Genome-wide identification of the bHLH gene family in Scutellaria baicalensis and their relationship with baicalin biosynthesis under drought stress by Yingxin Sun, Beier Wang, Lichao Zhang, Xiaohan Zheng, Peng Xu, Meng Zhang, Meiguang Han, Peng Di, Mei Han, Lin Cheng, Limin Yang

“…Gene duplication events were analyzed, and cis-element analysis was conducted to explore regulatory factors. The expression patterns of these genes in different tissues and under drought stress were investigated using transcriptome data and qRT-PCR analysis. …”
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Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immun... by Qian Yang, Ruijing Zhang, Peng Tang, Yu Sun, Candice Johnson, Jason Saredy, Susu Wu, Jiwei Wang, Yifan Lu, Fatma Saaoud, Ying Shao, Charles Drummer, Keman Xu, Daohai Yu, Rongshan Li, Shuping Ge, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…We used microarray datasets from the NCBI GEO DataSet repository and conducted comprehensive data-mining analyses, where we examined the gene expression of 1376 innate immune regulators (innatome genes (IGs) in cells treated with LIUS. …”
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Soybean and avocado unsaponifiables: a review of their potential use in the treatment of osteoarthritis by Ana Sabucedo-Suárez, Ana Sabucedo-Suárez, Mónica López-Peña, Mónica López-Peña, María Permuy, María Permuy, Fernando Muñóz, Fernando Muñóz

“…The literature review was conducted manually through Pubmed, Scopus and Web of Science (WOS) databases, covering studies from 2000 to 2022 with terms like “osteoarthritis,” “OA,” “animal models,” “ASU,” and “soy/avocado.” …”
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Effectiveness of purple leaves (Graptophyllum pictum L. Griff) and hydroxyapatite as socket preservation biomaterials by Ratri Maya Sitalaksmi, Rizkipriyanto Azharpratomo, Shafira Ninditya Irsan, Primanda Nur Rahmania, Sisca Meida Wati, Syafira Salsabila Adam, Kavanila Bilbalqish, Khairul Anuar bin Shariff, Harry Laksono, Agus Dahlan, Devi Rianti

“…The study groups were as follows: Group 1: Ad-MSCs; Group 2: Ad-MSCs + αmem; Group 3: Ad-MSCs + osteogenic medium + 1 % nano-extract of Purple leaves & Hydroxyapatite; Group 4: Ad-MSCs + osteogenic medium + 2 % nano-extract of Purple leaves & Hydroxyapatite. Observations were conducted on days 7, 14, and 21. Results: The combination of nanosuspension extract of Purple leaves and hydroxyapatite significantly increased the expression of RUNX2, OSX, OPN,ALP and calcium deposition compared to other groups. …”
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Network-wide effects of pallidal deep brain stimulation normalised abnormal cerebellar cortical activity in the dystonic animal model by Fabiana Santana Kragelund, Konstantinos Spiliotis, Marco Heerdegen, Tina Sellmann, Henning Bathel, Anika Lüttig, Angelika Richter, Jens Starke, Rüdiger Köhling, Denise Franz

“…This study explores how pallidal DBS alters spatiotemporal pattern formation of neuronal dynamics within the cerebellar cortex in a dystonic animal model, the dtsz hamster. Methods: We conducted in vitro analysis using a high-density microelectrode array (HD-MEA) in the cerebellar cortex. …”
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Duplex qPCR for detecting and differentiating porcine epidemic diarrhea virus GI and GII subtypes by Bin Wang, Wang Han, Di Wu, Yue Jing, Li Ma, Feiyang Jiang, Shusen Ji, Lianmei Bai, Xiuju Yu, Wei Hou, Shouyu Wang, Haidong Wang

“…PCR is the most commonly used technique for PEDV diagnosis in practical clinics, however, reported works still suffer from shortcomings, for example, most of them cannot differentiate GI and GII subtypes, they suffer from low sensitivity, and some primer sequences are no longer able to match the mutant strains.MethodsTo address these issues, we conducted a comprehensive analysis by comparing the sequences of the PEDV S protein in the existing NCBI database with a recently isolated epidemic strain of PEDV, named SX0818-2022, of subtype GIIa from Shanxi, China. …”
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Dynamic analysis of growth characteristics, secondary metabolites accumulation, and an in-depth understanding of anthraquinones biosynthesis in Rubia cordifolia Linn. by Conglong Lian, Conglong Lian, Conglong Lian, Xiuyu Liu, Xiuyu Liu, Kaihua Guo, Kaihua Guo, Hao Yang, Hao Yang, Jingfan Yang, Jingfan Yang, Jinxu Lan, Jinxu Lan, Suiqing Chen, Suiqing Chen, Suiqing Chen, Suiqing Chen

“…With the current depletion of natural resources of R. cordifolia, it is critical to conduct cultivation studies on the R. cordifolia. …”
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Sitravatinib in combination with nivolumab plus ipilimumab in patients with advanced clear cell renal cell carcinoma: a phase 1 trial by Pavlos Msaouel, Kai Yu, Ying Yuan, Jianfeng Chen, Xinmiao Yan, Menuka Karki, Fei Duan, Rahul A. Sheth, Priya Rao, Kanishka Sircar, Amishi Y. Shah, Amado J. Zurita, Giannicola Genovese, Min Li, Chih-Chen Yeh, Minghao Dang, Guangchun Han, Yanshuo Chu, Max Hallin, Peter Olson, Rui Yang, Daniela Slavin, Hirak Der-Torossian, Curtis D. Chin, Nizar M. Tannir, Linghua Wang, Jianjun Gao

“…Abstract We conducted a phase I trial to determine the optimal dose of triplet therapy with the tyrosine kinase inhibitor sitravatinib plus nivolumab plus ipilimumab in 22 previously untreated patients with advanced clear cell renal cell carcinoma. …”
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Clinical Research Network: JHCRN Infrastructure and Lessons Learned by Rahul Kashyap, Gayane Yenokyan, Robert Joyner, Melissa Gerstenhaber, Mary Alderfer, Erika Siegrist, Joan Moore, Channing J. Paller, Hanan Aboumatar, James J. Potter, Stanley Watkins Jr, John E. Niederhuber, Daniel E. Ford, Adrian Dobs

“…As of August 2024, total 81 studies‐clinical trials, cohort studies, and comparative effectiveness research have been conducted, with funding from the NIH, private foundations, and industry. …”
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Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus by Dongdong Lin, Cong Tang, Junbin Wang, Yun Yang, Hao Yang, Yanan Zhou, Wenhai Yu, Bai Li, Qing Huang, Haixuan Wang, Ran An, Xiaoming Liang, Yuhuan Yan, Longhai Yuan, Xuena Du, Yuxia Yuan, Yanwen Li, Shuaiyao Lu

“…Abstract Chikungunya virus (CHIKV) is a mosquito‐borne alphavirus that is primarily known for causing severe joint and muscle symptoms, but its pathological effects have extended beyond these tissues. In this study, we conducted a comprehensive proteomic analysis across various organs in rodent and nonhuman primate models to investigate CHIKV's impact on organs beyond joints and muscles and to identify key host factors involved in its pathogenesis. …”
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“We need workable micronutrient data!”: a qualitative study assessing the need for integrated micronutrient data to support evidence-based decisions by Indian food system stakehold... by Rupinder Sahota, Jaswant S. Khokhar, Aakash Deep, Aakash Deep, Katherine P. Adams, Arindam Das, E. Louise Ander, E. Louise Ander, Edward J. M. Joy, Edward J. M. Joy

“…A qualitative, descriptive study was conducted, with purposive sampling of stakeholders from state and national-level government, development agencies, non-governmental organisations, research institutes, private organisations, and academia. …”
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High expression of SULF1 is associated with adverse prognosis in breast cancer brain metastasis by Yitong Li, Tingting Feng, Qinghong Wang, Yue Wu, Jue Wang, Wenlong Zhang, Qi Kong

“…Further investigation related to SULF1 was conducted using online databases such as Kaplan–Meier Plotter and cBioPortal. …”
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Incidence and pathological features of IgA nephropathy before and during the COVID-19 pandemic by Wen Liu, Ricong Xu, Di Wu, Zhihang Su, Yuan Cheng, Haofei Hu, Xinzhou Zhang, Qijun Wan

“…In this study, we analyzed kidney biopsy results from two medical institutions, covering the timeframe from January 2016 to May 2023. We conducted statistical analyses on various glomerular diseases according to their corresponding pathological diagnoses. …”
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The Dutch-translated cultural competence assessment scale for nurses: Cross-cultural adaptation and validation by P.B. Sutharson, J.M. Maaskant, A.M. Eskes

“…We used a cross-sectional design and conducted the study in two phases. Nurses from all over the Netherlands were recruited through the newsletter of the Dutch nurses association and internal distribution by healthcare organisations. …”
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Immunotargeting of Integrin αβ for Single-Photon Emission Computed Tomography and Near-Infrared Fluorescence Imaging in a Pancreatic Cancer Model by Winn Aung MBBS, PhD, Atsushi B. Tsuji PhD, Hitomi Sudo PhD, Aya Sugyo M.Ed, Takako Furukawa PhD, Yoshinori Ukai PhD, Yoshikazu Kurosawa PhD, Tsuneo Saga MD, PhD

“…After injection of 111 In-labeled probe to tumor-bearing mice, biodistribution, SPECT, autoradiography (ARG), and immunohistochemical (IHC) studies were conducted. After administration of ICG-labeled probe, in vivo and ex vivo NIR imaging and fluorescence microscopy of tumors were performed. …”
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Evidence of Rehabilitative Impact of Progressive Resistance Training (PRT) Programs in Parkinson Disease: An Umbrella Review by T. Paolucci, S. Sbardella, C. La Russa, F. Agostini, M. Mangone, L. Tramontana, A. Bernetti, M. Paoloni, L. Pezzi, R. G. Bellomo, V. Santilli, R. Saggini

“…The PubMed, PEDro, Scopus, and Cochrane Library databases were searched from January 2009 to August 2019 for systematic reviews and meta-analyses conducted in English. The populations included had diagnoses of PD and consisted of males and females aged >18 years old. …”
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Effects of repetitive thermal loads on microstructure and mechanical properties of potassium-doped tungsten alloy as plasma facing material by Hui Wang, Zhuo-Ming Xie, Da-Huan Zhu, Mu-Lan Yu, Yin-Juan Fu, Rui Liu, Xian-Ping Wang, Qian-Feng Fang, Chang-Song Liu, Xue-Bang Wu

“…Thermal load tests were conducted with a single-pulse duration of 1 s at absorbed power densities of 10, 13, 15 and 20 MW m ^−2 for 50 cycles at room temperature. …”
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Naked-Eye Molecular Testing for the Detection of <i>Xylella fastidiosa</i> in Mallorca (Balearic Island) Almond Orchards by Colorimetric LAMP by Amoia Serafina Serena, Ana Falcón-Piñeiro, Milica Pastar, José Manuel Garcìa-Madero, Nicoletta Contaldo, Mikael Muegge, Stéphane Compant, Pasquale Saldarelli, Angelantonio Minafra

“…Following tissue homogenization, an alkaline treatment for target DNA extraction was conducted before the cLAMP test. The cLAMP assay was able to detect up to 100 CFU/mL of the <i>Xf</i> bacterial suspension diluted in healthy almond sap. …”
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Diagnosis and management of de novo non-specific spinal infections: European Association of Neurosurgical Societies (EANS) Spine Section Delphi consensus recommendations by Andreas Kramer, Santhosh G. Thavarajasingam, Jonathan Neuhoff, Benjamin Davies, Giuseppe Barbagallo, Bertrand Debono, Bart Depreitere, Sven O. Eicker, Nikolay Gabrovsky, Marisa L. Gandia-Gonzalez, Marcel Ivanov, Radek Kaiser, Stanislav Kaprovoy, Nikolay Konovalov, Jesus Lafuente, Andrzej Maciejczak, Bernhard Meyer, Paulo Pereira, Yana Petrova, Wilco C. Peul, Carla Reizinho, Yu-Mi Ryang, Nico Sampron, Ralph Schär, Enrico Tessitore, Claudius Thomé, Jake Timothy, Carmen Vleggeert-Lankamp, Andreas K. Demetriades, Ehab Shiban, Florian Ringel

“…Material and methods: A Delphi process was conducted with 26 experts from the European Association of Neurosurgical Societies (EANS). …”
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Three-dimensional quantitative temporomandibular joint changes in skeletal class I malocclusion treated with extraction and non-extraction protocols: a comparative study of fixed o... by Majedh Abdo Ali Al-Somairi, Bowen Zheng, Xaiofeng Yang, Yongxin Zhang, Maged S. Alhammadi, Hao xu, Najah Alhashimi, Bushra Sufyan Almaqrami, Naseem Ali Al –Worafi, Enas Senan Alyafrusee, Barakat Al-Tayar, Yi Liu

“…Statistical analyses were conducted to compare the mean changes in intra- and inter-groups. …”
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