Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice by Yingbin Lin, Xinqun Luo, Fangyu Wang, Huange Cai, Yuanxiang Lin, Dezhi Kang, Wenhua Fang

“…Behavior tests (MWM, EPM, OFT, TST, FST) were conducted to assess cognition, anxiety, and depression-like behaviors. …”
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Sustainable remediation of Cd-contaminated farmland through the rotation of rapeseed–rice varieties with different Cd accumulation potentials by Liang Wang, Qiqing Liu, Jingyi Fu, Yuxuan Xiao, Jun Yang, Xiaoyong Liao

“…To investigate the remediation effects of different accumulation varieties in rapeseed−rice cropping systems and their influence on Cd migration and transportation, field experiments were conducted based on different planting combinations (FWHR, conventional rice variety (HR) monoculture under fallow; FWLR, low Cd-accumulating rice variety (LR) monoculture under fallow; LOLR, LO (low Cd-accumulating rapeseed variety)-LR rotation; LOHR, LO-HR rotation; HOLR, HO (high Cd-accumulating rapeseed variety)-LR rotation; HOHR, HO-HR rotation). …”
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Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells by Chu-An Wang, Ya-Chin Hou, Yi-Kai Hong, Yu-Jing Tai, Chieh Shen, Pei-Chi Hou, Jhao-Lin Fu, Cheng-Lin Wu, Siao Muk Cheng, Daw-Yang Hwang, Yung-Yeh Su, Yan-Shen Shan, Shaw-Jenq Tsai

“…Methods Single-cell RNA sequencing and analysis of primary PDAC tumors were conducted. Genetically engineered pancreas-specific Kras-mutated, dual specificity phosphatase-2 (Dusp2) knockout mouse models were established. …”
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Liver damage in patients living with HIV on antiretroviral treatment with normal baseline liver function and without HBV/HCV infection: an 11-year retrospective cohort study in Gua... by Jun Yu, Hao Liang, Fengxiang Qin, Junjun Jiang, Chunwei Qin, Yunxuan Huang, Bingyu Liang, Yuexiang Xu, Jiegang Huang, Zhiliang Xu, Chuanyi Ning, Yanyan Liao, Ning Zang, Jingzhen Lai, Wudi Wei, Li Ye, Xionglin Qin

“…Objective To characterise the association between duration of exposure to antiretroviral treatment (ART) and liver damage in HIV patients with an initially normal baseline liver function and without hepatitis B virus (HBV)/hepatitis C virus (HCV) infection.Methods A retrospective cohort study was conducted in HIV-infected individuals with normal liver function parameters at ART initiation and without HBV/HCV infection, from 14 April 2004 to 13 April 2015 in Guigang city, Guangxi, China. …”
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Pre-eclampsia as a predictor of early-onset cardiovascular impairment among young women (PREECARDIA study): protocol for a prospective cohort study by Albertino Damasceno, Amabelia Rodrigues, Nuno Lunet, Ruben Turé, Eunice Barai, Almame Cissé, Gabriel Sanca, Tida Iafa, Waldir Jalo, Bubacar Embalo, Marcos Dju, Vasco Iala

“…Hence, this study aims to assess the association between pre-eclampsia and cardiovascular impairment within the first year after delivery, among younger women in SSA.Methods and analysis This is a prospective cohort study conducted at Hospital Nacional Simão Mendes in Bissau, Guinea-Bissau. …”
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CFTR Expression Analysis for Subtyping of Human Pancreatic Cancer Organoids by Alexander Hennig, Laura Wolf, Beatrix Jahnke, Heike Polster, Therese Seidlitz, Kristin Werner, Daniela E. Aust, Jochen Hampe, Marius Distler, Jürgen Weitz, Daniel E. Stange, Thilo Welsch

“…Immunofluorescence staining was established and done for 10 organoid lines for cystic fibrosis transmembrane conductance regulator (CFTR) and KRT81. Quantitative real-time PCR (qPCR) was performed for CFTR and HNF1A. …”
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Prior Anticoagulation and Risk of Hemorrhagic Transformation in Acute Stroke: A Post Hoc Analysis of the PRODAST Study by Gerrit M. Grosse, Anika Hüsing, Andreas Stang, Nils Kuklik, Marcus Brinkmann, Martin Grond, Jens D. Rollnik, Lars Marquardt, Andrea Kraft, Eckhard Schlemm, Carsten Eggers, Christoph C. Eschenfelder, Christian Weimar, Hans‐Christoph Diener

“…Methods and Results This is a post hoc analysis of the prospective, multicenter, observational PRODAST (Prospective Record of the Use of Dabigatran in Patients With Acute Stroke or TIA) study, which was conducted in 86 stroke units in Germany between July 2015 and November 2020. …”
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A preliminary study on the reference intervals of vitamin K in some areas of Beijing with normal physical examination population by Lin Chen, Meiqi Chen, Shi Cheng, Jiaxin Fei, Dan Xu, Xueyun Hou, Nannan Li, Yuliang Yuan, Guijian Liu, Cheng An

“…Finally, preliminary clinical validation was conducted on 60 apparent healthy individuals undergoing physical examination. …”
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Electromagnetic navigation system for computed tomography-guided synchronous percutaneous lung biopsy and microwave ablation of pulmonary nodules: a prospective, single-center, sin... by Shengwei Li, Zhixin Bie, Yuanming Li, Jie Sun, Jiangxu Zhang, Xiangyu Zi, Runqi Guo, Xiao-Guang Li

“…Background The purpose of this study was to clinically evaluate the safety and effectiveness of the electromagnetic navigation (EMN) system designed for computed tomography (CT)-guided synchronous percutaneous lung biopsy and microwave ablation (MWA) of pulmonary nodules.Methods This prospective, single-center, single-arm clinical cohort study was conducted in Beijing Hospital from March 2023 to May 2023. …”
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Impact of growing conditions on the gum properties of different genotypes of guar (Cyamopsis tetragonoloba (L.) Taub.) by I. V. Kruchina-Bogdanov, E. V. Miroshnichenko, R. A. Shaukharov, E. N. Kantemirova, M. A. Golovina, K. M. Abdullaev, A. V. Balashov, E. V. Rusinova, P. G. Rusinov, E. K. Potokina

“…To understand this, ecogeographical tests of 13 guar accessions from the VIR collection were conducted at the experimental stations of the Vavilov Institute (VIR), where climatic conditions correspond to the temperature requirements of the crop. …”
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Cerebellum abnormalities in vascular mild cognitive impairment with depression symptom patients: A multimodal magnetic resonance imaging study by Yirong Chen, Liling Chen, Liyu Hu, Jianjun Wang, Jinhuan Zhang, Hanqing Lyu, Jinping Xu, Jianxiang Chen, Haibo Yu

“…Multimodal MRI scans were conducted, assessing gray matter volume and resting-state functional connectivity (RSFC) in the cerebellum. …”
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Gestational diabetes mellitus and offspring’s carotid intima–media thickness at birth: MySweetHeart Cohort study by Umberto Simeoni, Antje Horsch, Arnaud Chiolero, Yvan Vial, Nicole Sekarski, Jardena J Puder, Pascal Bovet, Stefano Di Bernardo, Yvan Mivelaz, Adina Mihaela Epure, Sandrine Estoppey Younes, Bobby Stuijfzand, Leah Gilbert, Stefano Lanzi, Justine Gross, Stefano Di Bernardo, Dan Quansah, Jean-Benoît Rossel, Amar Arhab, Sandrine Estoppey Younes, Seyda Mayerat

“…We assessed whether GDM is associated with increased CIMT in the offspring at birth.Design and setting MySweetHeart Cohort is a prospective cohort study conducted in Switzerland.Participants, exposure and outcome measures This work included pregnant women with and without GDM at 24–32 weeks of gestation and their singleton live-born offspring with data on the primary outcome of CIMT. …”
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Rapid antigen testing by community health workers for detection of SARS-CoV-2 in Dhaka, Bangladesh: a cross-sectional study by Mahbubur Rahman, Ayesha Sania, Seonjoo Lee, Tahmina Shirin, A S M Alamgir, Yael K Rayport, Ahmed Nawsher Alam, Joanna Andrecka, Eric Brum, Fergus Chadwick, Tasnuva Chowdhury, Zakiul Hasan, Davina L Hill, Farzana Khan, Mikolaj Kundegorski, Motahara Tasneem, Katie Hampson

“…Objective To evaluate the diagnostic performance and feasibility of rapid antigen testing for SARS-CoV-2 detection in low-income communities.Design We conducted a cross-sectional community-based diagnostic accuracy study. …”
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Effectiveness of a pharmacist-led tele-psychiatric clinic in managing drug-related problems by Majed Al Shakhori, Savera Arain, Suhaj Abdulsalim, Mohammed Salim Karattuthodi, Marwa Al Dhamen, Shoruq Almutairi, Shabeer Ali Thorakkattil, Dina Alahmdi, Vijayanarayana Kunhikatta, Abdul Sammad AlJishi

“…Additionally, the research assessed physicians' acceptance of pharmacists' recommendations for managing these DRPs.Methods: A cohort retrospective study was conducted at a leading tertiary care hospital in Saudi Arabia spanning from January 2023 to January 2024 in a psychiatry setting. …”
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Feasibility study of a randomised controlled trial of preoperative and postoperative nutritional supplementation in major lung surgery by Amelia Swift, Sebastian T Lugg, Babu Naidu, Nikolaos Efstathiou, Amy Kerr, Hazem Fallouh, Maninder Kalkat, Richard Steyn, Salma Kadiri, Ehab Bishay, Krishna Kholia, Venessa Rogers

“…However, it is uncertain whether modifying or optimising perioperative nutritional state with oral supplements results in a reduction in malnutrition, complications or quality of life.Design A randomised, open label, controlled feasibility study was conducted to assess the feasibility of carrying out a large multicentre randomised trial of nutritional intervention. …”
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Typological and cumulative approaches to risk and adversity in Child and Adolescent Mental Health Services (CAMHS): Retrospective cohort analysis in South London by Barry Coughlan, Nicole Marshall, Matt Woolgar, Julia Mannes, Paige Erkiert, Ayla Humphrey, Jack Smith, Taliah Drayak, Francesca Crozier-Roche, Tessa Morgan, Dustin Hutchinson, David Graham, Rick Hood, Robbie Duschinsky

“…Outcomes: Risk in its various conceptualisations was consistently and robustly associated with conduct disorder. Risk also tended to be associated with more face-to-face appointments, missed appointments, and referral to social services. …”
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Correlation Between Systemic Inflammation, Gut Microbiome Dysbiosis and Postoperative Complications After the Modified Whipple Procedure by Gelu Mihai Breaza, Florin Emil Hut, Octavian Cretu, Simona-Alina Abu-Awwad, Ahmed Abu-Awwad, Laurențiu Vasile Sima, Radu Gheorghe Dan, Cristina Ana-Maria Dan, Raluca Maria Closca, Flavia Zara

“…This study explores the clinical, immunological, and microbiome-related factors influencing postoperative complications, focusing on the interplay between patient comorbidities, systemic inflammation, and gut dysbiosis. (2) Methods: A retrospective analysis was conducted on 123 patients undergoing the modified Whipple procedure for pancreatic head tumors. …”
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Uptake and hesitancy of the second booster dose of COVID-19 vaccine among the general population in China after the surge period of the COVID-19 pandemic: a large-scale national st... by Xin Liu, You Xin, Ling Zhang, Yijin Wu, Shu Jing, Zhenwei Dai, Tianrui Ren, Xiaoyang Liu, Jiaqi Fu, Xu Chen, Weijun Xiao, Hao Wang, Yiman Huang, Wenjun Wang, Xiaofen Gu, Li Ma, Shaokai Zhang, Yanqin Yu, Li Li, Tianzuo Gao, Tianyou Zhao, Yimin Qu, Xinyan Liu, Xiaoyou Su, Youlin Qiao

“…Methods A cross-sectional survey was conducted between January 5 to February 9, 2023. Variables including sociodemographics, mental health, COVID-19 infection status, COVID-19 vaccination status, and vaccine hesitancy were collected. …”
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Optimal timing of pharmacoinvasive strategy and its impact on clinical and economic outcomes in patients with ST-elevation myocardial infarction: a real-world perspective by Andrea Dias Stephanus, Alice Pacheco Santos, Ana Carolina Machado Rodrigues da Cunha, Ana Carolina Augusto Rocha, Amanda de Amorim Meireles, Mariana Guimarães Souza de Oliveira, Pietra Arissa Coelho Matsunaga, Alexandre Anderson de Sousa Munhoz Soares, Alexandre Anderson de Sousa Munhoz Soares, Ana Claudia Cavalcante Nogueira, Ana Claudia Cavalcante Nogueira, Ana Claudia Cavalcante Nogueira, Ana Claudia Cavalcante Nogueira, Adriana de J. B. de Almeida Guimarães, Adriana de J. B. de Almeida Guimarães, Gustavo de Almeida Alexim, Alessandra M. Campos-Staffico, Luiz Sergio Fernandes de Carvalho, Luiz Sergio Fernandes de Carvalho, Luiz Sergio Fernandes de Carvalho

“…Multivariable logistic regression models were used to assess the association between lysis-PCI timing and outcomes. Cost analyses were conducted from the perspective of Brazilian public healthcare system, with values converted to international dollars (Int$) for broader applicability.ResultsEvery 4-h delay in lysis-PCI was associated with a 44% reduction in in-hospital mortality [OR = 0.560 (95% CI: 0.381–0.775); p = 0.001] and a 13% decrease in 4p-MACE [OR = 0.877 (95% CI: 0.811–0.948); p = 0.001]. …”
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Antibodies against neuronal surface antigens in acute stroke: a systematic review and meta-analysis by Matteo Paolucci, Andrea Zini, Luana Morelli, Luana Morelli, Rocco Liguori, Rocco Liguori, Maria Pia Giannoccaro, Maria Pia Giannoccaro

“…However, their role in stroke is far from being understood.MethodsWe conducted a systematic review and meta-analysis to investigate: 1) the frequency of NSA-Abs in patients with acute stroke compared to controls; 2) the de novo appearance of NSA-Abs after stroke; and 3) their effects on the clinical outcome.ResultsWe included nine studies in the qualitative analysis and seven in the quantitative analysis. …”
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