Health loss and economic burden of asthma in China: a qualitative review based on existing literature by Peng Zhang, Jiaxin Xu, Baichuan Xu, Yiyin Zhang, Yang Xie

“…Economic burden studies reported annual direct costs from $348 to $1187 per capita, indirect costs from $7 to $1195, and hospitalization costs from $177 to $1547, influenced by frequency and severity of acute exacerbation, comorbidities, and treatment adherence. Quality assessment revealed moderate overall quality, with gaps in sensitivity analyses and cost data transparency. …”
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Impact of vaccination against SARS-CoV-2 on mortality risk, ICU admission rate, and hospitalization length in hospitalized COVID-19 patients: a cross-sectional study by Behnam Maleki, Amir M. Sadeghian, Mitra Ranjbar

“…Older age independently predicted higher mortality (OR: 1.062, 95%CI: 1.030–1.095), ICU admission (OR: 1.047, 95%CI: 1.027–1.068), and longer hospital stays (estimate: 0.027, 95%CI: 0.012–0.043). Multiple comorbidities were associated with higher mortality and longer hospitalization (OR: 1.794, 95%CI: 1.244–2.587; estimate: 0.395, 95%CI: 0.142–0.648). …”
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Tracheostomies for respiratory failure are associated with a high inpatient mortality: a potential trigger to reconsider goals of care by Mackenzie Cook, Cameron Colbert, Aaron D Streblow, Scott P Sherry, Konrad Dobbertin

“…In this model, no single comorbid condition or length of stay (LOS) variable was predictive of death before discharge. …”
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Endovascular versus Surgical Lower Extremity Revascularization among Patients with Chronic Kidney Disease by Qingzheng Chen, Jialin Han, Gomathy Parvathinathan, Elsie Ross, Margaret R. Stedman, Tara I. Chang

“…Multiple factors must be considered when counseling patients with CKD, who have a high burden of comorbid conditions. Clinical trials should include more patients with kidney disease, who are often otherwise excluded from participation, to better understand the most effective treatment strategies for this vulnerable patient population.…”
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Systematic review of spontaneous reports of myocarditis and pericarditis in transplant recipients and immunocompromised patients following COVID-19 mRNA vaccination by Saad Shakir, Samantha Lane, Alison Yeomans

“…Objectives To determine whether spontaneous reporting rates of myocarditis and pericarditis differed in immunocompromised patients compared with the whole population overall, and in terms of demographics, vaccine dose and time-to-onset.Design Systematic review of spontaneously reported data from the European Union/European Economic Area (EU/EEA), the USA and the UK.Data sources EudraVigilance (EU/EEA), Vaccine Adverse Event Reporting System (VAERS; USA) and the Medicines and Healthcare products Regulatory Agency (UK) spontaneous reporting databases were searched from date of vaccine launch to 1 December 2021.Eligibility criteria Publicly available spontaneous reporting data for ‘myocarditis’ and ‘pericarditis’ from EU/EEA and USA following COVID-19 messenger RNA vaccines. Reports with comorbidities or concurrent medication indicative of transplantation, HIV infection or cancer (‘immunocompromised’ population) were compared with each overall database population.Data extraction and synthesis Two researchers extracted data. …”
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Predicting Discharge Location among Low-Energy Hip Fracture Patients Using the Score for Trauma Triage in the Geriatric and Middle-Aged (STTGMA) by Sanjit R. Konda, Hesham Saleh, Ariana Lott, Kenneth A. Egol

“…On initial evaluation in the Emergency Department, each patient’s age, comorbidities, injury severity, and functional status were utilized to calculate a STTGMA score. …”
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Comparison of 3 Aging Metrics in Dual Declines to Capture All-Cause Dementia and Mortality Risk: Cohort Study by Anying Bai, Shan He, Yu Jiang, Weihao Xu, Zhanyi Lin

“…Cox proportional hazards regression analysis was employed to evaluate the effects of MCR, PCDS, and CF on incident all-cause dementia and mortality, controlling for socioeconomic and lifestyle factors, as well as medical comorbidities. Discrimination analysis was conducted to assess and compare the predictive accuracy of the 3 aging metrics. …”
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Real-world treatment patterns and survival outcomes in men with metastatic castration-resistant prostate cancer in Finland: a national, population-based cohort study by Antti Rannikko, Olivia Hölsä, Trude Ågesen, Mattias Ekman, Riikka Mattila

“…Those who received no life-prolonging treatment(s) (28% overall) were older with more comorbidities than treated patients. After 2018, the proportion of patients who received life-prolonging treatments increased from 61% to 80%. …”
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The safety and efficacy of neutral electrolyzed water solution for wound irrigation: post-market clinical follow-up study by Veronika Valdová, Vladimíra Štěpánová, Lenka Lapčíková

“…The most common diagnoses were venous leg ulcer, pressure ulcer, diabetic foot ulcer, and traumatic wound. The most common comorbidities and risk factors were obesity, diabetes mellitus, and peripheral artery disease. …”
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PROMISE: Prognostic Radiomic Outcome Measurement in Acute Subdural Hematoma Evacuation Post-Craniotomy by Alexandru Guranda, Antonia Richter, Johannes Wach, Erdem Güresir, Martin Vychopen

“…Clinical parameters, including SOFA score, APACHE score, pupillary response, comorbidities, age, anticoagulation status, and preoperative haematocrit and haemoglobin levels, were also evaluated. …”
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Temporal changes in prevalence and severity of pulmonary hypertension, and relationship to outcomes in coarctation of aorta by Ahmed Younis, Yogesh N.V. Reddy, William R. Miranda, Ahmed T. Abdelhalim, Barry A. Borlaug, Heidi M. Connolly, Alexander C. Egbe

“…Of 392 patients, 50 (13 %) died, and Δ RVSP was associated with mortality (adjusted hazard ratio 1.19 [1.08–1.31] per 5 mmHg increase, p = 0.006) after adjustment for baseline RVSP, demographic indices, comorbidities, and echocardiographic indices. Conclusions: These findings underscore the clinical importance of pH in COA and supports the need for new strategies for prevention and treatment of LA and LV dysfunction, which should in turn, slow the pace of pH progression in this population. …”
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Association between socioeconomic status and patient-reported outcome at 1 year after shoulder arthroplasty for osteoarthritis or cuff-tear arthropathy: a nationwide cohort study o... by Marie L Jensen, Epaminondas M Valsamis, Alexander S Madrid, Bo S Olsen, Jeppe V Rasmussen

“…Univariable and multivariable linear regression was used to identify the association between socioeconomic factors and the WOOS index at 1 year following primary shoulder arthroplasty adjusted for age, sex, underlying diagnosis, implant design, and comorbidities. We examined socioeconomic factors including employment status, marital status, education, and income. …”
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Etiology of Emergency Visit and In-Hospital Outcomes of Patients with COPD by Xueyang Zhang, Qingtao Zhou, Shengfeng Wang, Qingbian Ma, Yongchang Sun

“…Multivariate logistic analysis showed that age, atrial fibrillation, NT-pro BNP ≥300 pg/ml, and blood pH <7.3 were independent risk factors for ICU admission. Age, comorbid malignancy, NT-pro BNP ≥1800 pg/ml, and pneumonia on CT scan were independent risk factors for hospital mortality in patients with AECOPD. …”
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Deep Learning and Radiomics in Triple-Negative Breast Cancer: Predicting Long-Term Prognosis and Clinical Outcomes by Cheng C, Wang Y, Zhao J, Wu D, Li H, Zhao H

“…Among these, biomarker detection and pathological assessments are invasive, time-intensive procedures that may be difficult for patients with severe comorbidities and high complication risks. Thus, there is an urgent need for new, supportive tools in TNBC diagnosis and treatment. …”
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Prevalence of Lp(a) in a real-world Portuguese cohort: implications for cardiovascular risk assessment by Miguel Saraiva, Jonatas Garcez, Beatriz Tavares da Silva, Inês Poças Ferreira, José Carlos Oliveira, Isabel Palma

“…Demographic and anthropometric data, laboratory values, relevant comorbidities and lipid-lowering medication were collected. …”
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Multimodal smoking cessation treatment combining repetitive transcranial magnetic stimulation, cognitive behavioral therapy, and nicotine replacement in veterans with posttraumatic... by Jonathan R Young, Carri S Polick, Andrew M Michael, Moritz Dannhauer, Jeffrey T Galla, Mariah K Evans, Addison Troutman, Angela C Kirby, Michelle F Dennis, Claire W Papanikolas, Zhi-De Deng, Scott D Moore, Eric A Dedert, Merideth A Addicott, Lawrence G Appelbaum, Jean C Beckham

“…Fifty eligible veterans with comorbid TUD and PTSD will be randomly assigned to active-iTBS + cognitive behavioral therapy (CBT) + nicotine replacement therapy (NRT) (n = 25) or sham-iTBS + CBT + NRT (n = 25). …”
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Laparoscopic and Endoscopic cooperative surgery as Rescue-treatment for Advanced gastric Cancer in patients Unfit for Surgery (LE-RACUS): protocol for a feasibility study by Henrik Maltzman, Masami Omae, Fredrik Klevebro, Francisco Baldaque-Silva, Ioannis Rouvelas

“…Some patients cannot tolerate such treatment because of old age or comorbidities. In this study, we want to test the feasibility of Laparoscopic and Endoscopic Cooperative Surgery (LECS) as a less invasive treatment option. …”
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The Efficiency of Anterior Repositioning Splints in the Management of Pain Related to Temporomandibular Joint Disc Displacement with Reduction by Malgorzata Pihut, Malgorzata Gorecka, Piotr Ceranowicz, Mieszko Wieckiewicz

“…The research material consisted of 112 patients, aged 24 to 45 years, of both genders, who reported for treatment at the Consulting Room of Temporomandibular Joint Dysfunctions at the Jagiellonian University in Cracow between 2014 and 2016 due to pain in the area of the temporomandibular joint(s) and noise(s) of temporomandibular joint(s) present during jaw movements with comorbid contracture of masticatory muscles. Subjects were examined according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) protocol and, after diagnosis of painful disc displacement with reduction and masticatory muscle contracture, they were assigned randomly to either the study or control groups (56 patients in each). …”
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Comparison of the efficacy and safety of bupropion versus aripiprazole augmentation in adults with treatment-resistant depression: a nationwide cohort study in South Korea by Dong Yun Lee, Rae Woong Park, Soo Min Jeon

“… Abstract Background Treatment-resistant depression (TRD) affects 10–30% of patients with major depressive disorder, leading to increased comorbidities, higher mortality, and significant economic and social burdens. …”
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Access to robot-assisted total knee arthroplasty varies significantly by race/ethnicity by Jessica Schmerler, Victoria E. Bergstein, Whitney Kagabo, Harpal S. Khanuja, Julius K. Oni, Vishal Hegde

“…Multivariable logistic regressions, controlling for demographics and comorbidities significantly different on univariate analysis, were constructed to determine whether race/ethnicity was associated with likelihood of undergoing RA-TKA relative to conventional TKA. …”
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