Editorial: Integrating machine learning with physics-based modeling of physiological systems by Jae H. Lee, Hao Gao, Michael Döllinger

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ImageDoubler: image-based doublet identification in single-cell sequencing by Kaiwen Deng, Xinya Xu, Manqi Zhou, Hongyang Li, Evan T. Keller, Gregory Shelley, Annie Lu, Lana Garmire, Yuanfang Guan

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Modeling dynamic changes in type 1 diabetes progression:Quantifying $\beta$-cell variation after the appearance ofislet-specific autoimmune responses by Patrick Nelson, Noah Smith, Stanca Ciupe, Weiping Zou, Gilbert S. Omenn, Massimo Pietropaolo

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Gene Regulatory Network of Human GM-CSF-Secreting T Helper Cells by Szabolcs Éliás, Angelika Schmidt, David Gomez-Cabrero, Jesper Tegnér

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Integrated cancer cell-specific single-cell RNA-seq datasets of immune checkpoint blockade-treated patients by Mahnoor N. Gondal, Marcin Cieslik, Arul M. Chinnaiyan

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diaTracer enables spectrum-centric analysis of diaPASEF proteomics data by Kai Li, Guo Ci Teo, Kevin L. Yang, Fengchao Yu, Alexey I. Nesvizhskii

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Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex by Maxine Bi, Xudong Wang, Jinan Wang, Jun Xu, Wenkai Sun, Victor Ayo Adediwura, Yinglong Miao, Yifan Cheng, Libin Ye

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Biomaterial-assisted organoid technology for disease modeling and drug screening by Yunyuan Shao, Juncheng Wang, Anqi Jin, Shicui Jiang, Lanjie Lei, Liangle Liu

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End-to-End Stroke Imaging Analysis Using Effective Connectivity and Interpretable Artificial Intelligence by Wojciech Ciezobka, Joan Falco-Roget, Cemal Koba, Alessandro Crimi

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RETRACTED ARTICLE: Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats by Jakob Steinfeldt, Benjamin Wild, Thore Buergel, Maik Pietzner, Julius Upmeier zu Belzen, Andre Vauvelle, Stefan Hegselmann, Spiros Denaxas, Harry Hemingway, Claudia Langenberg, Ulf Landmesser, John Deanfield, Roland Eils

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dotears: Scalable and consistent directed acyclic graph estimation using observational and interventional data by Albert Xue, Jingyou Rao, Sriram Sankararaman, Harold Pimentel

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Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy by Saber Imani, Xiaoyan Li, Keyi Chen, Mazaher Maghsoudloo, Parham Jabbarzadeh Kaboli, Mehrdad Hashemi, Mehrdad Hashemi, Saloomeh Khoushab, Saloomeh Khoushab, Xiaoping Li

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Enhanced hydrogel loading of quercetin-loaded hollow mesoporous cerium dioxide nanoparticles for skin flap survival by Xiangjun Liu, Yikun Ju, Pu Yang, Naisi Shen, Yunyuan Shao, Anqi Yang, Rui Wu, Lanjie Lei, Bairong Fang

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Tissue Regeneration in Dentistry by Kazuo Tanne, Petros Papagerakis, Gianpaolo Papaccio, Chiaki Kitamura, Kotaro Tanimoto

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Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons by Calum Harvey, Alicja Nowak, Sai Zhang, Tobias Moll, Annika K Weimer, Aina Mogas Barcons, Cleide Dos Santos Souza, Laura Ferraiuolo, Kevin Kenna, Noah Zaitlen, Christa Caggiano, Pamela J Shaw, Michael P Snyder, Jonathan Mill, Eilis Hannon, Johnathan Cooper-Knock

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Systematic collection, annotation, and pattern analysis of viral vaccines in the VIOLIN vaccine knowledgebase by Anthony Huffman, Mehul Gautam, Arya Gandhi, Priscilla Du, Lauren Austin, Kallan Roan, Jie Zheng, Yongqun He, Yongqun He

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AI education for clinicians by Tim Schubert, Tim Oosterlinck, Robert D. Stevens, Patrick H. Maxwell, Mihaela van der Schaar

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Leveraging AI to automate detection and quantification of extrachromosomal DNA to decode drug responses by Kohen Goble, Aarav Mehta, Damien Guilbaud, Jacob Fessler, Jingting Chen, William Nenad, William Nenad, Christina G. Ford, Oliver Cope, Darby Cheng, William Dennis, Nithya Gurumurthy, Yue Wang, Kriti Shukla, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk

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Editorial: Community series in towards precision medicine for immune-mediated disorders: advances in using big data and artificial intelligence to understand heterogeneity in infla... by Xu-jie Zhou, Xu-jie Zhou, Xu-jie Zhou, Xu-jie Zhou, Xu-jie Zhou, Yasmina Laouar, Lam C. Tsoi, Lam C. Tsoi, Lam C. Tsoi, Lam C. Tsoi

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Comparing self reported and physiological sleep quality from consumer devices to depression and neurocognitive performance by Samir Akre, Zachary D. Cohen, Amelia Welborn, Tomislav D. Zbozinek, Brunilda Balliu, Michelle G. Craske, Alex A. T. Bui

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