Real-world clinical experience with secukinumab in psoriatic arthritis: an observational study and a literature review by Eleonora Celletti, Giulio Gualdi, Emanuela Sabatini, Francesco Cipollone, Fabio Lobefaro, Paolo Amerio

“…An observational study was conducted on adult subjects with PsA and comorbidities, treated with secukinumab after prior therapy with conventional disease-modifying anti-rheumatic drugs or biological agents that were discontinued due to lack of efficacy or adverse drug reactions. …”
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The effect of cheese intake on osteoarthritis: a Mendelian randomization study by Song Wen, Zehan Huang, Bin Zhang, Yuqing Huang

“…The primary analysis employed the inverse variance weighted (IVW) method, while complementary analyses were conducted using the weighted median, MR-Egger, and weighted mode methods. …”
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Role of CX3CL1/CX3CR1 Signaling Axis Activity in Osteoporosis by Piotr Wojdasiewicz, Pawel Turczyn, Barbara Dobies-Krzesniak, Justyna Frasunska, Beata Tarnacka

“…Cell-to-cell inflammatory information transfer occurs via factors including cytokines which form a complex network of cell humoral correlation, called cytokine network. Recently conducted studies revealed the participation of CX3CL1 chemokine in the pathogenesis of osteoporosis. …”
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Conceptualising cultural safety at an Indigenous-focused midwifery practice in Toronto, Canada: qualitative interviews with Indigenous and non-Indigenous clients by Michelle Firestone, Sara H Wolfe, Cheryllee Bourgeois, Janet K Smylie, Mackenzie E Churchill, Helle Moeller

“…This study explored how Indigenous and non-Indigenous clients at an urban, Indigenous-focused midwifery practice in Toronto, Canada (Seventh Generation Midwives Toronto, SGMT) conceptualised and experienced culturally safe care.Design and setting Interviews were conducted with former clients of SGMT as a part of a larger evaluation of the practice. …”
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B Cell Activation, Differentiation, and Their Potential Molecular Mechanisms in Osteoarthritic Synovial Tissue by Lu P, Li Y, Yang S, Yao H, Tu B, Ning R

“…Immunofluorescence staining of joint synovium from OA mice at different stages was conducted to assess mice joint synovium B cell activation and differentiation. …”
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Current update on surgical management for spinal tuberculosis: a scientific mapping of worldwide publications by Romaniyanto Romaniyanto, Muhana Fawwazy Ilyas, Aldebaran Lado, Daffa Sadewa, Daffa Sadewa, Dykall Naf'an Dzikri, Enrico Ananda Budiono, Enrico Ananda Budiono

“…Despite antitubercular drug therapy being the primary treatment, surgical intervention is often required in cases of spinal instability or neurological complications. This study aims to conduct a comprehensive bibliometric analysis of worldwide publications related to the surgical management of spinal TB and to compare contributions from orthopaedic surgery and neurosurgery in this field.MethodsA bibliometric analysis was performed using data from the Scopus database, covering publications from 1896 to 2024. …”
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Cost-utility of behavioural activation for mitigating psychological impacts of COVID-19 on socially isolated older adults with depression and multiple long-term conditions compared... by Simon Gilbody, Caroline Fairhurst, Catherine Hewitt, Dean McMillan, Carolyn Chew-Graham, Della Bailey, David Ekers, Steve Parrott, Elizabeth Littlewood, Peter Coventry, Han-I Wang, Kalpita Baird

“…Sensitivity analyses were conducted to assess the robustness of the primary analysis.Findings Primary analysis indicated that BA generated a small cost-saving (£62.34 per older adult; 95% CI: −£120.44 to £239.70) while QALY improvements remained unchanged (0.007; 95% CI −0.036 to 0.022) compared with usual care. …”
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Towards a conceptual framework of the working alliance in a blended low-intensity cognitive behavioural therapy intervention for depression in primary mental health care: a qualita... by Sarah Smith, Caroline Free, Daniel Michelson, Jesus Montero-Marin, Ricardo Araya, Asmae Doukani, Arlinda Cerga-Pashoja, Ritsuko Kakuma

“…A thematic analysis was conducted using a constant comparative method informed by grounded theory.Setting Recruitment was carried out in four psychological primary care services across the UK.Participants Nineteen trial participants with major depressive disorder who completed at least one computerised program and face-to-face session with a PWP in the b-CBT arm were recruited to the study.Results Qualitative interviews that were guided by WA theory and patient involvement, revealed four themes: (1) a healthcare provider (PWP and computerised program) with good interpersonal competencies for building a working relationship with the client (‘bond’); (2) collaborative efforts between the client and the provider to appropriately identify what the client hopes to achieve through therapy (‘goals’); (3) the selection of acceptable therapeutic activities that address client goals and the availability of responsive support (‘task’) and (4) the promotion of active engagement and autonomous problem solving (‘usability heuristics’). …”
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Prevalence of organic central precocious puberty in males: criteria for a high index of suspicion by Maria Elisa Amodeo, Annalisa Deodati, Stefania Pedicelli, Giulia Mirra, Valentina Pampanini, Stefano Cianfarani

“…Design: An observational study was conducted in 102 otherwise healthy boys with CPP diagnosed from 1998 to 2023 in a single tertiary center. …”
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The research progress and prospects of circadian rhythm in obesity: a bibliometric analysis by Ye Dou, Xiaojin Guo, Xuefei Wang, Aolong He, Fanghe Li, Kuo Gao

“…This article aims to conduct an extensive bibliometric analysis to deepen our understanding of the relationship between circadian rhythms and obesity.MethodsThe literature related to the circadian rhythm of obesity, published from the inception of the Web of Science Core Collection (WoSCC) until June 30, 2024, was extracted from the WoSCC databases (SCIE, SSCI, ESCI). …”
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The Application of an Intelligent <i>Agaricus bisporus</i>-Harvesting Device Based on FES-YOLOv5s by Hao Ma, Yulong Ding, Hongwei Cui, Jiangtao Ji, Xin Jin, Tianhang Ding, Jiaoling Wang

“…To confirm the impact of vibration on the harvesting process, a stepper motor drive test was conducted using both trapezoidal and S-curve acceleration and deceleration motor control algorithms. …”
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Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial by Liu Y, Li X, Zhang M, Men Y, Wang Y, Zhu X, Zheng L

“…The objectives of this study were to assess the effect of high-fat and high-calorie food on the pharmacokinetic (PK) profile and safety of HA121-28 tablet in healthy subjects.Patients and Methods: A single-dose, randomized, open-label, two-period, crossover-designed phase I clinical trial was conducted. Subjects received 200 mg HA121-28 in the fasted state or with high-fat and high-calorie breakfast. …”
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Association between triglyceride/high density lipoprotein ratio and incidence risk of Parkinson’s disease: a population-based cohort study by Yoonkyung Chang, Ju-young Park, Tae-Jin Song

“…Our study aimed to investigate the association between the triglyceride/high-density lipoprotein (TG/HDL) ratio (which represents insulin resistance), and the incidence risk of PD in the general population. This study was conducted using data from the National Health Insurance Service-Health Screening Cohort Database of South Korea (2002–2019). …”
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The Role of Microelements of Lumbar Disc Degeneration in Patients Undergoing Lumbar Spine Surgery by Sadiq R. Karkush, Manal K. Rasheed, Ali T. Abdul Wahid, Ahmed R. Majeed

“…Methods: A case-control study was conducted in Ghazi Al-Hariri Hospital in Baghdad, Iraq, during the period from October 2023 to January 2024. …”
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Transforming Triple Cropping System to Four Crops Pattern: An Approach of Enhancing System Productivity through Intensifying Land Use System in Bangladesh by Md. Aminul Islam, Md. Jahedul Islam, M. Akkas Ali, A. S. M. Mahbubur Rahman Khan, Md. Faruque Hossain, Md. Moniruzzaman

“…With this view to increase crop productivity, production efficiency, land use efficiency, and economic return through intensifying cropping intensity as well as crop diversity by transforming three crops pattern to four crops, the experiment was conducted in High Ganges River Floodplain Soils under the Agro-Ecological Zone (AEZ) 11 at Pali, Durgapur, under the Multilocation Testing Site, Puthia, Rajshahi, for two consecutive years 2014-15 and 2015-16. …”
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Research through service: Meeting Chinese international college students’ mental health needs by Changming Duan, Jingru Chen, Fenglan Li, Mi Zhou, Xiubin Lin, Shengnan Li

“…Group sessions were conducted in Chinese and emphasized experiential activities aimed at enhancing participants’ cultural confidence and fostering a growth-oriented, positive mindset. …”
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Children’s and Their Parents’ Experiences With Home-Based Guided Hypnotherapy: Qualitative Study by Ilse N Ganzevoort, Adriëlla L van der Veen, Manna A Alma, Marjolein Y Berger, Gea A Holtman

“…A total of 23 interviews were conducted with 10 children and 15 parents. Six themes emerged from questionnaire data and interviews: impression of the exercises, not for everyone, influence of perceived effect, integrating exercises in daily life, content and practicalities of the website, and customization to personal preferences. …”
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Stunting and Its Determinants among Children Aged 6–59 Months in Northern Ethiopia: A Cross-Sectional Study by Shiferaw Abeway, Bereket Gebremichael, Rajalakshmi Murugan, Masresha Assefa, Yohannes Mehretie Adinew

“…A community-based cross-sectional study was conducted among 410 children aged between 6 and 59 months. …”
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Exploring the gender difference in type 2 diabetes incidence in a Swiss cohort using latent class analysis: an intersectional approach by Julien Vaucher, Michael Amiguet, Carole Clair, Joelle Schwarz, Jeanne Marie Barbier, Aurélie M Lasserre

“…The aim of this study was to highlight the intersectional social position of the participants and disentangle its role from administrative sex in predicting the development of type 2 diabetes.Methods Using CoLaus|PsyCoLaus study, a Swiss single-centre prospective cohort initiated in 2003 and including 6733 participants (age 35–75 years; 54% women) at baseline, we conducted latent class analyses using gender-related variables (eg, risk-taking behaviours, gender roles represented by employment status, etc) and socioeconomic determinants at baseline (2003–2006) to construct intersectional classes and we tested their association with the development of type 2 diabetes at follow-up (2018–2021).Results Of the 6733 participants enrolled at baseline, 3409 were included in our analyses (50.6%). …”
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Climate change as a wildlife health threat: a scoping review by Sabrina S. Greening, Lucie R. Pascarosa, Avery L. Munster, Roderick B. Gagne, Julie C. Ellis

“…Here, we performed a scoping review to identify scholarly articles from 2008 onwards with a focus on climate change impacts on wildlife health. Searches were conducted in Web of Science, Zoological Record, Scopus, Ovid CAB Abstracts, and ProQuest Dissertations and Theses. …”
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