Peptide-based vaccine targeting IL17A attenuates experimental spondyloarthritis in HLA-B27 transgenic rats by Tetsuya Tomita, Hiromi Rakugi, Hiroki Hayashi, Ryuichi Morishita, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Hironori Nakagami

“…Enzyme-linked immunospot (ELISpot) assays for IL4- and interferon-γ-secreting splenocytes were conducted to evaluate IL17A-specific T cell activation. …”
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Population genetic analysis of clinical Mycobacterium abscessus complex strains in China by Xiangchen Li, Xiangchen Li, Yelei Zhu, Yewei Lu, Kunyang Wu, Yang Che, Xiaomeng Wang, Weixin Wang, Junli Gao, Junshun Gao, Zhengwei Liu, Zhengwei Liu, Zhuxian Zhou

“…BackgroundTo explore the genetic characteristics of the Mycobacterium abscessus complex (MABC) population in China, given its rising clinical importance among nontuberculous mycobacteria.MethodsWe conducted population genetic analyses on 360 MABC genomes from China, focusing on core genome multilocus sequence typing (cgMLST), pan-genome characterization, population genetics, and antimicrobial resistance gene profiling.ResultsOur analysis identified 273 M. abscessus subsp. abscessus (MabA) and 87 M. abscessus subsp. massiliense (MabM) isolates, uncovering 68 sequence types (STs), with ST5 being the most common. cgMLST classified 33.3% of isolates into six dominant circulating clones (DCCs) and 49.4% into 59 genomic clusters at a threshold of 25 different alleles, including 18 international clusters linking Chinese isolates with seven other countries. …”
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Advancing early detection of organ damage and cardiovascular risk prevention: the Suzhou cardiometabolic health study protocol - exploring the role of oral microbiome and metabolic... by Mengmeng Zhu, Mengmeng Zhu, Yiwen Li, Wenting Wang, Longkun Liu, Wenwu Liu, Jiayu Yu, Qian Xu, Jing Cui, Yanfei Liu, Keji Chen, Yue Liu, Yue Liu

“…This study introduces oral (tongue coating) microbiota as metabolic markers for the first time, in combination with multiple metabolic factors, to explore their potential in assessing subclinical target organ damage and optimizing cardiovascular risk stratification, in order to provide a new path for the early identification and intervention of CVD.MethodsThis study is a prospective cohort study aimed at assessing the association between tongue coating microbiota characteristics and multiple metabolic factors with subclinical target organ damage, and identifying high-risk groups suitable for cardiovascular 1.5-level prevention. The study will be conducted in Suzhou City, Jiangsu Province, China, planning to include 5000-6000 eligible subjects, with inclusion criteria of age ≥18 years, excluding individuals with a history of CVD and other serious diseases. …”
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Study protocol for a pragmatic randomised controlled trial of comparing enhanced acceptance and commitment therapy plus (+) added to usual aftercare versus usual aftercare only, in... by Imran Khan, Stephanie J. C. Taylor, Clare Robinson, Elisavet Moschopoulou, Paul McCrone, Liam Bourke, Mohamed Thaha, Kamaldeep Bhui, Derek Rosario, Damien Ridge, Sheila Donovan, Ania Korszun, Paul Little, Adrienne Morgan, Olivier Quentin, Rebecca Roylance, Peter White, Trudie Chalder

“…We also recognise the importance of exercise and vocational activity on QoL and therefore will integrate options for physical activity and return to work/vocational support, thus ACT Plus (+). Methods We will conduct a multi-centre, pragmatic, theory driven, randomised controlled trial. …”
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Delineation of reduced CTV2 on the basis of the characteristics and distribution of cervical lymph node metastasis in nasopharyngeal carcinoma by Zhiqiang Wang, Yi Yang, Chunlei Ge, Rui Tian, Sheng Cheng, Jingyu Gao, Yan Wang, Qi Yue, Zhiwei Wang, Qingqing He, Yuchuan Xu, Yan Li, Xudong Feng, Yanli Yang, Yong Zhang

“…Using MIM software, we integrated all patients’ lymph node images onto the template CT images and conducted an in-depth analysis of their distribution characteristics and metastatic patterns. …”
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Association between migraine severity and sleep quality: a nationwide cross-sectional study by Nura A. Almansour, Nura A. Almansour, Seham S. Alsalamah, Seham S. Alsalamah, Razan S. Alsubaie, Razan S. Alsubaie, Nada N. Alshathri, Nada N. Alshathri, Yasmeen A. Alhedyan, Yasmeen A. Alhedyan, Faisal Y. Althekair’s, Faisal Y. Althekair’s, Faisal Y. Althekair’s

“…This study therefore aimed to determine the association between sleep quality and migraine severity.MethodsA comparative cross-sectional study was conducted with 1,399 participants across all regions of Saudi Arabia from August to October 2023 using standardized questionnaires. …”
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Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial by Anlong Li, Runze Huang, Han Ge, Dajie Liu, Shaochun Liu, Yingxue Jia, Jiaying Chai, Xinyi Zheng, Lijun Liu, Chen Gan, Jian Xu, Ling Cheng, Mingjun Zhang, Huaidong Cheng

“…Assessments of quality of life, sleep disturbances, psychological distress, activation, avoidance, and physical activity levels were conducted at baseline (T0), four weeks later (T1), and post-intervention (T2). …”
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Site-specific immunoglobulin G N-glycosylation is associated with gastric cancer progression by Tingting Xu, Jianmin Huang, Jiajing Lin, Yuanyuan Liu, Yi Wang, Wenkang Shen, Jianjie He, Shuyun Chen, Xi Zhu, Yuqin Que, Mengting Hu, Yu Chen, Liming Cheng, Honghao He, Xin Liu, Si Liu

“…A comprehensive bioinformatics analysis was also conducted to investigate the differential expression of N-glycosylation-related genes and their potential roles in GC pathogenesis. …”
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Validation of the role of apolipoproteins in coronary artery disease patients with impaired kidney function for prognosis: a prospective cohort study in China by Zixiang Ye, Enmin Xie, Zhangyu Lin, Chenxi Song, Rui zhang, Haoyu Wang, Yongbao Zhang, Kefei Dou

“…Subgroup analyses according to kidney function were conducted. Result During a median follow-up of 3.1 years, 324 MACE events were observed. …”
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Diastolic Cardiac Function Improvement by Liraglutide Is Mainly Body Weight Reduction Dependent but Independently Contributes to B-Type Natriuretic Peptide Reduction in Patients wi... by Kunimasa Yagi, Teruhiko Imamura, Hayato Tada, Daisuke Chujo, Jianhui Liu, Yuuki Shima, Azusa Ohbatake, Yukiko Miyamoto, Satoko Okazaki, Naoko Ito, Kaoru Nakano, Masataka Shikata, Asako Enkaku, Akiko Takikawa, Hisae Honoki, Shiho Fujisaka, Hideki Origasa, Kazuyuki Tobe

“…A single-arm prospective study was conducted among Japanese patients with type 2 diabetes having preserved ejection fraction. …”
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Association between plasma perfluoroalkyl substances and high-grade serous ovarian cancer overall survival: A nested case-control study by Wei-Yi Xing, Fang-Hua Liu, Dong-Dong Wang, Jia-Ming Liu, Wen-Rui Zheng, Jia-Xin Liu, Lang Wu, Yue-Yang Zhao, He-Li Xu, Yi-Zi Li, Yi-Fan Wei, Dong-Hui Huang, Xiao-Ying Li, Song Gao, Qi-Peng Ma, Ting-Ting Gong, Qi-Jun Wu

“…Objective: To explore the association between plasma PFASs and high-grade serous ovarian cancer (HGSOC) overall survival (OS) in the population who did not smoke. Methods: We conducted a nested case-control study within the Ovarian Cancer Follow-Up Study, matching 159 dead patients and 159 survival ones based on body mass index, sample date, and age at diagnosis. …”
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Determinants of continuation on HIV pre-exposure propylaxis among female sex workers at a referral hospital in Uganda: a mixed methods study using COM-B model by Samuel Kawuma, Rodgers Katwesigye, Happy Walusaga, Praise Akatukunda, Joan Nangendo, Charles Kabugo, Moses R. Kamya, Fred C. Semitala

“…This study evaluated PrEP continuation among FSWs and explored potential determinants of PrEP adherence within a public referral hospital in urban Uganda. Methods We conducted an explanatory sequential mixed method study at Kiruddu National referral hospital in Uganda. …”
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Genetic profiling of extended-spectrum β-Lactamase and carbapenemase-producing Escherichia coli O157:H7 from clinical samples among diarrheal patients in Shashemene, Ethiopia by Shimelis Teshome Ayalneh, Biruk Yeshitela Beshah, Yeonji Jeon, Ashenafi Alemu Wami, Seifegebriel Teshome, Solomon Gebreselassie, Se Eun Park, Mekonnen Teferi, Woldaregay Erku Abegaz

“…Additionally, screening for the production of ESBL (combined disk method) and carbapenemase (modified carbapenem inactivation method) was conducted. Isolates that tested positive for ESBL and carbapenemase production were further analyzed, targeting five genes (bla NDM, bla KPC, bla CTX−M, bla TEM, and bla SHV) associated with ESBL and carbapenemase production. …”
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Development and evaluation of optimized PCR and indirect ELISA for the detection of Morganella morganii in dairy cows by Meihua Zhang, Jiayi Li, Jianfeng Xue, Huiling Xu, Muzi Li, Yibo Xia, Changxi Qi, Pu Zhang, Yongxia Liu, Jianzhu Liu

“…Clinical evaluation was conducted using 771 fecal and nasal fluid samples collected from dairy farms in five regions. …”
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Identification of Adulterated Deer Blood Crystals in Traditional Chinese Medicine Based on MALDI-TOF MS Peptide Fingerprints Technique by Shen-xing WANG, Ling CAO, Qing HUANG, Cong-yu MA, Jian-bin PAN, Hao-dong ZHAO, Hai-wei SHI, Bin DI, Hong-yuan CHEN

“…Thereafter, a one-way controlled variable experiment was conducted to determine the optimal matrix for MALDI-TOF MS analysis. …”
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Comparison of ultrasonographic features between two types of hepatic echinococcosis and hepatoblastoma in children by Yi Tao, Hanqing Kong, Jiawu Li, Zhizhi Tan, Jun Wang, Yan Luo

“…This study aimed to compare and analyze the ultrasonographic and contrast-enhanced ultrasound (CEUS) characteristics of hepatic CE, AE, and hepatoblastoma in children, providing more imaging evidence for accurate clinical diagnosis.MethodsA retrospective analysis was conducted on preoperative data from children with pathologically confirmed hepatic echinococcosis in our hospital between 2012 and 2024. …”
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Prevalence and Determinants of Peripheral Neuropathy among Type 2 Adult Diabetes Patients Attending Jimma University Medical Center, Southwest Ethiopia, 2019, an Institutional-Base... by Daba Abdissa, Nigusse Hamba, Kumsa Kene, Deriba Abera Bedane, Guluma Etana, Dassalegn Muleta, Asfaw Gerbi

“…A hospital-based cross-sectional study was conducted at Jimma University Medical Center on 366 type 2diabetic patients. …”
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The institutionalisation of research and innovation in Swiss sports federations – Analysis of the status quo by Cornel Gübeli, Hippolyt Kempf, Solange Emmenegger, Christelle Ganné-Chedeville

“…Methods In order to answer the research question, a qualitative content analysis was conducted on publicly available documents (website, strategy documents and annual reports) of 30 Swiss sports federations. …”
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Therapeutic effectiveness of three commercial anthelmintics against strongylids in buffalo calves (Bubalus bubalis) by David Uzcátegui, Víctor Gutiérrez, María Rodríguez, Andrea González, Alfredo Sánchez

“…The effectiveness of the anthelmintics was estimated through faecal egg count (FEC) reduction percentage. The study was conducted in a buffalo system dedicated to milk and meat production with crossbreed animals (Murrah and Mediterranean breeds) in the South of Lake Maracaibo, Venezuela. …”
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Seasonal Mathematical Model of Salmonellosis Transmission and the Role of Contaminated Environments and Food Products by Mohammed H. Alharbi, Fawaz K. Alalhareth, Mahmoud A. Ibrahim

“…The model was able to conduct an analysis based on the estimated 0.606 value of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi mathvariant="script">R</mi><mn>0</mn></msub></semantics></math></inline-formula>, and this meant that the model was able to fit reasonably well for both the cumulative and the new individual case data, which in turn, suggests the disease is curable. …”
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