Association of hepatitis B virus DNA levels with efficacy and safety and the impact of antiviral therapy on prognosis in liver cancer patients receiving immune checkpoint inhibitor... by Hongxia Cui, Su Li, Wu Lv, Jing Xiang

“…Subgroup analysis, publication bias, and sensitivity analysis were conducted with STATA 14.0.ResultsThis meta-analysis comprised 17 articles involving a total of 2,130 patients. …”
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The Effect of Cumin on the Formation of <i>β</i>-Carboline Heterocyclic Amines in Smoked Meat and Simulated Systems by Xiuxiu Liu, Wenyu Chen, Minghao Sun, Xufang Lv, Xing Shen, Zhongping Chai, Maomao Zeng

“…The novelty of our research lies in the comprehensive comparative analysis of cumin extracts from different origins, which has not been fully explored in previous studies. We first conducted a quantitative analysis of the total phenol and flavonoid content in cumin extracts from the three origins and evaluated their antioxidant capacities. …”
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Adult-plant resistance and a suitable method of reaction determination to scald and net form net blotch in malt barley genotypes at a hot spot location in Ethiopia by Girma Ababa, Tigist Shiferaw, Wami Hailu, Wondimu Fekadu, Sentayehu Alamerew

“…Again, several methods of genotype reaction determination were assessed to select a suitable method. Field trial was conducted using a simple lattice design. The grain yield of ten middle rows (5 m2) was evaluated, and the results were converted to t ha−1. …”
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The Efficacy and Brain Network Mechanism of Acupuncture for Knee Osteoarthritis: A Study Protocol for Randomized Controlled Neuroimaging Trial by Sun YY, Wang ML, Zhao RH, Hao MY, Song S, Zhou Y, Zhang N

“…Forty healthy subjects will be recruited for observation, with a single MRI scan conducted only at baseline (− 1– 0 week). The primary efficacy indicator will be the change in NRS score after four weeks of treatment, with secondary outcomes including WOMAC, STAI, and safety assessments. fMRI observations will employ independent component analysis, brain network construction, and functional connectivity, complemented by Pearson correlation analysis to explore the relationship between brain responses and clinical improvements.Conclusion: This study will initially uncover how acupuncture intervention for chronic KOA pain centrally regulates and exerts therapeutic effects through the modulation of abnormal brain network functional connectivity patterns, with a demonstrated long-term effect.Ethics and Dissemination: This study has been approved by the ethics committee of Shandong University of Traditional Chinese Medicine Affiliated Hospital ((2024) Lunshen No. (028) - KY).Clinical Trial Registration: This study has been approved by registered in the Chinese Clinical Trial Registry (ChiCTR2400083695).Keywords: acupuncture, knee osteoarthritis, neuroimaging, RCT, protocol…”
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Problematic Internet use among resident physicians at St. Paul’s Hospital Millennium Medical College in Addis Ababa, Ethiopia by Yiknashewa Solomon Mekonnen, Selamawit Alemayehu Tessema, Solomon Dhabi Bedane, Askalemariam Bikiss Ali

“…Methods An institutional-based cross-sectional study was conducted from September 1, 2023, to November 25, 2023, at St. …”
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Altered circadian rhythmicity of the QT interval predicts mortality in a large real-world academic hospital population by Rutger R. van de Leur, Bastiaan C. du Pré, Markella I. Printezi, Rutger J. Hassink, Pieter A. Doevendans, René van Es, Linda W. van Laake

“…Sinus rhythm ECGs without QRS conduction or ST-segment abnormalities obtained at the wards or outpatient clinic were included. …”
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Assessing and optimizing the potential for climate change mitigation and carbon sequestration in urban residential green spaces: energizing sustainable cities by Hancheng Liu, Jialong Zhang, Zijun Wang

“…This study aimed to evaluate the carbon sequestration potential of common plant species in urban residential areas and provide recommendations for optimizing green space design and management.MethodsThe research was conducted in four residential areas of Nanjing, China, where key growth parameters of 20 plant species, including evergreen trees, deciduous trees, evergreen shrubs, and deciduous shrubs, were measured. …”
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Effect of E-learning clinical management of substance-dependent pregnant women on the knowledge and clinical skill performance of midwives: a randomized controlled trial by Hasti Heidarian, Manoosh Mehrabi, Parvin Ghaemmaghami, Roksana Janghorban

“…Methods A randomized controlled trial based on e-learning was conducted in Shiraz, Iran. One hundred midwives working in governmental maternity hospitals were recruited and randomly assigned to the intervention (n = 50) or control (n = 50) group through blocked randomization. …”
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Geospatial distribution and predictors of postnatal care utilization during the critical time in Ethiopia using EDHS 2019: A spatial and geographical weighted regression analysis. by Muluken Chanie Agimas, Tigabu Kidie Tesfie, Nebiyu Mekonnen Derseh, Meron Asmamaw, Habtamu Wagnew Abuhay, Getaneh Awoke Yismaw

“…The spatial variation of postnatal care during the critical time was assessed using the Getis-Ord Gi* statistic; Moran's I statistics were conducted to test the autocorrelation; and Sat Scan statistics were also used to show the statistically significant clusters of early PNC utilization in Ethiopia. …”
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Multicenter Randomized Controlled Trial Comparing the Contribution of Proxabrushes with Regular Toothbrushes and Only Regular Toothbrushes to the Oral Health of Thai Elderly by Orachad Gururatana, Warangkana Vejvithee, Narisa Ekpatcha

“…Multicenter randomized controlled trial, parallel grouped, open label, blocked randomization was used at each province to allocate treatment. The study was conducted at public hospitals in 16 provinces in Thailand between November 2019 and January 2020. …”
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Real-World Analysis of Weight Gain and Body Mass Index Increase Among Patients with HIV-1 Using Antiretroviral Regimen Containing Tenofovir Alafenamide, Tenofovir Disoproxil Fumara... by Bruno Emond, Carmine Rossi, Rachel Rogers, Patrick Lefebvre, Marie-Hélène Lafeuille, Prina Donga

“…**Methods:** A retrospective longitudinal study was conducted using Decision Resources Group’s electronic medical records (July 17, 2017-March 1, 2020). …”
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Effects of exogenous SLs on growth and physiological characteristics of flue-cured tobacco seedlings under different degrees of drought stress by Xiao-dong Wang, Yi-nan Zhang, Xiao-guo Wang, Ye Zhuang, Shao-hua Ge

“…Strigolactones can alleviate damage caused by various abiotic stresses in plants; however, limited research has been conducted on their ability to enhance drought tolerance in tobacco.MethodsThis study evaluated the drought tolerance of ‘Qin Tobacco 96’ (drought-tolerant) and ‘Yun Tobacco 116’ (moisture-sensitive) before and after the application of gibberellic acid lactone at a concentration of 0.2 mg·L⁻¹ under three drought conditions: mild, moderate, and severe. …”
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Ethical attitudes of the future Russian officials and businessmen: Comparative analysis by A. A. Maksimenko, O. S. Deyneka, D. V. Krylova, E. V. Zabelina, E. A. Bulgakova

“…The present empirical study aimed to identify the ethical attitudes of future officials in comparison with future entrepreneurs, as well as with the employees of commercial companies and government officials.Methodology and research methods. The authors conducted an online research. The research involved 874 people. …”
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Bacterial profile and antibiotic susceptibility pattern of adult lower respiratory tract infections in Colombo, Sri Lanka by Nadeesha Amarasinghe, Muthulingam Athavan, Deepal Jayamanne, Yamuna Rajapakshe, Aflah Sadikeen, Kirthi Gunasekara, Amitha Fernando, Lilani Karunanayake

“…Introduction: Lower respiratory tract infections (LRTIs) remain the deadliest communicable disease around the world. This study was conducted to identify the bacterial etiology of LRTIs among patients who attended the Central Chest Clinic in city of Colombo, Sri Lanka and their antibiotic susceptibility profile to enable clinicians to take decisions on effective empirical antibiotics. …”
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Exploring the mediating role of blood metabolites in the relationship between gut microbiota and gastric cancer risk: a Mendelian randomization study by Xiaocheng Li, Xiaocheng Li, Huapeng Lin, Huapeng Lin, Huapeng Lin, Jing Peng, Jianping Gong

“…However, the causal nature of these associations remains uncertain.MethodsWe utilized summary data from genome-wide association studies (GWAS) on GM (European, n=8,956), blood metabolites (European, n=120,241; East Asian, n=4,435), and GC (European, n=476,116; East Asian, n=167,122) to perform a bidirectional Mendelian randomization (MR) analysis, investigating the causal effects of GM and metabolites on GC risk. Additionally, we conducted mediation analysis (two-step MR) to identify potential metabolite mediators in the GM-GC relationship.ResultsWe identified twelve negative and seven positive associations between specific GM taxa and GC risk. …”
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Associations between lipid-lowering drugs and urate and gout outcomes: a Mendelian randomization study by Min Liu, Na Yin, Yuhang Zhu, Aili Du, Chunyuan Cai, Pengyuan Leng

“…These estimates were further refined through various approaches including MR-Egger, the weighted median method, simple and weighted models, and leave-one-out analyses to conduct sensitivity analyses.ResultThe analytical outcomes utilizing the IVW method indicated that inhibitors of HMGCR were correlated with an elevated risk of developing gout (IVW: OR [95%CI] = 1.25 [1.03, 1.46], p=0.0436), while PCSK9 inhibitors were linked to heightened levels of urate (IVW: OR [95%CI] = 1.06 [1.01,1.10], p=0.0167). …”
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Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study by Hongwei Wang, Fangying Tian, Caizheng Yang, Xinyu Cui, Yongxia Ding, Ming Zhao, Xueyu Wang, Shanshan Ge

“…It has been suggested that Hp infection affects the development of MetS in the host, but the causal relationship between the two has not been confirmed. Methods We conducted a two-sample Mendelian randomization study to investigate the causal effect of Hp infection with MetS and its components. …”
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Evaluation of two electronic-rehabilitation programmes for persistent knee pain: protocol for a randomised feasibility trial by Philip G Conaghan, Kim L Bennell, Mark Conner, Rana S Hinman, Sarah R Kingsbury, Elizabeth M A Hensor, Gretl A McHugh, Christine Comer, Dawn Groves-Williams, Rachel K Nelligan

“…If considered feasible and acceptable, a definitive randomised controlled trial can be conducted to investigate the clinical effectiveness and cost-effectiveness of one or both interventions with a view to implementation in routine care.Ethics and dissemination The trial was approved by the West of Scotland Research Ethics Committee 5 (Reference: 20/WS/0006). …”
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Isolation and Characterization of Coronavirus and Rotavirus Associated with Calves in Central Part of Oromia, Ethiopia by Umer Seid, Fufa Dawo, Asamino Tesfaye, Munera Ahmednur

“…A cross-sectional study was conducted with the aim of isolation and molecular characterization of coronavirus and rotavirus from calves in the central part of Oromia (Bishoftu, Sebata, Holeta, and Addis Ababa), Ethiopia, from November 2018 to May 2019. …”
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Transcranial photobiomodulation for reducing symptoms of autism spectrum disorder and modulating brain electrophysiology in children aged 2–7: an open label study by Yuli Fradkin, Joaquin A. Anguera, Alexander J. Simon, Luis De Taboada, Eugenia Steingold

“…BackgroundSmall pilot studies have indicated that transcranial photobiomodulation (tPBM) may help alleviate symptoms of neurological conditions like depression, traumatic brain injury and Autism Spectrum Disorder (ASD).ObjectiveTo examine the effect of tPBM on the behavioral symptoms of ASD and brain electrophysiology in children aged 2–7.MethodsWe conducted an open label, one-arm study with 23 participants, aged 2–7, previously diagnosed with ASD. …”
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