Identification of core genes related to exosomes and screening of potential targets in periodontitis using transcriptome profiling at the single-cell level by Wufanbieke Baheti, Diwen Dong, Congcong Li, Xiaotao Chen

“…Gene set enrichment analysis (GSEA) and immunoinfiltration analysis were conducted based on core genes. To pinpoint key cell types influencing the progression of periodontal at the single-cell level, a series of single-cell analyses covering pseudo-time series analysis were accomplished. …”
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Establishment and validation of predictive model of ARDS in critically ill patients by Senhao Wei, Hua Zhang, Hao Li, Chao Li, Ziyuan Shen, Yiyuan Yin, Zhukai Cong, Zhaojin Zeng, Qinggang Ge, Dongfeng Li, Xi Zhu

“…Methods This prospective cohort study in China was conducted on critically ill patients to derivate and validate the prediction model. …”
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Prothrombin complex concentrate for reversal of oral anticoagulants in patients with oral anticoagulation-related critical bleeding: a systematic review of randomised clinical tria... by Christian Ovesen, Jan Purrucker, Josefine Grundtvig, Theis Bech Mikkelsen, Christian Gluud, Janus Christian Jakobsen, Hanne Christensen, Thorsten Steiner

“…Pre-specified primary outcomes were all-cause mortality, health-related quality of life, and serious adverse events for which meta-analyses, Trial Sequential Analysis, and GRADE assessments were conducted. Results Three trials, randomising a total of 291 participants, evaluated PCC against two different active comparators in participants with VKA-related critical bleeding, and two trials, randomising a total of 534 participants, evaluated PCC against two different active comparators in participants with factor Xa-related critical bleeding. …”
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Effect of environmental enrichment on relapse rates in patients with severe alcohol use disorder: protocol for a randomised controlled trial by Lila Barillot, Claudia Chauvet, Marc Besnier, Nematollah Jaafari, Marcello Solinas, Armand Chatard

“…Our EE will allow an enhancement of the standard intervention, and will combine several promising enrichment factors identified in the literature—physical activity, cognitive stimulation, mindfulness and virtual reality (VR).Methods and analysis A randomised controlled trial involving 135 participants receiving treatment for severe AUD will be conducted. Patients will be randomised to an intervention enhancement group or a control group. …”
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Comprehensive metabolite profiling and evaluation of anti-nociceptive and anti-inflammatory potencies of Nypa fruticans (Wurmb.) leaves: Experimental and in-silico approaches by Farhana Islam, Md. Aktaruzzaman, Md. Tarikul Islam, Fariya Islam Rodru, Saquiba Yesmine

“…In vitro antioxidant studies were conducted to determine the antioxidative properties of EENF. …”
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Does the Systemic Immune Inflammation Index and Plasma Atherogenic Index Predict Poor Prognosis in Patients Undergoing Mitral Balloon Valvuloplasty? by Nergiz Aydın, Sefa Tatar, Ahmet Taha Şahin, Yakup Alsancak

“…A 5-year follow-up was conducted in patients with mitral stenosis who underwent PMBV, assessing all-cause mortality, major adverse cardiovascular events (MACE), surgical need for the mitral valve, and requirement for repeat PMBV. …”
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“Enhancing equitable impact: ethical, legal, and sustainable approaches in short-term surgical outreach for global child health” by Zoe Blumenthal, Walid A. Farhat, Kelly McQueen

“…In response, there is an increasing call for a more comprehensive approach that incorporates capacity building and establish robust frameworks that ensure quality improvement, outcomes analysis, ethical conduct, sustainability, and equitable impact of short-term medical and surgical missions within global health. …”
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Somatic comorbidities and health related uncertainty among Swedish adolescents with ADHD by Sara Lundqvist, Sara Lundqvist, Sara Röjås, Kourosh Bador, Maria Råstam, Nóra Kerekes, Nóra Kerekes

“…A cross-sectional study was conducted among a convenient sample of Swedish upper secondary school students aged 15 to 19 years. …”
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Trends and ethnic disparity in endometrial cancer mortality in South Africa (1999-2018): A population-based Age-period-cohort and Join point regression analyses. by Gbenga Olorunfemi, Elena Libhaber, Oliver Chukwujekwu Ezechi, Eustasius Musenge

“…The overall and ethnic trends of endometrial cancer mortality was assessed using the Join point regression model, while Age-period-cohort (APC) regression modelling was conducted to estimate the effect of age, calendar period and birth cohort.…”
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Analisis Sistim Manajemen Dokumentasi Keperawatan pada Poliklinik Gigi Rumah Sakit di Bukittinggi by Dewi Rosmalia, Rizanda Machmud, Haryadi Mangkuto

“…The objective of this study was to analyze nursing documentation management system in a hospital dental clinic based nursing care standards. The study was conducted with qualitative analysis methods, data sources derived from observations, documents and in-depth interviews. …”
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Conditioning factors for the scientific productivity of undergraduate students of health sciences at a private Peruvian University: A cross-sectional analytical study [version 3; p... by Oriana Rivera-Lozada, Isabel Cristina Rivera-Lozada, César Antonio Bonilla-Asalde

“…Methods A cross-sectional analytical observational study was conducted. The study population was 4104 students enrolled during the 2021-I semester in the Faculty of Health Sciences of a private Peruvian university. …”
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Analisis Pelaksanaan Pelayanan Kesehatan Berdasarkan Prinsip Good Corporate Governance di Rumah Sakit Umum Daerah (RSUD) Padang Pariaman by Engga Lift Irwanto, Roni Ekha Putera, Ria Ariany

“…The principles of good corporate governance are transparency, accountability, responsibility, independence and justice. Researchers conduct research using descriptive qualitative research methods to describe the implementation of problems in more detail, key research data obtained through the process of interviews with relevant informants and document data as additional data reinforcing research arguments. …”
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Association between pre-pregnancy maternal stress and small for gestational age: a population-based retrospective cohort study by Manman Chen, Qiongjie Zhou, Yuanyuan Li, Qu Lu, Anying Bai, Fangyi Ruan, Yandan Liu, Yu Jiang, Xiaotian Li

“…Data were extracted from the National Preconception Health Care Project (NPHCP), conducted between 2010 and 2012, which encompassed preconception health-related information from 572,989 individuals across various regions in China. …”
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Professional Action Competence in Education for Sustainability Among Pre-service Physical Education Teachers: A Mixed Method Approach by Valérian Cece, Thomas Royet, Olivier Vors, Vanessa Lentillon-Kaestner

“…Additionally, they were asked to respond to open-ended questions indicating: (1) the words they associate with the concept of sustainability and EfS, and (2) examples of how physical education can educate students about sustainability, to conduct an external assessment of pre-service PE teachers’ pedagogical content knowledge in EfS. …”
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Assessment of adolescent physical development using body mass index and body self-perception by G.M. Cherniakova, O.H. Avdiievska, H.M. Danylenko

“…The purpose of this study is to assess the characteristics of self-perception of children with low body weight, normal body weight, overweight and obesity. This study was conducted in Kharkiv secondary schools in November 2021. …”
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FABLDroid: Malware detection based on hybrid analysis with factor analysis and broad learning methods for android applications by Kazım Kılıç, İsmail Atacak, İbrahim Alper Doğru

“…As a result of the experiments conducted using different rates of expansion with the broad learning method, a 98.20% accuracy value was achieved on the real device dataset with the proposed architecture. …”
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Long-acting family planning uptake and associated factors among women in the reproductive age group in East Africa: multilevel analysis by Ermias Bekele Enyew, Abiyu Abadi Tareke, Habtamu Setegn Ngusie, Mulugeta Desalegn Kasaye, Shimels Derso Kebede, Mahider Shimelis Feyisa

“…A community-based cross-sectional study was conducted on the most recent Demographic and Health Surveys in 12 East African countries. …”
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Characteristics of the First Italian Older Adults Vaccinated with an Adjuvanted Respiratory Syncytial Virus (RSV) Vaccine by Alexander Domnich, Andrea Orsi, Piero Luigi Lai, Elvira Massaro, Carlo-Simone Trombetta, Julieta Pastorino, Charlott Roihl, Marianna Pianta, Giancarlo Icardi, Donatella Panatto

“…<i>Materials and Methods</i>: This cross-sectional study was conducted in 2024 in Liguria (Italy). Individuals aged ≥60 years with no contraindications to the adjuvanted vaccine RSVPreF3 OA were eligible. …”
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First-in-human phase 1 study of the arginase inhibitor INCB001158 alone or combined with pembrolizumab in patients with advanced or metastatic solid tumours by Michael Smith, Aung Naing, Todd Bauer, Kyriakos P Papadopoulos, Osama Rahma, Elena Garralda, Glenn J Hanna, Michael J Pishvaian, Xuejun Chen, Sven Gogov, Omar Saavedra, Howard Kallender, LuLu Cheng, Emil Kuriakose

“…Objective The arginase inhibitor INCB001158 was evaluated for safety (primary endpoint) in locally advanced or metastatic solid tumours; pharmacokinetics, pharmacodynamics and efficacy were also assessed.Methods and analysis In this non-randomised, open-label, three-part phase 1 study, INCB001158 was orally administered two times per day as monotherapy or in combination with intravenous pembrolizumab 200 mg every 3 weeks. Dose expansion was conducted in tumour-type cohorts (with or without prior anti−PD-1/PD-L1 (programmed death protein 1/programmed death ligand 1) therapy).Results A total of 107 patients received INCB001158 50–150 mg two times per day as monotherapy, and 153 patients, including 6 with moderate renal impairment, received INCB001158 50–100 mg two times per day combined with pembrolizumab. …”
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Primary repair vs arthroscopic reconstruction for proximal anterior cruciate ligament tears: a comparative study by Sergey A. Gerasimov, Ekaterina A. Morozova, Daria A. Naida, Denis O. Kolmakov, Andrey A. Zykin, Ekaterina V. Khramtsova

“…In the period from 2020 to 2023, we conducted randomized prospective multicenter control comparative study, which enrolled 170 patients with the ACL tear types A, B, E according to the Gächter classification. …”
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