The interplay of sex and genotype in disease associations: a comprehensive network analysis in the UK Biobank by Vivek Sriram, Jakob Woerner, Yong-Yeol Ahn, Dokyoon Kim

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N-acetylated sugars in clownfish and damselfish skin mucus as messengers involved in chemical recognition by anemone host by Sara Heim, Tony Teav, Fabio Cortesi, Hector Gallart-Ayala, Julijana Ivanisevic, Nicolas Salamin

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Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ by Jinsai Shang, Douglas J Kojetin

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Development and characterization of orthotopic patient-derived xenograft models of peritoneal metastatic mucinous appendiceal adenocarcinoma by I. Ito, V.K. Pattalachinti, A.M.G. Yousef, S. Chowdhury, M.M. Fanaeian, E. Haque, B.B. Gunes, M. Yousef, E.R. Salle, M.A. Zeineddine, S. Ji, R. Li, W. Wang, B.A. Helmink, M.W. Taggart, M.G. White, K.F. Fournier, N.W. Fowlkes, J.P. Shen

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Protocol for reconstructing ancestral genomes from present-day samples by applying local ancestry inference by Xiaoxi Zhang, Baonan Wang, Jia Wen, Yang Gao, Yuwen Pan, Shuhua Xu

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The left amygdala is genetically sexually-dimorphic: multi-omics analysis of structural MRI volumes by Yuanyuan Gui, Geyu Zhou, Shuya Cui, Hongyu Li, Hui Lu, Hongyu Zhao

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Pochonia chlamydosporia synergistically supports systemic plant defense response in Phacelia tanacetifolia against Meloidogyne hapla by Jana Könker, Jana Könker, Sanja Zenker, Sanja Zenker, Anja Meierhenrich, Anja Meierhenrich, Anant Patel, Karl-Josef Dietz, Karl-Josef Dietz

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SNP rs9364554 Modulates Androgen Receptor Binding and Drug Response in Prostate Cancer by Yuqian Yan, Lei Shi, Tao Ma, Liguo Wang, Haojie Huang

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Modern transcriptome data processing algorithms: a review of methods and results of approbation by M. V. Sprindzuk, L. P. Titov, A. P. Konchits, L. V. Mozharovskaya

“…Analysis of bioinformatics data is an actual problem in modern computational biology and applied mathematics. With the development of biotechnology and tools for obtaining and processing such information, unresolved issues of the development and application of new algorithms and software have emerged.Authors propose practical algorithms and methods for processing transcriptomic data for efficient results of annotation, visualization and interpretation of bioinformatics data.…”
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Editorial: Novel pharmacological targets and strategies to treat neglected global diseases (NGDs): an LMIC perspective by Kishor M. Wasan, Kishor M. Wasan, Somia Iqtadar, Celestin Nzanzu Mudogo, Miguel Angel Chávez-Fumagalli

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Lingguizhugan Decoction Protects against High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress and Activating Cholesterol Secretion by Lili Yang, Weili Lin, Colleen A. Nugent, Shijun Hao, Haiyan Song, Tao Liu, Peiyong Zheng

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Human Population Admixture in Asia by Shuhua Xu

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Deep learning in microbiome analysis: a comprehensive review of neural network models by Piotr Przymus, Krzysztof Rykaczewski, Adrián Martín-Segura, Jaak Truu, Enrique Carrillo De Santa Pau, Mikhail Kolev, Mikhail Kolev, Irina Naskinova, Aleksandra Gruca, Alexia Sampri, Alexia Sampri, Marcus Frohme, Alina Nechyporenko, Alina Nechyporenko

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Development of a metabolome-based respiratory infection prognostic during COVID-19 arrival by John I. Robinson, Laura R. Marks, Andrew L. Hinton, Jane A. O'Halloran, Charles W. Goss, Peter J. Mucha, Jeffrey P. Henderson

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On the sensitivity of feature ranked lists for large-scale biological data by Danuta Gaweł, Krzysztof Fujarewicz

“…The problem of feature selection for large-scale genomic data, for example from DNA microarray experiments, is one of the fundamental and well-investigated problems in modern computational biology.From the computational point of view, a selected gene list should be characterized by good predictive power and should be understood and well explained from the biological point of view.Recently, another feature of selected gene lists is increasingly investigated, namely their stability which measures how the content and/or the gene order change when the data are perturbed.In this paper we propose a new approach to analysis of gene list stability, termed the sensitivity index, that does not require any data perturbationand allows the gene list that is most reliable in a biological sense to be chosen.…”
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Patients with Ankylosing Spondylitis and Low Disease Activity because of Anti-TNF-Alpha Therapy Have Higher TRAIL Levels Than Controls: A Potential Compensatory Effect by Fernanda Genre, Raquel López-Mejías, Javier Rueda-Gotor, José A. Miranda-Filloy, Begoña Ubilla, Beatriz Carnero-López, Natalia Palmou-Fontana, Inés Gómez-Acebo, Ricardo Blanco, Trinitario Pina, Rodrigo Ochoa, Carlos González-Juanatey, Javier Llorca, Miguel A. González-Gay

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Inhibition of Glutamate‐to‐Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells by Tao Yu, Kevin Van der Jeught, Haiqi Zhu, Zhuolong Zhou, Samantha Sharma, Sheng Liu, Haniyeh Eyvani, Ka Man So, Naresh Singh, Jia Wang, George E. Sandusky, Yunlong Liu, Mateusz Opyrchal, Sha Cao, Jun Wan, Chi Zhang, Xinna Zhang

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Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia by Sabrina Grundtner, Julia R. Sondermann, Feng Xian, Daniel Malzl, Daniel Segelcke, Esther M. Pogatzki-Zahn, Jörg Menche, David Gómez-Varela, Manuela Schmidt

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Comparative Inference of Duplicated Genes Produced by Polyploidization in Soybean Genome by Yanmei Yang, Jinpeng Wang, Jianyong Di

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Two long-term, risk-free treatments for oral cancer: Sarcodictyin and Elutherobin by Dhanraj Ganapathy, Annathai Pitchai, Namasivayam Subhapradha, Pasiyappazham Ramasamy

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