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36801
Metagenomic insights into the development of microbial communities of straw and leaf composts
Published 2025-01-01“…To study this process, a long-term experiment was conducted on the decomposition of oat straw and leaf litter using soil as a microbial inoculum.MethodsCombined analyses of enzymatic activity and NGS data for 16S rRNA gene amplicon and full metagenome sequencing were applied to study taxonomic, carbohydrate-active enzyme (CAZy), and polysaccharide utilization loci (PULs) composition of microbial communities at different stages of decomposition between substrates.ResultsIn straw degradation, the microbial community demonstrated higher amylase, protease, catalase, and cellulase activities, while peroxidase, invertase, and polyphenol oxidase were more active in leaf litter. …”
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36802
Integrated serum metabolomics and network pharmacology reveal molecular mechanism of Qixue Huazheng formula on peritoneal fibrosis
Published 2025-01-01“…Western blotting (WB), quantitative real-time PCR (qRT-PCR), TdT-mediated dUTP Nick-End Labeling (TUNEL) staining, and flow cytometry were conducted.ResultsQXHZF had potent therapeutic efficacy against PF according to WB, qRT-PCR, and pathological section examination. …”
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36803
Effects of Calliandra and Sesbania on Daily Milk Production in Dairy Cows on Commercial Smallholder Farms in Kenya
Published 2020-01-01“…Descriptive and univariable statistical analyses were conducted, and multivariable mixed-model regression was used for identification of factors associated (P<0.05) with daily milk production. …”
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36804
Integrated communication support program for oncologists, caregivers and patients with rapidly progressing advanced cancer to promote patient-centered communication: J-SUPPORT 1904...
Published 2020-09-01“…The primary endpoint is the intergroup difference between before-intervention and after-intervention patient-centred communication behaviours during oncology visits.Ethics and dissemination This study is conducted in accordance with the ethical guidelines for clinical studies published by Japan’s Ministry of Education, Cultural, Sports, Science and Technology, the Ministry of Health, Labour and Welfare, and the ethical principles established for research on humans stipulated in the Declaration of Helsinki and further amendments thereto. …”
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36805
Waste ceramic powder for sustainable concrete production as supplementary cementitious material
Published 2025-02-01“…Subsequently, several tests, including compressive strength (CS), splitting tensile strength (STS), and flexural strength (FS), were conducted on the specimens to assess the effectiveness of concrete fabricated using WCP. …”
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36806
Response of the germinable soil seed bank of temperate Leymus chinensis meadows to mowing regimes
Published 2025-01-01“…Thus, germinable soil seed banks are critical for restoring overexploited meadows. In this study, we conducted germination experiments on 135 soil samples from various depths to comprehensively analyze the germinable seed bank under different mowing regimes. …”
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36807
Dyssynchronous heart failure models in canines: New insights into electrocardiographic, echocardiographic and histological features
Published 2025-01-01“…Three weeks of follow‐up were conducted to observe the changes in cardiac function and myocardial staining was performed at the end of the experiment. …”
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36808
Identifying biomarkers for epilepsy after cerebral malaria in Zambian children: rationale and design of a prospective observational study
Published 2022-07-01“…Our goal is to develop a predictive PME index composed of EEG and clinical history metrics that are highly feasible to obtain in low-resourced regions.Methods and analyses This prospective observational study being conducted in Eastern Zambia will recruit 250 children aged 6 months to 11 years presenting with acute CM and follow them for two years. …”
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36809
Structured lactation support for mothers of very low birthweight preterm infants and establishment of human donor milk banks in German NICUs (Neo-MILK): protocol for a hybrid type...
Published 2025-02-01“…This protocol describes the design of a study evaluating the effectiveness, implementation and economic aspects of an intervention, which aims to ensure access to MOM or HDM for VLBW infants from the first day of life in German neonatal intensive care units (NICUs).Methods and analysis The hybrid type 1 effectiveness-implementation cluster-randomised controlled trial, using a stepped-wedge design, will be conducted in 15 level I and level II NICUs across Germany over 26 months. …”
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36810
Rab21-Targeted Nano Drug Delivery System-Based FFPG for Efficient Paclitaxel Delivery to Inhibit Lung Cancer Progression
Published 2025-01-01“…<b>Background/Objectives</b>: <i>Platycodon grandiflorus</i> (PG) has been widely researched as a conductant drug for the treatment of lung diseases by ancient and modern traditional Chinese medicine (TCM) practitioners. …”
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36811
Complex immunohistochemical and molecular study on 5 cases of ovarian juvenile granulosa cell tumors reveals a consistent alteration in the PI3K/AKT/mTOR signaling pathway
Published 2025-01-01“…Abstract Background Juvenile granulosa cell tumor (JGCT) of the ovary is a rare tumor with distinct clinicopathological and hormonal features primarily affecting young women and children. We conducted a complex clinicopathological, immunohistochemical, and molecular analysis of five cases of JGCT. …”
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36812
MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB
Published 2025-01-01“…Methods In this study, we conducted comprehensive in vitro experiments to elucidate the effects of sEVs isolated from the serum of elderly donors on the senescence of BMMSCs. …”
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36813
Save a trip: Clinical outcomes of cardiac allografts recovered by local surgeons compared to recipient center surgeons.
Published 2025-02-01“…Results: 218 recovery attempts were included, 25 conducted by local surgeons. Donor demographics between the two groups were similar, with a mean age of 31.5±10 years. …”
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36814
Efficacy and safety of home-based transcranial direct current stimulation as adjunct treatment for cognitive improvement in major depressive disorder: A double-blind, randomized, m...
Published 2025-01-01“…Methods This double-blind, sham-controlled, randomized trial divided participants into low-intensity (1 mA, n = 47), high-intensity (2 mA, n = 49), and sham (n = 45) groups, receiving 42 daily tDCS sessions, including weekends and holidays, targeting the dorsolateral prefrontal cortex for 30 minutes. Assessments were conducted at baseline and weeks 2, 4, and 6. The primary outcome was cognitive improvement assessed by changes in total accuracy on the 2-back test from baseline to week 6. …”
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36815
Study of antifungal susceptibility pattern of various Candida species with reference to conventional and automated methods in a tertiary care hospital
Published 2025-01-01“…Materials and Methods: A cross-sectional observational study was conducted in a tertiary care hospital from February 2021- August 2022. …”
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36816
Prevalence of piriformis syndrome and its associated risk factors among university students in Pakistan: a cross-sectional study
Published 2025-01-01“…Objective To determine the prevalence of piriformis syndrome (PS) among undergraduate university health sciences students aged 18 to 25 and assess the significant predictors of PS regardless of its type and severe PS in particular.Design A cross-sectional study.Setting The study was conducted at a tertiary care hospital of a public university in Pakistan from December 2023 to May 2024.Participants A total of 190 subjects enrolled in the study who met the eligibility criteria, which included being an undergraduate health sciences student (medical and allied health specialities), aged 18 up to 25 years, and willing to participate in the study. …”
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36817
Is avoidable diabetes-related hospitalization in older patients with type 2 diabetes mellitus associated with increased health expenditure?: A nationwide retrospective cohort study...
Published 2025-01-01“…Inverse Probability of Treatment Weighting (IPTW) analysis was conducted to enhance the robustness of the results. …”
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36818
Biochemical Characteristics of Bone Mineral Metabolism before and throughout the First Year after Kidney Transplantation, Persistent Hyperparathyroidism, and Risk Factors in a Lati...
Published 2020-01-01“…Material and Methods: A retrospective study was conducted in 74 patients aged 18–50 years with evolution of 12 months after KT and estimated glomerular filtration rate (eGFR) >60 ml/min; biochemical data of bone mineral metabolism before and at 1, 3, 6, and 12 months of KT were registered. …”
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36819
Balancing legume-cereal proportions in cover crop mixtures to minimize N2O emissions
Published 2025-02-01“…To address these knowledge gaps, we conducted a two-phase greenhouse experiment. In the first phase, cover crops were grown encompassing six treatments: control (no cover crop), pure vetch (Vicia villosa Roth), pure rye (Secale cereale L.), and mixtures with 33 %, 50 % and 66 % of the pure rye sowing rate paired with 66 %, 50 % and 33 % of the pure vetch sowing rate, respectively. …”
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36820
Incidence and risk of endocrine and metabolic abnormalities linked to PARP inhibitors in solid tumors: a meta-analysis
Published 2025-01-01“…Purpose Our aim was to evaluate the potential impact of PARPi on endocrine and metabolic disruptions in clinical trials. Data sources We conducted a comprehensive search across the Medline, EMBASE, PubMed, and Web of Science databases, along with the ClinicalTrials.gov registry. …”
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