ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice by Lakshini Weerasekera, Caroline Rudnicka, Qing-Xiang Sang, Joanne E. Curran, Matthew P. Johnson, Eric K. Moses, Harald H. H. Göring, John Blangero, Jana Hricova, Markus Schlaich, Vance B. Matthews

“…To determine the potential novel role of ADAM19 in the metabolic syndrome, we first conducted microarray studies on peripheral blood mononuclear cells from a well-characterised human cohort. …”
Get full text

Association between nutritional status, daily nutrition delivery and clinical outcomes of critically ill adult patients admitted to the intensive care unit: a protocol for Isfahan... by Awat Feizi, Sabrina Schlesinger, Nafiseh Shokri-Mashhadi, Somayeh Rajaii, Milad Nasiri Jounaghani

“…Introduction There is currently limited information regarding the association between the modified Nutrition Risk in Critically Ill (mNUTRIC) score, nutrition delivery and clinical outcomes in critically ill patients admitted to the intensive care unit (ICU) section.Methods and analysis The Isfahan-ICU study is a multicentre, prospective observational cohort study that will be conducted on critically ill adults treated in the trauma or medical ICU sections of six hospitals to investigate whether clinical outcomes, including length of ICU stay and 30-day survival, vary by the mNUTRIC score at admission or the 7-day nutrition delivery. …”
Get full text

Psychometric properties of the Moroccan dialect versions of the Perceived Stress Scale and the Center for Epidemiologic Studies Depression Scale among Moroccan university students by Younes RAMI, Hicham KHABBACHE, Jamal AMRAOUI, Driss AIT ALI, Zakaria ABIDLI, Abdulmohsen MOHAMMED ABDULLAH ALKHULAYFI, Mahmood BAHRAMIZADEH, Hassan LAABOUB, Amelia RIZZO, Bouabid BADAOUI, Şeyhmus AKSOY, Lukasz SZARPAK, Murat YILDIRIM, Francesco CHIRICO

“…The objective is to evaluate the reliability and validity of these scales for assessing perceived stress and depressive symptoms among this population. Methods: We conducted a cross-sectional survey of 204 Moroccan university students. …”
Get full text

Simulation of Software Development Team Productivity Incorporating Social and Human Factors: A System Dynamics Model by Luz Marcela Restrepo-Tamayo, Gloria Piedad Gasca-Hurtado, Johnny Valencia-Calvo

“…Estimating project time is part of the planning stage and is mainly conducted using methods based on technical factors. …”
Get full text

Boosting the thermal efficiency of a flat-tube parabolic trough solar collector with the introduction of innovative slashed triangular prism turbulators by Sultan Alshehery, Qasem Al Mdallal, Ahmed A. Altohamy, Lotfi Ben Said, Mohamed Bouzidi, Turki Alkathiri, Lioua Kolsi

“…For the first time, an innovative turbulator known as the triangular prisms turbulator (TPT) has been utilized, with its geometry specifically designed to fit precisely within the flat tube. Tests were conducted on various geometric parameters, including turbulator lengths (l) of 5–20 mm, slash areas (A) ranging from 4 to 40 mm2, and clearance (C) from 0.25 to 1 mm. …”
Get full text

Engagement factors affect academic success through study approaches among physical education and sport university students: a mediation analysis by Amayra Tannoubi, Amayra Tannoubi, Tore Bonsaksen, Tore Bonsaksen, Gry Mørk, Farruh Ahmedov, Edi Setiawan, Fairouz Azaiez

“…Analyses of associations were conducted through linear regression analysis and mediation analysis.ResultsResults from the linear regression analysis showed correlations between academic engagement factors, study approach variables, and GPA, with higher GPA correlating with higher scores on behavioral engagement, cognitive engagement, surface theory task, and deep theory task, and with lower scores on surface practical task. …”
Get full text

Serum Potassium and Glucose Regulation in the ADDITION-Leicester Screening Study by Patrice Carter, Danielle H. Bodicoat, Lauren M. Quinn, Francesco Zaccardi, David R. Webb, Kamlesh Khunti, Melanie J. Davies

“…Tests for associations between baseline characteristics and K+ quartiles were conducted using linear regression models. Results. …”
Get full text

Predictive value of serum procalcitonin level for the diagnosis of bloodstream infections in hematological patients by Qi Sun, Qingsong Lin, Yanxia Lv, Zhiying Tian, Qiushuang Yan, Yaqing Yu, Xue Fu, Hongjing Yao, Fujun Sun, Yonghui Xia, Guoqing Zhu, Sizhou Feng

“…However, the cut-off value of PCT for the diagnosis of bloodstream infections in patients with hematolgic diseases is still unclear and unreliable. Methods We conducted a retrospective study involving 2299 cases with hematological diseases and who had been performed blood culture and PCT test within 24 h. …”
Get full text

Mitigating overconfidence bias: A cross-sectional pilot study of male maintenance workers in the engineering sector by Luca DI GIAMPAOLO, Federica MARINO, Claudia GIURGOLA, Piergiorgio ASTOLFI, Luca COPPETA, Simone DE SIO, Paola BORRELLI, Teresa GALANTI, Laura FORCELLA, Maria Elisa MAIOLO, Kavita BATRA, Murat YILDIRIM, Hicham KHABBACHE, Amelia RIZZO, Mahmood BAHRAMIZADEH, Hiroo WADA, Qiao NIU, Hector NIETO, Francesco CHIRICO

“…Methods: The study was conducted among the employees of a large metalworking company in central Italy over a three-months period. …”
Get full text

Clinical performance of real-time nanopore metagenomic sequencing for rapid identification of bacterial pathogens in cerebrospinal fluid: a pilot study by Yoon Hyun Sung, Yong Kuk Ju, Hak Jun Lee, Seung Min Park, Jin Woong Suh, Jeong Yeon Kim, Jang Wook Sohn, Young Kyung Yoon

“…Abstract This study aimed to evaluate the usefulness of amplicon-based real-time metagenomic sequencing applied to cerebrospinal fluid (CSF) for identifying the causative agents of bacterial meningitis. We conducted a 16S rRNA amplicon sequencing using a nanopore-based platform, alongside routine polymerase chain reaction (PCR) testing or bacterial culture, to compare its clinical performance in pathogen detection on CSF samples. …”
Get full text

A Promising Approach to Ultra‐Flexible 1 Ah Lithium–Sulfur Batteries Using Oxygen‐Functionalized Single‐Walled Carbon Nanotubes by Junyoung Heo, Jeong‐Won Hong, Ha Won Gu, Junghwan Sung, Dong‐Hee Kim, Jung Hoon Kim, Sung Kang, You‐Jin Lee, Hye Young Choi, Doohun Kim, Kang‐Jun Baeg, Joong Tark Han, Jun‐Woo Park

“…In this study, an innovative approach is proposed utilizing highly oxidized single‐walled carbon nanotubes (Ox‐SWCNTs) as a conductive fibrous scaffold and functional interlayer in sulfur cathodes and separators, respectively, to demonstrate large‐area and ultra‐flexible Li‐S batteries with enhanced energy density. …”
Get full text

Histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine model by Yu Sato, Matthew Kutnya, Biniyam Abebe, Mohammed S. El Kurdi, Martijn Cox, Richard W. Bianco, Bart Meuris, Yoshinobu Onuma, Patrick W. Serruys, Renu Virmani

“…Pathological evaluation was conducted at 12 months.ResultsIn the XABG group, two sheep died perioperatively; two were sacrificed at 3 months (1 occluded, 1 patent) and two at 6 months (both patent). …”
Get full text

Efficient Spectral-Spatial Fusion With Multiscale and Adaptive Attention for Hyperspectral Image Classification by Xiaoqing Wan, Feng Chen, Weizhe Gao, Yupeng He, Hui Liu, Zhize Li

“…Extensive experiments conducted on four public datasets (Houston2013, Botswana, WHU-Hi-HanChuan and WHU-Hi-HongHu) demonstrate that the proposed ESSF method significantly outperforms nine other state-of-the-art methods in terms of classification accuracy.…”
Get full text

Automated Quantification of Neuropad Improves Its Diagnostic Ability in Patients with Diabetic Neuropathy by Georgios Ponirakis, Hassan Fadavi, Ioannis N. Petropoulos, Shazli Azmi, Maryam Ferdousi, Mohammad A. Dabbah, Ahmad Kheyami, Uazman Alam, Omar Asghar, Andrew Marshall, Mitra Tavakoli, Ahmed Al-Ahmar, Saad Javed, Maria Jeziorska, Rayaz A. Malik

“…The diagnostic performance of Neuropad was compared between the categorical and continuous (image-analysis (Sudometrics)) outputs to diagnose diabetic peripheral neuropathy (DPN). 110 subjects with type 1 and 2 diabetes underwent assessment with Neuropad, Neuropathy Disability Score (NDS), peroneal motor nerve conduction velocity (PMNCV), sural nerve action potential (SNAP), Deep Breathing-Heart Rate Variability (DB-HRV), intraepidermal nerve fibre density (IENFD), and corneal confocal microscopy (CCM). 46/110 patients had DPN according to the Toronto consensus. …”
Get full text

Exploring post-rehabilitation plasticity with intra-cerebral recordings on anomic profiles by Agnès Trébuchon, Agnès Trébuchon, Alexia Fasola, Véronique Sabadell, Véronique Sabadell, Anne-Sophie Dubarry, Romain Carron, Romain Carron, Fabrice Bartolomei, Fabrice Bartolomei, F.-Xavier Alario

“…Time-frequency analyses were conducted on intracranial signals, and comparisons were made between baseline and post-therapy conditions for each patient.ResultsHalf of the patients demonstrated improved naming skills following the treatment. …”
Get full text

Frameworks for the design and reporting of anaesthesia interventions in perioperative clinical trials by Karen D. Coulman, Lucy Elliott, Natalie S. Blencowe, Joyce Yeung, Leila Rooshenas, Robert J. Hinchliffe, Ronelle Mouton, Eric Albrecht, David Bosanquet, Kariem El-Boghdadly, Gudrun Kunst, Mandeep Phull, Helen Galley, Ben Gibbison, Suzanne Harrogate, Anna Simpson, Jasmeet Soar, Michael Gillies, Mr James Glasbey, Sina Grape, David Hewson, Simon Howell, Louise Savic, Alan MacFarlane, Brendan McGrath, Ciara O'Donnell, Jon Silversides, Katrina Pirie, Andrew Toner

“…Methods: This study comprised three phases: (1) initial framework development—text describing the delivery of anaesthetic interventions was coded and categorised into components using thematic analysis; (2) refinement of frameworks—facilitated structured group discussions were conducted with perioperative clinicians, researchers, and journal editors to elicit additional framework categories and consider clarity and feasibility; (3) framework testing and further refinement—cognitive interviews with professionals undertaking trials evaluating anaesthesia interventions to test the feasibility of using the frameworks in contemporary perioperative trials. …”
Get full text

Key elements for designing effective second victim support interventions: a focus group study in European clinical settings by José Joaquín Mira, Irene Carrillo, Kris Vanhaecht, Deborah Seys, Massimiliano Panella, Susanna Tella, Katja Schrøder, Reinhard Strametz, Paulo Sousa, Bojana Knezevic, Kaja Pölluste, Eva Gil-Hernández, Hana Knežević Krajina, Sofia Guerra Paiva, Einav Srulovici

“…Peer support is recognised as the most effective, feasible and acceptable intervention to mitigate its impact.Objective To define a set of success factors when designing interventions to support SVs in health and care facilities based on expertise in different European countries.Setting International collaboration involving countries with diverse cultures, structures and legal frameworks.Design Qualitative research.Method Focus groups involving a total of 43 participants were conducted in five countries. Prominent professionals in European peer support interventions were engaged. …”
Get full text

Prehabilitation during neoadjuvant therapy in patients with cancer of the upper gastrointestinal tract and rectum—the study protocol by Irina Chmelova, Irina Chmelova, Dalibor Pastucha, Dalibor Pastucha, Tomas Hudecek, Zdenek Guran, Zdenek Guran, Sona Ciecotkova, Lubomír Martínek, Jana Zubikova, Alena Matlova, Jakub Dolezel, Dana Salounova, Jakub Chmelo

“…This is a single group study design, with all patients enrolled receiving the intervention.MethodsThis is an interventional feasibility study of a prehabilitation programme in the form of physical training conducted at home. The training consists of progressively dosed walking and strength exercises for selected muscle groups. …”
Get full text

Metabolomics insights into doxorubicin and 5-fluorouracil combination therapy in triple-negative breast cancer: a xenograft mouse model study by Mai M. Hassanein, Mai M. Hassanein, Yousra A. Hagyousif, Yousra A. Hagyousif, Ruba A. Zenati, Ruba A. Zenati, Hamza M. Al-Hroub, Farman Matloob Khan, Ahmad Y. Abuhelwa, Ahmad Y. Abuhelwa, Karem H. Alzoubi, Karem H. Alzoubi, Nelson C. Soares, Nelson C. Soares, Waseem El-Huneidi, Waseem El-Huneidi, Eman Abu-Gharbieh, Eman Abu-Gharbieh, Eman Abu-Gharbieh, Hany Omar, Hany Omar, Dana M. Zaher, Yasser Bustanji, Yasser Bustanji, Yasser Bustanji, Mohammad H. Semreen, Mohammad H. Semreen

“…This study aimed to investigate the effects of doxorubicin (DOX) and 5-fluorouracil (5-FU) as monotherapies and in combination using an established MDA-MB-231 xenograft model in female BALB/C nude mice employing advanced metabolomics analysis to identify molecular alterations induced by these treatments.MethodsWe conducted comprehensive plasma and tumor tissue sample profiling using ultra-high-performance liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry (UHPLC-ESI-QTOF-MS).ResultsEach treatment group exhibited unique metabolic profiles in plasma and tumor analysis. …”
Get full text

Effect of Aromatherapy using Lavender Oil on Audio and Visual Reaction Time: A Quasi-experimental Study by Saroj Chaudhary, Manjinder Kaur, Suman Sharma, Naren Kurmi, Khushboo Shrimali, Soniya Pipliwal, Muskan Singh

“…Materials and Methods: This quasi-experimental study was conducted on 30 healthy volunteers after obtaining the clearance from ethics committee and informed consent from the participant. …”
Get full text