically Support Vector Machine (SVM), Decision Tree (DT), and Logistic Regression (LR), were implemented in Python 3.10.2.ResultsAnalysis of demographic characteristics revealed that the average BI score in the “With Speech impediments” group was 49.46, significantly lower than the average score of 85.11 in the “Without Speech impediments” group. …”
Get full text