Superior persistence of ustekinumab compared to anti-TNF in vedolizumab-experienced inflammatory bowel diseases patients: a real-world cohort study by Horng-Yih Chiu, Chia-Jung Kuo, Ming-Wei Lai, Ren-Chin Wu, Chien-Ming Chen, Cheng-Tang Chiu, Yu-Bin Pan, Cheng-Hsun Chiu, Puo-Hsien Le

“…Methods This retrospective study analyzed VDZ-experienced IBD patients treated with UST or anti-TNF (adalimumab and infliximab) from May 2019 to January 2024. We conducted a comparative analysis of the 52-week treatment persistence between UST and anti-TNF therapies, while also identifying independent predictors that influence 52-week persistence. …”
Get full text

Development and Validation of the Self-Stigma Scale for Secondary Vocational Students (SSS-SVS) by Leng J, Cai H, Liu F, Shi X, Fan Z

“…Future studies should expand the sample and conduct cross-cultural verification.Conclusion: The SSS-SVS is a reliable and valid instrument for assessing secondary vocational students’ self-stigma, providing support for developing relevant programs and policies. …”
Get full text

Oyster Mushroom (Pleurotus ostreatus) Ethanolic Extract Inhibits Pparg Expression While Maintaining the Methylation of the Pparg Promoter During 3T3-L1 Adipocyte Differentiation by Ariyanto EF, Farahana AK, Sudirman GSJ, Widiarsih E, Qomarilla N, Rahayu NS, Wikayani TP, Heryaman H, Wira DW, Triatin RD, Bashari MH, Pamela Y, Pratiwi YS, Ghozali M

“…Eko Fuji Ariyanto,1,2 Anastasya Kania Farahana,3 Gabriella Sachiko Jannesha Sudirman,3 Erlina Widiarsih,4 Nurul Qomarilla,5 Nurul Setia Rahayu,4 Tenny Putri Wikayani,5 Henhen Heryaman,1 Dwi Wahyudha Wira,1 Rima Destya Triatin,1,2 Muhammad Hasan Bashari,1 Yunisa Pamela,1 Yuni Susanti Pratiwi,1 Mohammad Ghozali1 1Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia; 2Research Center for Medical Genetics, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 3Undergraduate Program of Medical Doctor, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia; 4Molecular Genetics Laboratory, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 5Cell Culture Laboratory, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, IndonesiaCorrespondence: Eko Fuji Ariyanto, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia, Tel +6281316099791, Email fuji@unpad.ac.idPurpose: This study aims to provide new insights into the potential of oyster mushroom (Pleurotus ostreatus) ethanolic extract in preventing obesity through the inhibition of Pparg expression and modulation of methylation level on Pparg promoter during 3T3-L1 adipocyte differentiation.Methods: This in vitro quantitative experimental study was conducted by treating the 3T3-L1 cell line differentiated using 0.5 mM methyl-isobutyl-xanthine, 1 μM dexamethasone, and 10 μg/mL insulin-containing medium with oyster mushroom ethanolic extract. …”
Get full text

Serological Evidence of Infectious Laryngotracheitis Infection and Associated Risk Factors in Chickens in Northwestern Ethiopia by Mastewal Birhan, Ashenafi Syoum, Saddam Mohammed Ibrahim, Tewodros Fentahun, Addisu Mohammed, Nega Berhane, Molalegne Bitew, Esayas Gelaye, Malede Birhan Atanaw, Belayneh Getachew, Bereket Dessalegn, Anmaw Shite Abat, Kassahun Berrie, Kassaye Adamu, Takele Abayneh

“…A cross-sectional study was conducted from November 2020 to June 2021 in three selected zones of the Amhara region (Central Gondar, South Gondar, and West Gojjam zones), Ethiopia, with the objective of estimating the seroprevalence of ILTV in chickens and identifying and quantifying associated risk factors. …”
Get full text

A Problem of Perspective: Religions in Africa or African Traditional Religion by Osman Şahin

“…This has led to the continuation of the reductionist and generalising approach in the relevant literature. Studies conducted from this perspective have typically situated African religions within frameworks that emphasize concepts such as the Supreme Being, spirits, ancestor veneration, magic, and sorcery. …”
Get full text

Does binge drinking between the age of 18 and 25 years predict alcohol dependence in adulthood? A retrospective case–control study in France by Marie-Pierre Tavolacci, Joel Ladner, Pierre Déchelotte, Quentin Berthon, Damiano Cerasuolo, Alexandre Baguet

“…Objective A retrospective case–control study was conducted to evaluate whether frequent binge drinking between the age of 18 and 25 years was a risk factor for alcohol dependence in adulthood.Setting The Department of Addictive Medicine and the Clinical Investigation Center of a university hospital in France.Participants Cases were alcohol-dependent patients between 25 and 45 years and diagnosed by a psychiatrist. …”
Get full text

Improvement of the management system of the pharmaceutical service of the health care institution by Ye.V. Zalyhina

“…The purpose of the work is the formation of principles for improving pharmaceutical management in a health care institution by monitoring and analyzing prescription errors at all stages of drug use. The study was conducted on the basis of LLC "Endotechnomed", surgical clinic "Garvis" in the period 01.09.2019-29.02.2024 and was approved by the commission on biomedical ethics. …”
Get full text

Identifikasi Bakteri Coliform pada Kontak Permukaan Galon Air Minum Isi Ulang Distribusi Akhir di Kecamatan Bungus by Herik Okta Jonanda, Aziz Djamal, Yulistini .

“…</em><em>The objective of this study was to </em><em>determine the microbiological quality of the contact surface in gallons at the end of the distribution in the Bungus District. The study was conducted at the depot refill drinking water in the Bungus District</em><em> </em><em> Padang in April 2014 to October 2014. …”
Get full text

Experimental study on strength degradation and meso-structural characteristics of saturated sandstone under freeze-thaw cycles by Haotian XIE, Ying XU, Qiangqiang ZHENG, Meilu YU, Shoudong XIE, Chengjie LI

“…In order to investigate the mechanical properties and microstructural degradation patterns of slope rocks subjected to freeze-thaw cycles, this study conducted static compression tests on fully saturated sandstone specimens exposed to varying numbers of freeze-thaw cycles (0、20、40、60、80 cycles). …”
Get full text

Optimasi Pertanian Padi: Peramalan Curah Hujan Berbasis Arima Untuk Penentuan Waktu Tanam Yang Tepat by Sofi Defiyanti, Betha Nurina Sari, Tesa Nur Padilah

“…Dasarian rainfall predictions have been conducted using the ARIMA (1,0,1) method based on historical data over five years from West Java province at the West Java Climatology Station, yielding the smallest AIC value of 2078.28. …”
Get full text

Clinicopathological characteristics and survival outcomes of women aged ≤45 and >45 years with endometrial adenocarcinoma in tertiary referral hospital: a 21-year cohort study by Tarinee Manchana, Pinyada Panyavaranant, Juthamas Rattanachaipipat

“…Objective This study aimed to compare clinicopathological characteristics and oncological outcomes in patients with endometrial cancer aged ≤45 and &gt;45 years, with a focus on identifying distinct traits and prognostic factors in younger patients.Design A retrospective cohort study.Setting The study was conducted at King Chulalongkorn Memorial Hospital, Bangkok, Thailand, with a restricted study population from 1996 to 2016.Participants A total of 1114 patients diagnosed with endometrial cancer and underwent surgery were strictly selected, excluding those who had received primary radiotherapy or had uterine sarcoma. …”
Get full text

Differential Equations to Predict the Number of Students as a Basis for Accreditation Preparation Study Program Policy by Agus Miftakus Surur, Nisvu Nanda Saputra, Ummiy Fauziyah Laili, Hasnah Binti Mohamed, Atika Anggraini, Nourma Yulita

“…Therefore, researchers conducted research by predicting the number of Natural Sciences Education students at IAIN Kediri. …”
Get full text

Unveiling the digital future: perspectives of Hungarian physicians under 35 years old on eHealth solutions by Zsuzsa Győrffy, Zsuzsa Győrffy, Bence Döbrössy, Julianna Boros, Julianna Boros, Edmond Girasek

“…Our aim was to examine how under 35-year-old Hungarian physicians relate to digital technologies, the advantages and disadvantages they perceive, and how they would like to incorporate these technologies into their everyday medical practice.MethodsAs part of the “E-physicians and E-patients in Hungary” study, we conducted an online representative survey among medical practitioners in Hungary between July 2021 and May 2022 (n = 1,774). …”
Get full text

Deciphering salt-responsive NB-ARC genes in rice transcriptomic data: A bioinformatics approach with gene expression validation by Saputro Triono Bagus, Wardhani Fila Oxi, Sholihah Nur Fadlilatus, Ermavitalini Dini, Purnama Putut Rakhmad, Nurhidayati Tutik

“…This research focuses on pinpointing candidate genes suitable for functional markers. We conducted an in silico analysis of the NB-ARC gene family across three transcriptomic datasets of rice under salt stress. …”
Get full text

Changes in quality of life 5 years after sleeve gastrectomy: a prospective cohort study by Karl Ove Hufthammer, Tone Merete Norekvål, Grethe S Tell, Ronette L Kolotkin, Tone Nygaard Flølo, Anny Aasprang, Villy Våge, John Roger Andersen

“…We investigated 5-year trajectories in QOL and their associations with weight loss after SG.Design A prospective cohort study.Setting The study was conducted in a single Norwegian bariatric surgery centre.Participants Out of 150 operated patients, 127 were included. …”
Get full text

Ethnic disparities in HbA1c and hypoglycemia among youth with type 1 diabetes: beyond access to technology, social deprivation and mean blood glucose by Suma Uday, John Stuart Pemberton, Zhide Fang, Stuart A Chalew

“…We aimed to determine if HbA1c ethnic disparity persists after accounting for the above variables.Research design and methods A retrospective analysis of participants who received structured education in continuous glucose monitoring (CGM) use was conducted at a tertiary center. HbA1c was paired with glucose metrics from 90-day CGM data. …”
Get full text

Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis by Li-wei Huang, Hua-min Li, Bei He, Xiao-bo Wang, Qi-zhi Zhang, Wen-xing Peng

“…A systematic search of PubMed, Embase, and the Cochrane Library was conducted up to March 17, 2024. The primary outcomes included hypertension, palpitations, and chest pain, with pooled effect estimate reported as proportions and odds ratios (ORs) with 95% confidence intervals (CIs). …”
Get full text

A deep learning-based method for the intelligent identification of the quantity of coals flushed out during borehole hydraulic flushing by Xiaojun LI, Mingyang ZHAO, Miao LI

“…MethodsFirst, the first-level detection was completed using the YOLOv8n algorithm, which, combined with the ResNet34 and PP-OCRv4 algorithms via parallel cascade, was then employed to conduct second-level processing. Through the above processing and in combination with the method for classification status discrimination based on tracking frame numbers, the framework of an algorithm for automatically calculating the quantity of coals flushed out was established. …”
Get full text

Comprehensive analysis of the 5-HTTLPR allelic polymorphism effect on behavioral and neurophysiological indicators of executive control in people from different ethnic groups in Si... by A. N. Savostyanov, D. V. Bazovkina, S. A. Lashin, S. S. Tamozhnikov, A. E. Saprygin, T. N. Astakhova, U. N. Kavai-ool, N. V. Borisova, A. G. Karpova

“…The aim of this study is a research of associations between the allelic the 5-HTTLPR polymorphism and the individual scores of the personal anxiety level, as well as the behavioral and neurophysiological indicators of the ability to self-control over motor reactions in the SSP. The study was conducted among people from three ethno-regional groups: healthy Caucasoids from Novosibirsk, the Mongoloid groups of the indigenous population of the Tuva Republic and Sakha Republic (Yakutia). …”
Get full text

The clinical application and anatomical analysis of proximal peroneal artery perforator in free fibula flap based on CTA by Yitong Zhao, Danwei Xiang, Lina Song, Zhujiajun Cui, Xingwu Zheng, Tianyu Zhang, Huihui Yang, Yongzhen Fu, Qilin Liu

“…Methods A comprehensive review was conducted involving 50 patients who underwent CTA examinations. …”
Get full text